TR200101358T2 - Sıvı doldurulmuş kapsüllerin imalat süreci - Google Patents

Sıvı doldurulmuş kapsüllerin imalat süreci

Info

Publication number
TR200101358T2
TR200101358T2 TR2001/01358T TR200101358T TR200101358T2 TR 200101358 T2 TR200101358 T2 TR 200101358T2 TR 2001/01358 T TR2001/01358 T TR 2001/01358T TR 200101358 T TR200101358 T TR 200101358T TR 200101358 T2 TR200101358 T2 TR 200101358T2
Authority
TR
Turkey
Prior art keywords
capsules
present
manufacturing process
capsule
liquid filled
Prior art date
Application number
TR2001/01358T
Other languages
English (en)
Inventor
Alex Ranier
Gerhards J�Rden
Kraemer-Pittrof Ingeborg
Oeschger Richard
Rades Thomas
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101358T2 publication Critical patent/TR200101358T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Basic Packing Technique (AREA)
  • Confectionery (AREA)

Abstract

Mevcut bulus, shear duyarli bir dolgu kütlesinin bir kapsülün içine konulmasi için bir süreçle ilgilidir. Bu süreç, bahsedilen dolgu kütlesinin kapsül içine konulmadan hemen önce isitilip ardindan da sogutulmasi ile tanimlanir. Bulus, bahsedilen süreç ile temin edilebilen kapsüllerle de ilgilidir. Mevcut bulusa göre süreç, yüksek ve sabit çözgünlük oranlari gösteren kapsülleri de temin edebilir. Aktif etmenin kendisi hizlica çözünebilir oldugundan dolayi, içeri alinan aktif etmen miktari azaltilmistir. Böylece tibbi sürecin toplam maliyetleri de düsürülmüstür. Mevcut bulusa göre,süreç ile üretilen kapsüllerin yüksek homojenligi (ve bundan dolayi yüksek ve sabit çözünürlük orani), ortaya çikarilabilir bir biyolojik bulunabilirliligi ve içinde bulundurdugu aktif etmenin iyilestirici etkisini garantiler.
TR2001/01358T 1998-11-17 1999-11-11 Sıvı doldurulmuş kapsüllerin imalat süreci TR200101358T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98121831 1998-11-17

Publications (1)

Publication Number Publication Date
TR200101358T2 true TR200101358T2 (tr) 2001-12-21

Family

ID=8232985

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01358T TR200101358T2 (tr) 1998-11-17 1999-11-11 Sıvı doldurulmuş kapsüllerin imalat süreci

Country Status (35)

Country Link
US (1) US6352717B2 (tr)
EP (1) EP1131037B1 (tr)
JP (1) JP3623166B2 (tr)
KR (1) KR100446118B1 (tr)
CN (1) CN1172649C (tr)
AR (1) AR020013A1 (tr)
AT (1) ATE274895T1 (tr)
AU (1) AU751446B2 (tr)
BR (1) BR9915444B1 (tr)
CA (1) CA2350943C (tr)
CO (1) CO5150161A1 (tr)
CZ (1) CZ299800B6 (tr)
DE (1) DE69919889T2 (tr)
DK (1) DK1131037T3 (tr)
ES (1) ES2228141T3 (tr)
HK (1) HK1042227B (tr)
HR (1) HRP20010341A2 (tr)
HU (1) HU226498B1 (tr)
ID (1) ID30128A (tr)
IL (2) IL143119A0 (tr)
MA (1) MA26761A1 (tr)
MY (1) MY120081A (tr)
NO (1) NO20012384D0 (tr)
NZ (1) NZ511663A (tr)
PE (1) PE20001240A1 (tr)
PL (1) PL190382B1 (tr)
PT (1) PT1131037E (tr)
RU (1) RU2219911C2 (tr)
SI (1) SI1131037T1 (tr)
TR (1) TR200101358T2 (tr)
TW (1) TWI221767B (tr)
UY (1) UY25803A1 (tr)
WO (1) WO2000028942A1 (tr)
YU (1) YU33001A (tr)
ZA (1) ZA200103891B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041742A2 (en) * 1999-12-09 2001-06-14 Alza Corporation Antiviral medication
GB0027954D0 (en) * 2000-11-16 2001-01-03 Mw Encap Ltd Liquid filled capsules
ATE320237T1 (de) * 2000-12-20 2006-04-15 Swiss Caps Rechte & Lizenzen Rotary-die-verfahren und füllkeil zum herstellen von kapseln, insbesondere weichkapseln
US7247010B2 (en) * 2003-10-01 2007-07-24 Technophar Equipment & Service Limited Servo control for capsule making machine
GB0712972D0 (en) * 2007-07-04 2007-08-15 Glaxosmithkline Consumer Healt Formulation
EP2042180A1 (de) * 2007-09-28 2009-04-01 Swiss Caps Rechte und Lizenzen AG Phytosterol-haltige Präparate
AR075244A1 (es) * 2009-02-04 2011-03-16 Kalamazoo Holdings Inc Composiciones y metodos para mejorar la estabilidad de alimentos, bebidas, suplementos nutricionales y cosmeticos
US8727754B2 (en) 2009-03-26 2014-05-20 Swiss Caps Rechte Und Lizenzen Ag Method and device for producing soft capsules
JP6106592B2 (ja) * 2011-09-02 2017-04-05 株式会社三協 カプセル製造装置における内包液の供給用ポンプユニット 並びにこのポンプユニットを適用したカプセル剤の製造装置並びに製造方法 並びにこれによって製造されるカプセル剤
US10568811B2 (en) * 2016-02-22 2020-02-25 R.P. Scherer Technologies, Llc Multiple-fluid injection pump
CN109645530A (zh) * 2019-01-09 2019-04-19 安徽亳药千草国药股份有限公司 一种用于灌注富硒灵芝孢子油的软胶囊机

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Publication number Priority date Publication date Assignee Title
US2692404A (en) * 1949-12-07 1954-10-26 Gennell Capsulations Inc Method and apparatus for forming capsules
JPS56163656A (en) * 1980-05-22 1981-12-16 Nippon Elanco Device for filling hard gelatin capsule with viscous substance
US4656066A (en) * 1982-12-20 1987-04-07 Warner-Lambert Company Apparatus and method for sealing capsules
JPS59131355A (ja) * 1983-01-17 1984-07-28 森下仁丹株式会社 多重軟カプセルの製法
US4609403A (en) * 1984-03-12 1986-09-02 Warner-Lambert Company Foam soft gelatin capsules and their method of manufacture
DE8536337U1 (de) * 1985-12-23 1986-02-13 R.P. Scherer GmbH, 6930 Eberbach Füllkeil für eine Maschine zum Herstellen von Gelatinekapseln
FI80828C (fi) * 1988-04-08 1990-08-10 Piscina Oy Anordning foer vaermning av en vattenbaedd.
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
DK1033128T4 (da) * 1993-09-28 2012-03-19 Scherer Gmbh R P Blød gelatinekapselfremstilling
GB9403449D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
KR960016371U (ko) * 1994-11-11 1996-06-17 김덕흥 소프트젤라틴 캡슐제조기의 젤라틴시트 냉각장치

Also Published As

Publication number Publication date
EP1131037B1 (en) 2004-09-01
HUP0104464A2 (hu) 2002-03-28
ID30128A (id) 2001-11-08
YU33001A (sh) 2004-05-12
TWI221767B (en) 2004-10-11
DE69919889T2 (de) 2005-09-15
MA26761A1 (fr) 2004-12-20
SI1131037T1 (en) 2004-12-31
DE69919889D1 (de) 2004-10-07
KR100446118B1 (ko) 2004-08-30
NO20012384L (no) 2001-05-15
PE20001240A1 (es) 2000-11-14
HK1042227B (zh) 2005-03-18
IL143119A0 (en) 2002-04-21
MY120081A (en) 2005-08-30
AU1775100A (en) 2000-06-05
BR9915444B1 (pt) 2013-10-22
BR9915444A (pt) 2001-08-07
HRP20010341A2 (en) 2002-06-30
AU751446B2 (en) 2002-08-15
EP1131037A1 (en) 2001-09-12
PL190382B1 (pl) 2005-12-30
NZ511663A (en) 2003-08-29
CO5150161A1 (es) 2002-04-29
CN1326335A (zh) 2001-12-12
CZ299800B6 (cs) 2008-11-26
US20020006417A1 (en) 2002-01-17
IL143119A (en) 2007-05-15
NO20012384D0 (no) 2001-05-15
WO2000028942A1 (en) 2000-05-25
HK1042227A1 (en) 2002-08-09
HUP0104464A3 (en) 2006-06-28
AR020013A1 (es) 2002-03-27
JP3623166B2 (ja) 2005-02-23
CZ20011644A3 (cs) 2001-08-15
ZA200103891B (en) 2002-08-14
CA2350943A1 (en) 2000-05-25
CA2350943C (en) 2006-06-20
ES2228141T3 (es) 2005-04-01
RU2219911C2 (ru) 2003-12-27
UY25803A1 (es) 2000-08-21
DK1131037T3 (da) 2005-01-10
PL348350A1 (en) 2002-05-20
JP2002529200A (ja) 2002-09-10
US6352717B2 (en) 2002-03-05
KR20010075711A (ko) 2001-08-09
HU226498B1 (en) 2009-03-02
PT1131037E (pt) 2004-12-31
CN1172649C (zh) 2004-10-27
ATE274895T1 (de) 2004-09-15

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