CO4480024A1 - Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo - Google Patents
Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzoInfo
- Publication number
- CO4480024A1 CO4480024A1 CO95046243A CO95046243A CO4480024A1 CO 4480024 A1 CO4480024 A1 CO 4480024A1 CO 95046243 A CO95046243 A CO 95046243A CO 95046243 A CO95046243 A CO 95046243A CO 4480024 A1 CO4480024 A1 CO 4480024A1
- Authority
- CO
- Colombia
- Prior art keywords
- ltb4
- antagonists
- benzopyrans
- benzo
- new
- Prior art date
Links
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 3
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000003448 neutrophilic effect Effects 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32287694A | 1994-10-13 | 1994-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4480024A1 true CO4480024A1 (es) | 1997-07-09 |
Family
ID=23256829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95046243A CO4480024A1 (es) | 1994-10-13 | 1995-10-04 | Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6051601A (enExample) |
| EP (1) | EP0785930A1 (enExample) |
| JP (1) | JP2983295B2 (enExample) |
| KR (1) | KR100232341B1 (enExample) |
| CN (1) | CN1160399A (enExample) |
| AU (1) | AU696890B2 (enExample) |
| BR (1) | BR9504385A (enExample) |
| CA (1) | CA2201742A1 (enExample) |
| CO (1) | CO4480024A1 (enExample) |
| CZ (1) | CZ111797A3 (enExample) |
| FI (1) | FI971524A7 (enExample) |
| HU (1) | HUT77515A (enExample) |
| IL (1) | IL115529A0 (enExample) |
| MX (1) | MX9702731A (enExample) |
| NO (1) | NO971672L (enExample) |
| NZ (1) | NZ285156A (enExample) |
| PE (1) | PE10897A1 (enExample) |
| PL (1) | PL319688A1 (enExample) |
| RU (1) | RU2128655C1 (enExample) |
| TR (1) | TR199501270A2 (enExample) |
| TW (1) | TW304941B (enExample) |
| WO (1) | WO1996011920A1 (enExample) |
| ZA (1) | ZA958597B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0925292T3 (da) * | 1996-09-16 | 2004-01-12 | Pfizer | Fremgangsmåder og mellemprodukter til fremstilling af substituerede chromanolderivater |
| WO1998025616A1 (en) * | 1996-12-13 | 1998-06-18 | Eli Lilly And Company | Leukotriene antagonists for cerebral focal stroke |
| IL128731A0 (en) * | 1998-03-12 | 2000-01-31 | Pfizer Prod Inc | Method of preventing allograft rejection |
| EP0963755A3 (en) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| MXPA03006876A (es) * | 2001-01-30 | 2003-11-13 | Pfizer Prod Inc | Intermedios y procedimientos para preparar derivados de cromanol sustituido. |
| AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
| BR0311970A (pt) | 2002-06-19 | 2005-03-29 | Biovitrum Ab | Novos compostos, seu uso e preparação |
| JP2008506768A (ja) * | 2004-07-22 | 2008-03-06 | ファルマシア コーポレーション | Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物 |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| MX2007007103A (es) * | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
| AU2005328328A1 (en) | 2005-02-25 | 2006-09-08 | Galileo Pharmaceuticals, Inc. | Spiro-heterocyclic chromans, thiochromans and dihydroquinolines |
| US7842713B2 (en) * | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
| US7749995B2 (en) * | 2006-05-11 | 2010-07-06 | Janssen Pharmaceutica Nv | 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors |
| EP2034998A1 (en) | 2006-05-11 | 2009-03-18 | Janssen Pharmaceutica, N.V. | 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors |
| GEP20135793B (en) | 2008-09-11 | 2013-03-25 | Pfizer | Heteroaryls amide derivatives and their use as glucokinase activators |
| DK2406253T3 (da) | 2009-03-11 | 2013-08-12 | Pfizer | Benzofuranylderivater anvendt som glucokinase-inhibitorer |
| WO2013123081A2 (en) | 2012-02-14 | 2013-08-22 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox) |
| CN102920692A (zh) * | 2012-10-25 | 2013-02-13 | 中国人民解放军第二军医大学 | (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用 |
| EA201792028A1 (ru) | 2015-03-13 | 2018-04-30 | Форма Терапьютикс, Инк. | Альфа-цинамидные соединения и композиции как ингибиторы hdac8 |
| US10029995B2 (en) | 2015-09-03 | 2018-07-24 | Forma Therapeutics, Inc. | [6,6] fused bicyclic HDAC8 inhibitors |
| WO2017095725A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| EP3383389B1 (en) | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| WO2017095722A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| EP3383868B1 (en) * | 2015-11-30 | 2022-10-05 | Merck Sharp & Dohme LLC | Aryl sulfonamides as blt1 antagonists |
| US20190216790A1 (en) * | 2016-10-13 | 2019-07-18 | The Regents Of The University Of California | Methods for Treating Pruritis |
| CN119700747B (zh) * | 2025-02-26 | 2025-05-06 | 云南农业大学 | 苦杏碱醇a在制备防治骨质疏松症产品中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU469247A3 (ru) * | 1972-01-14 | 1975-04-30 | Майлз Лабораториз Инк (Фирма) | Способ получени производных хромона |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| CA2019335C (en) * | 1989-06-27 | 2000-08-01 | Mitoshi Konno | Phenylalkan (en)oic acids |
| US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
| US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| ES2098547T3 (es) * | 1992-01-23 | 1997-05-01 | Pfizer | Benzopirano y otros antagonistas de ltb4 relacionados. |
| MX9300312A (es) * | 1992-01-23 | 1993-07-31 | Pfizer | Antagonistas benzopiranicos y relacionado de ltb. |
-
1995
- 1995-05-26 RU RU97105834A patent/RU2128655C1/ru active
- 1995-05-26 WO PCT/IB1995/000401 patent/WO1996011920A1/en not_active Ceased
- 1995-05-26 CN CN95195608A patent/CN1160399A/zh active Pending
- 1995-05-26 NZ NZ285156A patent/NZ285156A/xx unknown
- 1995-05-26 AU AU24167/95A patent/AU696890B2/en not_active Ceased
- 1995-05-26 MX MX9702731A patent/MX9702731A/es unknown
- 1995-05-26 EP EP95918114A patent/EP0785930A1/en not_active Withdrawn
- 1995-05-26 CZ CZ971117A patent/CZ111797A3/cs unknown
- 1995-05-26 HU HU9702048A patent/HUT77515A/hu unknown
- 1995-05-26 JP JP8513057A patent/JP2983295B2/ja not_active Expired - Lifetime
- 1995-05-26 PL PL95319688A patent/PL319688A1/xx unknown
- 1995-05-26 US US08/809,728 patent/US6051601A/en not_active Expired - Fee Related
- 1995-05-26 CA CA002201742A patent/CA2201742A1/en not_active Abandoned
- 1995-05-26 KR KR1019970702392A patent/KR100232341B1/ko not_active Expired - Fee Related
- 1995-10-04 CO CO95046243A patent/CO4480024A1/es unknown
- 1995-10-06 IL IL11552995A patent/IL115529A0/xx unknown
- 1995-10-10 PE PE1995281391A patent/PE10897A1/es not_active Application Discontinuation
- 1995-10-11 BR BR9504385A patent/BR9504385A/pt not_active Application Discontinuation
- 1995-10-12 ZA ZA958597A patent/ZA958597B/xx unknown
- 1995-10-13 TW TW084110874A patent/TW304941B/zh active
- 1995-10-13 TR TR95/01270A patent/TR199501270A2/xx unknown
-
1997
- 1997-04-11 NO NO971672A patent/NO971672L/no not_active Application Discontinuation
- 1997-04-11 FI FI971524A patent/FI971524A7/fi unknown
-
2000
- 2000-01-28 US US09/493,707 patent/US6133286A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX9702731A (es) | 1997-06-28 |
| FI971524A0 (fi) | 1997-04-11 |
| RU2128655C1 (ru) | 1999-04-10 |
| US6051601A (en) | 2000-04-18 |
| TW304941B (enExample) | 1997-05-11 |
| CN1160399A (zh) | 1997-09-24 |
| KR100232341B1 (ko) | 2000-07-01 |
| WO1996011920A1 (en) | 1996-04-25 |
| EP0785930A1 (en) | 1997-07-30 |
| CA2201742A1 (en) | 1996-04-25 |
| ZA958597B (en) | 1997-04-14 |
| JPH09512035A (ja) | 1997-12-02 |
| AU696890B2 (en) | 1998-09-24 |
| CZ111797A3 (cs) | 1998-07-15 |
| IL115529A0 (en) | 1996-01-19 |
| FI971524A7 (fi) | 1997-04-11 |
| KR970706270A (ko) | 1997-11-03 |
| NO971672D0 (no) | 1997-04-11 |
| PE10897A1 (es) | 1997-04-21 |
| NZ285156A (en) | 1999-01-28 |
| JP2983295B2 (ja) | 1999-11-29 |
| TR199501270A2 (tr) | 1996-06-21 |
| HUT77515A (hu) | 1998-05-28 |
| BR9504385A (pt) | 1997-05-27 |
| US6133286A (en) | 2000-10-17 |
| PL319688A1 (en) | 1997-08-18 |
| NO971672L (no) | 1997-06-11 |
| AU2416795A (en) | 1996-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4480024A1 (es) | Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo | |
| ES2221183T3 (es) | Compuestos oxicarbamilo que inhiben la adhesion de leucocitos mediada por vla-4. | |
| ES2186015T3 (es) | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol. | |
| SV2002000289A (es) | Antagonistas del factor liberador de la corticotropina ref. pc10759/20117/bb | |
| AR002289A1 (es) | Derivados de acetamida, procedimiento para prepararlos, las composiciones farmaceuticas que los contienen y las aplicaciones de dichos compuestos comoansioliticos y en el tratamiento de enfermedades inmuno-inflamatorias. | |
| PT1315504E (pt) | 1-alfa-hidroxi-2-metileno-19-nor-homopregnacalciferol e suas aplicacoes terapeuticas | |
| PA8508201A1 (es) | Derivados de heterociclo-alquilsulfonil pirazolo como agentes anti-inflamatorios/analgesicos | |
| SV1995000006A (es) | Acido micofenolico 6-substituido y sus derivados | |
| PT92821A (pt) | Processo para a preparacao composicoes farmaceuticas para o combate de doencas do tipo psoriase, bem como doencas inflamatorias, incorporando azelastina como substancia activa | |
| Gunderson | Pharmacotherapy for patients with borderline personality disorder | |
| AR012193A1 (es) | Nuevas combinaciones terapeuticas | |
| ES2068955T3 (es) | Derivados de 1,2,3,4-tetrahidro-9-acridinamina. | |
| AR026726A1 (es) | Nuevos compuestos antitromboticos y composiciones farmaceuticas que los contienen | |
| ES2131513T3 (es) | Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos. | |
| ES2126674T3 (es) | Empleo de o-esteres de l-carnitina con acidos aromaticos para el tratamiento de dermatosis. | |
| ES2061681T3 (es) | Cromados sustituidos y compuestos relacionados en el tratamiento del asma. | |
| MX9203409A (es) | Proteinas bcrfi como inhibidores de la gama interferona. | |
| ES2170390T3 (es) | Fluorenonas alquiloxiamino-substituidas y su uso como inhibidores de la proteina kinasa-c. | |
| ES2129040T3 (es) | Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas. | |
| ES2125356T3 (es) | Empleo de leflunomida para la inhibicion de interleuquina 8. | |
| ES2112832T3 (es) | Derivados carbamoilicos. | |
| BR9916919A (pt) | Compósito de sulfonamida e seu uso | |
| GT199900167A (es) | Nuevos bis-benzimidazoles. | |
| ES2063261T3 (es) | 1-(3-(heteroarilmetoxi)fenil) alcanoles sustituidos y compuestos relacionados en el tratamiento de asma, artritis y enfermedades relacionadas. | |
| ES2063578T3 (es) | Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa. |