MXPA04003516A - Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos. - Google Patents

Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos.

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Publication number
MXPA04003516A
MXPA04003516A MXPA04003516A MXPA04003516A MXPA04003516A MX PA04003516 A MXPA04003516 A MX PA04003516A MX PA04003516 A MXPA04003516 A MX PA04003516A MX PA04003516 A MXPA04003516 A MX PA04003516A MX PA04003516 A MXPA04003516 A MX PA04003516A
Authority
MX
Mexico
Prior art keywords
pde
hydroxyphenyl
inhibitors
alkoxy
treatment
Prior art date
Application number
MXPA04003516A
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English (en)
Inventor
Tehim Ashok
Original Assignee
Memory Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp filed Critical Memory Pharm Corp
Publication of MXPA04003516A publication Critical patent/MXPA04003516A/es

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Abstract

La presente invencion se refiere a la inhibicion selectiva de PDE4 que se logra mediante los compuestos de 4-(fenil substituido)-2-pirrolidona. Los compuestos tienen inhibicion mejorada de PDE4 segun se compara a los compuestos similares al rolipram y muestran selectividad con relacion a la inhibicion de otras clases de PDEs. Los compuestos de la presente invencion son de la formula (I), en donde R1, R2 y R3 son como se definen en la presente.
MXPA04003516A 2001-10-16 2002-10-16 Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos. MXPA04003516A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32931401P 2001-10-16 2001-10-16
PCT/US2002/032834 WO2003032981A1 (en) 2001-10-16 2002-10-16 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes

Publications (1)

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MXPA04003516A true MXPA04003516A (es) 2004-07-23

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MXPA04003516A MXPA04003516A (es) 2001-10-16 2002-10-16 Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos.

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US (3) US7235579B2 (es)
EP (1) EP1435944B1 (es)
JP (2) JP4484515B2 (es)
KR (2) KR100951218B1 (es)
CN (1) CN1604776A (es)
AT (1) ATE444065T1 (es)
AU (1) AU2002335015B8 (es)
BR (1) BR0213660A (es)
CA (1) CA2463469A1 (es)
CO (1) CO5570674A2 (es)
DE (1) DE60233884D1 (es)
ES (1) ES2334650T3 (es)
HR (1) HRP20040409A2 (es)
IL (1) IL161317A0 (es)
MX (1) MXPA04003516A (es)
NO (1) NO20042024L (es)
NZ (1) NZ532288A (es)
RU (2) RU2340600C2 (es)
WO (1) WO2003032981A1 (es)
ZA (1) ZA200402856B (es)

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