CO5150161A1 - Procedimiento para encapsular masas de relleno de saquinavir sensibles al cizallamiento y capsulas obtenidas mediante el mismo - Google Patents
Procedimiento para encapsular masas de relleno de saquinavir sensibles al cizallamiento y capsulas obtenidas mediante el mismoInfo
- Publication number
- CO5150161A1 CO5150161A1 CO99071570A CO99071570A CO5150161A1 CO 5150161 A1 CO5150161 A1 CO 5150161A1 CO 99071570 A CO99071570 A CO 99071570A CO 99071570 A CO99071570 A CO 99071570A CO 5150161 A1 CO5150161 A1 CO 5150161A1
- Authority
- CO
- Colombia
- Prior art keywords
- filling
- encapsulating
- saquinavir
- shearing
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002775 capsule Substances 0.000 title abstract 3
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 title 1
- 229960001852 saquinavir Drugs 0.000 title 1
- 238000002347 injection Methods 0.000 abstract 3
- 239000007924 injection Substances 0.000 abstract 3
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000003507 refrigerant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Confectionery (AREA)
- Basic Packing Technique (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un procedimiento para el encapsulado de una masa de relleno sensible al cizallamiento, dentro de una cápsula, caracterizado porque dicha masa de relleno se calienta y seguidamente se enfría, inmediatamente antes del encapsulado.El procedimiento de acuerdo con la reivindicación 2, en el que la masa de relleno se calienta a una temperatura entre 0 y 20°C por encima de su punto de fusión, y seguidamente se enfría a una temperatura entre 35 y 20°C.El procedimiento de acuerdo con una cualquiera de las reivindicaciones precedentes, comprendiendo los siguientes pasos:a) introducción de la masa de relleno en un depósito de alimentación (3);b) conducción de la masa de relleno desde el tanque de alimentación (3) a una bomba dosificadora (4);c) dosificación de la masa de relleno a través de un calentador (5) y un refrigerante (6) a una cuña de inyección (7); d) inyección de la masa de relleno calentada y seguidamente enfriada del paso c), de la cuña de inyección (7) a las cápsulas.<EMI FILE="99071570_1" ID="1" IMF=JPEG >
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98121831 | 1998-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5150161A1 true CO5150161A1 (es) | 2002-04-29 |
Family
ID=8232985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99071570A CO5150161A1 (es) | 1998-11-17 | 1999-11-12 | Procedimiento para encapsular masas de relleno de saquinavir sensibles al cizallamiento y capsulas obtenidas mediante el mismo |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6352717B2 (es) |
| EP (1) | EP1131037B1 (es) |
| JP (1) | JP3623166B2 (es) |
| KR (1) | KR100446118B1 (es) |
| CN (1) | CN1172649C (es) |
| AR (1) | AR020013A1 (es) |
| AT (1) | ATE274895T1 (es) |
| AU (1) | AU751446B2 (es) |
| BR (1) | BR9915444B1 (es) |
| CA (1) | CA2350943C (es) |
| CO (1) | CO5150161A1 (es) |
| CZ (1) | CZ299800B6 (es) |
| DE (1) | DE69919889T2 (es) |
| DK (1) | DK1131037T3 (es) |
| ES (1) | ES2228141T3 (es) |
| HK (1) | HK1042227B (es) |
| HR (1) | HRP20010341A2 (es) |
| HU (1) | HU226498B1 (es) |
| ID (1) | ID30128A (es) |
| IL (2) | IL143119A0 (es) |
| MA (1) | MA26761A1 (es) |
| MY (1) | MY120081A (es) |
| NO (1) | NO20012384L (es) |
| NZ (1) | NZ511663A (es) |
| PE (1) | PE20001240A1 (es) |
| PL (1) | PL190382B1 (es) |
| PT (1) | PT1131037E (es) |
| RU (1) | RU2219911C2 (es) |
| SI (1) | SI1131037T1 (es) |
| TR (1) | TR200101358T2 (es) |
| TW (1) | TWI221767B (es) |
| UY (1) | UY25803A1 (es) |
| WO (1) | WO2000028942A1 (es) |
| YU (1) | YU33001A (es) |
| ZA (1) | ZA200103891B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003516345A (ja) * | 1999-12-09 | 2003-05-13 | アルザ・コーポレーション | 抗ウイルス剤 |
| GB0027954D0 (en) * | 2000-11-16 | 2001-01-03 | Mw Encap Ltd | Liquid filled capsules |
| EP1216680B1 (de) * | 2000-12-20 | 2006-03-15 | Swiss Caps Rechte und Lizenzen AG | Rotary-Die-Verfahren und Füllkeil zum Herstellen von Kapseln, insbesondere Weichkapseln |
| US7247010B2 (en) | 2003-10-01 | 2007-07-24 | Technophar Equipment & Service Limited | Servo control for capsule making machine |
| GB0712972D0 (en) * | 2007-07-04 | 2007-08-15 | Glaxosmithkline Consumer Healt | Formulation |
| EP2042180A1 (de) * | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Phytosterol-haltige Präparate |
| AR075244A1 (es) * | 2009-02-04 | 2011-03-16 | Kalamazoo Holdings Inc | Composiciones y metodos para mejorar la estabilidad de alimentos, bebidas, suplementos nutricionales y cosmeticos |
| CA2760744C (en) | 2009-03-26 | 2017-05-30 | Swiss Caps Rechte Und Lizenzen Ag | Method and device for producing soft capsules |
| WO2013031972A1 (ja) * | 2011-09-02 | 2013-03-07 | 株式会社三協 | カプセル製造装置における内包液の供給用ポンプユニット 並びにこのポンプユニットを適用したカプセル剤の製造装置並びに製造方法 並びにこれによって製造されるカプセル剤 |
| US10568811B2 (en) * | 2016-02-22 | 2020-02-25 | R.P. Scherer Technologies, Llc | Multiple-fluid injection pump |
| CN109645530A (zh) * | 2019-01-09 | 2019-04-19 | 安徽亳药千草国药股份有限公司 | 一种用于灌注富硒灵芝孢子油的软胶囊机 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2692404A (en) * | 1949-12-07 | 1954-10-26 | Gennell Capsulations Inc | Method and apparatus for forming capsules |
| JPS56163656A (en) * | 1980-05-22 | 1981-12-16 | Nippon Elanco | Device for filling hard gelatin capsule with viscous substance |
| US4656066A (en) * | 1982-12-20 | 1987-04-07 | Warner-Lambert Company | Apparatus and method for sealing capsules |
| JPS59131355A (ja) * | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
| US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
| DE8536337U1 (de) * | 1985-12-23 | 1986-02-13 | R.P. Scherer GmbH, 6930 Eberbach | Füllkeil für eine Maschine zum Herstellen von Gelatinekapseln |
| FI80828C (fi) * | 1988-04-08 | 1990-08-10 | Piscina Oy | Anordning foer vaermning av en vattenbaedd. |
| IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| EP0649651B1 (en) * | 1993-09-28 | 2000-12-13 | R.P. Scherer GmbH | Soft gelatin capsule manufacture |
| GB9403449D0 (en) * | 1994-02-23 | 1994-04-13 | Wellcome Found | Therapeutic benzonitriles |
| KR960016371U (ko) * | 1994-11-11 | 1996-06-17 | 김덕흥 | 소프트젤라틴 캡슐제조기의 젤라틴시트 냉각장치 |
-
1999
- 1999-11-11 ES ES99960972T patent/ES2228141T3/es not_active Expired - Lifetime
- 1999-11-11 JP JP2000581990A patent/JP3623166B2/ja not_active Expired - Fee Related
- 1999-11-11 CN CNB998133957A patent/CN1172649C/zh not_active Expired - Fee Related
- 1999-11-11 WO PCT/EP1999/008684 patent/WO2000028942A1/en active IP Right Grant
- 1999-11-11 KR KR10-2001-7006100A patent/KR100446118B1/ko not_active IP Right Cessation
- 1999-11-11 NZ NZ511663A patent/NZ511663A/en unknown
- 1999-11-11 RU RU2001116598/15A patent/RU2219911C2/ru not_active IP Right Cessation
- 1999-11-11 EP EP99960972A patent/EP1131037B1/en not_active Expired - Lifetime
- 1999-11-11 IL IL14311999A patent/IL143119A0/xx active IP Right Grant
- 1999-11-11 TR TR2001/01358T patent/TR200101358T2/xx unknown
- 1999-11-11 YU YU33001A patent/YU33001A/sh unknown
- 1999-11-11 ID IDW00200101061A patent/ID30128A/id unknown
- 1999-11-11 AT AT99960972T patent/ATE274895T1/de active
- 1999-11-11 DK DK99960972T patent/DK1131037T3/da active
- 1999-11-11 HU HU0104464A patent/HU226498B1/hu not_active IP Right Cessation
- 1999-11-11 SI SI9930658T patent/SI1131037T1/xx unknown
- 1999-11-11 AU AU17751/00A patent/AU751446B2/en not_active Ceased
- 1999-11-11 BR BRPI9915444-7B1A patent/BR9915444B1/pt not_active IP Right Cessation
- 1999-11-11 PT PT99960972T patent/PT1131037E/pt unknown
- 1999-11-11 CZ CZ20011644A patent/CZ299800B6/cs not_active IP Right Cessation
- 1999-11-11 CA CA002350943A patent/CA2350943C/en not_active Expired - Fee Related
- 1999-11-11 PL PL99348350A patent/PL190382B1/pl unknown
- 1999-11-11 DE DE69919889T patent/DE69919889T2/de not_active Expired - Lifetime
- 1999-11-12 CO CO99071570A patent/CO5150161A1/es unknown
- 1999-11-12 PE PE1999001152A patent/PE20001240A1/es not_active Application Discontinuation
- 1999-11-15 MY MYPI99004954A patent/MY120081A/en unknown
- 1999-11-15 AR ARP990105797A patent/AR020013A1/es active IP Right Grant
- 1999-11-16 US US09/440,731 patent/US6352717B2/en not_active Expired - Lifetime
- 1999-11-16 UY UY25803A patent/UY25803A1/es unknown
-
2000
- 2000-01-13 TW TW089100452A patent/TWI221767B/zh not_active IP Right Cessation
-
2001
- 2001-05-11 HR HR20010341A patent/HRP20010341A2/hr not_active Application Discontinuation
- 2001-05-14 IL IL143119A patent/IL143119A/en not_active IP Right Cessation
- 2001-05-14 MA MA26195A patent/MA26761A1/fr unknown
- 2001-05-14 ZA ZA200103891A patent/ZA200103891B/xx unknown
- 2001-05-15 NO NO20012384A patent/NO20012384L/no not_active Application Discontinuation
-
2002
- 2002-04-30 HK HK02103227.7A patent/HK1042227B/zh not_active IP Right Cessation
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