CN1960731B - 调节炎性和转移过程的方法 - Google Patents

调节炎性和转移过程的方法 Download PDF

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Publication number
CN1960731B
CN1960731B CN2005800095231A CN200580009523A CN1960731B CN 1960731 B CN1960731 B CN 1960731B CN 2005800095231 A CN2005800095231 A CN 2005800095231A CN 200580009523 A CN200580009523 A CN 200580009523A CN 1960731 B CN1960731 B CN 1960731B
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China
Prior art keywords
benzimidazol
quinolin
amino
ylamino
oct
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Expired - Fee Related
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CN2005800095231A
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English (en)
Chinese (zh)
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CN1960731A (zh
Inventor
S·H·李
C·C·海斯
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NOVARTIS VACCINES and DIAGNOSTIC Inc
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Novartis Vaccines and Diagnostics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2005800095231A 2004-02-20 2005-02-18 调节炎性和转移过程的方法 Expired - Fee Related CN1960731B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US54639504P 2004-02-20 2004-02-20
US60/546,395 2004-02-20
US54710304P 2004-02-23 2004-02-23
US60/547,103 2004-02-23
US55477104P 2004-03-19 2004-03-19
US60/554,771 2004-03-19
PCT/US2005/005316 WO2005082340A2 (en) 2004-02-20 2005-02-18 Modulation of inflammatory and metastatic processes

Publications (2)

Publication Number Publication Date
CN1960731A CN1960731A (zh) 2007-05-09
CN1960731B true CN1960731B (zh) 2011-12-07

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CN2005800095231A Expired - Fee Related CN1960731B (zh) 2004-02-20 2005-02-18 调节炎性和转移过程的方法

Country Status (10)

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US (1) US7875624B2 (https=)
EP (1) EP1718306A2 (https=)
JP (1) JP5019884B2 (https=)
CN (1) CN1960731B (https=)
AU (1) AU2005216904B2 (https=)
BR (1) BRPI0507891A (https=)
CA (1) CA2556872C (https=)
IL (1) IL177574A0 (https=)
RU (1) RU2377988C2 (https=)
WO (1) WO2005082340A2 (https=)

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CA2556872A1 (en) 2005-09-09
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AU2005216904B2 (en) 2010-11-25
RU2006133536A (ru) 2008-03-27
WO2005082340A2 (en) 2005-09-09
EP1718306A2 (en) 2006-11-08
US7875624B2 (en) 2011-01-25
IL177574A0 (en) 2006-12-10
CA2556872C (en) 2015-05-12
US20050239825A1 (en) 2005-10-27
CN1960731A (zh) 2007-05-09
AU2005216904A1 (en) 2005-09-09
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JP5019884B2 (ja) 2012-09-05
RU2377988C2 (ru) 2010-01-10

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