BR112017002641A2 - compostos bicíclicos substituídos - Google Patents

compostos bicíclicos substituídos

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Publication number
BR112017002641A2
BR112017002641A2 BR112017002641A BR112017002641A BR112017002641A2 BR 112017002641 A2 BR112017002641 A2 BR 112017002641A2 BR 112017002641 A BR112017002641 A BR 112017002641A BR 112017002641 A BR112017002641 A BR 112017002641A BR 112017002641 A2 BR112017002641 A2 BR 112017002641A2
Authority
BR
Brazil
Prior art keywords
compounds
substituted bicyclic
bicyclic compounds
iii
diseases
Prior art date
Application number
BR112017002641A
Other languages
English (en)
Other versions
BR112017002641B1 (pt
Inventor
J Dyckman Alaric
Marcoux David
Xiao Hai-Yun
L Gilmore John
g yang Michael
G Murali Dhar T
Xiao Zili
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112017002641A2 publication Critical patent/BR112017002641A2/pt
Publication of BR112017002641B1 publication Critical patent/BR112017002641B1/pt

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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Abstract

são descritos compostos de fórmulas (i), (ii), (iii), (iv), e (v): (i) (ii) (iii) (iv) (v) e/ou um sal do mesmo, em que r1 é -oh ou -op(o)(oh)2, e x1, x2, x3, r2, r2a, ra, rb, e rc são definidos aqui. são também descritos méto-dos de uso de tais compostos como agonistas seletivos para receptor s1p1 de proteína g, e composições farmacêuticas compreendendo tais compostos. estes compostos são úteis no tratamento, prevenção, ou retardo da progressão de doenças ou distúrbios em uma variedade de áreas terapêuticas, tais como doenças autoimunes e doença vascu-lar.
BR112017002641-4A 2014-08-20 2015-08-20 Compostos bicíclicos substituídos, uso dos mesmos e composição farmacêutica BR112017002641B1 (pt)

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US201462039622P 2014-08-20 2014-08-20
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PCT/US2015/046005 WO2016028959A1 (en) 2014-08-20 2015-08-20 Substituted bicyclic compounds

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