CO2017002312A2 - Compuestos bicíclicos sustituidos - Google Patents

Compuestos bicíclicos sustituidos

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Publication number
CO2017002312A2
CO2017002312A2 CONC2017/0002312A CO2017002312A CO2017002312A2 CO 2017002312 A2 CO2017002312 A2 CO 2017002312A2 CO 2017002312 A CO2017002312 A CO 2017002312A CO 2017002312 A2 CO2017002312 A2 CO 2017002312A2
Authority
CO
Colombia
Prior art keywords
compounds
substituted bicyclic
bicyclic compounds
diseases
slowing
Prior art date
Application number
CONC2017/0002312A
Other languages
English (en)
Inventor
Hai-Yun Xiao
Alaric J Dyckman
Zili Xiao
Michael G Yang
T G Murali Dhar
John L Gilmore
David Marcoux
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO2017002312A2 publication Critical patent/CO2017002312A2/es

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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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Abstract

Compuestos de las Fórmulas (I), (II), (III), (IV) y (V), y/o una sal de estos, en donde R1 es -OH u -OP(O)(OH)2, y X1, X2, X3, R2, R2a, Ra, Rb y Rc se definen en la presente. También se describen métodos para usar estos compuestos como agonistas selectivos del receptor S1P1 acoplado a la proteína G, y composiciones farmacéuticas que comprenden estos compuestos. Estos compuestos son útiles para el tratamiento, la prevención o la ralentización de la progresión de enfermedades o trastornos en varias áreas terapéuticas, tales como enfermedades autoinmunitarias y vasculares.
CONC2017/0002312A 2014-08-20 2017-03-08 Compuestos bicíclicos sustituidos CO2017002312A2 (es)

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