CN1933744A - Nicotine-reducing agent and nicotine reduction method - Google Patents

Nicotine-reducing agent and nicotine reduction method Download PDF

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Publication number
CN1933744A
CN1933744A CN 200580008846 CN200580008846A CN1933744A CN 1933744 A CN1933744 A CN 1933744A CN 200580008846 CN200580008846 CN 200580008846 CN 200580008846 A CN200580008846 A CN 200580008846A CN 1933744 A CN1933744 A CN 1933744A
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China
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nicotine
depressant
gum
cigarette
water
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CN 200580008846
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CN100566610C (en
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小岛直人
大本俊郎
小坂井淳
岩渕久克
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San Ei Gen FFI Inc
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San Ei Gen FFI Inc
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Abstract

A nicotine-reducing agent and a smoking device for reducing nicotine which are to be used for lowering the nicotine content in the tobacco mainstream smoke; and a method of lowering the nicotine content in the tobacco mainstream smoke by using the nicotine-reducing agent or the smoking device for reducing nicotine as described above. This nicotine-reducing agent may comprise an aqueous liquid composition containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxyprpylmethylcellulose and carageenan and having a viscosity of from 500 to 3000 mPa<.>s.

Description

The reduction method of nicotine depressant and nicotine
Technical field
The present invention relates to be used for being reduced in the nicotine depressant and the nicotine reduction smoking equipment of the contained nicotine content of cigarette mainstream smoke.In addition, the present invention relates to use smoking equipment, from the cigarette mainstream smoke, reduce the method for nicotine content and the method for reduction tar content by using above-mentioned nicotine depressant or nicotine to reduce.
Background technology
In the cigarette of cigarette, allegedly contain the 4000 kinds of chemical substances of having an appointment, wherein have harmful substances and cause oncofetal substance.Wherein, as the representative example of harmful substance contained in the cigarette of cigarette, can enumerate nicotine, tar and carbon monoxide.Therefore, in the past since, in order from the cigarette of cigarette, to get rid of these harmful substances, studied the whole bag of tricks.
As these method, for example, propose the cigarette of cigarette contact, the method (patent documentation 1～3) of contained nicotine content in the cigarette (mainstream smoke) of the cigarette of reduction suction with water by water being contained be immersed in the filtration mouth of Smoking pipe.This method has easy character soluble in water based on nicotine contained in the cigarette of cigarette.But the filtration mouth at Smoking pipe has the structure that contains water like this, can see the effect of removing nicotine, and the water that contains harmful nicotine and tar ingredients when still existing in smoking enters the mouth with cigarette, flows into the tendency in the body.
As method to this prevention or elimination, proposition cooperates the method (patent documentation 4) of cyclodextrin and water absorbent polymer etc. in the suction inlet filter tip of cigarette, as the composition of the filtration mouth of the Smoking pipe of installing, using in the suction inlet portion of cigarette, use the scheme of the method (patent documentation 5 or 6) etc. of porous polymer.But the former cooperates the method for water absorbent polymer in cigarette suction inlet filter tip, because the suction inlet filter tip adsorbs volume water under high humidity, so the inspiratory resistance during smoking increases, and the problem that exists smoking itself to become difficult.
Keep the filter-tip wooden and plastic smoking cessation pipe (patent documentation 7) of impregnation mucus in also known, the trouble of accessory is installed when having smoking in the method.In addition, also known cigarette filter tip and the suction inlet face on be coated with the gelation thing thinly, with its former state ground or insert carry out smoking in the pipe take off nicotine tar agent (patent documentation 8), the gelation thing does not soak in the filter tip of cigarette, the gelation thing that remains on the filter tip disperses in mouth, when producing unhappy sensation, the smoking difficulty that becomes.
But as getting rid of harmful substance from the cigarette of cigarette, particularly getting rid of the method for nicotine, what must consider is the dependence of smoker to nicotine.The people of smoking, because usually nicotine is had dependence psychology or health, so, reduce the nicotine intake sharp, may not be preferred for the smoker, wish to reduce the nicotine intake according to health and the psychological condition of this moment.So, can reduce interimly and even relax dependency degree, and then also may reach smoking cessation the health of the psychology of nicotine.Therefore, seek not to be merely to reduce nicotine content, but smoker oneself can regulate the method for nicotine intake according to the situation of oneself.
Patent documentation 1: the Japan Patent spy opens clear 48-53871 communique
Patent documentation 2: the Japan Patent spy opens clear 50-130579 communique
Patent documentation 3: the Japan Patent spy opens clear 62-198378 communique
Patent documentation 4: the Japan Patent spy opens clear 51-32799 communique
Patent documentation 5: the Japan Patent spy opens clear 62-179376 communique
Patent documentation 6: the Japan Patent spy opens clear 47-30900 communique
Patent documentation 7: the Japan Patent spy opens clear 56-18583 communique
Patent documentation 8: the Japan Patent spy opens clear 61-177972 communique
Summary of the invention
The object of the present invention is to provide the nicotine depressant and the nicotine reduction smoking equipment that are used for being reduced in the contained nicotine content of cigarette mainstream smoke.In addition, the object of the present invention is to provide by using above-mentioned nicotine depressant or nicotine to reduce and use smoking equipment, from the cigarette mainstream smoke, reduce the method for nicotine content and the method that reduces tar content.
The inventor etc. to be used for being reduced in the contained nicotine content of cigarette mainstream smoke and to further investigate in order to develop, discovery contains tamarind seed glue (tamarind seed gum), xanthans (xanthan gum), locust bean gum kinds of specific polysaccharides classes such as (locust bean gum), viscosity is adjusted into the water-based liquid composition of 500～3000mPas, the ability excellence that nicotine is removed in absorption from the cigarette mainstream smoke, even make it to be contained in the filtration mouth of cigarette and smoking equipment, also influence smoking hardly.In addition, the inventor etc. are by using these polysaccharides, in addition as required, by these polysaccharides and carbohydrate are used in combination, can obtain being not easy to be subjected to the influence of temperature Change and long preservation generation, through the water-based liquid composition that can have stable viscosity and proterties whole season, then, confirm that such water-based liquid composition can state nicotine reduction method aspect on the implementation and become suitable nicotine depressant.
The inventor etc. also confirm by increasing the use amount (to filter-tip dosage) of this water-based liquid composition, the amount of the nicotine that increase can be removed from the cigarette mainstream smoke.Like this, just mean that smoker oneself can control the nicotine content that is sucked in the body by smoking simply by the use amount of regulating this water-based liquid composition.Promptly, if according to above-mentioned water-based liquid composition, by the dependency degree of nicotine being increased this use amount (to filter-tip dosage) by stages according to the smoker, can reduce the nicotine content that is sucked in the body by stages, so, mitigation becomes the generation of the nicotine dependence disease of greatest problem aspect smoking cessation, finally can reach smoking cessation.
The present invention is based on that such opinion finishes.That is, the present invention comprises following embodiment:
1. 1 kinds of nicotine depressants of item are by containing at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide (pullulan), psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the water-based liquid composition formation that viscosity is 500～3000mPas.
An item 2. as 1 a described nicotine depressant, polysaccharide is at least a kind that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum and the pectin.
An item 3. as 1 a described nicotine depressant, polysaccharide is at least a kind that is selected from tamarind seed glue, locust bean gum and the xanthans.
An item 4. as 1 a described nicotine depressant also contain carbohydrate.
An item 5. as 4 a described nicotine depressant, carbohydrate is at least a kind that is selected from trehalose, maltose, sucrose, glucose, fructose, maltose, D-sorbite, maltitol, lactitol, erythrite, xylitol and the dextrin.
An item 6. as 4 a described nicotine depressant, carbohydrate is at least a kind that is selected from trehalose and the maltose.
An item 7. as 1 a described nicotine depressant are in the maintenance of filtration mouth, the use of smoking equipment.
8. 1 kinds containers dress nicotine depressants, the nicotine depressant that filling is made of item 1 described water-based liquid composition in container and forming.
In addition,,, can be fit to use the formula container that drips here as container.
9. 1 kinds of nicotines of item reduce uses smoking equipment, has the filtration mouth that keeps 1 a described nicotine depressant.
10. 1 kinds of items as 9 a described nicotine reduce uses smoking equipments, it is characterized in that, described nicotine reduces and is included in an end with smoking equipment and has attract mouthful, have in the other end cigarette holder (holder) body that cigarette inserts mouthful and the filter tip that is provided with in this cigarette holder body, keeps 1 a described nicotine depressant and constitute in described filter tip.
11. 1 kinds of nicotines of item reduce uses smoking equipments, it is to be included in an end to have attract mouthful, have in the other end cigarette holder body that cigarette inserts mouthful and the filter-tip cigarette holder that is provided with in this cigarette holder body, also has strap clamp block (cap) that the attraction oral-lateral at above-mentioned cigarette holder body can load and unload in addition and inserts the lid that oral-lateral can load and unload the cigarette of above-mentioned cigarette holder body.
12. 1 kinds as 11 a described nicotine reduce use smoking equipment, it is characterized in that, keeps item 1 described nicotine depressant and constitute in filter tip.
13. 1 kinds of methods that reduce the nicotine content in the cigarette mainstream smoke, the step that is included in the smoking equipment filter tip that contains 1 a described nicotine depressant, the mainstream smoke of cigarette is passed through.
In addition, water-based liquid composition of the present invention (nicotine depressant) shown in the experimental example 4, by using this water-based liquid composition, not only can be reduced in nicotine content contained in the cigarette mainstream smoke as described later, and tar content is reduced.Therefore, above-mentioned " nicotine depressant " and " nicotine reduce use smoking equipment " respectively can be in other words: " tar depressant " and " tar reduction smoking equipment ", perhaps " nicotine and tar depressant " and " nicotine and tar reduction smoking equipment ".In addition, from reducing the viewpoint of tar, the present invention also provides following method.
14. 1 kinds of methods that reduce the tar content in the cigarette mainstream smoke of item, has in the filter tip of the smoking equipment that contains a kind of polysaccharide being selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide (pullulan), psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, water-based liquid composition (tar depressant) that viscosity is 500～3000mPas the step that the cigarette mainstream smoke is passed through at least.
As described above, the nicotine depressant of the application of the invention (water-based liquid composition), the nicotine dependence degree that becomes and to relax the smoker.Therefore, from such viewpoint, the present invention also provides following method.
15. couples of testees that smoking habit is arranged of item, use has the filter-tip smoking equipment that contains at least a kind of polysaccharide being selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, water-based liquid composition (tar depressant) that viscosity is 500～3000mPas, makes it smoking and the method for this testee's of mitigation of constituting nicotine dependence degree.
The present invention provides following purposes about water-based liquid composition of the present invention.
Item 16. contains at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide (pullulan), psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the use of water-based liquid composition in modulation nicotine depressant or tar depressant that viscosity is 500～3000mPas.
An item 17. as 16 a described use, the water-based liquid composition also contains carbohydrate.
An item 18. as 17 a described use, above-mentioned carbohydrate is at least a kind that is selected from trehalose, maltose, sucrose, glucose, fructose, maltose, D-sorbite, maltitol, lactitol, erythrite, xylitol and the dextrin.
Item 19. contains at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide (pullulan), psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the use of water-based liquid composition in reducing nicotine or tar that viscosity is 500～3000mPas.
An item 20. as 19 a described use, the water-based liquid composition also contains carbohydrate.
An item 21. as 20 a described use, above-mentioned carbohydrate is at least a kind that is selected from trehalose, maltose, sucrose, glucose, fructose, maltose, D-sorbite, maltitol, lactitol, erythrite, xylitol and the dextrin.
Description of drawings
Fig. 1 is expression reduces cigarette holder 1 outward appearance of a mode using smoking equipment as a nicotine of the present invention plane.
Fig. 2 is the plane that expression nicotine of the present invention reduces cigarette holder 11 outward appearances of the another way of using smoking equipment.
Fig. 3 is the side view of the cigarette holder 11 of Fig. 2.
Fig. 4 is the III-III line sectional view of Fig. 2.
Fig. 5 is the IV-IV line sectional view of Fig. 3.
Fig. 6 is illustrated in the side view that the state of lid 77 is installed on the strap clamp block 66 of cigarette holder 11 of Fig. 2.
Fig. 7 is the longitdinal cross-section diagram of Fig. 6.
Fig. 8 is the nicotine reduced rate of expression nicotine depressant of the present invention (water-based liquid composition) and the figure (experimental example 4) of tar reduced rate.
Symbol description
1. reduce the cigarette holder of a mode using smoking equipment as nicotine of the present invention
2. filter tip (maintaining part)
3. cigarette holder body
4. suction inlet portion
5. cigarette is inserted mouth
6. strap clamp is blocked a shot
7. lid
8. be used for the strap clamp block is inserted the jut of suction inlet portion
9. the peristome of strap clamp block
10. edge portion (rim)
11. reduce the cigarette holder of the another way of using smoking equipment as nicotine of the present invention
The specific embodiment
(1) nicotine depressant
Nicotine depressant of the present invention, it is characterized in that, constitute by containing the water-based liquid composition that is selected from least a kind of polysaccharide in tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan.
Tamarind seed glue (Tamarind seed gum) be can from as the perennial dicotyledon tamarind of pulse family ( Tamarindus GrandifloraPERS.) water-soluble polysaccharides that seed obtains.Locust bean gum be can from the pulse family algaroba ( Ceratonia Siliqua) the polysaccharide that obtains of seed.Xanthans (Xantham gum) be the yellow sporangium of microorganism sarson ( Xanthomonas Campestris) the fermentation polysaccharide that produces.Tara gum (Tara gum) be can from silvenine (マ PVC) Ke Tala ( Actinidia CallosaLINDL.) water-soluble polysaccharides that seed obtains.Guar gum (Guar gum) be can from the pulse family cluster bean ( Cyamopsis TetragonolobasTAUB.) polysaccharide that obtains or the product that obtains with enzyme (hemicellulase) decomposition guar gum.Pectin (Pectin) is that can to extract what obtain from citrus and apple etc. by water be the polysaccharide of main component with the polygalacturonic acid that methylates.By its esterification degree (DE) (content of methoxyl group), can rough classification be that HM pectin is (in whole galacturonic acids, the ratio of occupying of polygalacturonic acid of methylating is more than 50%) and LM pectin (in whole galacturonic acids, the ratio of occupying of the galacturonic acid that methylates is below 50%).In the present invention, do not distinguish HM pectin and LM pectin, can use.
Pulullan polysaccharide (Pullulan) be black yeast ( Aureobasidiumpullulans[DEBary] ARN.) polysaccharide of Chan Shenging.Psyllium seed gum (Psyllium seed gum) be can from the Plantaginaceae Asiatic plantain ( PlantagoovataFORSK.) or the polysaccharide that obtains of the seed of congener.Carrageenan (Carrageenan) be can from the Gigartinaceae Bostrychia montagnei ( ChondruscrispusLYNGB.), the China fir sea sedge ( Gigartina TenellaHARV.), red tail feather dish section Eucheuma ( EucheumamuricatumW.v.BOSS forma depaupaerata W.v.BOSSE), Hypneacea is frozen in the leaf of husky dish (Hypneajaponica TANAKA) etc. and is extracted the polysaccharide that obtains with water.This polysaccharide can be categorized as kappa (κ), iota (τ), lambda (λ) 3 classes.In the present invention, do not distinguish kappa carrageenan, τ-carrageenan, λ-carrageenan, can use, but can use λ-carrageenan with being more suitable for.
These polysaccharides and methylcellulose, carboxymethyl cellulose and hydroxypropyl methylcellulose all are as being called the raw material that food is extensively commercially available with the food additives of tackifier and tackify stabilizing agent etc., utilize.In the present invention, be not particularly limited ground, can extensively utilize in the past as food additives commercially available tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and carrageenan.
Wherein preferred polysaccharide is tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum and pectin, and particularly preferred polysaccharide is tamarind seed glue, locust bean gum and xanthans.
Nicotine depressant of the present invention is characterized in that, is made of the water-based liquid composition with 500～3000mPas viscosity.Here, viscosity refers to 20 ℃, uses the Type B rotation viscometer (viscosity uses No. 3 rotors when 2000mPas is following, use No. 4 rotors during greater than this viscosity), the viscosity that obtains with 60rpm, 1 minute mensuration.Preferred viscosity is 500～2500mPas, 1000～2500mPas more preferably.
The water-based liquid composition is adjusted into method of viscosity like this has no particular limits, can be by selecting the solvent of the above-mentioned various polysaccharides of dissolving, or the ratio of regulating the polysaccharide that uses, or cooperate other one-tenth to grade and carry out.
The solvent that uses in the dissolving of above-mentioned polysaccharides such as tamarind seed glue, xanthans or locust bean gum if can dissolve the solvent of these compositions, just has no particular limits.From security and convenience, preferably water.In addition, in the scope of not damaging effect of the present invention, also can be used in combination water and ethanol, propane diols or glycerine etc.
Above-mentioned polysaccharide (tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and carrageenan), can use a kind of active ingredient separately, also can use according to making up arbitrarily as desired more than 2 kinds as nicotine depressant of the present invention.As these combinations that is fit to, without limits, can illustration tamarind seed glue and the combination of combination, tamarind seed glue and the tara gum of combination, locust bean gum and the methylcellulose of combination, tamarind seed glue and the xanthans of locust bean gum and the combination of tamarind seed glue and guar gum.
The ratio of the above-mentioned polysaccharide (tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose or carrageenan) that in nicotine depressant (water-based liquid composition), cooperates, the nicotine depressant that obtains (water-based liquid composition) if viscosity for the scope of above-mentioned 500～3000mPas, be preferably 500～2500mPas, the such ratio of 1000～2500mPas more preferably, just have no particular limits.
For example, as the ratio of the polysaccharide that in the nicotine depressant (water-based liquid composition) of 100 weight %, uses, can be illustrated in the ratio of record in the table 1.
Table 1
(weight %)
Common ratio Preferred ratio Preferred ratio
Tamarind seed glue 1.5～3.0 1.5～2.5 2.0～2.5
Locust bean gum 0.5～1.5 0.5～1.25 0.75～1.25
Xanthans 0.5～3.0 0.5～2.5 1.0～2.5
Tara gum 0.5～1.2 0.5～1.0 0.6～1.0
Guar gum 0.5～1.5 0.5～1.25 0.75～1.25
Pectin 4.0～10.0 4.0～8.0 5.0～8.0
Pulullan polysaccharide 15.0～25.0 15.0～22.5 17.5～22.5
Psyllium seed gum 0.6～2.0 0.6～1.75 0.75～1.75
Methylcellulose 2.0～4.0 2.0～3.5 2.5～3.5
Carboxymethyl cellulose 1.5～3.0 1.5～2.5 2.0～2.5
Hydroxypropyl methylcellulose 2.0～5.0 2.0～4.0 3.0～4.0
Carrageenan 1.0～2.5 1.0～2.25 1.5～2.25
These compositions are at random made up when using more than 2 kinds, its portfolio ratio and use level are standard with above-mentioned each cooperation ratio also, can be with the viscosity of the nicotine depressant (water-based liquid composition) that obtains 500～3000mPas scope, be preferably 500～2500mPas, more preferably 1000～2500mPas adjusts decision as index.For example, when being used in combination tamarind seed glue and locust bean gum, as the cooperation ratio of each composition, tamarind seed glue that can relative 1 weight portion of illustration, locust bean gum is 0.1～10 weight portion above-mentionedly, be preferably 0.2～5 weight portion.When being used in combination tamarind seed glue and xanthans, as the cooperation ratio of each composition, tamarind seed glue that can relative 1 weight portion of illustration, xanthans is 0.02～1 weight portion, be preferably 0.05～0.5 weight portion.In addition, when being used in combination methylcellulose and locust bean gum, as the cooperation ratio of each composition, methylcellulose that can relative 1 weight portion of illustration, locust bean gum be 0.2～20 weight portion, be preferably 0.5～10 weight portion.In addition, when being used in combination tamarind seed glue and tara gum, as the cooperation ratio of each composition, tamarind seed glue that can relative 1 weight portion of illustration, tara gum is 0.1～10 weight portion, be preferably 0.2～5 weight portion.In addition, when being used in combination tamarind seed glue and guar gum, as the cooperation ratio of each composition, tamarind seed glue that can relative 1 weight portion of illustration, guar gum is 0.1～10 weight portion, be preferably 0.2～5 weight portion.
Nicotine depressant of the present invention, at least a kind of polysaccharide in being selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and carrageenan, in the scope of not damaging effect of the present invention, can cooperate carbohydrate.By in above-mentioned polysaccharide, making up carbohydrate, can improve viscosity and viscosity stability, can improve the reduced rate of nicotine and tar.
The carbohydrate that be fit to use in the present invention can illustration glucose, the monose or these the reduced sugar (for example D-sorbite, xylitol, erythrite) of fructose, galactolipin, mannose, wood sugar, erythrose etc.; The disaccharides or these the reduced sugar (for example maltitol, lactitol) of trehalose, maltose, isomaltose, black mold sugar, cellobiose, sucrose, lactose etc.; The compound sugar of beet compound sugar, maltose compound sugar, isomaltose compound sugar, fructose oligosaccharides, galactolipin compound sugar, wood sugar compound sugar, newborn fructo-oligose etc. or these reduced sugar; Dextrin and maltose etc. from the sugar of starch or these reduced sugar (for example reduce maltose).
Preferably can enumerate the monose or these the reduced sugar (D-sorbite, xylitol, erythrite) of glucose, fructose etc.; Disaccharides or these reduced sugars (maltitol, lactitol) such as trehalose, maltose, sucrose; Dextrin and maltose.More preferably the starch sugar of glucose and reduced sugar thereof (D-sorbite), maltose and reduced sugar (maltitol), trehalose, dextrin and maltose etc. (utilizes enzyme or acid, make that starch decomposes, enzyme shifts, enzyme in conjunction with and the monosaccharide, compound sugar and the reduzate thereof that obtain), especially preferably D-sorbite, trehalose and maltose.
These can be independent a kind or make up arbitrarily more than 2 kinds and use, and is used in combination with above-mentioned polysaccharide.As preferred combination, can illustration trehalose and maltose, D-sorbite and maltose etc.
The ratio of these carbohydrates that in nicotine depressant of the present invention (100 weight %), cooperate, have no particular limits, can be with the viscosity of final nicotine depressant 500～3000mPas scope, be preferably 500～2500mPas, more preferably 1000～2500mPas such adjust decision as index.For example, as carbohydrate, the ratio of this carbohydrate when using maltose and reduction maltose can illustration be generally 5～60 weight %, be preferably 10～50 weight %, the scope of 10～40 weight % more preferably.In addition, as carbohydrate, the ratio of this carbohydrate when using sugared beyond above-mentioned can illustration be generally 5～50 weight %, be preferably 10～40 weight %, the scope of 10～30 weight % more preferably.
In nicotine depressant of the present invention, except that mentioned component (polysaccharide, carbohydrate), in the scope of not damaging effect of the present invention, also can at random cooperate composition with tackifying.As composition so, can enumerate cassia gum (cassia gum); glucomannans (glucomannan); deacylated tRNA fundamental mode gellan gum; the natural type gellan gum; Bacillus natto glue; hydroxypropyl cellulose (HPC); polyvinylpyrrolidone (PVP); alginates; propylene glycol alginate; Arabic gum; bassora gum (tragacanth gum); dawa gum (ghatti gum); soybean polysaccharides; macrophomopsis glue; sandlwood carbohydrate gum (rhamsan gum); welan gum (welangum); Karaya Gum; starch; producing starch; chemical starch; fermented cellulosic; tackify compositions such as agar.These both can use a kind, also can make up use more than 2 kinds arbitrarily.In addition, these compositions water soluble ingredient preferably.Be preferably Arabic gum, soybean polysaccharides, Karaya Gum.
In nicotine depressant of the present invention, except that mentioned component (polysaccharide, carbohydrate), in the scope of not damaging effect of the present invention, also can at random cooperate other composition.As composition so, also can the illustration sweetener (sucrose for example, Aspartame sugar (aspartame), acesulfame potassium, the high-intensity sweeteners of asccharin etc.), natural or synthetic colouring matter, spices, acid flavoring (citric acid for example, tartaric acid, the organic acid of ascorbic acid etc.), preserve material (Sodium Benzoate for example, potassium sorbate etc.), polyphenoils (tea catechin for example, anthocyanin (anthocyanin), the Polyphenols of isoflavones etc.), various medicinal herbs and extract thereof (chamomile (chamomile), aloe (Aloe arborescens Mill), Echinacea (Echinacea), hops (hop), lemon balm (melissa) etc.), amino acid, mineral matter or vitamins etc.These compositions also are preferably water soluble ingredient.
Nicotine depressant of the present invention, being selected from least a kind of polysaccharide or these at least a kind of polysaccharide and above-mentioned at least a kind of carbohydrate in tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan as active ingredient, as required, the combination above-mentioned composition arbitrarily, can modulate by in aqueous solvent, dissolving.In addition, when dissolving, also can add gentle heat treated as required.
In addition, nicotine depressant of the present invention does not limit its Acidity of Aikalinity (pH) especially, can at random set, and as an example, can enumerate the faintly acid of pH3～5, particularly pH3.5～4.5.
Pei Zhi nicotine depressant of the present invention (water-based liquid composition) like this makes it to remain on the filtration mouth of smoking equipment and uses.The form that keeps has no particular limits, the form (impregnation) that nicotine depressant of the present invention (water-based liquid composition) supply with can be filtered mouth, keep with wet condition, and supply with any one form of filtering mouth, making it to keep form with drying regime.From efficiently removing the aspect of nicotine, preferably keep (impregnation) with moisture state.
As the filtration mouth of smoking equipment, the suction inlet that can enumerate cigarette particularly filters the filtration mouth in mouth, Smoking pipe and the cigarette holder (cover the suction inlet portion of smoking and use cigarette holder).
Make nicotine depressant (water-based liquid composition) remain on the method for the filtration mouth of smoking equipment, be not particularly limited.For example, can enumerate the method for filtration mouth direct impregnation in the liquid of nicotine depressant (water-based liquid composition) with smoking equipment, with method at filtration mouth coating nicotine depressant, but, can compatibly enumerate the method that the liquid of nicotine depressant (water-based liquid composition) is dripped to the filtration mouth of smoking equipment with 1 (about 50mg)～several, preferred 1～5 ratio from the viewpoint of health.
In this wise nicotine depressant of the present invention (water-based liquid composition) is dropped in when filtering the mouth use, unrestricted, but the droplet of the preferred drop of this nicotine depressant (water-based liquid composition) is relatively good.In addition, unrestricted, but nicotine depressant of the present invention (water-based liquid composition) promptly is soaked in the filtration mouth by impregnation at filtration mouth where applicable, preferably spreads all over all.Nicotine depressant of the present invention (water-based liquid composition) comprises at the filtration mouth of smoking equipment, when attracting, and the pressure that does not preferably produce suction uprises, becomes the difficult undesirable condition of inhaling and liquid from filtering disperse undesirable condition to mouth of mouth.
Nicotine depressant of the present invention (water-based liquid composition), as basis, use is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, at least a kind of polysaccharide in hydroxypropyl methylcellulose and the carrageenan, in addition, as required, make up above-mentioned carbohydrate, being modulated into viscosity is 500～3000mPas, be preferably 500～2500mPas, more preferably the water-based liquid composition of 1000～2500mPas scope can possess above-mentioned feature.Also the nicotine depressant (water-based liquid composition) that is fit to because of the present invention suppresses by temperature and preserves the viscosity variation that produces, so, through 1 year, have stable viscosity and proterties.Therefore, even also tackify indistinctively during the low temperature in winter has to the proper viscosity that drips and soak into and do not produce unfavorable condition in smoking (attraction) that filters mouth.
Nicotine depressant of the present invention (water-based liquid composition) is usually to be filled in the state supply market in the container.Hold the container of such nicotine depressant, have no particular limits, but as described above, nicotine depressant of the present invention, because use with the form of suitably dripping, so, preferably be filled in the formula of the dripping container of (comprising the dropping pipet formula).The formula of dripping container if having the part of aqueous content (the water-based liquid composition) that can drop by drop drip, just has no particular limits.For example, can itself become the dropping pipet formula by the illustration container, from can directly the drip form of content (water-based liquid composition) of the oral area of container, cap (block) at container possesses the dropping pipet function, to block a shot as the dropping pipet utilization form of dripping from container sucking-off content etc.
The container size (capacity) of holding the nicotine depressant, have no particular limits, but from purposes of the present invention, use amount and viewpoint easy to carry, usually, hope is the such size (capacity) of content (water-based liquid composition) that can hold 1～100mL capacity, preferred 2～20mL.
(2) nicotine reduction smoking equipment
The invention provides a kind of nicotine reduction smoking equipment.In smoking equipment of the present invention, remove the smoking equipment have filter-tip cigarette (below, for itself and the apparatus that uses in following smoking are distinguished, be called " cigarette " separately) in addition, comprise that Smoking pipe (comprising China tobacco pipe (kiseru)), cigarette holder (coat the suction inlet of cigarette etc. and use.Comprise disposable.) and the apparatus (below, for itself and above-mentioned cigarette are distinguished, be called " pipe " separately) that sucks cigarette (comprising cigarette, pipe tobacco) that the cartridge type (cartridge) pack into and to use waits and tobacco leaf volume etc. in cigarette holder.
Here, pipe have at least cigarette accommodation section or cigarette insert mouth, suction inlet portion, from above-mentioned cigarette accommodation section or cigarette insert the pipe in place (maintaining part) that mouth imports the path (conduit part) of suction inlet portion with cigarette and is used to keep the nicotine depressant (water-based liquid composition) of the invention described above.
Smoking equipment of the present invention is, by in the maintaining part that has above-mentioned filter-tip cigarette filter mouth or aforementioned tube, make it to keep the nicotine depressant (water-based liquid composition) of the invention described above, the nicotine of the nicotine content that attracts in can reducing when smoking by body reduces uses smoking equipment.
The part that the maintaining part setting of pipe is passed through the cigarette mainstream smoke can keep nicotine depressant of the present invention (water-based liquid composition) just passable if form, and is not particular about its structure and material especially.For example, the parts that are made of porous matter such as paper, nonwoven, fiber and sponges can be installed or are filled in the part that the cigarette mainstream smoke passes through forms.In addition, as material, illustration cellulose acetate, fatty acid polyglycol ester compounds, cellulose esters etc. ad lib.
Pipe of the present invention (smoking equipment) has and utilizes the mainstream smoke that makes cigarette by maintaining this maintaining part of above-mentioned nicotine depressant (water-based liquid composition), removes the action effect of nicotine.Therefore, the maintaining part of this pipe also can be used as and filters the mouth definition.In this sense, in this manual, with the maintaining part of this pipe, the filtration mouth combination with above-mentioned cigarette is generically and collectively referred to as " the filtration mouth of smoking equipment " sometimes.
Capacity to the filter tip (the filtration mouth of cigarette, the maintaining part of pipe) of smoking equipment of the present invention also has no particular limits.Preferably have and to stablize the capacity that keeps above-mentioned nicotine depressant (water-based liquid composition) as much as possible, but if can keep that above-mentioned nicotine depressant (water-based liquid composition) is at least about 50～250mg, the capacity about preferred 50～150mg, can in using usually obstacle not appear just.
Without limits, but reduce a mode with smoking equipment as nicotine of the present invention, can illustration as shown in Figure 1 cigarette holder 1 or at the cigarette holder 11 of Fig. 2～as shown in Figure 7.
Cigarette holder 1 is provided with filter tip 2 in cigarette holder body 3, as maintaining part, become the nicotine depressant that can keep the invention described above.Cigarette holder body 3 at one end portion has suction inlet portion 4, has cigarette insertion mouth 5 in the other end.The periphery of the suction inlet portion 4 of cigarette holder body 3 and its become flat form nearby, form with mouth to hold in the month easily.The present invention reduces this cigarette holder 1 that a mode with smoking equipment provides as nicotine, keeps the nicotine depressant of the invention described above in advance at its filtration mouth.
Cigarette holder 11 also with above-mentioned same, is provided with filter tip 2 in cigarette holder body 3, as maintaining part, become and can keep nicotine depressant of the present invention.The cigarette holder 11 that provides with smoking equipment is provided as nicotine in the present invention, the nicotine depressant that also can on its filter tip 2, keep the invention described above in advance, in addition, in use, also can filter the nicotine depressant that mouth is supplied with the invention described above, make it to keep using at this.
Below, with reference to the structure of Fig. 2～7 these cigarette holders 11 of explanation.
Cigarette holder body 3, at one end portion has suction inlet portion 4, has cigarette in the other end and inserts mouth 5.The periphery of the suction inlet portion 4 of cigarette holder body 3 and its become flat form nearby, form with mouth to hold in the month easily.Cigarette holder 11 can have the strap clamp block 6 that can load and unload in a side of cigarette holder body 3 again and have the lid 7 that can load and unload at the opposite side of cigarette holder body 3.In illustrated example, strap clamp block 6 is installed in a side of the suction inlet portion 4 of cigarette holder body 3, and lid 7 is installed in the side that cigarette holder body 3 cigarettes are inserted mouth 5.Strap clamp block 6 has the jut 8 that is used to insert suction inlet portion 4.
Strap clamp block 6 and lid 7 are installed on cigarette holder body 3, can prevent the volatilization that when filter tip 2 impregnation nicotine depressants, produces.In addition, the folder of strap clamp block 6 when non-smoking, can be stayed breast pocket etc.Strap clamp block 6 preferably make with pen usually with the similar shape of folder.
Strap clamp block 6 and lid 7 constitute and can load and unload.In illustrated example, constitute at the peristome 9 of strap clamp block 6 and can embed lid 7 and install.Lid 7 has edge portion 10, and edge portion 10 becomes the retainer of blocking a shot with lid 7 embedding strap clamps at 6 o'clock.When smoking, on strap clamp block 6, lid 7 is installed, be fixed on breast pocket etc. with clip, can prevent losing of lid 7.
(3) method of the nicotine content in the minimizing cigarette mainstream smoke
The invention provides the method that reduces the nicotine content in the cigarette mainstream smoke.This method makes filtration mouth that above-mentioned nicotine depressant (water-based liquid composition) is contained in smoking equipment [for example, the suction inlet filter tip of cigarette or the filter tip of Smoking pipe and cigarette holder], when smoking, can implement by this filter tip by making the cigarette mainstream smoke.
According to the nicotine reduction method that produces by the present invention, only in the filter tip of smoking equipment, contain the nicotine depressant (water-based liquid composition) of the invention described above, just can reduce the nicotine content in the mainstream smoke that is sucked in the body by smoking wittingly.In addition, shown in the experimental example, except that nicotine content, also can reduce the tar content in the mainstream smoke wittingly as described later.Therefore, the present invention provides the method that reduces the tar content in the cigarette mainstream smoke simultaneously.
In addition, shown in experimental example,,, can reduce nicotine content and tar content in the mainstream smoke more according to this recruitment by being increased in the amount of nicotine depressant contained in the filter tip (water-based liquid composition).The capacity of the nicotine depressant that in filter tip, keeps (water-based liquid composition), if the capacity that in filter tip, can keep, just have no particular limits, but can illustration be equivalent to common 1～several amount (about 50～hundreds of mg), preferably be equivalent to 1～5 amount (about 50～250mg) scope.
The main cause of smoking cessation difficulty is health and psychological dependence to the nicotine in the mainstream smoke that is contained in cigarette.Therefore,,, can reduce the nicotine content that is sucked in the body in smoking limit, limit, thus, can relax nicotine dependence disease at leisure even smoking becomes the testee of custom according to nicotine reduction method of the present invention.In addition,, regulate its use amount (to filter-tip dosage), can control the nicotine content in the mainstream smoke of suction by smoker oneself if according to nicotine depressant of the present invention.Therefore, the smoker reduces the picked-up of nicotine by stages according to own dependence situation to nicotine, finally removes nicotine dependence, becomes to reach smoking cessation.
Embodiment
Below, use following experimental example and embodiment to specifically describe content of the present invention.But the present invention is not limited to these.In addition, there is not the what is called " part " of special record to refer to " weight portion ".
In addition, the compound supplier who uses in following experimental example is as follows.The ※ mark refers to San-Ei Gen F. F. I. INC (SAN-EI GEN F.F.I., registration mark INC.).
Tamarind seed glue: VIS TOP ※D-2033, San-Ei Gen F. F. I. INC
Locust bean gum: VIS TOP ※D-30, San-Ei Gen F. F. I. INC
Xanthans: SAN ACE ※C, San-Ei Gen F. F. I. INC
Tara gum: VIS TOP ※D-2101, San-Ei Gen F. F. I. INC
Guar gum: VIS TOP ※D-2029, San-Ei Gen F. F. I. INC
Pulullan polysaccharide: pulullan polysaccharide PF-20 (micro mist), (strain) woods are former
Psyllium seed gum: SOALLYUM PG-200, MRC Polysaccharide Co., Ltd.
HM pectin: VIS TOP ※D-2220, San-Ei Gen F. F. I. INC
LM pectin: VIS TOP ※D-402, San-Ei Gen F. F. I. INC
λ-carrageenan: CARRAGEENAN (カ ラ ギ ニ Application) CSL-1, San-Ei Gen F. F. I. INC
Trehalose: Treha micro mist (trade name), (strain) woods are former
Maltose (sour saccharification maltose): Syrup low (trade name), Kogo Starch Co., Ltd.
Soybean polysaccharides: SM-920 (trade name), San-Ei Gen F. F. I. INC
Trisodium citrate: trisodium citrate F (trade name), San-Ei Gen F. F. I. INC
Glycine: glycine P (trade name), organic synthesis pharmaceutical industries
L-ascorbic acid: Viscorin 80M (trade name), Daiichi Fine-chemicals, Co., Ltd.
Tea catechin: SD green-tea extract powder (green tea extract powder) NO.16714, San-Ei Gen F. F. I. INC
Radix Glycyrrhizae powder: LICOZIN P-1 (trade name), Ikeda saccharification industry (strain)
Experimental example 1
(1) modulation of water-based liquid composition
Prescription modulation water-based liquid composition (embodiment 1～15) according to record in table 2.Particularly, at first in ion exchange water, add the polysaccharide (tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pulullan polysaccharide, psyllium seed gum, HM pectin, LM pectin, λ-carrageenan, carboxymethyl cellulose) and the trehalose of table 1 record, with the dissolving that heats while stirring in 80 ℃, 10 minutes.In addition,, be added in the ion exchange water, with 60 ℃, 10 minutes, again with dissolving while stirring in 10 ℃, 10 minutes with trehalose to methylcellulose in the polysaccharide (embodiment 14) and hydroxypropyl methylcellulose (embodiment 15).
In these, add respectively the Sodium Benzoate aqueous solution be dissolved in advance in the ion exchange water, aqueous citric acid solution, trisodium citrate aqueous solution, colouring matter (red No. 2, red No. 40) the aqueous solution, mix.Become 100 weight % with the whole amounts of ion exchange water adjustment, modulate each water-based liquid composition (embodiment 1～15).
(2) the proterties evaluation of water-based liquid composition
Use Type B rotation viscometer (using No. 4 rotors when viscosity is used No. 3 rotors, viscosity greater than this scope when 2000mPas is following), with 20 ℃, 60rpm, 1 minute the viscosity (initial stage viscosity) of above-mentioned each the water-based liquid composition (embodiment 1～15) that obtains of condition mensuration.In addition, it was preserved for 3 weeks, after this measure viscosity (viscosity after the preservation), obtain viscosity survival rate (%) according to following formula, according to following benchmark evaluation viscosity stability with condition same as described above with 50 ℃ conditions.
Viscosity survival rate (%)=(viscosity after the preservation/initial stage viscosity) * 100
＜viscosity stability 〉
Viscosity survival rate (%) Estimate Scoring
More than 81% ◎ 9
61～80％ ○ 6
41～60％ △ 3
Below 40% × 0
(3) evaluation of use feeling
After above-mentioned each water-based liquid composition (embodiment 1～15) that obtains is adjusted into 20 ℃, drip 2 (about 100mg), measure the time (accessibility evaluation) that liquid immersion needs in the filter tip at the leading section of cigarette filter mouth.In addition, be judged as constantly to soak into the drop complete obiteration on filter tip surface and finish.In addition, after confirming the liquid immersion filter tip, carry out smoking, estimate when smoking liquid whether back suction (back suction evaluation) in mouth.In addition, the accessibility evaluation and the back suction evaluation of each water-based liquid composition (embodiment 1～15) are all undertaken by same people according to following benchmark.In addition, the back suction evaluation is implemented by sucking 3 mainstream smokes.
＜to filter-tip liquid accessibility 〉
Soak into the time that needs Estimate Scoring
Below 10 seconds ◎ 6
11～30 seconds ○ 4
31～60 seconds △ 2
More than 61 seconds × 0
＜back suction in mouth 〉
The degree of back suction Estimate Scoring
Almost do not have ◎ 3
Have a little ○ 2
Do not have slightly △ 1
Have × 0
(4) result
The result who in table 2, adds up to evaluation of measuring in the expression above-mentioned (2) and (3).In addition, based on adding up to the result who obtains, will be illustrated in the table 2 as overall merit according to the result of following benchmark evaluation with above-mentioned (2) and (3).
＜overall merit 〉
Add up to scoring Estimate
15～18 minutes ◎
11～14 minutes ○
7～10 minutes △
0～6 minute ×
Table 2
Composition and assessment item Addition (%) and evaluation result
Embodiment
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Tamarind seed glue 1.8 1.4 1.4
Locust bean gum 1.0 0.2
Xanthans 1.2 0.2
Tara gum 0.7
Guar gum 1.0
Pulullan polysaccharide 18
Psyllium seed gum 0.8
HM pectin 4.0
LM pectin 4.5
λ-carrageenan 1.6
Carboxymethyl cellulose 1.8
Methylcellulose 2.5
Hydroxypropyl methylcellulose 3.0
Trehalose 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25
Sodium Benzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Citric acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Trisodium citrate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05
Red No. 2 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Red No. 40 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Viscosity (60rpm) 1890 1480 1850 1920 1510 1440 1780 2300 1320 1280 1080 1020 2640 1220 1530
The pH of solution 3.60 3.59 3.89 3.56 3.69 3.60 3.59 3.91 3.73 3.59 4.46 4.50 3.92 3.60 3.58
To filter-tip accessibility *1 ○ ○ △ ○ ○ ○ ○ ○ △ ○ ◎ ◎ △ ○ △
Back suction in mouth *2 ◎ ○ △ ◎ ○ △ △ ◎ ◎ △ △ △ ◎ ◎ ◎
Viscosity stability *3 ○ ○ ◎ ○ ◎ △ △ △ ◎ △ △ △ ○ △ △
Overall merit *4 ○ ○ ○ ○ ◎ △ △ △ ○ △ △ △ ○ △ △
Experimental example 2
(1) modulation of water-based liquid composition
According to the prescription of record in table 3, modulation water-based liquid composition (embodiment 16～25).Particularly, at first in ion exchange water, add each carbohydrate (trehalose, sucrose, glucose, fructose, maltose, D-sorbite, maltitol, erythrite, xylitol, dextrin) of tamarind seed glue and xanthans, record in table 3, with the dissolving that heats while stirring in 80 ℃, 10 minutes.In these, add the aqueous solution, the mixing of the Sodium Benzoate aqueous solution be dissolved in advance in the ion exchange water, aqueous citric acid solution, trisodium citrate aqueous solution, colouring matter (red No. 2, red No. 40) respectively.Become 100 weight % with the whole amounts of ion exchange water adjustment, modulate each water-based liquid composition (embodiment 16～25).
(2) the proterties evaluation of water-based liquid composition
Similarly measure the initial stage viscosity of above-mentioned each water-based liquid composition (embodiment 16～25) that obtains with experimental example 1.In addition, similarly measure with the viscosity (viscosity after the preservation) after 50 ℃ of 3 weeks of preservation, obtain viscosity survival rate (%), estimate the viscosity stability of each water-based liquid composition with experimental example 1.
(3) evaluation of use feeling
With experimental example 1 (3) similarly, with above-mentioned each water-based liquid composition (embodiment 16～25) (being adjusted into 20 ℃) that obtains, drop in the leading section of cigarette filter mouth, estimate the accessibility (accessibility evaluation) of liquid in filter tip.In addition, similarly, estimate the back suction in mouth when smoking (back suction evaluation).
(4) result
The result who in table 3, adds up to expression above-mentioned (2) and (3) evaluation of measuring.
In addition, based on adding up to the result obtain with above-mentioned (2) and (3), will be illustrated in table 3 as overall merit according to result with the same benchmark evaluation of experimental example 1.
Table 3
Addition (%) and evaluation result
Embodiment
16 17 18 19 20 21 22 23 24 25
Tamarind seed glue 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6
Xanthans 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Trehalose 25
Sucrose 25
Glucose 25
Fructose 25
Maltose 25
D-sorbite 25
Maltitol 25
Erythrite 25
Xylitol 25
Dextrin 25
Sodium Benzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Citric acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Trisodium citrate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05
Red No. 2 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Red No. 40 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Viscosity (60rpm) 1590 1710 1440 1510 1640 1560 1800 1490 1490 1140
The pH of solution 3.62 3.58 3.56 3.67 3.60 3.70 3.66 3.66 3.69 3.74
To filter-tip accessibility ○ ○ ○ ○ ○ ○ ○ ○ ○ △
Back suction in mouth ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ △
Viscosity stability ◎ ◎ ◎ △ ◎ ○ ◎ ○ ◎ ◎
Overall merit ◎ ◎ ◎ △ ◎ ○ ◎ ○ ◎ ○
Experimental example 3
(1) modulation of water-based liquid composition
According to the prescription of record in table 4, by following order modulation water-based liquid composition (embodiment 26～29).To each the water-based liquid composition that obtains, use Type B rotation viscometer (No. 3 rotors), measure viscosity with 20 ℃, 60rpm, 1 minute condition.
(i) embodiment 26
The water of room temperature is stirred on the limit, drops into locust bean gum slightly, heats in the limit, arrive 90 ℃ after, stirring and dissolving 10 minutes again under 90 ℃.Then, drop into trehalose, stir again, drop into methylcellulose slightly, be cooled to 20 ℃.To wherein dropping into citric acid, glycine, L-ascorbic acid, tea catechin, trisodium citrate, Radix Glycyrrhizae powder, add colouring matter again.In addition, citric acid, glycine, L-ascorbic acid and tea catechin all are dissolved in the low amounts of water in advance and use.In addition, trisodium citrate and Radix Glycyrrhizae powder dissolve trisodium citrate in low amounts of water, add the Radix Glycyrrhizae powder dissolution therein and use.After the modulation, all measure (100 weight %), in container after the filling,, obtain water-based liquid composition (embodiment 26) with 65 ℃ of heat sterilizations 10 minutes with the water correction.
(ii) embodiment 27
80 ℃ water is stirred on the limit, and the limit is dropped into tamarind seed glue and xanthans slightly, stirs dissolving (solution A) in 10 minutes down at 80 ℃.In addition, 80 ℃ water, the powder mixture that the limit is dropped into soybean polysaccharides and trehalose are slightly stirred in the limit, 80 ℃ of dissolvings down.Drop into glycine, adipic acid, L-ascorbic acid, tea catechin therein, drop into again, add the Radix Glycyrrhizae powder therein and the solution that obtains, add colouring matter (solution B) by in low amounts of water, dissolving trisodium citrate.At combination solution A, solution B and maltose, after mixing, all measure (100 weight %) with the water correction, in container after the filling,, obtain water-based liquid composition (embodiment 27) with 65 ℃ of heat sterilizations 10 minutes.
(iii) embodiment 28
Except not using xanthans, the order by same with the foregoing description 27 obtains water-based liquid composition (embodiment 28).
(iv) embodiment 29
Except not using tamarind seed glue, the order by same with the foregoing description 27 obtains water-based liquid composition (embodiment 29).
Table 4
(weight %)
Raw material Embodiment 26 Embodiment 27 Embodiment 28 Embodiment 29
Tamarind seed glue - 1.2 1.5 -
Locust bean gum 0.7 - - -
Xanthans - 0.2 - 1.0
Methylcellulose 0.4 - - -
Trehalose 28.0 21.0 21.0 21.0
Maltose - 10.0 10.0 10.0
Soybean polysaccharides - 1.0 1.0 1.0
Citric acid 0.25 - - -
Trisodium citrate 0.05 0.05 0.05 0.05
Glycine 0.05 2.0 2.0 2.0
Adipic acid - 0.55 0.55 0.55
The L-ascorbic acid 0.05 0.1 0.1 0.1
Tea catechin 0.05 0.05 0.05 0.05
The Radix Glycyrrhizae powder 0.025 0.025 0.025 0.025
Colouring matter 0.25 0.25 0.25 0.25
Water Surplus Surplus Surplus Surplus
All measure 100.00 100.00 100.00 100.00
pH 3.3 3.9 3.9 3.9
Viscosity (mPas) 1640 1550 1510 1320
(2) the viscosity stability evaluation of water-based liquid composition
In above-mentioned each water-based liquid composition (embodiment 26～29) that obtains,, make temperature be changed to 40 ℃, the state of observation liquid from 10 ℃ for the water-based liquid composition of embodiment 26.Its result, the water-based liquid composition of embodiment 26 and variations in temperature (10 ℃ → 40 ℃) are irrelevant, keep lubricious state.
In addition,, preserve down, measure, estimate viscosity stability through after a while viscosity (after preserving 3,7,10,14,21 and 28 days) at 37 ℃ to the water-based liquid composition of embodiment 27～29.The viscosimetric analysis condition is same as described above.Ecbatic in table 5.In addition, viscosity stability is represented the viscosity survival rate (%) that the formula of basis record in experimental example 1 (2) is calculated.
Table 5
Between storage life (day) Viscosity survival rate (%) after 37 ℃ of preservations
Embodiment 27 Embodiment 28 Embodiment 29
0 100％ 100％ 100％
3 97％ 93％ 96％
7 97％ 92％ 95％
10 96％ 91％ 95％
14 96％ 85％ 99％
21 95％ Undetermined 93％
28 100％ 82％ 90％
From the result of above-mentioned table, use the water-based liquid composition of the embodiment 26～29 of locust bean gum, tamarind seed glue or xanthans modulation, because long-time the preservation and variations in temperature, viscosity is not significant to be changed, and almost has certain proterties.
(3) evaluation of use feeling
After above-mentioned each water-based liquid composition (embodiment 26～29) that obtains is adjusted into 20 ℃, at the leading section of cigarette filter mouth drip 2 (about 100mg), similarly measure liquid immersion to the interior time of filter tip with experimental example 1 (3), estimate the accessibility (accessibility evaluation) of liquid.Then, confirm that liquid immersion behind filter tip, carries out smoking, estimate have or not (this being generically and collectively referred to as " easness of smoking ") of the easy suction degree of cigarette and the back suction of liquid composition in mouth.In addition, the evaluation of the accessibility of each water-based liquid composition and smoking easness is all undertaken by same people.In addition, the evaluation of smoking easness is implemented by sucking 3 mainstream smokes.After also observing smoking, the variable color degree of filtering mouth.
(4) result
The water-based liquid composition of embodiment 26～29 all when the leading section of cigarette filter drips, evenly soaks into about 15 seconds, when smoking, does not have the problem that liquid disperses in mouth, suction is difficult in addition.In addition, the filtration mouth after smoking all becomes black, compares as can be known and the situation that does not have impregnation water-based liquid composition, has more nicotine and tar to become trapped in the cigarette filter mouth.
Experimental example 4
Use the water-based liquid composition (embodiment 27) of modulation in the experimental example 3, estimate the effect of removing of the nicotine of water-based liquid composition of the present invention and tar.
Concrete, at cigarette (Mild Seven Light, Japan Tobacco Inc.: nicotine content 0.7mg, tar content 8mg) filter tip leading section, with the drip water-based liquid composition of embodiment 27 of the ratio of 1 (about 50mg), 2 (about 100mg) or 3 (about 150mg), measure nicotine content contained in the cigarette cigarette and tar content immediately.In addition, experiment replaces above-mentioned water-based liquid composition in contrast, makes water (1,2,3), with above-mentioned same operation, measures contained nicotine content and tar content in the cigarette cigarette.Respectively as 100%, nicotine content and tar content contained from the cigarette cigarette with above-mentioned water-based liquid composition or water treatment are calculated nicotine reduced rate (%) and tar reduced rate (%) respectively with nicotine content contained in water-based liquid composition and all no untreated cigarette cigarette of water and tar content.
In addition, the contained nicotine content and the mensuration of tar content in the cigarette cigarette are carried out according to equalling into No. 174 (Japan) definite methods of Finance Ministry bulletin in the first year shown in following.In addition, each experiment all uses 10 cigarettes to carry out.
The mensuration of＜nicotine content and tar content 〉
1. the adjustment of cigarette
The cigarette of using in mensuration under 22 ± 1 ℃ and 60 ± 2% humidity, is preserved more than 2 days, below 7 days in advance, prepares its condition in advance.
2. utensil and device
(1) smoking apparatus: piston pump type
(2) cigarette trap: use to have the filter-tip cigarette holder of glass fibre.Filter tip uses diameter 44mm, thickness 1～2mm, has the diameter that captures more than 99.9% in the 140mm/ speed of second is the filter tip of the dioctyl phthalate all particles ability more than the 0.3 μ m.Filter tip pressure in this speed drops to 93mmH 2Below the O (900Pa).In addition, filter tip use acrylic resin adhesive content is the filter tip below 5%.
(3) gas chromatograph
(i) the determination of moisture condition determination of gas chromatograph
Post: internal diameter is that 2～3mm, length are the glass system of 1.2～1.8m
Filler: Porapak Q (Waters production) (80～100 orders (mesh)) or have filler with its equal above performance
Temperature: thermostat (170～180 ℃), injection portion (230～250 ℃), detector (250 ℃)
Carrier gas: helium
Flow velocity: 40ml/ minute
Detector: pyroconductivity type detector
(ii) nicotine is measured the condition determination with gas chromatograph
Post: internal diameter is that 2～3mm, length are the glass system of 1.8～2.7m
Filler: the filler of coating polyethylene glycol-20W (10 weight %) and potassium hydroxide (2 weight %) or have and its filler of above performance on an equal basis in 60～80 purpose Chromosorb W (Chromosorb W) that clean with acid and distilled water
Temperature: thermostat (170～180 ℃), injection portion (230～250 ℃), detector (250 ℃)
Carrier gas: helium or nitrogen
Flow velocity: 20～40ml/ minute
Detector: flame ionization ditector
3. test operation and calculating
(1) capture of crude tar oil
In cigarette holder, insert the aspiration port 9 ± 1mm that measures with cigarette,, carry out smoking, till stub length reaches 30mm, capture crude tar oil (by the particle part in the cigarette cigarette of filter tip capture) by with following condition smoking.In addition, in order to capture crude tar oil, the mensuration that makes it smoking is that per 1 smoking port is 5 with the number of cigarette.
＜smoking condition 〉
Smoking capacity (in 1 smoking, sucking the volume of the cigarette of cigarette): 35 ± 0.3ml
The smoking time (1 needed time of smoking): 2 ± 0.1 seconds
The smoking cycle (time): 60 ± 1 seconds from smoking to next smoking
Smoking waveform (aerosol spraying profile): be that peaked bell type, its Peak Flow Rate are arranged is 25～30ml/ second between 0.8～1.2 second when beginning by smoking.
(2) the crude tar oil amount calculates
With the weight of 0.1mg unit's weighing cigarette trap before and after smoking, calculate crude tar oil amount (mg/ props up) from its weight difference by following formula, reach decimal point following 2 (casting out below 3).
Crude tar oil amount=[the preceding cigarette trap weight (mg) of cigarette trap weight (mg)-smoking after the smoking]/number of smoking
(3) modulation of sample solution
Folding capture has the filter tip of crude tar oil, with the internal face of its inboard wiping cigarette holder, again with the internal face of untapped 1/4 filter tip wiping cigarette holder.With these filter tips and 10ml extract solvent [isopropyl alcohol: ethanol: the mixed solvent of anethole=4974: 25: 1 (Capacity Ratio), below identical] container of packing into, vibration, the modulation sample solution.
(4) mensuration of the amount of moisture in the crude tar oil
In gas chromatograph, inject 1 μ l sample solution, obtain the moisture peak area ratio of relative ethanol peak area, use the inspection amount line made from (6) method (i), measure the amount of moisture (mg/ props up) in the sample solution, reach decimal point following 2 (casting out below 3).Deduct 1 contained filter tip per day amount of moisture from this value, become the amount of moisture in the crude tar oil.In addition, each measures each sample solution 2 times, obtains mean value.
(5) mensuration of the nicotine content in the crude tar oil
In gas chromatograph, inject 1 μ l sample solution, obtain the nicotine peak area ratio of relative anethole peak area, the inspection amount line that use is made with (6) method is (ii) measured the nicotine content (mg/ props up) in the sample solution, reaches decimal point following 2 (casting out below 3).In addition, each measures each sample solution 2 times, obtains mean value.
The making of (6) inspection amount line
(i) making of water inspection amount line
To be included in the mode of the amount of moisture scope that estimation exists in the crude tar oil, set the distilled water of different amounts more than 4 kinds, in these distilled water, add 10ml respectively and extract solvent, modulation standard liquid.In gas chromatograph, inject 1 this titer of μ l, obtain the moisture peak area ratio of relative ethanol peak area, repeatedly after 2 these operations, from the relation making inspection amount line of the water yield of peak area ratio and interpolation.
The (ii) making of nicotine inspection amount line
To be included in the mode of the nicotine content scope that estimation exists in the crude tar oil, set the nicotine of different amounts more than 4 kinds, in these nicotines, add 10ml respectively and extract solvent, modulation standard liquid.In gas chromatograph, inject 1 this titer of μ l, obtain the nicotine peak area ratio of relative anethole peak area, after 2 these operations, make inspection amount line repeatedly from the relation of peak area ratio and nicotine content.
(7) tar content calculates
Tar content (mg/ props up) is calculated by the amount of moisture and the nicotine content that deduct the crude tar oil from the crude tar oil amount, reaches following 2 of decimal point.
At Fig. 8 ecbatic.
As can be seen from Figure 8, with the filter tip of nicotine depressant of the present invention (water-based liquid composition) supply cigarette, nicotine content and tar content contained in the cigarette mainstream smoke can reduce more than 50%.In addition, from figure as can be known, the nicotine of nicotine depressant of the present invention (water-based liquid composition) and tar reduce effect, the effect when only making water, 2～5 times the effect of having an appointment.Also from figure as can be known, along with filter-tip nicotine depressant (water-based liquid composition) amount of the cigarette of increasing supply, nicotine and tar reduce effect and also increase.From then on as can be known, by the use amount (to filter-tip dosage) of regulating nicotine depressant of the present invention (water-based liquid composition), can be controlled at contained nicotine content and tar content in the suitable cigarette mainstream smoke.
The utilizability of industry
As mentioned above, contain nicotine depressant of the present invention by the filtration mouth at smoking equipment and carry out smoking, contained nicotine is filtered nicotine depressant in the mouth and effectively captures and remove in the cigarette mainstream smoke. The nicotine depressant that is more suitable for of the present invention, based on having specific polysaccharide and having suitable viscosity, can drip well with droplet at the filtration mouth, in addition, drip and between the fiber that filters mouth, spread equably rapidly afterwards, and stop filtering mouth. Therefore, even smoking, the nicotine depressant does not disperse in mouth yet, and in addition, suction resistance is also little, can with usually unchangeably smoking, thus, can effectively remove nicotine.
In addition, suitable nicotine depressant of the present invention, because the viscosity that can suppress to be produced by temperature changes, so, even also tackify inadequately not during winter low temperature maintains the proper viscosity under the common behaviour in service. Thus, even the outdoor of winter also has and indoor same viscosity, so, be difficult to produce the problem to the difficult that drips that filters mouth.
Use nicotine depressant of the present invention, nicotine and tar ingredients contained in the cigarette mainstream smoke are removed effectively, have a large amount of nicotines and tar ingredients to adhere at the filtration mouth of smoking equipment during than common smoking. Nicotine depressant of the present invention also can use by the filter tip in Smoking pipe and cigarette holder, by directly using on the filter tip of cigarette itself, can reducing the nicotine in the mainstream smoke. At this moment, can directly throw away after the smoking, than using Smoking pipe and cigarette holder, business efficiency is also improved.
In addition, nicotine depressant of the present invention, along with being increased in amount contained in the smoking equipment, the nicotine content that captures the filtration mouth of cigarette also increases. Therefore, by the use amount of nicotine depressant of the present invention, reduce the nicotine intake interimly, so, relax at leisure the nicotine dependence outbreak in the smoking cessation of joint cigarette, become and may give up smoking.

Claims (14)

1. nicotine depressant is characterized in that:
By contain at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the water-based liquid composition that viscosity is 500～3000mPas constitutes.
2. nicotine depressant as claimed in claim 1 is characterized in that:
Polysaccharide is at least a kind that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum and the pectin.
3. nicotine depressant as claimed in claim 1 is characterized in that:
Polysaccharide is at least a kind that is selected from tamarind seed glue, locust bean gum and the xanthans.
4. nicotine depressant as claimed in claim 1 is characterized in that:
Also contain carbohydrate.
5. nicotine depressant as claimed in claim 4 is characterized in that:
Carbohydrate is at least a kind that is selected from trehalose, maltose, sucrose, glucose, fructose, maltose, D-sorbite, maltitol, lactitol, erythrite, xylitol and the dextrin.
6. nicotine depressant as claimed in claim 4 is characterized in that:
Carbohydrate is at least a kind that is selected from trehalose and the maltose.
7. nicotine depressant as claimed in claim 1 is characterized in that:
Filtration mouth at smoking equipment keeps, uses.
8. a container is adorned the nicotine depressant, it is characterized in that:
The nicotine depressant that filling is made of the described water-based liquid composition of claim 1 in container and forming.
9. smoking equipment is used in a nicotine reduction, it is characterized in that:
Have and keep the described Buddhist nun of claim 1 to account for the filtration mouth of fourth depressant.
10. smoking equipment is used in a nicotine reduction as claimed in claim 9, it is characterized in that:
Described nicotine reduces and is included in an end with smoking equipment and has attract mouthful, have in the other end cigarette holder body that cigarette inserts mouthful and the filter tip that is provided with in this cigarette holder body, keeps the described nicotine depressant of claim 1 and constitute in described filter tip.
11. a method that reduces the nicotine content in the cigarette mainstream smoke is characterized in that:
The step that be included in the smoking equipment filter tip that contains the described nicotine depressant of claim 1, the cigarette mainstream smoke is passed through.
12. a method that reduces the tar content in the cigarette mainstream smoke is characterized in that:
The step that be included in the smoking equipment filter tip that contains the described nicotine depressant of claim 1, the cigarette mainstream smoke is passed through.
13. contain at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the use of water-based liquid composition in modulation nicotine depressant or tar depressant that viscosity is 500～3000mPas.
14. contain at least a kind of polysaccharide that is selected from tamarind seed glue, locust bean gum, xanthans, tara gum, guar gum, pectin, pulullan polysaccharide, psyllium seed gum, methylcellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose and the carrageenan, the use of water-based liquid composition in reducing nicotine or tar that viscosity is 500～3000mPas.
CNB2005800088469A 2004-02-19 2005-02-18 The reduction method of nicotine depressant and nicotine Expired - Fee Related CN100566610C (en)

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