CO4700433A1 - Nuevas sulfonamidas heterociclicas oxigenadas inhibidoras de la proteasa aspartilo - Google Patents
Nuevas sulfonamidas heterociclicas oxigenadas inhibidoras de la proteasa aspartiloInfo
- Publication number
- CO4700433A1 CO4700433A1 CO96019067A CO96019067A CO4700433A1 CO 4700433 A1 CO4700433 A1 CO 4700433A1 CO 96019067 A CO96019067 A CO 96019067A CO 96019067 A CO96019067 A CO 96019067A CO 4700433 A1 CO4700433 A1 CO 4700433A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- optionally
- independently selected
- het
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Un compuesto de fórmula I:en el cual:cada R1 está independientemente seleccionado del grupo que consiste en -C(O)-, -S(O)2 - -C(O)-C(O)-, -O-C(O)-O -S(O)2 , -NR2 -S(O)2 , -NR2 -C(O)- y -NR2 -C(O)-C(O)-; cada A está independientemente seleccionado del grupo que consiste en heterociclos monocíclicos oxigenados no aromáticos de 5-7 miembros que contienen de 1-3 oxígenos endocíclicos, que pueden estar opcionalmente benzofusionados, opcionalmente enlazados a través de un ligador alquilo C1 -C3 y opcionalmente fusionados con un heterociclo monocíclico de 5-7 miembros que contiene desde 1-2 heteroátomos endocíclicos, y del cual se han excluído expresamente tetrahidrofurano y tetrahidrofurotetrahidrofurano; cada Het está independientemente seleccionado del grupo que consiste en carbociclo C3 -C7 ; arilo C6 -C10 ; fenilo fusionado con heterociclo; y heterociclo; en el cual cualquier miembro de dicho Het puede estar opcionalmente substituído con uno o más substituyentes seleccionados del grupo que consiste en oxo, -OR2 , -R2 , -N(R2 )(R2 ), -NHOH, -R2 -OH, -CN, CO2 R2 , -C(O)-R2 , -C(O)NR2 -(R2 ), -S(O)2 - (NR2 )(R2 ), N(R2 )- C(O)-R2 , -S(O)n -R2 , OCF3 , -S(O)n -R6 , (-N(R2 )- S(O)2 (R2 ), halo, -CF3 , -NO2 , -R6 y -O-R6 ; cada R2 está independientemente seleccionado del grupo que consiste en H y alquilo C1 -C3 opcionalmente substituído con R6 ;cada R3 está independientemente seleccionado del grupo que consiste en H, Het, alquilo C1 -C6 y alquenilo C2 -C6 donde cualquier miembro de dicho R3 , excepto H, puede estar opcionalmente substituído con uno o más substituyentes seleccionados del grupo que consiste en -OR2 , -C(O)--NH(R2 ), -S(O)n -(R2 )(R2 ) Het, -CN, -SR2 , CO2 R2 , NR2 -C(O)R2 ; cada n es independientemente 1 ó 2;cada D y D´ está independientemente seleccionado del grupo que consiste en R6 ; alquilo C1 -C5 que puede estar opcionalmente substituído con uno o más grupos seleccionados de -OR2 , -R3 , -S-R6 y R6 ; alquenilo C2 -C4 que puede estar opcionalmente substituido con uno más grupos seleccionados del grupo que consiste en -OR2 , -R3 , -O-R6 y R6 ; y carbociclo C3 -C6 , que puede estar opcionalmente substituido con o fusionado con R6 ; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/424,810 US5691372A (en) | 1995-04-19 | 1995-04-19 | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4700433A1 true CO4700433A1 (es) | 1998-12-29 |
Family
ID=23683966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO96019067A CO4700433A1 (es) | 1995-04-19 | 1996-04-19 | Nuevas sulfonamidas heterociclicas oxigenadas inhibidoras de la proteasa aspartilo |
Country Status (35)
Country | Link |
---|---|
US (2) | US5691372A (es) |
EP (3) | EP1136479B1 (es) |
JP (1) | JP4240532B2 (es) |
KR (1) | KR100485237B1 (es) |
CN (1) | CN1110491C (es) |
AP (2) | AP9600827A0 (es) |
AR (1) | AR004663A1 (es) |
AT (3) | ATE314360T1 (es) |
AU (1) | AU712913B2 (es) |
BG (1) | BG102041A (es) |
BR (1) | BR9608033A (es) |
CA (1) | CA2217745C (es) |
CO (1) | CO4700433A1 (es) |
CZ (1) | CZ329497A3 (es) |
DE (3) | DE69618779T2 (es) |
DK (1) | DK0833826T3 (es) |
EA (1) | EA000906B1 (es) |
EE (1) | EE9700254A (es) |
ES (3) | ES2351970T3 (es) |
GE (1) | GEP20001915B (es) |
HK (2) | HK1092791A1 (es) |
HU (1) | HUP9801948A3 (es) |
IL (1) | IL117962A0 (es) |
IS (1) | IS4575A (es) |
MY (1) | MY115797A (es) |
NO (1) | NO974744D0 (es) |
NZ (1) | NZ307342A (es) |
PE (1) | PE43697A1 (es) |
PL (1) | PL322904A1 (es) |
PT (1) | PT833826E (es) |
SK (1) | SK143097A3 (es) |
TR (1) | TR199701194T1 (es) |
TW (1) | TW404945B (es) |
WO (1) | WO1996033187A1 (es) |
ZA (1) | ZA962891B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
KR100336699B1 (ko) | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
US5874449A (en) * | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
JP2002515051A (ja) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | ヘテロ環式チオエステルのn−結合スルホンアミド |
CA2289654A1 (en) * | 1997-05-17 | 1998-11-26 | Glaxo Group Limited | Antiviral combinations containing the carbocyclic nucleoside 1592u89 |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6576231B2 (en) * | 1997-09-12 | 2003-06-10 | Schering Ag | Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
AU2092599A (en) * | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
AU767728B2 (en) * | 1998-06-19 | 2003-11-20 | Vertex Pharmaceuticals Incorporated | Sulfonamide inhibitors of aspartyl protease |
ATE500823T1 (de) | 1998-06-23 | 2011-03-15 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Arzneimittel zur behandlung von hiv-infizierten säugetieren |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
TWI260322B (en) | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
SI1159278T1 (sl) * | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inhibitorji aspartil proteaze |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
SK287153B6 (sk) * | 1999-10-06 | 2010-01-07 | Tibotec Pharmaceuticals Ltd. | Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5- ylsulfonyl)(izobutyl)amino]1-benzyl-2-hydroxypropyl}karbamát, jeho použitie a farmaceutický prípravok s jeho obsahom |
US7135465B2 (en) | 2000-03-30 | 2006-11-14 | Bristol-Myers Squibb Company | Sustained release beadlets containing stavudine |
SK288232B6 (sk) * | 2001-04-09 | 2014-11-04 | Tibotec Pharmaceuticals Ltd. | 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie |
EP1472536A4 (en) * | 2002-01-07 | 2007-02-14 | Sequoia Pharmaceuticals | VERSATILE INHIBITORS |
US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
AU2003300375A1 (en) * | 2002-10-11 | 2004-05-04 | Semplastics, L.L.C. | Retaining ring for use on a carrier of a polishing apparatus |
CA2507484A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US20080194554A1 (en) * | 2005-03-11 | 2008-08-14 | Mclean Ed W | Hiv Protease Inhibitors |
JP2007202679A (ja) * | 2006-01-31 | 2007-08-16 | Juki Corp | ミシンの糸調子装置 |
JP2007202833A (ja) * | 2006-02-02 | 2007-08-16 | Juki Corp | ミシンの糸調子装置 |
EP2491785A1 (en) * | 2006-11-21 | 2012-08-29 | Purdue Research Foundation | Method and compositions for treating HIV infections |
EP2244571A4 (en) | 2008-01-17 | 2014-02-19 | Purdue Research Foundation | SMALL INHIBITORY MOLECULES OF HIV PROTEASES |
US8791135B2 (en) | 2008-07-01 | 2014-07-29 | Purdue Research Foundation | Nonpeptide HIV-1 protease inhibitors |
EP2304043A4 (en) | 2008-07-09 | 2012-05-30 | Purdue Research Foundation | HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE |
CN105272991B (zh) * | 2014-06-26 | 2017-11-07 | 成都中医药大学 | 一种化合物晶型 |
US11090030B2 (en) | 2016-11-10 | 2021-08-17 | Leltek Inc. | Ultrasound apparatus and ultrasound emission method |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3743722A (en) * | 1971-07-14 | 1973-07-03 | Abbott Lab | Anti-coagulant isolation |
FR2459235A1 (fr) * | 1979-06-14 | 1981-01-09 | Sanofi Sa | Nouveaux derives de sulfonyl-aniline, leur procede de preparation et leur application therapeutique |
JPS5946252A (ja) * | 1982-09-09 | 1984-03-15 | Dainippon Ink & Chem Inc | 含フツ素アミノカルボキシレ−トおよびその製法 |
JPS5948449A (ja) * | 1982-09-13 | 1984-03-19 | Dainippon Ink & Chem Inc | 直鎖状含フツ素アニオン化合物およびその製造方法 |
JPS6171830A (ja) * | 1984-09-17 | 1986-04-12 | Dainippon Ink & Chem Inc | 界面活性剤組成物 |
US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
US4629724A (en) * | 1984-12-03 | 1986-12-16 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitors |
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
CH676988A5 (es) * | 1987-01-21 | 1991-03-28 | Sandoz Ag | |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
IL91780A (en) * | 1988-10-04 | 1995-08-31 | Abbott Lab | History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them |
WO1990007330A1 (en) * | 1989-01-06 | 1990-07-12 | The Regents Of The University Of California | Selection method for specific useful pharmaceutical compounds |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5151438A (en) * | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
IE902295A1 (en) * | 1989-07-07 | 1991-01-16 | Abbott Lab | Amino acid analog cck antagonists |
GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
CA2084087A1 (en) * | 1990-06-01 | 1991-12-02 | Prabhakar Kondaji Jadhav | 1,4-diamino 2,3-dihydroxy butanes |
TW225540B (es) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
EP0558673B1 (en) * | 1990-11-19 | 1996-04-17 | Monsanto Company | Retroviral protease inhibitors |
AU662114B2 (en) * | 1990-11-19 | 1995-08-24 | Monsanto Company | Retroviral protease inhibitors |
ATE147378T1 (de) * | 1990-11-19 | 1997-01-15 | Monsanto Co | Retrovirale protease inhibitoren |
EP0813868B1 (en) * | 1990-11-19 | 2005-06-01 | Monsanto Company | Retroviral protease inhibitors |
IE20010533A1 (en) * | 1990-11-20 | 2003-03-05 | Abbott Lab | Intermediates for preparing retroviral protease inhibiting compounds |
DE69224703T2 (de) * | 1991-11-08 | 1998-10-15 | Merck & Co Inc | HIV-Protease-Inhibitoren verwendbar in der AIDS-Behandlung |
EP0641333B1 (en) * | 1992-05-20 | 1996-08-14 | G.D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
WO1993023379A1 (en) * | 1992-05-21 | 1993-11-25 | Monsanto Company | Retroviral protease inhibitors |
KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
DK0656888T3 (da) * | 1992-08-25 | 1998-02-09 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfonamider, anvendelige som retrovirale protease-inhibitorer |
US5463104A (en) * | 1992-08-25 | 1995-10-31 | G. D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
AU5547094A (en) * | 1992-10-30 | 1994-05-24 | G.D. Searle & Co. | Hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
EP0666843B1 (en) * | 1992-10-30 | 1999-08-18 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors |
AU6135294A (en) * | 1993-02-12 | 1994-08-29 | Merck & Co., Inc. | Piperazine derivatives as hiv protease inhibitors |
JP3419539B2 (ja) * | 1993-02-17 | 2003-06-23 | 中外製薬株式会社 | インドリン−2−オン誘導体 |
DE69415326T2 (de) * | 1993-08-24 | 1999-06-02 | Searle & Co | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
-
1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
-
1996
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en active IP Right Grant
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 EP EP01113575A patent/EP1136479B1/en not_active Expired - Lifetime
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active IP Right Cessation
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 EP EP05028389A patent/EP1637528B1/en not_active Expired - Lifetime
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 EP EP96913811A patent/EP0833826B1/en not_active Expired - Lifetime
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
-
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744D0/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime
-
1998
- 1998-09-22 HK HK06110563.0A patent/HK1092791A1/xx not_active IP Right Cessation
- 1998-09-22 HK HK98110833A patent/HK1009811A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4700433A1 (es) | Nuevas sulfonamidas heterociclicas oxigenadas inhibidoras de la proteasa aspartilo | |
CO4990992A1 (es) | Profarmacos de compuestos de sulfonamida como inhibidores de aspartil proteasa | |
AR105836A1 (es) | Compuestos y composiciones útiles para tratar trastornos relacionados con ntrk | |
AR113765A1 (es) | Inhibidores de la proteasa del vih | |
AR055144A1 (es) | Inhibidor de secrecion acida | |
PE20220141A1 (es) | Inhibidores de la proteina tirosina fosfatasa | |
AR123127A1 (es) | Compuestos y métodos de uso | |
AR111407A1 (es) | Compuestos inhibidores de ask1 y usos de los mismos | |
PE20011055A1 (es) | Compuestos de imidazolidin 2,4-diona sustituida y procedimientos para su preparacion | |
AR118724A1 (es) | Inhibidores de dihidroorotato deshidrogenasa | |
CO6260136A2 (es) | Metodo para preparar derivados de 5-haloalquil-4,5-dihidroisoxazol | |
BR0114657A (pt) | Compostos de benzamida e seu uso | |
ES2191484T3 (es) | Compuestos heterociclicos como inhibidores de enzimas de rotamasa. | |
AR070263A1 (es) | Derivados de oxazepinopirimidinona arilamido sustituidos, utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, medicamentos que los contienen y proceso de preparacion e intermediarios. | |
AR118613A1 (es) | Compuestos de oxadiazol para controlar o prevenir hongos fitopatogénicos | |
AR115085A1 (es) | DERIVADOS DE 3-AMINO-2,4,6-TRIAZINA COMO INHIBIDORES DE LA TIROSINA CINASA DE BRUTON (Btk) | |
CO5580762A2 (es) | Analogos de lipoxina a4 | |
ES2087097T3 (es) | Derivados de acidos fenilcarboxilicos que contienen un heterociclo. | |
AR111594A1 (es) | Agentes inhibidores de la tirosina quinasa de bruton | |
AR109650A1 (es) | Compuestos de heteroarilcarboxamida como inhibidores de ripk2 | |
AR114679A1 (es) | Compuestos heterocíclicos fungicidas | |
CO6150150A2 (es) | Derivados de 7-alquinil-1,8-naftiridonas su prepacion y su aplicacion en terapeutica | |
AR102731A1 (es) | Compuestos espiroisoquinolin-1,4-piperidínicos con actividad multimodal contra el dolor | |
CO4940477A1 (es) | Inhibidores de proteasa | |
AR119376A1 (es) | Compuestos heterocíclicos |