CN1943781B - 用于改善动脉粥样硬化的口服给药的肽 - Google Patents

用于改善动脉粥样硬化的口服给药的肽 Download PDF

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CN1943781B
CN1943781B CN2006101006689A CN200610100668A CN1943781B CN 1943781 B CN1943781 B CN 1943781B CN 2006101006689 A CN2006101006689 A CN 2006101006689A CN 200610100668 A CN200610100668 A CN 200610100668A CN 1943781 B CN1943781 B CN 1943781B
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peptide
seq
peptides
ldl
item
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CN1943781A (zh
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艾伦·M·福格尔曼
加塔达哈里·M·阿南萨拉梅亚
默罕穆德·纳瓦布
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
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    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
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  • Virology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
CN2006101006689A 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽 Expired - Lifetime CN1943781B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/645,454 US6664230B1 (en) 2000-08-24 2000-08-24 Orally administered peptides to ameliorate atherosclerosis
US09/645,454 2000-08-24

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
CN200510103876A Division CN100579984C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNB018172806A Division CN1224419C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽

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CN1943781A CN1943781A (zh) 2007-04-11
CN1943781B true CN1943781B (zh) 2011-01-12

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Application Number Title Priority Date Filing Date
CN2006101006689A Expired - Lifetime CN1943781B (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNB018172806A Expired - Lifetime CN1224419C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNA2006101006706A Pending CN1911439A (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNA2006101006674A Pending CN1931358A (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CN200510103876A Expired - Lifetime CN100579984C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CN200610100669.3A Expired - Lifetime CN1931359B (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽

Family Applications After (5)

Application Number Title Priority Date Filing Date
CNB018172806A Expired - Lifetime CN1224419C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNA2006101006706A Pending CN1911439A (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CNA2006101006674A Pending CN1931358A (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CN200510103876A Expired - Lifetime CN100579984C (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽
CN200610100669.3A Expired - Lifetime CN1931359B (zh) 2000-08-24 2001-08-23 用于改善动脉粥样硬化的口服给药的肽

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Country Link
US (2) US6664230B1 (https=)
EP (3) EP1864675B1 (https=)
JP (6) JP3822167B2 (https=)
CN (6) CN1943781B (https=)
AT (2) ATE464060T1 (https=)
AU (4) AU2001286732B2 (https=)
CA (3) CA2639651C (https=)
CY (1) CY1110204T1 (https=)
DE (2) DE60144543D1 (https=)
DK (1) DK1318828T3 (https=)
EA (2) EA006488B1 (https=)
ES (2) ES2438779T3 (https=)
IL (3) IL154545A0 (https=)
PT (1) PT1318828E (https=)
WO (1) WO2002015923A1 (https=)

Cited By (5)

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US7994132B2 (en) 2000-08-24 2011-08-09 The Regents Of The University Of California Peptides for treatment of scleroderma
US8048851B2 (en) 2000-08-24 2011-11-01 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US8236754B2 (en) 2004-12-06 2012-08-07 The Regents Of The University Of California Methods for improving the structure and function of arterioles
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease

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* Cited by examiner, † Cited by third party
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US7144862B2 (en) * 2000-08-24 2006-12-05 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7166578B2 (en) * 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
US6664230B1 (en) * 2000-08-24 2003-12-16 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US6930085B2 (en) * 2002-04-05 2005-08-16 The Regents Of The University Of California G-type peptides to ameliorate atherosclerosis
DE10222234A1 (de) * 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Kontroll- und Kalibrationsmaterial für Blutgerinnungstests
EP1558275A4 (en) * 2002-10-30 2009-06-24 Us Health TARGETING OF B1 (CLA-1) BUTARY RECEPTOR FOR THE TREATMENT OF INFECTION, SEPSIS AND INFLAMMATION
CA2514303C (en) * 2002-11-13 2012-09-18 The Uab Research Foundation Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
US20050159362A1 (en) * 2003-04-22 2005-07-21 Sircar Jagadish C. Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
TW200503747A (en) * 2003-04-22 2005-02-01 Avanir Pharmaceuticals Peptide mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
GB0311081D0 (en) * 2003-05-14 2003-06-18 Btg Internat Limted Treatment of neurodegenerative conditions
FI20060154A7 (fi) * 2003-08-18 2006-05-11 Btg Int Ltd Neurogeneratiivisten tilojen hoito
ES2381551T3 (es) 2003-12-05 2012-05-29 The Cleveland Clinic Foundation Marcadores de riesgo para enfermedad cardiovascular
GB0329958D0 (en) 2003-12-24 2004-01-28 Univ Manchester Treatment of viral infections
GB0404374D0 (en) 2004-02-27 2004-03-31 Univ Manchester Treatment of bacterial infections
ATE463254T1 (de) * 2004-04-15 2010-04-15 Athera Biotechnologies Ab Antikörper gegen phosphorylcholinkonjugate
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
TW200603794A (en) * 2004-06-09 2006-02-01 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
US20060009487A1 (en) * 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
EP1753782A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
KR101185609B1 (ko) * 2004-07-16 2012-09-24 트러스티즈 오브 터프츠 칼리지 아포리포단백질 ａ１ 미메틱 및 이의 용도
US7378396B2 (en) 2004-08-11 2008-05-27 The Cleveland Clinic Foundation Therapeutic agents and methods for cardiovascular disease
EP1789035A2 (en) * 2004-08-11 2007-05-30 The Regents of the University of California-San Francisco Orally administered small peptides synergize statin activity
AU2005287004B2 (en) * 2004-09-16 2011-03-17 The Regents Of The University Of California G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
WO2006053754A1 (en) * 2004-11-19 2006-05-26 Novartis Ag COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
GB0504333D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Treatment of cytokine dysregulation
GB0504362D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
MX2007013430A (es) 2005-04-29 2008-03-19 Univ California Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria.
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
GR1005428B (el) * 2005-05-27 2007-02-01 Χαραλαμπος Αλεξοπουλος Συνθετικα λιποπεπτιδια με αντιαθηρογονο δραση, που εμποδιζουν την οξειδωση της λιποπρωτεϊνης χαμηλης πυκνοτητας (ldl) και αναστελλουν την απενεργοποιηση του ενζυμου της paf ακετυλοϋδρολασης (paf-ah)
GB0513096D0 (en) * 2005-06-28 2005-08-03 Strathclyde Treatment of microbial infections
WO2007055873A2 (en) * 2005-11-04 2007-05-18 Avanir Pharmaceuticals Process for the manufacture of peptide facilitators of reverse cholesterol transport
WO2007059372A2 (en) * 2005-11-09 2007-05-24 St. Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
ES2402823T3 (es) * 2006-06-01 2013-05-09 Institut De Cardiologie De Montreal Compuesto para uso en el tratamiento de estenosis valvular
US20080206142A1 (en) * 2006-06-16 2008-08-28 Lipid Sciences, Inc. Novel Peptides That Promote Lipid Efflux
US20080227686A1 (en) * 2006-06-16 2008-09-18 Lipid Sciences, Inc. Novel Peptides that Promote Lipid Efflux
EP2041174A2 (en) * 2006-06-16 2009-04-01 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
AU2007284801A1 (en) 2006-08-08 2008-02-21 The Regents Of The University Of Californina Salicylanilides enhance oral delivery of therapeutic peptides
WO2008039843A2 (en) * 2006-09-26 2008-04-03 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
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