CO5570674A2 - Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos - Google Patents
Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicosInfo
- Publication number
- CO5570674A2 CO5570674A2 CO04034582A CO04034582A CO5570674A2 CO 5570674 A2 CO5570674 A2 CO 5570674A2 CO 04034582 A CO04034582 A CO 04034582A CO 04034582 A CO04034582 A CO 04034582A CO 5570674 A2 CO5570674 A2 CO 5570674A2
- Authority
- CO
- Colombia
- Prior art keywords
- hidroxifenil
- pirrolidone
- alcoxi
- pde
- inhibitors
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract
1.- Un compuesto de Fórmula I: donde X es O;R1 es alquilo con entre 1 y 8 átomos de carbono donde optativamente uno o más grupos -CH2CH2- se reemplazan en cada caso con grupos -CH=CH- o - C=C-,alquilo con entre 1 y 8 átomos de carbono que está sustituido una o más veces por halógeno, oxo o combinaciones de los mismos donde optativamente uno o más grupos -CH2CH2- se reemplazan en cada caso con grupos -CH=CH- o -C=C-,cicloalquilo con entre 3 y 8 átomos de carbono, que no está sustituido o está sustituido una o más veces por halógeno, oxo, alquilo con entre 1 y 4 átomos de carbono o combinaciones de los mismos, un grupo heterocíclico, que es saturado, parcialmente saturado o totalmente insaturado, con entre 5 y 10 átomos en el anillo en donde al menos un átomo del anillo es un átomo de N, O o S que no está sustituido o está sustituido una o más veces por halógeno, arilo, alquilo, alcoxi, ciano, trifluorometilo, nitro, oxo, amino, alquilamino, dialquilamino, o combinaciones de los mismos,arilo con entre 6 y 14 átomos de carbono, que no está sustituido o está sustituido una o más veces por halógeno, CF3, OCF3, alquilo, hidroxi, alcoxi, nitro, metilendioxi, etilendioxi, amino, alquilamino, dialquilamino, hidroxialquilo, hidroxialcoxi, carboxi, ciano, acilo, alcoxicarbonilo, alquiltio, alquilsulfinilo, alquilsulfonilo, fenoxi, acilamido y aciloxi o combinaciones de los mismos, arilalquilo con entre 8 y 16 átomos de carbono, que está insustituido o sustituido una o más veces por halógeno, CF3, OCF3, alquilo, hidroxi, alcoxi, nitro, metilendioxi, etilendioxi, amino, alquilamino, dialquilamino, hidroxialquilo, hidroxialcoxi, carboxi, ciano, acilo, alcoxicarbonilo, alquiltio, alquilsulfinilo, alquilsulfonilo, fenoxi, acilamido y aciloxi o combinaciones de los mismos,un grupo carbocíclico parcialmente insaturado con entre 5 y 14 átomos de carbono, que no está sustituido o está sustituido una o más veces por halógeno, alquilo, alcoxi, nitro, ciano, oxo, o combinaciones de los mismos,arilalquenilo con entre 8 y 16 átomos de carbono, donde la porción alquenilo tiene hasta 5 átomos de carbono, ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US32931401P | 2001-10-16 | 2001-10-16 |
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CO5570674A2 true CO5570674A2 (es) | 2005-10-31 |
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CO04034582A CO5570674A2 (es) | 2001-10-16 | 2004-04-15 | Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos |
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US (3) | US7235579B2 (es) |
EP (1) | EP1435944B1 (es) |
JP (2) | JP4484515B2 (es) |
KR (2) | KR100951218B1 (es) |
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AT (1) | ATE444065T1 (es) |
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HR (1) | HRP20040409A2 (es) |
IL (1) | IL161317A0 (es) |
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US9931318B2 (en) | 2003-04-08 | 2018-04-03 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
US8153646B2 (en) | 2000-08-10 | 2012-04-10 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
WO2002054066A2 (en) * | 2000-12-14 | 2002-07-11 | The Burnham Institute | Non-apoptotic forms of cell death and methods of modulation |
RU2340600C2 (ru) | 2001-10-16 | 2008-12-10 | Мемори Фармасьютиклз Корпорейшн | Производные 4-(4-алкокси-3-гидроксифенил)-2-пирролидона в качестве ингибиторов pde-4 для лечения неврологических синдромов |
US20030157053A1 (en) * | 2002-02-19 | 2003-08-21 | Sabina Sperandio | Modulators of paraptosis and related methods |
US7495016B2 (en) | 2002-10-21 | 2009-02-24 | Irm Llc | Pyrrolidones with anti-HIV activity |
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
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- 2002-10-16 ES ES02801710T patent/ES2334650T3/es not_active Expired - Lifetime
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- 2002-10-16 DE DE60233884T patent/DE60233884D1/de not_active Expired - Lifetime
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- 2002-10-16 CN CNA028251024A patent/CN1604776A/zh active Pending
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- 2002-10-16 EP EP02801710A patent/EP1435944B1/en not_active Expired - Lifetime
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- 2002-10-16 WO PCT/US2002/032834 patent/WO2003032981A1/en active Application Filing
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CN1604776A (zh) | 2005-04-06 |
AU2002335015B2 (en) | 2006-11-02 |
HRP20040409A2 (en) | 2005-06-30 |
JP2005508961A (ja) | 2005-04-07 |
EP1435944B1 (en) | 2009-09-30 |
KR100951218B1 (ko) | 2010-04-05 |
NO20042024L (no) | 2004-05-14 |
AU2002335015B8 (en) | 2006-11-30 |
JP4484515B2 (ja) | 2010-06-16 |
US7235579B2 (en) | 2007-06-26 |
ES2334650T3 (es) | 2010-03-15 |
CA2463469A1 (en) | 2003-04-24 |
NZ532288A (en) | 2005-12-23 |
BR0213660A (pt) | 2004-08-24 |
KR20090080573A (ko) | 2009-07-24 |
ZA200402856B (en) | 2005-01-25 |
US20030139406A1 (en) | 2003-07-24 |
KR20050037404A (ko) | 2005-04-21 |
DE60233884D1 (de) | 2009-11-12 |
RU2004115333A (ru) | 2005-10-27 |
ATE444065T1 (de) | 2009-10-15 |
US20050272803A1 (en) | 2005-12-08 |
EP1435944A1 (en) | 2004-07-14 |
RU2340600C2 (ru) | 2008-12-10 |
IL161317A0 (en) | 2004-09-27 |
RU2008123376A (ru) | 2009-12-27 |
MXPA04003516A (es) | 2004-07-23 |
US20090176799A1 (en) | 2009-07-09 |
WO2003032981A1 (en) | 2003-04-24 |
JP2009286797A (ja) | 2009-12-10 |
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