JP3882125B2 - Nicotine reducing agent and method for reducing nicotine - Google Patents

Description

  The present invention relates to a nicotine-reducing agent and a nicotine-reducing smoking device that are used to reduce the amount of nicotine contained in the mainstream smoke of tobacco. Moreover, this invention relates to the method of reducing the amount of nicotine from the mainstream smoke of tobacco, and the method of reducing the amount of tar by using the said nicotine reducing agent or the smoking implement for nicotine reduction.

  It is said that cigarette smoke contains about 4000 kinds of chemical substances, and it is also known that there are harmful substances and carcinogenic substances in them. Among these, nicotine, tar, and carbon monoxide can be given as representative examples of harmful substances contained in tobacco smoke. Thus, various methods for eliminating these harmful substances from tobacco smoke have been tried.

  As such a method, for example, a method for reducing the amount of nicotine contained in the smoke of smoke to be inhaled (mainstream smoke) by impregnating the filter portion of the smoking pipe with water and bringing the smoke of tobacco into contact with water has been proposed. (Patent Documents 1 to 3). This method is based on the fact that nicotine contained in tobacco smoke has a property of being easily dissolved in water. However, those that have a structure in which water is contained in the filter part of the smoking pipe can expect the effect of removing nicotine, but water containing nicotine and tar that are harmful when smoking enters the mouth with smoke and enters the body. There is a risk of inflow.

  As a method of preventing or eliminating this, a method of blending cyclodextrin or a water-absorbing polymer into a tobacco suction filter (Patent Document 4), and a porous component as a component of a filter portion of a smoking pipe used by being attached to a tobacco suction portion. A method using a polymer (Patent Document 5 or 6) has been proposed. However, the method of blending a water-absorbing polymer with the former cigarette mouth filter, the mouth filter absorbs a large amount of water under high humidity conditions, increasing the intake resistance during smoking and making smoking itself difficult. There's a problem.

  Furthermore, wooden and plastic smoking pipes with built-in filters impregnated with mucus are also known (Patent Document 7), but this method has the trouble of attaching accessories when smoking. In addition, a nicotine tar agent is also known in which a gelled product is thinly applied to a tobacco filter or suction surface and then smoked as it is or inserted into a pipe (Patent Document 8). The gelled material that does not infiltrate and remains on the filter scatters in the mouth, causing discomfort and makes suction difficult.

By the way, it is the smoker's dependence on smokers that must be considered as a method for eliminating harmful substances, particularly nicotine, from tobacco smoke. Because smokers are usually psychologically or physically dependent on nicotine, abruptly reducing nicotine intake is not always desirable for smokers, and changes in their physical condition and psychological state It is desirable to reduce nicotine intake accordingly. By doing so, the psychological and physical dependence on nicotine can be reduced or alleviated step by step, and smoking cessation can be achieved. For this reason, there is a need for a method that enables smokers themselves to adjust their nicotine intake according to their own situation, rather than simply reducing the amount of nicotine uniformly.
JP 48-53871 A JP 50-130579 A Japanese Patent Laid-Open No. 62-198378 JP 51-32799 A Japanese Patent Laid-Open No. 62-179376 JP 47-30900 A JP-A-56-18583 JP-A 61-177972

  The objective of this invention is providing the nicotine reducing agent used in order to reduce the amount of nicotine contained in the mainstream smoke of tobacco, and the smoking implement for nicotine reduction. Moreover, the objective of this invention is providing the method of reducing the amount of nicotine from the mainstream smoke of tobacco, and the method of reducing the amount of tar by using the said nicotine reducing agent or the smoking implement for nicotine reduction.

  The inventors have conducted extensive research to develop a method for reducing the amount of nicotine contained in the mainstream smoke of cigarettes. Specific polysaccharides such as tamarind seed gum, xanthan gum, locust bean gum, etc. The aqueous liquid composition with a viscosity adjusted to 500 to 3000 mPa · s is excellent in the ability to adsorb and remove nicotine from the mainstream smoke of tobacco, and even if it is included in the filter part of tobacco or smoking equipment I found that it had almost no effect on smoking. In addition, the present inventors use these polysaccharides and, if necessary, use these polysaccharides in combination with saccharides, so that they are less susceptible to changes in temperature and long-term storage and are stable throughout the season. It was confirmed that an aqueous liquid composition having the above-described viscosity and properties can be obtained, and that the aqueous liquid composition can be a suitable nicotine reducing agent for carrying out the above-described nicotine reduction method.

Furthermore, the present inventors have confirmed that the amount of nicotine that can be removed from the mainstream smoke of tobacco increases by increasing the amount of the aqueous liquid composition used (the amount applied to the filter). This means that the smoker himself can easily control the amount of nicotine inhaled by smoking by adjusting the amount of the aqueous liquid composition used. That is, according to the aqueous liquid composition, the amount of nicotine inhaled into the body is increased stepwise by increasing the amount used (applied amount to the filter) in accordance with the nicotine dependence of the smoker. In this way, it is possible to alleviate the occurrence of nicotine dependence, which is the biggest problem in quitting smoking, and finally achieve smoking cessation.
The present invention has been completed based on such findings. That is, the present invention includes the following embodiments;
Item 1. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; A nicotine reducing agent comprising an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s.
Item 2. Item 2. The nicotine reducing agent according to Item 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, and pectin.
Item 3. Item 2. The nicotine reducing agent according to Item 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, and xanthan gum.
Item 4. Furthermore, the nicotine reducing agent of claim | item 1 which contains saccharides.
Item 5. Item 5. The nicotine reducing agent according to Item 4, wherein the saccharide is at least one selected from the group consisting of trehalose, starch syrup, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol, and dextrin.
Item 6. Item 5. The nicotine reducing agent according to Item 4, wherein the saccharide is at least one selected from the group consisting of trehalose and chickenpox.
Item 7. Item 2. The nicotine reducing agent according to Item 1, which is used by being held in a filter of a smoking tool.
Item 8. Item 10. A nicotine reducing agent in a container, wherein the nicotine reducing agent comprising the aqueous liquid composition according to Item 1 is filled in a container.

In addition, a dripping type container can be used suitably as a container here.
Item 9. A smoking device for reducing nicotine having a filter part holding the nicotine reducing agent according to Item 1.
Item 10. The nicotine-reducing smoking tool has a holder body having a suction port at one end and a tobacco insertion port at the other end, and a filter provided in the holder body. Item 10. The nicotine-reducing smoking device according to Item 9, wherein the nicotine-reducing agent is retained.
Item 11. A cigarette holder having a holder body having a suction port at one end and a cigarette insertion port at the other end, and a filter provided in the holder body, and further detachable from the suction port side of the holder body A smoking tool for reducing nicotine, comprising a cap with a clip and a detachable lid on the side of the holder body where the cigarette is inserted.
Item 12. 12. The nicotine-reducing smoking device according to claim 11, wherein the filter contains the nicotine-reducing agent according to claim 1.
Item 13. Item 8. A method for reducing the amount of nicotine in the mainstream smoke of tobacco, comprising a step of allowing the mainstream smoke of tobacco to pass through a filter of a smoking tool containing the nicotine reducing agent according to Item 1.

The aqueous liquid composition (nicotine reducing agent) of the present invention, as shown in Experimental Example 4 to be described later, can be used not only for the amount of nicotine contained in the mainstream smoke of tobacco but also for the amount of tar. Can be reduced. Therefore, the above-mentioned “nicotine reducing agent” and “nicotine reducing smoking device” are respectively “tar reducing agent” and “tar reducing smoking device” or “nicotine and tar reducing agent” and “nicotine and tar reducing agent”. It can be replaced with “smoking equipment”. Further, from the viewpoint of tar reduction, the present invention also provides the following method.
Item 14. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; A method for reducing the amount of tar in the mainstream smoke of tobacco, comprising the step of allowing the mainstream smoke of tobacco to pass through a filter of a smoking tool containing an aqueous liquid composition (tar reducing agent) having a viscosity of 500 to 3000 mPa · s. .

Furthermore, as described above, the use of the nicotine-reducing agent (aqueous liquid composition) of the present invention makes it possible to relieve the smoker's dependence on nicotine. Therefore, the present invention also provides the following method from this viewpoint.
Item 15. For subjects with smoking habits, at least selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan The subject's nicotine comprising smoking using a smoking device including a filter containing an aqueous liquid composition (nicotine reducing agent) containing one kind of polysaccharide and having a viscosity of 500 to 3000 mPa · s. A way to reduce dependency.

Further, the present invention provides the following uses for the aqueous liquid composition of the present invention.
Item 16. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; Use of an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s for the preparation of a nicotine reducing agent or a tar reducing agent.
Item 17. Item 17. The use according to Item 16, wherein the aqueous liquid composition further contains a saccharide.
Item 18. Item 18. The use according to Item 17, wherein the saccharide is at least one selected from the group consisting of trehalose, starch syrup, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol, and dextrin.
Item 19. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; Use of an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s for reducing nicotine or tar.
Item 20. Item 20. The use according to Item 19, wherein the aqueous liquid composition further contains a saccharide.
Item 21. Item 21. The use according to Item 20, wherein the saccharide is at least one selected from the group consisting of trehalose, starch syrup, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol, and dextrin.

FIG. 1 is a plan view showing the appearance of a cigarette holder 1 which is an embodiment of a smoking tool for reducing nicotine according to the present invention.
FIG. 2 is a plan view showing the appearance of a cigarette holder 11 which is another embodiment of the nicotine-reducing smoking tool according to the present invention.
FIG. 3 is a side view of the cigarette holder 11 of FIG.
4 is a cross-sectional view taken along line III-III in FIG.
5 is a cross-sectional view taken along line IV-IV in FIG.
FIG. 6 is a side view showing a state in which a lid 77 is attached to a cap 66 with a clip of the cigarette holder 11 of FIG.
7 is a longitudinal sectional view of FIG.
FIG. 8 is a graph showing the nicotine reduction rate and tar reduction rate of the nicotine reducing agent (aqueous liquid composition) of the present invention (Experimental Example 4).

Explanation of symbols

1. 1. Cigarette holder which is an embodiment of the nicotine-reducing smoking device of the present invention. Filter (holding part)
3. Holder body 4. 4. Suction part 5. Tobacco insertion slot 6. Cap with clip Lid 8. 8. Projection for inserting the cap with clip into the mouthpiece 9. Cap opening with clip Buttocks 11. The cigarette holder which is another one aspect | mode of the smoking implement for nicotine reduction of this invention

(1) Nicotine reducing agent The nicotine reducing agent of the present invention comprises tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan. It consists of the aqueous liquid composition containing the at least 1 sort (s) of polysaccharide selected from these.

Tamarind seed gum is a water-soluble polysaccharide that can be obtained from the seeds of tamarind ( Tamarind grandiflora PERS.), A perennial dicotyledonous plant. Locust bean gum is a polysaccharide that can be obtained from the seeds of Ceratonia silliqua . Xantham gum is a fermented polysaccharide produced by the microorganism Xanthomonas campestris . Tara (Tara gum) is a actinidiaceae cod (Actinidia callosa LINDL.) Polysaccharide water-soluble can be obtained from the seeds of. Guar gum is a polysaccharide or guar gum obtainable from leguminous guars ( Cyamopsis tetragonolobas TAUB.) That has been degraded with an enzyme (such as hemicellulase). Pectin is a polysaccharide mainly composed of methylated polygalacturonic acid that can be obtained by water extraction from citrus fruits and apples. Depending on the degree of esterification (DE) (the content of methoxyl groups), HM pectin (the proportion of methylated galacturonic acid accounts for 50% or more of all galacturonic acids) and LM pectin (of all galacturonic acids, methylated) Galacturonic acid accounts for 50% or less). In the present invention, any one of HM pectin and LM pectin can be used.

Pullulan is a polysaccharide produced by black yeast ( Aureobasidium pullulans [DE Bary] ARN.). Psyllium seed gum (Psyllium seed gum) is a polysaccharide which can be obtained from plantaginaceae blond psyllium (Plantagoovata FORSK.) Or same genus plant seeds. Carrageenan (Carrageenan), the Suginori School of Irish moss (Chondruscrispus LYNGB.), Suginori (Gigartina tenella HARV.), Mirin family Eucheuma (Eucheumamuricatum W.v.BOSS forma depaupaerata W.v.BOSSE), Ibaranori family Kagiibaranori (Hypneajaponica TANAKA ) And other polysaccharides that can be obtained by extraction with water. This can be divided into three categories: kappa (κ), iota (ι), and lambda (λ). In the present invention, any of κ-carrageenan, ι-carrageenan and λ-carrageenan can be used, but λ-carrageenan can be more preferably used.

  These polysaccharides, as well as methylcellulose, carboxymethylcellulose, and hydroxypropylmethylcellulose are all materials that are widely marketed and used as food additives such as food thickeners and thickeners. Also in the present invention, without particular limitation, tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxy, which have been conventionally marketed as food additives Propylmethylcellulose and carrageenan can be widely used.

  Among them, preferred polysaccharides are tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, and pectin, and particularly preferred polysaccharides are tamarind seed gum, locust bean gum, and xanthan gum.

  Furthermore, the nicotine reducing agent of the present invention is characterized by comprising an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s. Here, the viscosity is 20 ° C., using a B-type rotational viscometer (when the viscosity is 2000 mPa · s or less, use the rotor No. 3 and when exceeding the viscosity, use the rotor No. 4) at 60 rpm for 1 minute, Viscosity obtained by measurement. The preferred viscosity is 500 to 2500 mPa · s, more preferably 1000 to 2500 mPa · s.

  The method for adjusting the viscosity of the aqueous liquid composition is not particularly limited, but a solvent that dissolves each polysaccharide is selected, the ratio of the polysaccharide to be used is adjusted, and other components are blended. Etc.

  The solvent used for dissolving the polysaccharide such as tamarind seed gum, xanthan gum or locust bean gum is not particularly limited as long as it can dissolve these components. Water is preferable from the viewpoint of safety and convenience. In addition, water and ethanol, propylene glycol, glycerin, or the like can be used in combination as long as the effects of the present invention are not impaired.

  The above-mentioned polysaccharides (tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan) are used alone as a nicotine reducing agent of the present invention. As an active ingredient, it can be used in any combination of two or more as desired. Suitable combinations of these include, but are not limited to, a combination of tamarind seed gum and locust bean gum, a combination of tamarind seed gum and xanthan gum, a combination of locust bean gum and methylcellulose, a combination of tamarind seed gum and tara gum, and A combination of tamarind seed gum and guar gum can be exemplified.

  The above-mentioned polysaccharides (tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, or carrageenan) blended in a nicotine reducing agent (aqueous liquid composition) The ratio of the obtained nicotine reducing agent (aqueous liquid composition) is such that the viscosity is in the range of 500 to 3000 mPa · s, preferably 500 to 2500 mPa · s, more preferably 1000 to 2500 mPa · s. There is no particular limitation.

  For example, as a ratio of each polysaccharide used in 100% by weight of the nicotine reducing agent (aqueous liquid composition), the ratios shown in Table 1 can be exemplified.

  Even when two or more kinds of these components are arbitrarily used in combination, the combination ratio and blending amount are based on the above blending ratios, and the viscosity of the resulting nicotine reducing agent (aqueous liquid composition) is 500 to 3000 mPas. It can be adjusted and determined as an index in the range of s, preferably 500 to 2500 mPa · s, more preferably 1000 to 2500 mPa · s. For example, as described above, when using a combination of tamarind seed gum and locust bean gum, the blending ratio of each component is 0.1 to 10 parts by weight of locust bean gum with respect to 1 part by weight of tamarind seed gum, Preferably 0.2-5 weight part can be illustrated. When using a combination of tamarind seed gum and xanthan gum, the blending ratio of each component is 0.02-1 parts by weight of xanthan gum, preferably 0.05-0.5 parts by weight with respect to 1 part by weight of tamarind seed gum. Can be illustrated. When methyl cellulose and locust bean gum are used in combination, the blending ratio of each component is 0.2 to 20 parts by weight of locust bean gum, preferably 0.5 to 10 parts by weight with respect to 1 part by weight of methyl cellulose. Can be illustrated. Furthermore, when tamarind seed gum and tara gum are used in combination, the blending ratio of each component is 0.1 to 10 parts by weight, preferably 0.2 to 5 parts by weight, based on 1 part by weight of tamarind seed gum. The part can be exemplified. Moreover, when using it combining a tamarind seed gum and a guar gum, as a compounding ratio of each component, 0.1-10 weight part of guar gum with respect to 1 weight part of tamarind seed gum, Preferably 0.2-5 weight part is used. It can be illustrated.

  The nicotine reducing agent of the present invention is at least selected from the group consisting of the tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan. In addition to one kind of polysaccharide, saccharides can be blended within a range not impairing the effects of the present invention. By combining a saccharide with the polysaccharide, it is possible to improve viscosity and viscosity stability, or to improve the reduction rate of nicotine or tar.

  The saccharides preferably used in the present invention are monosaccharides such as glucose, fructose, galactose, mannose, xylose, erythrose, or reducing sugars thereof (for example, sorbitol, xylitol, erythritol); trehalose, maltose, isomaltose, nigerose, Disaccharides such as cellobiose, sucrose, lactose or reducing sugars thereof (for example, maltitol, lactitol); oligos such as beet oligosaccharides, maltooligosaccharides, isomaltoligosaccharides, fructooligosaccharides, galactooligosaccharides, xylooligosaccharides, and dairy oligosaccharides Examples thereof include sugars or reducing sugars thereof; sugars derived from starches such as dextrin and chickenpox, or reducing sugars thereof (for example, reducing starch syrup).

  Preferably, monosaccharides such as glucose and fructose or reducing sugars thereof (sorbitol, xylitol, erythritol); disaccharides such as trehalose, maltose, sucrose, or reducing sugars thereof (maltitol, lactitol); dextrin, and syrup be able to. More preferably, starch sugars such as glucose and its reducing sugar (sorbitol), maltose and its reducing sugar (maltitol), trehalose, dextrin and chickenpox (starch can be decomposed, enzyme-transferred and enzyme-bound using enzymes or acids). Monosaccharides, small saccharides and reduced products thereof), particularly preferably sorbitol, trehalose, and chickenpox.

  These can be used alone or in combination of two or more, in combination with the above polysaccharides. Preferred combinations include trehalose and chickenpox, sorbitol and chickenpox and the like.

  The ratio of these saccharides to be blended in the nicotine reducing agent (100% by weight) of the present invention is not particularly limited, and the viscosity of the final nicotine reducing agent is in the range of 500 to 3000 mPa · s, preferably 500 to 2500 mPa · s, More preferably, the adjustment can be determined with an index of 1000 to 2500 mPa · s. For example, the ratio of the saccharide in the case of using varicella or reduced varicella as the saccharide is usually 5 to 60% by weight, preferably 10 to 50% by weight, more preferably 10 to 40% by weight. it can. Moreover, as a saccharide | sugar other than the above when using saccharides other than the above, the range of the said saccharide is 5-50 weight% normally, Preferably it is 10-40 weight%, More preferably, the range of 10-30 weight% may be illustrated. it can.

  In the nicotine reducing agent of the present invention, in addition to the above components (polysaccharides and saccharides), a component having thickening can be arbitrarily blended within a range not impairing the effects of the present invention. Examples of such components include cassia gum, glucomannan, deacylated gellan gum, native gellan gum, natto gum, hydroxypropylcellulose (HPC), polyvinylpyrrolidone (PVP), alginate, propylene glycol alginate, gum arabic, tragacanth gum, gati gum And thickening ingredients such as soybean polysaccharide, macrohomopsis gum, rhamsan gum, welan gum, karaya gum, starch, modified starch, modified starch, fermented cellulose and agar. These can be used alone, or two or more can be used in any combination. Further, these components are preferably water-soluble components. Preferred are gum arabic, soybean polysaccharide, and karaya gum.

  Furthermore, in the nicotine reducing agent of the present invention, in addition to the above components (polysaccharides and saccharides), other components can be arbitrarily blended within a range not impairing the effects of the present invention. Such ingredients include sweeteners (for example, high-intensity sweeteners such as sucralose, aspartame, acesulfame potassium, saccharin), natural or synthetic colorants, flavors, acidulants (for example, organic acids such as citric acid, tartaric acid, ascorbic acid, etc. Acid), preservatives (for example, sodium benzoate, potassium sorbate, etc.), antioxidants (for example, polyphenols such as tea catechin, anthocyanin, isoflavone), various herbs and their extracts (chamomile, kidachia aloe, echinacea, hops) , Melissa, etc.), amino acids, minerals, vitamins and the like. These components are also preferably water-soluble components.

  The nicotine reducing agent of the present invention is selected from the group consisting of active ingredient tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan At least one polysaccharide, or at least one of these polysaccharides and the above-mentioned at least one saccharide, if necessary, in combination with any of the components described above, and preparing by dissolving in an aqueous solvent Can do. In the dissolution, heating or heat treatment may be performed as necessary.

  In addition, the nicotine reducing agent of the present invention is not particularly limited in its liquidity (pH) and can be arbitrarily set. However, as an example, it has a weak acidity of pH 3 to 5, particularly pH 3.5 to 4.5. Can be mentioned.

  The nicotine-reducing agent (aqueous liquid composition) of the present invention thus prepared is used while being held in the filter part of a smoking tool. A mode of holding is not particularly limited, but a mode (impregnation) in which the nicotine reducing agent (aqueous liquid composition) of the present invention is applied to the filter portion to hold it in a wet state (an impregnation), a mode in which the nicotine reducing agent is supplied to the filter unit and held in a dry state. Any of these may be used. The retention (impregnation) in a wet state is preferred because of its high nicotine removal effect.

  Specific examples of the filter part of the smoking tool include a cigarette mouth filter part, a filter part in a smoking pipe or cigarette holder (used on the cigarette mouth part).

  The method for retaining the nicotine reducing agent (aqueous liquid composition) in the filter part of the smoking device is not particularly limited. For example, a method of directly immersing a filter part of a smoking tool in a liquid of a nicotine reducing agent (aqueous liquid composition) or a method of applying a nicotine reducing agent to the filter part can be mentioned. The method of dripping the liquid of a reducing agent (aqueous liquid composition) in the ratio of 1 drop (about 50 mg)-several drops, Preferably 1 drop-5 drops to the filter part of a smoking tool can be mentioned suitably.

  As described above, when the nicotine reducing agent (aqueous liquid composition) of the present invention is used by being dropped onto the filter part, there is no limitation, but the nicotine reducing agent (aqueous liquid composition) has good droplet sharpness. Is preferred. Although not limited, it is preferable that the nicotine reducing agent (aqueous liquid composition) of the present invention quickly permeates and impregnates the filter part when applied to the filter part, and preferably spreads throughout. Furthermore, the nicotine-reducing agent (aqueous liquid composition) of the present invention has the disadvantage that the suction pressure increases and is difficult to absorb when it is contained in the filter part of a smoking tool and sucked, and the liquid is scattered from the filter part into the mouth. It is preferable that no inconvenience arises.

  The nicotine-reducing agent (aqueous liquid composition) of the present invention comprises, as basic components, tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan The viscosity is 500 to 3000 mPa · s, preferably 500 to 2500 mPa · s, more preferably 1000, using at least one polysaccharide selected from the group consisting of the above and, if necessary, in combination with the saccharides described above. By preparing as an aqueous liquid composition in the range of ˜2500 mPa · s, it is possible to have the above characteristics. Furthermore, the preferred nicotine-reducing agent (aqueous liquid composition) of the present invention has stable viscosity and properties throughout the year because the viscosity change due to temperature and storage is suppressed. For this reason, even if it is the time of the low temperature of winter, it has the moderate viscosity which does not produce inconvenience for dripping and osmosis | permeation to a filter part, and smoking (suction), without remarkably increasing.

  The nicotine reducing agent (aqueous liquid composition) of the present invention is usually supplied to the market in a state of being filled in a container. The container for storing such a nicotine reducing agent is not particularly limited. However, as described above, the nicotine reducing agent of the present invention is preferably used in a mode of dropping, and therefore includes a dropping type (including a dropper type). ) Is preferably filled in the container. A dripping type container will not be restrict | limited especially if it has a part which can dripped a liquid content (aqueous liquid composition) drop by drop. For example, the container itself is a dropper, and the contents (aqueous liquid composition) can be dropped directly from the mouth of the container. The lid part (cap) of the container has a dropper function, and the cap is dropped. The thing of the aspect which sucks out the content from a container and uses it as a drop can be illustrated.

  Furthermore, the size (capacity) of the container containing the nicotine reducing agent is not particularly limited, but from the viewpoint of the use of the present invention, the single use amount, and the convenience of carrying, the capacity is usually 1 to 100 mL, The size (volume) is preferably such that 2 to 20 mL of contents (aqueous liquid composition) can be accommodated.

(2) Smoking tool for reducing nicotine The present invention provides a smoking tool for reducing nicotine. The smoking device of the present invention includes a smoking device such as a cigarette with a filter (hereinafter, simply referred to as “tobacco” in order to distinguish it from the tool used for smoking below), a smoking pipe (including xels), a cigarette. Tools for sucking cigarettes (including cigarettes and chopped cigarettes) and cigars such as holders (used over cigarettes and other cigarettes, including disposables) and cartridges used in cigarette holders (Hereinafter simply referred to as “pipe” in order to distinguish this from the above tobacco).

  Here, the pipe includes at least a tobacco storage part or tobacco insertion port, a suction part, a passage (conduit part) for guiding smoke from the tobacco storage part or tobacco insertion part to the suction part, and the nicotine reducing agent (aqueous liquid) of the present invention described above. A portion (holding portion) for holding the composition) is provided.

  The smoking tool of the present invention is sucked into the body during smoking by holding the above-described nicotine reducing agent (aqueous liquid composition) of the present invention in the filter part of the tobacco with a filter or the holding part of the pipe. This is a nicotine-reducing smoking device that can reduce the amount of nicotine.

  The pipe holding portion is provided in a portion through which the mainstream smoke of tobacco passes and may be formed so as to be able to hold the nicotine reducing agent (aqueous liquid composition) of the present invention, and its structure and material are not particularly limited. . For example, it can be formed by attaching or filling a porous member such as paper, non-woven fabric, fiber, and sponge to a portion through which mainstream smoke of tobacco passes. In addition, as a raw material, a cellulose acetate, a fatty acid polyester compound, a cellulose ester etc. can be illustrated without a restriction | limiting.

  The pipe (smoking tool) of the present invention has the effect of removing nicotine by allowing the mainstream smoke of tobacco to pass through the holding part holding the nicotine reducing agent (aqueous liquid composition). It is. For this reason, the holding | maintenance part of the said pipe can also be defined as a filter part. In this sense, in this specification, the holding portion of the pipe may be collectively referred to as “filter portion of a smoking tool” together with the tobacco filter portion.

  The capacity of the filter (the tobacco filter part and the pipe holding part) of the smoking tool according to the present invention is not particularly limited. The nicotine reducing agent (aqueous liquid composition) preferably has a capacity capable of stably holding as much as possible, but the nicotine reducing agent (aqueous liquid composition) is preferably at least about 50 to 250 mg, preferably 50 If it is a capacity | capacitance which can be hold | maintained at about -150 mg, there will be no trouble in normal use.

Although it does not restrict | limit, Cigarette holder 1 as shown in FIG. 1 and the cigarette holder 11 as shown in FIGS. 2-7 can be illustrated as one aspect | mode of the smoking implement for nicotine reduction of this invention.

The cigarette holder 1 is provided with a filter 2 corresponding to a holding part in a holder body 3 so that the nicotine reducing agent of the present invention can be held. The holder body 3 includes a mouthpiece 4 at one end and a cigarette insertion port 5 at the other end. The holder body 3 has a flat shape around the suction port 4 and the vicinity thereof, and is easily held by the mouth. The cigarette holder 1 provided by the present invention as an embodiment of a smoking device for reducing nicotine is one in which the nicotine reducing agent of the present invention is held in advance in the filter portion.

Similarly to the above, the cigarette holder 11 is provided with the filter 2 corresponding to the holding portion in the holder main body 3 so that the nicotine reducing agent of the present invention can be held. The cigarette holder 11 provided by the present invention as a smoking tool for reducing nicotine may be one in which the nicotine reducing agent of the present invention is held in advance in the filter 2 , and when used, the nicotine reducing agent of the present invention described above. May be used by being supplied to the filter portion and held.

Hereinafter, the configuration of the cigarette holder 11 will be described with reference to FIGS.

The holder body 3 includes a mouthpiece 4 at one end and a cigarette insertion port 5 at the other end. The holder body 3 has a flat shape around the suction port 4 and the vicinity thereof, and is easily held by the mouth. Cigarette holder 11, and one clip cap 6 detachable from the side of the holder body 3 can further comprise a lid 7 detachable from the other side of the holder body 3. In the illustrated example, the clip cap 6 is mounted on the side of the suction portion 4 of the holder body 3, lid 7 is attached to 5-side holder body 3 cigarettes inserted port. The cap 6 with a clip includes a protrusion 8 for insertion into the mouthpiece 4 .

By attaching the cap 6 with a clip and the lid 7 to the holder body 3 , volatilization that occurs when the filter 2 is impregnated with a nicotine reducing agent can be prevented. Moreover, the clip of the cap 6 with a clip can be kept in a breast pocket etc. when not smoking. The cap 6 with a clip is preferably formed in a shape similar to a cap attached to a normal pen.

The cap 6 with a clip and the lid 7 are configured to be detachable. In the illustrated example, the lid 7 can be fitted and attached to the opening 9 of the cap 6 with a clip. Cover 7 has a flange portion 10, the flange portion 10 serves as a stopper when the fitting the lid 7 in the clip cap 6. At the time of smoking, the lid 7 is attached to the cap 6 with a clip, and the lid 7 can be prevented from being lost by holding it in a chest pocket or the like with the clip.
(3) Method for reducing the amount of nicotine in mainstream smoke of tobacco The present invention provides a method for reducing the amount of nicotine in mainstream smoke of tobacco. In this method, the nicotine-reducing agent (aqueous liquid composition) described above is included in a filter part of a smoking tool (for example, a cigarette suction filter or a filter of a smoking pipe or cigarette holder), so that the mainstream smoke of cigarettes is smoked during smoking. It can be carried out by passing through the filter.

  According to the method for reducing nicotine according to the present invention, the amount of nicotine in mainstream smoke that is inhaled into the body by smoking is significantly increased by simply including the aforementioned nicotine reducing agent (aqueous liquid composition) of the present invention in the filter of a smoking device. Can be reduced. In addition to the amount of nicotine, the amount of tar in mainstream smoke can be significantly reduced as shown in the experimental examples described later. Thus, the present invention also provides a method for reducing the amount of tar in the mainstream smoke of tobacco.

  Further, as shown in the experimental examples, by further increasing the amount of the nicotine reducing agent (aqueous liquid composition) included in the filter, the amount of nicotine and tar in the mainstream smoke is increased according to the amount of increase. Can be reduced. The volume of the nicotine reducing agent (aqueous liquid composition) to be retained in the filter is not particularly limited as long as it is a capacity that can be retained in the filter, but is usually 1 to several drops (about 50 to several hundred mg), preferably 1 A range corresponding to a drop to an equivalent amount of 5 drops (about 50 to 250 mg) can be exemplified.

  The main cause of smoking cessation is said to be physical and psychological dependence on nicotine in mainstream tobacco smoke. Therefore, according to the method for reducing nicotine according to the present invention, even a subject who has become addicted to smoking can reduce the amount of nicotine inhaled into the body while smoking, thereby gradually addicting to nicotine. Can be relaxed. Moreover, according to the nicotine reducing agent according to the present invention, the smoker himself / herself can control the amount of nicotine in the mainstream smoke to be inhaled by adjusting the amount of use (the amount applied to the filter). For this reason, the smoker can achieve smoking cessation by gradually reducing nicotine intake in accordance with his / her dependence on nicotine, and finally eliminating nicotine dependence.

  Hereinafter, the contents of the present invention will be specifically described with reference to the following experimental examples and examples. However, the present invention is not limited to these. Unless otherwise specified, “parts” means “parts by weight”.

In addition, the acquisition place of the compound used by the following experiment example is as follows. ^* Indicates that this is a registered trademark of Saneigen FFI Co., Ltd.
Tamarind Seed Gum: Bistop ^* D-2033, Saneigen FFI Co., Ltd.
Locust bean gum: Bistop ^* D-30, Saneigen FFI Co., Ltd.
Xanthan Gum: San Ace ^* C, San-Ei Gen FFI Co., Ltd.
Tara Gum: Bistop ^* D-2101, Saneigen FFI Co., Ltd.
Guar Gum: Bistop ^* D-2029, Saneigen FFI Co., Ltd.
Pullulan: Pullulan PF-20 (fine powder), Hayashibara Psyllium seed gum: Soalum PG-200, MRC polysaccharides
HM pectin: Bistop ^* D-2220, Saneigen FFI Co., Ltd.
LM pectin: Bistop ^* D-402, Saneigen FFI Co., Ltd.
λ-Carrageenan: Carrageenin CSL-1, Saneigen FFI Co., Ltd.
Trehalose: Treha fine powder (trade name), Hayashibara Minamata (acid saccharified starch syrup): Syrup low (brand name), Kogo Starch
Soybean polysaccharide: SM-920 (trade name), Saneigen FFI Co., Ltd.
Trisodium citrate: Trisodium citrate F (trade name), Saneigen FFI Co., Ltd.
Glycine: Glycine P (trade name), Organic Synthetic Chemical Industry L-Ascorbic acid: Viscoline 80M (trade name), Daiichi Fine Chemical Co., Ltd.
Tea catechin: SD green tea extract powder NO. 16714, Saneigen FFI Co., Ltd.
Licorice powder: Ricotin P-1 (trade name), Ikeda Saccharification Co., Ltd.
Experimental example 1
(1) Preparation of aqueous liquid composition According to the formulation described in Table 2, aqueous liquid compositions (Examples 1 to 15) were prepared. Specifically, the polysaccharides listed in Table 1 (tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pullulan, psyllium seed gum, HM pectin, LM pectin, λ-carrageenan, carboxymethyl cellulose) and trehalose are first included. It was added to ion-exchanged water and dissolved by stirring at 80 ° C. for 10 minutes while heating. Among the polysaccharides, methylcellulose (Example 14) and hydroxypropylmethylcellulose (Example 15) are added to ion-exchanged water together with trehalose and stirred at 60 ° C. for 10 minutes and further at 10 ° C. for 10 minutes. While dissolving.

A sodium benzoate aqueous solution, a citric acid aqueous solution, a trisodium citrate aqueous solution, and an aqueous solution of coloring agents (red No. 2 and red No. 40) previously dissolved in ion-exchanged water were added and mixed. The total amount was adjusted to 100% by weight with ion-exchanged water, and each aqueous liquid composition (Examples 1 to 15) was prepared.
(2) Property Evaluation of Aqueous Liquid Composition The viscosity of each of the aqueous liquid compositions (Examples 1 to 15) obtained above was measured using a B-type rotational viscometer (rotor No. 3 when the viscosity was 2000 mPa · s or less). Use, when the viscosity exceeded that, rotor No. 4 was used) and measured under the conditions of 20 ° C., 60 rpm, 1 minute (initial viscosity). This was stored at 50 ° C. for 3 weeks, and then the viscosity was measured under the same conditions as above (viscosity after storage). The residual viscosity (%) was determined according to the following formula, and the viscosity stability was determined according to the following criteria Evaluated.

（３）使用感の評価
上記で得られた各水性液状組成物（実施例１〜１５）を２０℃に調整した後、タバコのフィルター部の先端部に２滴（約１００ｍｇ）滴下し、液がフィルター内に浸透するのに要する時間を測定した（しみ込み性評価）。なお、フィルター表面の液滴が完全に消失した時点で浸透完了と判断した。また、液がフィルターに浸透したことを確認した後、喫煙し、煙を吸ったときに液が口内に吸い戻るか否かを評価した（吸い戻り性評価）。なお、各水性液状組成物（実施例１〜１５）の、しみ込み性評価及び吸い戻り性評価は、下記の基準に従って、すべて同一人物が行った。また、吸い戻り性評価は、３回主流煙を吸い込むことによって実施した。

（４）結果
上記（２）及び（３）で測定評価した結果を、表２に合わせて示す。また、合わせて、上記（２）及び（３）で得られた結果に基づいて、下記の基準により評価した結果を、総合評価として表２に示す。

Viscosity residual ratio (%) = (viscosity after storage / initial viscosity) × 100

(3) Evaluation of feeling of use After adjusting each aqueous liquid composition (Examples 1-15) obtained above to 20 degreeC, 2 drops (about 100 mg) are dripped at the front-end | tip part of the filter part of tobacco, and liquid Was measured for the time required to penetrate into the filter (penetration evaluation). In addition, it was judged that the permeation was completed when the droplets on the filter surface completely disappeared. In addition, after confirming that the liquid had permeated the filter, it was smoked, and whether or not the liquid was sucked back into the mouth when smoke was smoked was evaluated (evaluation of suckability). In addition, all the aqueous liquid compositions (Examples 1-15) performed the penetration | infiltration property evaluation and the sucking-back evaluation by the same person according to the following reference | standard. Moreover, the sucking-back evaluation was carried out by sucking mainstream smoke three times.

(4) Results The results measured and evaluated in the above (2) and (3) are shown in Table 2. In addition, based on the results obtained in (2) and (3) above, the results evaluated according to the following criteria are shown in Table 2 as comprehensive evaluation.

Experimental example 2
(1) Preparation of aqueous liquid composition An aqueous liquid composition (Examples 16 to 25) was prepared according to the formulation described in Table 3. Specifically, tamarind seed gum and xanthan gum and each saccharide described in Table 3 (trehalose, sucrose, glucose, fructose, maltose, sorbitol, maltitol, erythritol, xylitol, dextrin) are added to ion-exchanged water, The mixture was dissolved by heating at 80 ° C. for 10 minutes while stirring. A sodium benzoate aqueous solution, a citric acid aqueous solution, a trisodium citrate aqueous solution, and an aqueous solution of colorants (red No. 2 and red No. 40) previously dissolved in ion-exchanged water were added and mixed. The total amount was adjusted to 100% by weight with ion-exchanged water, and each aqueous liquid composition (Examples 16 to 25) was prepared.
(2) Property Evaluation of Aqueous Liquid Composition In the same manner as in Experimental Example 1, the initial viscosity of each aqueous liquid composition (Examples 16 to 25) obtained above was measured. Further, as in Experimental Example 1, the viscosity after storage at 50 ° C. for 3 weeks (viscosity after storage) was measured to determine the residual viscosity (%), and the viscosity stability of each aqueous liquid composition was evaluated. .
(3) Evaluation of feeling of use In the same manner as in Experimental Example 1 (3), each aqueous liquid composition (Examples 16 to 25) obtained above (adjusted to 20 ° C.) was applied to the tip of the tobacco filter part. The solution was dropped to evaluate the penetration of the liquid into the filter (penetration evaluation). Similarly, the ability of sucking back into the mouth when smoking was evaluated (sucking back evaluation).
(4) Results The results of measurement and evaluation in the above (2) and (3) are shown in Table 3.

  In addition, based on the results obtained in (2) and (3) above, the results of evaluation based on the same criteria as in Experimental Example 1 are shown in Table 3 as comprehensive evaluation.

Experimental example 3
(1) Preparation of aqueous liquid composition According to the formulation described in Table 4, aqueous liquid compositions (Examples 26 to 29) were prepared by the following procedure. About each obtained aqueous liquid composition, the viscosity was measured on 20 degreeC, 60 rpm, and 1 minute conditions using the B-type rotational viscometer (rotor No. 3).
(I) Example 26
Locust bean gum was added little by little while stirring water at room temperature. After reaching 90 ° C., the solution was stirred and dissolved at 90 ° C. for 10 minutes. Next, trehalose was added and further stirred, methylcellulose was added little by little and cooled to 20 ° C. Citric acid, glycine, L-ascorbic acid, tea catechin, trisodium citrate, and licorice powder were added thereto, and a colorant was further added. Citric acid, glycine, L-ascorbic acid, and tea catechin were all dissolved in a small amount of water in advance. Trisodium citrate and licorice powder were used by dissolving trisodium citrate in a small amount of water and adding licorice powder to this. After the preparation, the whole amount (100% by weight) was corrected with water, filled in a container, and sterilized by heating at 65 ° C. for 10 minutes to obtain an aqueous liquid composition (Example 26).
(Ii) Example 27
While stirring 80 ° C. water, tamarind seed gum and xanthan gum were added little by little, and stirred and dissolved at 80 ° C. for 10 minutes (solution A). Separately, while stirring 80 ° C. water, a powder mixture of soybean polysaccharide and trehalose was added little by little and dissolved at 80 ° C. Glycine, adipic acid, L-ascorbic acid, and tea catechin were added to this, and a solution obtained by adding licorice powder to trisodium citrate dissolved in water and adding a coloring agent (solution) B). Solution A, Solution B and chickenpox were mixed and stirred and mixed, then the total amount (100 wt%) was corrected with water, filled in a container, and then heat sterilized at 65 ° C. for 10 minutes to obtain an aqueous liquid composition (Example 27). ).
(Iii) Example 28
An aqueous liquid composition (Example 28) was obtained by the same procedure as in Example 27 except that xanthan gum was not used.
(Iv) Example 29
An aqueous liquid composition (Example 29) was obtained by the same procedure as in Example 27 except that tamarind seed gum was not used.

(2) Viscosity stability evaluation of aqueous liquid composition Among each aqueous liquid composition (Examples 26-29) obtained above, about the aqueous liquid composition of Example 26, temperature is 10 to 40 degreeC. The state of the liquid was observed. As a result, the aqueous liquid composition of Example 26 maintained a smooth state regardless of the temperature change (10 ° C. → 40 ° C.).

  For the aqueous liquid compositions of Examples 27 to 29, the viscosity was measured over time after storage at 37 ° C. (3 days, 7 days, 10 days, 14 days, 21 days and 28 days after storage), Viscosity stability was evaluated. The viscosity measurement conditions are the same as above. The results are shown in Table 5. The viscosity stability is indicated by the residual viscosity rate (%) calculated according to the formula described in Experimental Example 1 (2).

From the results of the above table, the aqueous liquid compositions of Examples 26 to 29 prepared using locust bean gum, tamarind seed gum or xanthan gum do not significantly change in viscosity due to long-term storage or temperature change, It became clear that it had almost constant properties.
(3) Evaluation of feeling of use After adjusting each aqueous liquid composition (Examples 26-29) obtained above to 20 degreeC, 2 drops (about 100 mg) are dripped at the front-end | tip part of the filter part of tobacco, Similarly to Experimental Example 1 (3), the penetration time of the liquid was evaluated by measuring the time for the liquid to penetrate into the filter (penetration evaluation). Next, after confirming that the liquid had permeated the filter, the smoked product was smoked, and the ease of sucking the cigarette and the presence or absence of the liquid composition sucking back into the mouth were evaluated (collectively, “ease of smoking”). In addition, the same person performed all evaluation of the penetration property and the easiness of smoking of each aqueous liquid composition. Moreover, evaluation of the ease of smoking was implemented by inhaling mainstream smoke 3 times. Furthermore, the degree of discoloration of the filter part was observed after smoking.
(4) Results Any of the aqueous liquid compositions of Examples 26 to 29 penetrates uniformly in about 15 seconds when dropped onto the tip of the tobacco filter, and the liquid scatters in the mouth during smoking, or inhalation occurs. There was no problem of difficulty. Furthermore, it turned out that all the filter parts after smoking are discolored black, and more nicotine and tar are trapped by the filter part of tobacco compared with the case where it is not impregnated with the aqueous liquid composition.

Experimental Example 4
Using the aqueous liquid composition (Example 27) prepared in Experimental Example 3, the nicotine and tar removal effects of the aqueous liquid composition of the present invention were evaluated.

  Specifically, 1 drop (about 50 mg) and 2 drops of the aqueous liquid composition of Example 27 were applied to the filter tip of tobacco (mild seven light, Japan Tobacco Inc .: nicotine content 0.7 mg, tar content 8 mg). (About 100 mg) or 3 drops (about 150 mg), and the amount of nicotine and tar contained in tobacco smoke was immediately measured. As a comparative experiment, the amount of nicotine and the amount of tar contained in tobacco smoke was measured in the same manner as described above using water (1 drop, 2 drops, 3 drops) instead of the aqueous liquid composition. Nicotine contained in the smoke of untreated tobacco that uses neither an aqueous liquid composition nor water, and the amount of nicotine and tar contained in untreated tobacco smoke as 100%, respectively. The nicotine reduction rate (%) and the tar reduction rate (%) were calculated from the amount and the tar amount, respectively.

In addition, the measurement of the amount of nicotine and the amount of tar contained in cigarette smoke was performed according to the method stipulated in Ministry of Finance Notification 174 (Japan) in 1989 as shown below. Each experiment was performed using 10 cigarettes.
<Measurement of nicotine content and tar content>
1. Preparation of tobacco Tobacco used for measurement is stored in advance under conditions of 22 ± 1 ° C. and 60 ± 2% humidity for 2 days to 7 days to prepare the conditions.
2. Apparatus and apparatus (1) Smoker: Piston pump type (2) Smoke collector: A cigarette holder equipped with a glass fiber filter is used. A filter having a diameter of 44 mm and a thickness of 1 to 2 mm and capable of collecting 99.9% or more of all particles of dioctyl phthalate having a diameter of 0.3 μm or more at a speed of 140 mm / second is used. The filter pressure drop at this speed is 93 mmH ₂ O (900 Pa) or less. A filter having an acrylic resin adhesive content of 5% or less is used.
(3) Gas chromatograph (i) Measurement conditions of gas chromatograph for moisture measurement Column: Glass made of glass having an inner diameter of 2-3 mm and a length of 1.2-1.8 m Filler: Polapack Q (manufactured by Waters) (80-100 mesh) Or a thing with performance equal to or higher than this Temperature: Thermostatic bath (170-180 ° C), injection part (230-250 ° C), detector (250 ° C)
Carrier gas: Helium Flow rate: 40 ml / min Detector: Thermal conductivity detector (ii) Measurement conditions of gas chromatograph for nicotine measurement Column: Glass packing material having an inner diameter of 2-3 mm and a length of 1.8-2.7 m : 60-80 mesh chromosolve W washed with acid and distilled water coated with polyethylene glycol-20W (10 wt%) and potassium hydroxide (2 wt%), or equivalent or better performance : Thermostatic bath (170-180 ° C), injection part (230-250 ° C), detector (250 ° C)
Carrier gas: helium or nitrogen Flow rate: 20-40 ml / min Detector: Hydrogen flame ionization detector Test operation and calculation (1) Collection of crude tar Insert the end of the measuring cigarette into the cigarette holder 9 ± 1 mm and smoke under the following conditions until the cigarette butt reaches 30 mm. And collect the crude tar (part of the particles in the tobacco smoke collected by the filter). Note that the number of measurement cigarettes to be smoked to collect the crude tar is 5 per smoking mouth.
<Smoking conditions>
Smoking capacity (volume of cigarette smoke inhaled by one smoking): 35 ± 0.3 ml
Smoking time (time required for one smoking): 2 ± 0.1 seconds Smoking cycle (time from smoking to the next smoking): 60 ± 1 seconds Smoking waveform (puff profile): 0.8 ~ from the start of smoking The bell type has a maximum value in 1.2 seconds, and the maximum flow rate is 25 to 30 ml / second.
(2) Calculation of the amount of crude tar Weigh the smoke collector before and after smoking in units of 0.1 mg, and calculate the crude tar amount (mg / piece) from the difference in weight to two decimal places (3 digits or less are rounded down). Calculated by the following equation.
Crude tar amount = [weight of smoke collector after smoking (mg) −weight of smoke collector before smoking (mg)] / number of smokers (3) Preparation of sample solution Fold the filter that collected the crude tar, Wipe the inner wall surface of the cigarette holder, and then wipe the inner wall surface of the cigarette holder with an unused 1/4 filter. Place 10 ml of these filters and extraction solvent (mixed solvent of isopropanol: ethanol: anethole = 4974: 25: 1 (volume ratio), the same applies hereinafter) into a container and shake to prepare a sample solution.
(4) Measurement of water content in crude tar 1 μl of sample solution was injected into a gas chromatograph, the peak area ratio of water to ethanol peak area was determined, and the calibration curve created by the method of (6) (i) was used. Measure the amount of water (mg / piece) in the sample solution to 2 decimal places (3 digits or less are discarded). From this, the average daily moisture content contained in the filter is subtracted to obtain the moisture content in the crude tar. In addition, it measures twice for every sample solution, and calculates | requires an average value.
(5) Measurement of the amount of nicotine in the crude tar 1 μl of the sample solution was injected into the gas chromatograph, the peak area ratio of nicotine to the peak area of anethole was determined, and the calibration curve created by the method of (6) (ii) was used. The amount of nicotine (mg / piece) in the sample solution is measured to 2 digits after the decimal point (3 digits are discarded). In addition, it measures twice for every sample solution, and calculates | requires an average value.
(6) Preparation of calibration curve (i) Preparation of water calibration curve Add 10 ml each of extraction solvent to four or more different amounts of distilled water covering the range of water content expected to exist in the crude tar. Prepare a standard solution. 1 μl of this standard solution is injected into a gas chromatograph, the ratio of the peak area of water to the peak area of ethanol is determined, and after repeating these operations twice, a calibration curve is created from the relationship between the peak area ratio and the amount of added water. .
(Ii) Preparation of calibration curve for nicotine A standard solution is prepared by adding 10 ml each of extraction solvent to four or more different amounts of nicotine covering the range of nicotine amounts expected to exist in the crude tar. 1 μl of this standard solution is injected into a gas chromatograph, the peak area ratio of nicotine to the peak area of anethole is determined, and after repeating these operations twice, a calibration curve is created from the relationship between the peak area ratio and the nicotine amount.
(7) Calculation of tar amount The tar amount (mg / piece) is calculated to 2 digits after the decimal point by subtracting the amount of water and nicotine in the crude tar from the amount of crude tar.

  The results are shown in FIG.

  As can be seen from FIG. 8, by applying the nicotine reducing agent (aqueous liquid composition) of the present invention to a tobacco filter, both the amount of nicotine and the amount of tar contained in the mainstream smoke of tobacco can be reduced by 50% or more. . Further, as can be seen from the figure, the nicotine and tar reducing effect of the nicotine reducing agent (aqueous liquid composition) of the present invention is about 2 to 5 times the effect when only water is used. Further, as can be seen from the figure, the effect of reducing nicotine and tar increases as the amount of the nicotine reducing agent (aqueous liquid composition) provided to the tobacco filter increases. From this, it is possible to appropriately control the amount of nicotine and the amount of tar contained in the mainstream smoke of tobacco by adjusting the amount of the nicotine reducing agent (aqueous liquid composition) of the present invention (the amount applied to the filter). I understand that I can do it.

  As described above, the nicotine reducing agent according to the present invention is contained in the filter part of the smoking tool and smoked, so that the nicotine contained in the mainstream smoke of the tobacco is efficiently captured by the nicotine reducing agent in the filter. Removed. The more preferable nicotine reducing agent according to the present invention has a specific polysaccharide and has an appropriate viscosity, so that it can be dripped cleanly on the filter part. It spreads quickly and evenly and stays in the filter section. For this reason, even if it smokes, a nicotine reducing agent does not scatter in a mouth, and there is also little sucking resistance, and it can smoke without changing normally, and it can still remove nicotine efficiently.

  Further, the preferred nicotine reducing agent according to the present invention suppresses a change in viscosity due to temperature, so that it does not increase in viscosity even at low temperatures in winter and has an appropriate viscosity under normal use conditions. To maintain. Thereby, even if it is the outdoors in winter, since it has the same viscosity as indoors, the problem that it becomes difficult to dripping to the filter part hardly occurs.

  By using the nicotine reducing agent according to the present invention, the nicotine and tar components contained in the mainstream smoke of tobacco are efficiently removed, and the nicotine and tar components in a larger amount than in normal smoking are contained in the filter part of the smoking tool. Will adhere. The nicotine-reducing agent of the present invention can be used for a filter in a smoking pipe or cigarette holder, but nicotine in mainstream smoke can be reduced by using it directly on a filter of tobacco itself. In this case, after smoking, it can be thrown away as it is, and the economic efficiency is improved as compared with the case of using a smoking pipe or cigarette holder.

  Moreover, the amount of nicotine trapped in the filter part of tobacco increases as the amount of the nicotine-reducing agent according to the present invention increases in the smoking device. Therefore, by increasing the amount of nicotine-reducing agent according to the present invention, the intake of nicotine can be reduced step by step, so that nicotine dependence onset under smoking and smoking cessation can be gradually relieved and smoking cessation achieved. Is possible.

Claims (14)

Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; A nicotine reducing agent comprising an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s. The nicotine reducing agent according to claim 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, and pectin. The nicotine reducing agent according to claim 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, and xanthan gum. Furthermore, the nicotine reducing agent of Claim 1 which contains saccharides. The nicotine reducing agent according to claim 4, wherein the saccharide is at least one selected from the group consisting of trehalose, starch syrup, glucose, fructose, maltose, sorbitol, maltitol, lactitol, erythritol, xylitol, and dextrin. The nicotine reducing agent according to claim 4, wherein the saccharide is at least one selected from the group consisting of trehalose and chickenpox. The nicotine reducing agent according to claim 1, wherein the nicotine reducing agent is used by being held in a filter part of a smoking tool. A nicotine reducing agent in a container, wherein the nicotine reducing agent comprising the aqueous liquid composition according to claim 1 is filled in a container. A smoking device for reducing nicotine having a filter part holding the nicotine reducing agent according to claim 1. The nicotine reducing smoking tool has a holder body having a suction port at one end and a cigarette insertion port at the other end, and a filter provided in the holder body. The nicotine-reducing smoking device according to claim 9, wherein the nicotine-reducing agent according to item 1 is retained. A method for reducing the amount of nicotine in the mainstream smoke of tobacco, comprising the step of allowing the mainstream smoke of tobacco to pass through the filter of the smoking device containing the nicotine-reducing agent according to claim 1. A method for reducing the amount of tar in the mainstream smoke of tobacco, comprising a step of allowing the mainstream smoke of tobacco to pass through a filter of a smoking tool containing the nicotine reducing agent according to claim 1. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; Use of an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s for the preparation of a nicotine reducing agent or a tar reducing agent. Containing at least one polysaccharide selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, and carrageenan; Use of an aqueous liquid composition having a viscosity of 500 to 3000 mPa · s for reducing nicotine or tar.

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