DE69635679D1 - Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease - Google Patents

Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease

Info

Publication number
DE69635679D1
DE69635679D1 DE69635679T DE69635679T DE69635679D1 DE 69635679 D1 DE69635679 D1 DE 69635679D1 DE 69635679 T DE69635679 T DE 69635679T DE 69635679 T DE69635679 T DE 69635679T DE 69635679 D1 DE69635679 D1 DE 69635679D1
Authority
DE
Germany
Prior art keywords
inhibitors
oxygen
sulfonamides
aspartyl protease
heterocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635679T
Other languages
English (en)
Other versions
DE69635679T2 (de
Inventor
Roger D Tung
Govinda Rao Bhisetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69635679D1 publication Critical patent/DE69635679D1/de
Publication of DE69635679T2 publication Critical patent/DE69635679T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69635679T 1995-04-19 1996-04-18 Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease Expired - Lifetime DE69635679T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US424810 1989-10-20
US08/424,810 US5691372A (en) 1995-04-19 1995-04-19 Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (2)

Publication Number Publication Date
DE69635679D1 true DE69635679D1 (de) 2006-02-02
DE69635679T2 DE69635679T2 (de) 2006-08-31

Family

ID=23683966

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69618779T Expired - Lifetime DE69618779T2 (de) 1995-04-19 1996-04-18 Sulfonamide die einen Sauerstoff-haltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease
DE69635679T Expired - Lifetime DE69635679T2 (de) 1995-04-19 1996-04-18 Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease
DE69638252T Expired - Lifetime DE69638252D1 (de) 1995-04-19 1996-04-18 Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69618779T Expired - Lifetime DE69618779T2 (de) 1995-04-19 1996-04-18 Sulfonamide die einen Sauerstoff-haltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69638252T Expired - Lifetime DE69638252D1 (de) 1995-04-19 1996-04-18 Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease

Country Status (35)

Country Link
US (2) US5691372A (de)
EP (3) EP1637528B1 (de)
JP (1) JP4240532B2 (de)
KR (1) KR100485237B1 (de)
CN (1) CN1110491C (de)
AP (2) AP9600827A0 (de)
AR (1) AR004663A1 (de)
AT (3) ATE212344T1 (de)
AU (1) AU712913B2 (de)
BG (1) BG102041A (de)
BR (1) BR9608033A (de)
CA (1) CA2217745C (de)
CO (1) CO4700433A1 (de)
CZ (1) CZ329497A3 (de)
DE (3) DE69618779T2 (de)
DK (1) DK0833826T3 (de)
EA (1) EA000906B1 (de)
EE (1) EE9700254A (de)
ES (3) ES2351970T3 (de)
GE (1) GEP20001915B (de)
HK (2) HK1009811A1 (de)
HU (1) HUP9801948A3 (de)
IL (1) IL117962A0 (de)
IS (1) IS4575A (de)
MY (1) MY115797A (de)
NO (1) NO974744D0 (de)
NZ (1) NZ307342A (de)
PE (1) PE43697A1 (de)
PL (1) PL322904A1 (de)
PT (1) PT833826E (de)
SK (1) SK143097A3 (de)
TR (1) TR199701194T1 (de)
TW (1) TW404945B (de)
WO (1) WO1996033187A1 (de)
ZA (1) ZA962891B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US7141609B2 (en) 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ATE172717T1 (de) 1992-08-25 1998-11-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US5874449A (en) * 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
EA002593B1 (ru) 1996-12-31 2002-06-27 Гилфорд Фармасьютикалз Инк. N-связанные сульфонамиды гетероциклических тиоэфиров
NZ500868A (en) * 1997-05-17 2001-08-31 Glaxo Group Ltd Antiviral combinations comprising 1592U89 and HIV protease inhibitors
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6576231B2 (en) * 1997-09-12 2003-06-10 Schering Ag Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
HUP0101598A3 (en) * 1997-12-24 2002-08-28 Vertex Pharmaceuticals Inc Cam Prodrugs of aspartyl protease inhibitors and medicaments containing them
PT1086076E (pt) * 1998-06-19 2005-05-31 Vertex Pharma Inibidores de sulfonamida de aspartil protease
EP2336134B1 (de) * 1998-06-23 2016-08-31 The United States of America, represented by the Secretary, Department of Health and Human Services Fitnesstest und Verfahren zur Verminderung von HIV-Resistenz gegen Therapie
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
TNSN00027A1 (fr) 1999-02-12 2005-11-10 Vertex Pharma Inhibiteurs de l'aspartyle protease
WO2000047551A2 (en) * 1999-02-12 2000-08-17 Vertex Pharmaceuticals Incorporated Inhibitors of aspartyl protease
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
PL204924B1 (pl) * 1999-10-06 2010-02-26 Tibotec Pharm Ltd Heksahydrofuro [2,3-b] furanylo-3-N-{3(1,3-benzodioksolilo-5-sulfonylo) (izobutylo) amino] -1-benzylo-2-hydroksypropylo} karbaminian oraz jego zastosowanie
PL366089A1 (en) 2000-03-30 2005-01-24 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
EA007383B1 (ru) * 2001-04-09 2006-10-27 Тиботек Фармасьютикалз Лтд. 2-(замещенный амино)бензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
US20040009890A1 (en) * 2002-01-07 2004-01-15 Erickson John W. Broad spectrum inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
WO2004033152A1 (en) * 2002-10-11 2004-04-22 Semplastics, L.L.C. Retaining ring for use on a carrier of a polishing apparatus
BR0316629A (pt) * 2002-11-27 2005-10-11 Elan Pharm Inc Uréias e carbamatos substituìdos
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US7763609B2 (en) * 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
EP1855672A4 (de) * 2005-03-11 2011-11-30 Glaxosmithkline Llc Hiv-proteasehemmer
JP2007202679A (ja) * 2006-01-31 2007-08-16 Juki Corp ミシンの糸調子装置
JP2007202833A (ja) * 2006-02-02 2007-08-16 Juki Corp ミシンの糸調子装置
EP2491785A1 (de) * 2006-11-21 2012-08-29 Purdue Research Foundation Verfahren und Zusammensetzungen zur Behandlung von HIV-Infektionen
EP2244571A4 (de) 2008-01-17 2014-02-19 Purdue Research Foundation Kleinmolekulare hemmer von hiv-proteasen
WO2010002994A1 (en) 2008-07-01 2010-01-07 Purdue Research Foundation Nonpeptide hiv-1 protease inhibitors
US8501961B2 (en) 2008-07-09 2013-08-06 Purdue Research Foundation HIV protease inhibitors and methods for using
CN105272991B (zh) * 2014-06-26 2017-11-07 成都中医药大学 一种化合物晶型
US11090030B2 (en) 2016-11-10 2021-08-17 Leltek Inc. Ultrasound apparatus and ultrasound emission method

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3743722A (en) * 1971-07-14 1973-07-03 Abbott Lab Anti-coagulant isolation
FR2459235A1 (fr) * 1979-06-14 1981-01-09 Sanofi Sa Nouveaux derives de sulfonyl-aniline, leur procede de preparation et leur application therapeutique
JPS5946252A (ja) * 1982-09-09 1984-03-15 Dainippon Ink & Chem Inc 含フツ素アミノカルボキシレ−トおよびその製法
JPS5948449A (ja) * 1982-09-13 1984-03-19 Dainippon Ink & Chem Inc 直鎖状含フツ素アニオン化合物およびその製造方法
JPS6171830A (ja) * 1984-09-17 1986-04-12 Dainippon Ink & Chem Inc 界面活性剤組成物
US4616088A (en) * 1984-10-29 1986-10-07 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitor
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
DE3635907A1 (de) * 1986-10-22 1988-04-28 Merck Patent Gmbh Hydroxy-aminosaeurederivate
CH676988A5 (de) * 1987-01-21 1991-03-28 Sandoz Ag
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
IL91780A (en) * 1988-10-04 1995-08-31 Abbott Lab History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
WO1990007329A1 (en) * 1989-01-06 1990-07-12 The Regents Of The University Of California Selection method for pharmacologically active compounds
US5151438A (en) * 1989-05-23 1992-09-29 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
IE902295A1 (en) * 1989-07-07 1991-01-16 Abbott Lab Amino acid analog cck antagonists
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
HUT64738A (en) * 1990-06-01 1994-02-28 Du Pont Merck Pharma Process for preparing 1,4-diamino-2,3-dihydroxi-butane compounds and pharmaceutical compositions contianing them
TW225540B (de) * 1990-06-28 1994-06-21 Shionogi & Co
HU9301446D0 (en) * 1990-11-19 1993-11-29 Monsanto Co Inhibitors or fetrovirus protease
ES2059296T3 (es) * 1990-11-19 1996-07-16 Monsanto Co Inhibidores de proteasas retrovirales.
ES2243959T3 (es) * 1990-11-19 2005-12-01 Monsanto Company Inhibidores de proteasas retrovirales.
AU662309B2 (en) * 1990-11-19 1995-08-31 Monsanto Company Retroviral protease inhibitors
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
KR100290516B1 (ko) * 1992-05-20 2001-09-17 죤 에이치. 뷰센 레트로바이러스프로테아제억제인자의합성에유용한중간생성물의제조방법
WO1993023379A1 (en) * 1992-05-21 1993-11-25 Monsanto Company Retroviral protease inhibitors
US5521219A (en) * 1992-08-25 1996-05-28 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ATE172717T1 (de) * 1992-08-25 1998-11-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
JP4091653B2 (ja) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー レトロウイルスプロテアーゼ阻害剤として有用なｎ−（アルカノイルアミノ−２−ヒドロキシプロピル）スルホンアミド
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US6156768A (en) * 1992-10-30 2000-12-05 G. D. Searle & Co. Alpha- and beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
CA2143191A1 (en) * 1992-10-30 1994-05-11 Michael L. Vazquez Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors
AU6135294A (en) * 1993-02-12 1994-08-29 Merck & Co., Inc. Piperazine derivatives as hiv protease inhibitors
TW281669B (de) * 1993-02-17 1996-07-21 Chugai Pharmaceutical Co Ltd
EP0715618B1 (de) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій

Also Published As

Publication number Publication date
PT833826E (pt) 2002-06-28
EE9700254A (et) 1998-04-15
KR100485237B1 (ko) 2005-09-30
HUP9801948A3 (en) 2002-04-29
DE69618779D1 (de) 2002-03-14
HUP9801948A2 (hu) 1999-09-28
CN1184474A (zh) 1998-06-10
EP1637528B1 (de) 2010-09-01
CA2217745A1 (en) 1996-10-24
EP0833826A1 (de) 1998-04-08
PL322904A1 (en) 1998-03-02
AP862A (en) 2000-08-04
DE69635679T2 (de) 2006-08-31
DK0833826T3 (da) 2002-05-06
AP9600827A0 (en) 1997-10-17
DE69618779T2 (de) 2002-08-29
ES2351970T3 (es) 2011-02-14
PE43697A1 (es) 1997-10-11
AU5665596A (en) 1996-11-07
TR199701194T1 (xx) 1998-03-21
EA199700330A1 (ru) 1998-04-30
IL117962A0 (en) 1996-08-04
US5990155A (en) 1999-11-23
AR004663A1 (es) 1999-03-10
NO974744L (no) 1997-10-14
HK1009811A1 (en) 1999-06-11
JP4240532B2 (ja) 2009-03-18
EA000906B1 (ru) 2000-06-26
US5691372A (en) 1997-11-25
ATE314360T1 (de) 2006-01-15
EP1136479B1 (de) 2005-12-28
ATE479674T1 (de) 2010-09-15
EP0833826B1 (de) 2002-01-23
CO4700433A1 (es) 1998-12-29
GEP20001915B (en) 2000-01-05
AU712913B2 (en) 1999-11-18
BG102041A (en) 1998-09-30
KR19990007823A (ko) 1999-01-25
CN1110491C (zh) 2003-06-04
HK1092791A1 (en) 2007-02-16
EP1136479A1 (de) 2001-09-26
NZ307342A (en) 1999-04-29
WO1996033187A1 (en) 1996-10-24
CA2217745C (en) 2011-07-05
SK143097A3 (en) 1998-03-04
NO974744D0 (no) 1997-10-14
AP9701104A0 (en) 1997-10-31
ES2171670T3 (es) 2002-09-16
TW404945B (en) 2000-09-11
CZ329497A3 (cs) 1998-03-18
ES2256117T3 (es) 2006-07-16
ZA962891B (en) 1996-10-15
MY115797A (en) 2003-09-30
ATE212344T1 (de) 2002-02-15
BR9608033A (pt) 1999-01-12
EP1637528A1 (de) 2006-03-22
IS4575A (is) 1997-10-02
DE69638252D1 (de) 2010-10-14
JPH11504628A (ja) 1999-04-27

Similar Documents

Publication Publication Date Title
DE69635679D1 (de) Sulfonamide, die einen sauerstoffhaltigen Heterozyklus enthalten als Inhibitoren von Aspartyl-Protease
NL300039I2 (nl) Sulfonamideremmers van HIV-aspartylprotease.
NO974722D0 (no) THF-inneholdende sulfonamidhemmere av aspartylprotease
ATE382042T1 (de) Sulfonamidderivate als wirkstoff-vorläufer von inhibitoren der aspartyl-protease
DE69311810D1 (de) N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren
FI925167A (fi) 2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer
NO20006405D0 (no) Sulfonamidinhibitorer for aspartylprotease
ATE71111T1 (de) Peptid-derivate, renin- und saeureprotease hemmende mittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition