CO4940488A1 - Derivados del 2-(purin-9-il) tetrahidrofuran-3,4-diol - Google Patents

Derivados del 2-(purin-9-il) tetrahidrofuran-3,4-diol

Info

Publication number
CO4940488A1
CO4940488A1 CO97074732A CO97074732A CO4940488A1 CO 4940488 A1 CO4940488 A1 CO 4940488A1 CO 97074732 A CO97074732 A CO 97074732A CO 97074732 A CO97074732 A CO 97074732A CO 4940488 A1 CO4940488 A1 CO 4940488A1
Authority
CO
Colombia
Prior art keywords
6alkyl
group
arylalkyl
formula
8alkyl
Prior art date
Application number
CO97074732A
Other languages
English (en)
Spanish (es)
Inventor
Brian Cox
Suzanne Elaine Keeling
David George Allen
Alison Judith Redgrave
David Barker
Hobbs Heather
Thomas Davis Roper
Joanna Victoria Geden
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9626852.9A external-priority patent/GB9626852D0/en
Priority claimed from GBGB9626845.3A external-priority patent/GB9626845D0/en
Priority claimed from GBGB9626846.1A external-priority patent/GB9626846D0/en
Priority claimed from GBGB9720536.3A external-priority patent/GB9720536D0/en
Priority claimed from GBGB9722730.0A external-priority patent/GB9722730D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO4940488A1 publication Critical patent/CO4940488A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CO97074732A 1996-12-24 1997-12-23 Derivados del 2-(purin-9-il) tetrahidrofuran-3,4-diol CO4940488A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9626852.9A GB9626852D0 (en) 1996-12-24 1996-12-24 Chemical compounds
GBGB9626845.3A GB9626845D0 (en) 1996-12-24 1996-12-24 Chemical compounds
GBGB9626846.1A GB9626846D0 (en) 1996-12-24 1996-12-24 Chemical compounds
GBGB9720536.3A GB9720536D0 (en) 1997-09-27 1997-09-27 Chemical compounds
GBGB9722730.0A GB9722730D0 (en) 1997-10-29 1997-10-29 Chemical compounds

Publications (1)

Publication Number Publication Date
CO4940488A1 true CO4940488A1 (es) 2000-07-24

Family

ID=27517393

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97074732A CO4940488A1 (es) 1996-12-24 1997-12-23 Derivados del 2-(purin-9-il) tetrahidrofuran-3,4-diol

Country Status (36)

Country Link
US (2) US6426337B1 (enExample)
EP (1) EP0948509B1 (enExample)
JP (1) JP4156035B2 (enExample)
KR (1) KR20000069682A (enExample)
CN (1) CN1246124A (enExample)
AP (1) AP1105A (enExample)
AR (1) AR011044A1 (enExample)
AT (1) ATE226212T1 (enExample)
AU (1) AU733684B2 (enExample)
BG (1) BG63310B1 (enExample)
BR (1) BR9714082A (enExample)
CA (1) CA2275271A1 (enExample)
CO (1) CO4940488A1 (enExample)
CZ (1) CZ230999A3 (enExample)
DE (1) DE69716468T2 (enExample)
DK (1) DK0948509T3 (enExample)
EA (1) EA001714B1 (enExample)
EE (1) EE04019B1 (enExample)
ES (1) ES2186015T3 (enExample)
GE (1) GEP20022656B (enExample)
HU (1) HUP0000673A3 (enExample)
ID (1) ID22271A (enExample)
IL (1) IL130547A0 (enExample)
IS (1) IS5089A (enExample)
NO (1) NO312840B1 (enExample)
NZ (1) NZ336332A (enExample)
OA (1) OA11071A (enExample)
PE (1) PE27499A1 (enExample)
PL (1) PL334218A1 (enExample)
PT (1) PT948509E (enExample)
SI (1) SI0948509T1 (enExample)
SK (1) SK86599A3 (enExample)
TR (1) TR199901905T2 (enExample)
TW (1) TW528755B (enExample)
WO (1) WO1998028319A1 (enExample)
YU (1) YU29099A (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
AR017457A1 (es) * 1998-02-14 2001-09-05 Glaxo Group Ltd Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias.
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
GB9813565D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
GB9813540D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
SK19542000A3 (sk) * 1998-06-23 2001-09-11 Glaxo Group Limited 2-(purin-9-yl)-tetrahydrofurn-3,4-diolov derivty, spsob ich vroby, farmaceutick prostriedok s ich obsahom, ich pouitie a medziprodukty
GB9930082D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
GB0104555D0 (en) * 2001-02-23 2001-04-11 Glaxo Group Ltd New Therapeutic method
WO2002072067A2 (en) * 2001-03-12 2002-09-19 Glaxo Group Limited Pharmaceutical aerosol formulation
JP2002338593A (ja) * 2001-05-22 2002-11-27 Ajinomoto Co Inc β−Ｄ−リボフラノース誘導体又はその光学異性体の製造方法
PE20030008A1 (es) * 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
ES2873875T3 (es) 2004-05-13 2021-11-04 Icos Corp Quinazolinonas como inhibidores de fosfatidilinositol 3-quinasa delta humano
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
AR049384A1 (es) * 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
ATE462704T1 (de) 2004-05-26 2010-04-15 Inotek Pharmaceuticals Corp Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür
RU2007114887A (ru) * 2004-09-20 2008-10-27 Инотек Фармасьютикалз Корпорейшн (Us) Производные пурина и способы их применения
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
CA2625664C (en) 2005-10-21 2016-01-05 Novartis Ag Human antibodies against il13 and therapeutic uses
GB0523845D0 (en) * 2005-11-23 2006-01-04 Glaxo Group Ltd Novel salts
JP5203214B2 (ja) * 2005-11-30 2013-06-05 イノテック ファーマシューティカルズ コーポレイション プリン化合物およびその使用方法
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1889846A1 (en) * 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
AU2007302263A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as P13K lipid kinase inhibitors
WO2008052734A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
CA2743642C (en) 2008-11-13 2017-09-19 Calistoga Pharmaceuticals, Inc. Therapies for hematologic malignancies
SI2391366T1 (sl) 2009-01-29 2013-01-31 Novartis Ag Substituirani benzimidazoli za zdravljenje astrocitomov
ES2548253T3 (es) * 2009-04-20 2015-10-15 Gilead Calistoga Llc Métodos para el tratamiento de tumores sólidos
MX2012000817A (es) 2009-07-21 2012-05-08 Gilead Calistoga Llc Tratamiento para desordenes del higado con inhibidores pi3k.
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
KR20120089643A (ko) 2009-08-12 2012-08-13 노파르티스 아게 헤테로시클릭 히드라존 화합물, 및 암 및 염증을 치료하기 위한 그의 용도
US9085560B2 (en) 2009-08-17 2015-07-21 Intellikine, Inc. Heterocyclic compounds and uses thereof
JP5775871B2 (ja) 2009-08-20 2015-09-09 ノバルティス アーゲー ヘテロ環式オキシム化合物
US20120238520A1 (en) * 2009-12-09 2012-09-20 David Lipson Novel Medical Use
EA025415B1 (ru) 2010-01-11 2016-12-30 Инотек Фармасьютикалз Корпорейшн Комбинация, набор и способ снижения внутриглазного давления
WO2011119969A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
US9993444B2 (en) 2011-01-10 2018-06-12 Invion, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
US9062045B2 (en) 2011-09-15 2015-06-23 Novartis Ag Triazolopyridine compounds
US20130209543A1 (en) 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
HRP20171204T1 (hr) 2012-01-26 2017-10-06 Inotek Pharmaceuticals Corporation Anhidridni polimorfi od [(2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin- 9-il)-3,4-dihidroksitetrahidrofuran-2-il)]metil-nitrata i postupci njihove proizvodnje
MD20140100A2 (ro) 2012-03-05 2015-01-31 Gilead Calistoga Llc Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei
ES2894830T3 (es) 2012-04-03 2022-02-16 Novartis Ag Productos combinados con inhibidores de tirosina·cinasa y su uso
AU2013317791B2 (en) * 2012-09-21 2018-05-10 Midwestern University Inhibitors of beta-hydrolase for treatment of cancer
WO2014151147A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
EA201591433A1 (ru) 2013-03-15 2015-12-30 Инотек Фармасьютикалс Корпорейшн Офтальмологические составы
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
EP3594215A1 (en) 2013-12-20 2020-01-15 Gilead Calistoga LLC Intermediate products in process methods for the preparation of phosphatidylinositol 3-kinase inhibitors
US9708327B2 (en) 2013-12-20 2017-07-18 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
NZ726360A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
KR20170036037A (ko) 2014-07-31 2017-03-31 노파르티스 아게 조합 요법
WO2018049145A1 (en) 2016-09-09 2018-03-15 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
CN112888696B (zh) 2018-06-21 2024-04-16 德琪医疗有限公司 外核苷酸酶抑制剂及其使用方法
AU2020294724A1 (en) * 2019-06-20 2022-01-20 Antengene Therapeutics Limited Ectonucleotidase inhibitors and methods of use thereof
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE768925A (fr) 1970-06-30 1971-11-03 Takeda Chemical Industries Ltd Derives d'adenosine et procede de preparation
DE2034785A1 (de) 1970-07-14 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof Adenosin 5 carbonsäurederivate
CA1019727A (en) 1971-03-18 1977-10-25 Abbott Laboratories Adenosine-5'-carboxylic acid amides
BE789773A (fr) 1971-10-08 1973-04-06 Schering Ag Adenosines n6 -substituees et leur procede de
US3864483A (en) 1972-03-22 1975-02-04 Abbott Lab Adenosine-5{40 -carboxylic acid amides
CA1082695A (en) 1972-04-10 1980-07-29 Francis E. Fischer Process for preparing adenosine-5'-carboxamides
US3966917A (en) 1974-07-30 1976-06-29 Abbott Laboratories Platelet aggregation inhibitors
DE2621470A1 (de) * 1976-05-14 1977-12-01 Pharma Waldhof Gmbh & Co Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung
US4167565A (en) 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
AU8379182A (en) 1981-06-04 1982-12-09 Procter & Gamble Company, The Composition of salicylates and purine derivatives
CA1239397A (en) 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
DE3406533A1 (de) 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
US4496643A (en) 1984-03-23 1985-01-29 Eastman Kodak Company Two-component dry electrostatic developer composition containing onium charge control agent
JPH0655756B2 (ja) 1984-04-18 1994-07-27 ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− 心臓血管拡張薬としてのｎ−６置換アデノシン誘導体
US5310731A (en) 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
US4663313A (en) 1984-10-26 1987-05-05 Warner-Lambert Company N6 -tricyclic adenosines for treating hypertension
AU575438B2 (en) 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines
US4738954A (en) 1985-11-06 1988-04-19 Warner-Lambert Company Novel N6 -substituted-5'-oxidized adenosine analogs
US4755594A (en) 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US5106837A (en) 1988-03-16 1992-04-21 The Scripps Research Institute Adenosine derivatives with therapeutic activity
US4767747A (en) 1986-08-28 1988-08-30 Warner-Lambert Company Method for treating congestive heart failure with N6 -acenaphthyl adenosine
AU8274187A (en) 1986-10-31 1988-05-25 Warner-Lambert Company Heteroaromatic derivatives of adenosine
WO1988003147A1 (en) 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
NL8702926A (nl) 1986-12-15 1988-07-01 Sandoz Ag Nieuwe furanuronzuurderivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.
PT86660B (pt) 1987-02-04 1992-02-28 Ciba Geigy Ag Processo para a preparacao de derivados de adenosina-5'-carboxamida
US4968697A (en) 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US4962194A (en) 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
US5219840A (en) 1987-04-06 1993-06-15 Sandoz Ltd. Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives
LU87181A1 (fr) 1987-04-06 1988-11-17 Sandoz Sa Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments
JPH0725785B2 (ja) 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US5506347A (en) 1993-02-03 1996-04-09 Gensia, Inc. Lyxofuranosyl analogues of adenosine
US5055569A (en) 1989-10-19 1991-10-08 G. D. Searle & Co. N-(6)-substituted adenosine compounds
PT95628A (pt) 1989-10-19 1991-09-30 Searle & Co Metodo de tratamento de perturbacoes de mobilidade gastrointestinal com composto de adenosina
US5140015A (en) 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5280015A (en) 1990-09-05 1994-01-18 The United States Of America As Represented By The Department Of Health And Human Services 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides
WO1992005177A1 (en) 1990-09-25 1992-04-02 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
FR2685918B1 (fr) 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687678B1 (fr) 1992-01-31 1995-03-31 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5424297A (en) 1992-04-27 1995-06-13 University Of Virginia Alumni Patents Foundation Adenosine dextran conjugates
AU4772493A (en) 1992-07-15 1994-02-14 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Sulfo-derivatives of adenosine
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
AU7331094A (en) 1993-07-13 1995-02-13 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The A3 adenosine receptor agonists
US5446046A (en) 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
WO1995018817A1 (fr) 1994-01-07 1995-07-13 Laboratoires Upsa Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant
GB9414208D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
GB9414193D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
AR011044A1 (es) 2000-08-02
AP1105A (en) 2002-09-04
TW528755B (en) 2003-04-21
AU733684B2 (en) 2001-05-24
SI0948509T1 (en) 2003-06-30
PE27499A1 (es) 1999-03-30
DK0948509T3 (da) 2003-02-24
OA11071A (en) 2002-11-18
YU29099A (sh) 2002-06-19
DE69716468D1 (de) 2002-11-21
US6426337B1 (en) 2002-07-30
JP2001506668A (ja) 2001-05-22
CZ230999A3 (cs) 1999-12-15
EA199900494A1 (ru) 2000-02-28
BR9714082A (pt) 2000-05-09
AP9901572A0 (en) 1999-06-30
EP0948509B1 (en) 2002-10-16
EE04019B1 (et) 2003-04-15
ID22271A (id) 1999-09-23
CN1246124A (zh) 2000-03-01
SK86599A3 (en) 2000-05-16
US6528494B2 (en) 2003-03-04
BG63310B1 (bg) 2001-09-28
HUP0000673A2 (hu) 2001-06-28
NO993114D0 (no) 1999-06-23
CA2275271A1 (en) 1998-07-02
TR199901905T2 (xx) 1999-10-21
ATE226212T1 (de) 2002-11-15
BG103518A (en) 2000-01-31
PL334218A1 (en) 2000-02-14
EA001714B1 (ru) 2001-08-27
NO993114L (no) 1999-08-23
JP4156035B2 (ja) 2008-09-24
DE69716468T2 (de) 2003-05-28
EP0948509A1 (en) 1999-10-13
NZ336332A (en) 2000-12-22
GEP20022656B (en) 2002-03-25
EE9900312A (et) 2000-02-15
IL130547A0 (en) 2000-06-01
KR20000069682A (ko) 2000-11-25
ES2186015T3 (es) 2003-05-01
NO312840B1 (no) 2002-07-08
PT948509E (pt) 2003-03-31
AU5762298A (en) 1998-07-17
WO1998028319A1 (en) 1998-07-02
IS5089A (is) 1999-06-22
HUP0000673A3 (en) 2003-01-28
US20020086850A1 (en) 2002-07-04

Similar Documents

Publication Publication Date Title
CO4940488A1 (es) Derivados del 2-(purin-9-il) tetrahidrofuran-3,4-diol
CO4980872A1 (es) Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol
DE3785315D1 (de) Erythromycin-a-derivate und verfahren zu ihrer herstellung.
FI912851A0 (fi) Cykliska amidderivat.
PH20468A (en) Novel pharmaceutically active di-esters of 3,5-dicarboxy-4-substituted-pyridines and pyrans
TW240227B (enExample)
ES2196614T3 (es) Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3.
ES438125A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas.
DE59107712D1 (de) Säurelabile Lösungsinhibitoren und darauf basierende positiv und negativ arbeitende strahlungsempfindliche Zusammensetzung
ES433680A1 (es) Procedimiento para la preparacion de derivados de arilpipe-razinicos de la adenina.
MY106997A (en) 10-(1-hydoxyethyil)-11-ooxo-1-azatricyclo [ 7.2.0.0(3,8) ] undec-2-ene-2-carboxylic acid esters and a process for preparing thereof
IL72641A0 (en) Herbicidal compositions and process containing 3,5-dicarboxylic acid esters of 2,6-bis-(fluoroalkyl)tetrahydropyrans and piperidines
MY136065A (en) Prodrugs to nmda receptor ligands
MX9302388A (es) Oxazolidinonas fungicidas y composicion fungicida que las contiene
ZA852359B (en) Enkephalinase inhibitors
ES8500910A1 (es) Un procedimiento para la preparacion de 6-(fenil sustituido)-3(2h)-piridazinonas.
BG60248B2 (en) Process for the preparation of phenoxyethylamine derivatives
AR246735A1 (es) Compuestos absorbedores de uv, procedimiento para prepararlos, composicion que los comprende y su aplicacion.
ES471872A1 (es) Un procedimiento de preparacion de tetrahidro-s-triazin-tio-nas acaricidas
YU254283A (en) Process for making new piridine-pirimidinone derivatives
TW356466B (en) Piperazine derivatives and pharmaceutical compositions containing the same for anti-cancer