NO974744L - Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease - Google Patents
Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylproteaseInfo
- Publication number
- NO974744L NO974744L NO974744A NO974744A NO974744L NO 974744 L NO974744 L NO 974744L NO 974744 A NO974744 A NO 974744A NO 974744 A NO974744 A NO 974744A NO 974744 L NO974744 L NO 974744L
- Authority
- NO
- Norway
- Prior art keywords
- hiv
- aspartyl protease
- heterocycle
- oxygen
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Foreliggende oppfinnelse vedrører en ny klasse sulfonamider som er aspartylproteasehemmere. Opp- finnelsen vedrører også farmasøytiske sammensetninger inneholdende disse forbindelser. Forbindelsene og de farmasøytiske sammensetninger ifølge oppfinnelsen er spesielt vel egnet for å hemme HIV-1- og HIV-2-prote- aseaktivitet, og kan derfor med fordel anvendes som antivirale midler mot HIV-1- og HIV-2-virus. Forelig- gende oppfinnelse vedrører dessuten fremgangsmåter for å hemme aktiviteten av HIV-aspartylprotease under anvendelse av forbindelsene ifølge oppfinnelsen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/424,810 US5691372A (en) | 1995-04-19 | 1995-04-19 | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
PCT/US1996/005473 WO1996033187A1 (en) | 1995-04-19 | 1996-04-18 | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease |
Publications (2)
Publication Number | Publication Date |
---|---|
NO974744D0 NO974744D0 (no) | 1997-10-14 |
NO974744L true NO974744L (no) | 1997-10-14 |
Family
ID=23683966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974744A NO974744L (no) | 1995-04-19 | 1997-10-14 | Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease |
Country Status (35)
Country | Link |
---|---|
US (2) | US5691372A (no) |
EP (3) | EP0833826B1 (no) |
JP (1) | JP4240532B2 (no) |
KR (1) | KR100485237B1 (no) |
CN (1) | CN1110491C (no) |
AP (2) | AP9600827A0 (no) |
AR (1) | AR004663A1 (no) |
AT (3) | ATE212344T1 (no) |
AU (1) | AU712913B2 (no) |
BG (1) | BG102041A (no) |
BR (1) | BR9608033A (no) |
CA (1) | CA2217745C (no) |
CO (1) | CO4700433A1 (no) |
CZ (1) | CZ329497A3 (no) |
DE (3) | DE69635679T2 (no) |
DK (1) | DK0833826T3 (no) |
EA (1) | EA000906B1 (no) |
EE (1) | EE9700254A (no) |
ES (3) | ES2256117T3 (no) |
GE (1) | GEP20001915B (no) |
HK (2) | HK1092791A1 (no) |
HU (1) | HUP9801948A3 (no) |
IL (1) | IL117962A0 (no) |
IS (1) | IS4575A (no) |
MY (1) | MY115797A (no) |
NO (1) | NO974744L (no) |
NZ (1) | NZ307342A (no) |
PE (1) | PE43697A1 (no) |
PL (1) | PL322904A1 (no) |
PT (1) | PT833826E (no) |
SK (1) | SK143097A3 (no) |
TR (1) | TR199701194T1 (no) |
TW (1) | TW404945B (no) |
WO (1) | WO1996033187A1 (no) |
ZA (1) | ZA962891B (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ATE218541T1 (de) | 1992-08-25 | 2002-06-15 | Searle & Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
US5874449A (en) * | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
EA002593B1 (ru) | 1996-12-31 | 2002-06-27 | Гилфорд Фармасьютикалз Инк. | N-связанные сульфонамиды гетероциклических тиоэфиров |
JP2001525840A (ja) * | 1997-05-17 | 2001-12-11 | グラクソ、グループ、リミテッド | 炭素環式ヌクレオシド1592u89を含有する抗ウイルス的組合せ |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6576231B2 (en) * | 1997-09-12 | 2003-06-10 | Schering Ag | Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor |
CA2316218A1 (en) * | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
BR9912169A (pt) | 1998-06-19 | 2001-04-10 | Vertex Pharma | Inibidores de sulfonamida de protease de aspartil |
DK1088098T4 (en) | 1998-06-23 | 2015-09-14 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Fitnessassay and methods for reducing HIV resistance to therapy |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
PT1159278E (pt) * | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inibidores de aspartil-protease |
TWI260322B (en) | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
EP1222192B8 (en) * | 1999-10-06 | 2008-10-01 | Tibotec Pharmaceuticals Ltd. | Hexahydrofuro¬2,3-b furan-3-yl-n- 3-¬(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino -1-benzyl-2-hydroxypropyl carbamate as retroviral protease inhibitor |
KR20030011805A (ko) | 2000-03-30 | 2003-02-11 | 브리스톨-마이어스스퀴브컴파니 | 스타부딘을 함유하는 서방성 비들렛 |
OA12464A (en) * | 2001-04-09 | 2006-05-24 | Tibotec Pharm Ltd | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors. |
US7109230B2 (en) * | 2002-01-07 | 2006-09-19 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
AU2003300375A1 (en) * | 2002-10-11 | 2004-05-04 | Semplastics, L.L.C. | Retaining ring for use on a carrier of a polishing apparatus |
AU2003293155A1 (en) * | 2002-11-27 | 2004-06-23 | Elan Pharmaceutical, Inc. | Substituted ureas and carbamates |
US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP1855672A4 (en) * | 2005-03-11 | 2011-11-30 | Glaxosmithkline Llc | HIV PROTEASE INHIBITORS |
JP2007202679A (ja) * | 2006-01-31 | 2007-08-16 | Juki Corp | ミシンの糸調子装置 |
JP2007202833A (ja) * | 2006-02-02 | 2007-08-16 | Juki Corp | ミシンの糸調子装置 |
EP2491785A1 (en) * | 2006-11-21 | 2012-08-29 | Purdue Research Foundation | Method and compositions for treating HIV infections |
US20110046199A1 (en) | 2008-01-17 | 2011-02-24 | Purdue Research Foundation | Small molecule inhibitors of hiv proteases |
WO2010002994A1 (en) | 2008-07-01 | 2010-01-07 | Purdue Research Foundation | Nonpeptide hiv-1 protease inhibitors |
EP2304043A4 (en) | 2008-07-09 | 2012-05-30 | Purdue Research Foundation | HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE |
CN105272991B (zh) * | 2014-06-26 | 2017-11-07 | 成都中医药大学 | 一种化合物晶型 |
US11090030B2 (en) | 2016-11-10 | 2021-08-17 | Leltek Inc. | Ultrasound apparatus and ultrasound emission method |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3743722A (en) * | 1971-07-14 | 1973-07-03 | Abbott Lab | Anti-coagulant isolation |
FR2459235A1 (fr) * | 1979-06-14 | 1981-01-09 | Sanofi Sa | Nouveaux derives de sulfonyl-aniline, leur procede de preparation et leur application therapeutique |
JPS5946252A (ja) * | 1982-09-09 | 1984-03-15 | Dainippon Ink & Chem Inc | 含フツ素アミノカルボキシレ−トおよびその製法 |
JPS5948449A (ja) * | 1982-09-13 | 1984-03-19 | Dainippon Ink & Chem Inc | 直鎖状含フツ素アニオン化合物およびその製造方法 |
JPS6171830A (ja) * | 1984-09-17 | 1986-04-12 | Dainippon Ink & Chem Inc | 界面活性剤組成物 |
US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
US4629724A (en) * | 1984-12-03 | 1986-12-16 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitors |
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
GB2200115B (en) * | 1987-01-21 | 1990-11-14 | Sandoz Ltd | Novel peptide derivatives, their production and use |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
IL91780A (en) * | 1988-10-04 | 1995-08-31 | Abbott Lab | History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them |
WO1990007330A1 (en) * | 1989-01-06 | 1990-07-12 | The Regents Of The University Of California | Selection method for specific useful pharmaceutical compounds |
US5151438A (en) * | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
IE902295A1 (en) * | 1989-07-07 | 1991-01-16 | Abbott Lab | Amino acid analog cck antagonists |
GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
HU9203505D0 (en) * | 1990-06-01 | 1993-01-28 | Du Pont Merck Pharma | 1,4-diamino-2,3-dihydroxi-butane compounds |
TW225540B (no) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
EP0558630B1 (en) * | 1990-11-19 | 1998-04-08 | Monsanto Company | Retroviral protease inhibitors |
DE69126987T2 (de) * | 1990-11-19 | 1998-03-05 | Monsanto Co | Retrovirale protease-inhibitoren |
ATE196466T1 (de) * | 1990-11-19 | 2000-10-15 | Monsanto Co | Inhibitoren retroviraler proteasen |
DK0558673T3 (da) * | 1990-11-19 | 1996-07-29 | Monsanto Co | Retrovirale proteaseinhibitorer |
IE20010533A1 (en) * | 1990-11-20 | 2003-03-05 | Abbott Lab | Intermediates for preparing retroviral protease inhibiting compounds |
SG52731A1 (en) * | 1991-11-08 | 1998-09-28 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids |
AU4253193A (en) * | 1992-05-20 | 1993-12-13 | G.D. Searle & Co. | Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors |
EP0957093A3 (en) * | 1992-05-21 | 2000-04-12 | Monsanto Company | Retrovial protease inhibitors |
ATE218541T1 (de) * | 1992-08-25 | 2002-06-15 | Searle & Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
ATE154800T1 (de) * | 1992-08-25 | 1997-07-15 | Searle & Co | N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren |
AU669223B2 (en) * | 1992-08-25 | 1996-05-30 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
DE69326077T2 (de) * | 1992-10-30 | 2000-01-27 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfaminsäuren verwendbar als inhibitoren retroviraler proteasen |
US6156768A (en) * | 1992-10-30 | 2000-12-05 | G. D. Searle & Co. | Alpha- and beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
WO1994018192A1 (en) * | 1993-02-12 | 1994-08-18 | Merck & Co., Inc. | Piperazine derivatives as hiv protease inhibitors |
JP3419539B2 (ja) * | 1993-02-17 | 2003-06-23 | 中外製薬株式会社 | インドリン−2−オン誘導体 |
DK0715618T3 (da) * | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
-
1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
-
1996
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active IP Right Cessation
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 EP EP96913811A patent/EP0833826B1/en not_active Expired - Lifetime
- 1996-04-18 EP EP05028389A patent/EP1637528B1/en not_active Expired - Lifetime
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en active IP Right Grant
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 EP EP01113575A patent/EP1136479B1/en not_active Expired - Lifetime
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
-
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744L/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime
-
1998
- 1998-09-22 HK HK06110563.0A patent/HK1092791A1/xx not_active IP Right Cessation
- 1998-09-22 HK HK98110833A patent/HK1009811A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO974744L (no) | Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease | |
NO20006405L (no) | Sulfonamidinhibitorer for aspartylprotease | |
MY142901A (en) | Novel sulfonamide inhibitors of aspartyl protease | |
EA199700331A1 (ru) | Тгф-содержащие сульфонамидные ингибиторы аспартил-протеазы | |
MX9603909A (es) | Derivados de sulfonamida como inhibidores de proteasa aspartilo. | |
MY137777A (en) | Inhibitors of aspartyl protease | |
KR950702960A (ko) | 레트로바이러스 프로테아제 저해제로서 유용한 히드록시에틸아미노 술폰아미드(hydroxyethylamino sulfonamides useful as retroviral protease inhibitors) | |
DE69624346D1 (de) | Verbindung der struktur aminosäure-hydroxyethylamino-sulfonamide als inhibitoren der retroviralen protease | |
DK0813543T3 (da) | Bis-aminosyrehydroxyethylaminsulfonamider som inhibitorer af retrovirale proteaser | |
NZ306026A (en) | N-[2-hydroxy-3-sulphonyl-amino]-3-(hydrocarbylsulphonyl)hydrocarbyl-amide derivatives | |
DE60024419D1 (en) | Aspartyl-protease-inhibitoren | |
NO974147L (no) | Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease | |
NO983435L (no) | Aspartylproteaseinhibitorer | |
MX9708055A (es) | Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado. | |
MX9708057A (es) | Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa. | |
MY135869A (en) | Inhibitors of aspartyl protease | |
TH57871B (th) | สารยับยั้งเอ็นไซม์แอสพาร์ทิลโปรตีเอส |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |