CO2017008156A2 - Derivados de 1-(4-(4-(pirimidin-5-il)tiazol-5-il)piperazin-1-il)etan-1-ona y análogos de piridina de los mismos como moduladores del receptor cxcr3, composiciones que los comprenden y métodos de elaboración - Google Patents
Derivados de 1-(4-(4-(pirimidin-5-il)tiazol-5-il)piperazin-1-il)etan-1-ona y análogos de piridina de los mismos como moduladores del receptor cxcr3, composiciones que los comprenden y métodos de elaboraciónInfo
- Publication number
- CO2017008156A2 CO2017008156A2 CONC2017/0008156A CO2017008156A CO2017008156A2 CO 2017008156 A2 CO2017008156 A2 CO 2017008156A2 CO 2017008156 A CO2017008156 A CO 2017008156A CO 2017008156 A2 CO2017008156 A2 CO 2017008156A2
- Authority
- CO
- Colombia
- Prior art keywords
- modulators
- ethan
- piperazin
- thiazol
- elaboration
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención se refiere a compuestos de Fórmula (I), en donde n, X, R1 y R2 son como se describe en la descripción, a sales farmacéuticamente aceptables de los mismos y al uso de dichos compuestos como medicamentos, especialmente como moduladores del receptor CXCR3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2015050696 | 2015-01-15 | ||
PCT/EP2016/050645 WO2016113344A1 (en) | 2015-01-15 | 2016-01-14 | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017008156A2 true CO2017008156A2 (es) | 2017-11-30 |
Family
ID=55129886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0008156A CO2017008156A2 (es) | 2015-01-15 | 2017-08-11 | Derivados de 1-(4-(4-(pirimidin-5-il)tiazol-5-il)piperazin-1-il)etan-1-ona y análogos de piridina de los mismos como moduladores del receptor cxcr3, composiciones que los comprenden y métodos de elaboración |
Country Status (38)
Country | Link |
---|---|
US (1) | US10053457B2 (es) |
EP (1) | EP3245203B1 (es) |
JP (1) | JP6337218B2 (es) |
KR (1) | KR101967083B1 (es) |
CN (1) | CN107250133B (es) |
AR (1) | AR103414A1 (es) |
AU (1) | AU2016207988B2 (es) |
BR (1) | BR112017015093A2 (es) |
CA (1) | CA2972952C (es) |
CL (1) | CL2017001831A1 (es) |
CO (1) | CO2017008156A2 (es) |
CY (1) | CY1121361T1 (es) |
DK (1) | DK3245203T3 (es) |
EA (1) | EA032927B1 (es) |
ES (1) | ES2709985T3 (es) |
HK (1) | HK1246789B (es) |
HR (1) | HRP20190024T1 (es) |
HU (1) | HUE042559T2 (es) |
IL (1) | IL253411B (es) |
LT (1) | LT3245203T (es) |
MA (1) | MA41337A (es) |
MX (1) | MX2017009288A (es) |
MY (1) | MY187614A (es) |
NZ (1) | NZ734542A (es) |
PE (1) | PE20171100A1 (es) |
PH (1) | PH12017501280B1 (es) |
PL (1) | PL3245203T3 (es) |
PT (1) | PT3245203T (es) |
RS (1) | RS58349B1 (es) |
SA (1) | SA517381905B1 (es) |
SG (1) | SG11201705617XA (es) |
SI (1) | SI3245203T1 (es) |
TN (1) | TN2017000278A1 (es) |
TR (1) | TR201900680T4 (es) |
TW (1) | TWI693221B (es) |
UA (1) | UA119805C2 (es) |
WO (1) | WO2016113344A1 (es) |
ZA (1) | ZA201705486B (es) |
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TR201900680T4 (tr) * | 2015-01-15 | 2019-02-21 | Idorsia Pharmaceuticals Ltd | CXCR3 Reseptör modülatörleri olarak hidroksialkil- piperazin türevleri. |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
WO2018011265A1 (en) * | 2016-07-13 | 2018-01-18 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
WO2020060964A1 (en) * | 2018-09-18 | 2020-03-26 | Alxerion Biotech Corp. | 1, 2, 4-oxadiazole derivatives and uses thereof |
AU2022215025A1 (en) | 2021-01-28 | 2023-09-14 | Idorsia Pharmaceuticals Ltd | Crystalline form of a piperazinyl-thiazole derivative |
WO2024052445A1 (en) | 2022-09-09 | 2024-03-14 | Idorsia Pharmaceuticals Ltd | Pharmaceutical combination comprising an anti-cd3 antibody and a cxcr3 antagonist |
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