CN110558605B

CN110558605B - Electronic cigarette liquid

Info

Publication number: CN110558605B
Application number: CN201910927116.2A
Authority: CN
Inventors: 许静; 姜兴涛; 伍鲲; 熊赞华; 李锐
Original assignee: Shenzhen Relx Technology Co Ltd
Current assignee: Shenzhen Relx Technology Co Ltd
Priority date: 2019-09-27
Filing date: 2019-09-27
Publication date: 2021-07-06
Anticipated expiration: 2039-09-27
Also published as: WO2021056526A1; CN110558605A

Abstract

The application relates to electronic cigarette liquid. The embodiment of the application provides an electronic cigarette liquid, which comprises nicotine, wherein the concentration of the nicotine in the electronic cigarette liquid is 14 mg/mL-20 mg/mL, and the acid value of the electronic cigarette liquid is 0.15 mgKOH/g-26 mgKOH/g. This electron tobacco juice can form through the atomizing and be used for the inspiratory aerial fog of user, and this aerial fog can effectively reduce the influence of smoking to the user to promote user experience.

Description

Electronic cigarette liquid

Technical Field

The present application relates to the field of electronic aerosols or electronic nebulization devices, in particular to electronic cigarette liquid.

Background

Traditional tobacco smoking has many possible side effects, which can cause various diseases such as pharyngolaryngitis, tracheitis, pneumonia, emphysema, asthma, lung cancer, cardiovascular diseases, gastric cancer, and fertility decline.

Harmful substances such as tar, suspended particles, carbon monoxide and the like harmful to human health are not easily generated in the electronic cigarette liquid through low-temperature atomization, and the harm to users and other people is far less than that of the traditional cigarette to human bodies. Therefore, electronic cigarettes and electronic atomization devices are attracting more and more attention.

How to further generate aerosol for inhalation by users, which reduces harmful effects on human bodies and improves beneficial effects on human bodies, by optimizing the composition in the electronic cigarette liquid is a research direction for the improvement of electronic cigarette products.

Disclosure of Invention

This application is through providing an electron tobacco juice, this electron tobacco juice can the produced aerial fog of its atomizing of effectual reduction to the influence of human body to improve the user experience of user when inhaling this aerial fog. The electronic cigarette liquid can provide safer, healthier and more comfortable aerosol for a user to inhale.

According to one aspect of the present application, there is provided an electronic cigarette liquid comprising: nicotine, wherein the concentration of the nicotine in the e-liquid is from about 14mg/mL to about 20mg/mL, and the acid value of the e-liquid is from about 0.15mgKOH/g to about 26 mgKOH/g.

In some embodiments, the e-liquid further comprises a cooling agent, wherein the cooling agent is present in the e-liquid in an amount of about 0.001% to about 10% by weight based on the total weight of the e-liquid.

In some embodiments, the e-liquid further comprises a flavoring, wherein the flavoring is present in the e-liquid in an amount of about 0.001% to about 10% by weight of the e-liquid, based on the total weight of the e-liquid.

In some embodiments, the e-liquid further comprises an organic acid, the weight of the organic acid in the e-liquid being about 3mg/mL to about 20mg/mL based on the total weight of the e-liquid.

According to another aspect of the present application, there is provided an aerosolization device comprising an e-liquid as described above, wherein the total weight of nicotine in the aerosolization device is less than or equal to 200 mg.

Additional aspects and advantages of embodiments of the present application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of embodiments of the present application.

Drawings

Figure 1 is a graph of extract concentration versus human cell viability for e-liquid according to some embodiments of the present application.

FIG. 2 is a graph of extract concentration versus number of human cell clones for a comparative example e-liquid according to the present application.

Detailed Description

Embodiments of the present application will be described in detail below. The examples of the present application should not be construed as limiting the present application.

Additionally, amounts, ratios, and other numerical values are sometimes presented herein in a range format. It is to be understood that such range format is used for convenience and brevity, and should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited.

As used herein, the terms "substantially," "generally," "substantially," "essentially," and "about" are used to describe and illustrate small variations. When used in conjunction with an event or circumstance, the terms can refer to instances where the event or circumstance occurs precisely as well as instances where the event or circumstance occurs in close proximity. For example, when used in conjunction with numerical values, the term can refer to a range of variation that is less than or equal to ± 10% of the stated numerical value, such as less than or equal to ± 5%, less than or equal to ± 4%, less than or equal to ± 3%, less than or equal to ± 2%, less than or equal to ± 1%, less than or equal to ± 0.5%, less than or equal to ± 0.1%, or less than or equal to ± 0.05%. For example, two numerical values are considered to be "substantially" identical if the difference between the two numerical values is less than or equal to ± 10% (e.g., less than or equal to ± 5%, less than or equal to ± 4%, less than or equal to ± 3%, less than or equal to ± 2%, less than or equal to ± 1%, less than or equal to ± 0.5%, less than or equal to ± 0.1%, or less than or equal to ± 0.05%) of the mean of the values.

In the detailed description and claims, a list of items linked by the term "at least one of," "at least one of," or other similar terms may mean any combination of the listed items. For example, if items a and B are listed, the phrase "at least one of a and B" means a only; only B; or A and B. In another example, if items A, B and C are listed, the phrase "at least one of A, B and C" means a only; or only B; only C; a and B (excluding C); a and C (excluding B); b and C (excluding A); or A, B and C. Item a may comprise a single element or multiple elements. Item B may comprise a single element or multiple elements. Item C may comprise a single element or multiple elements.

As used herein, the term "aerosol for inhalation by a user" can include, but is not limited to, aerosols, suspended liquids, cryogenic vapors, and volatile gases.

According to one aspect of the present application, there is provided an electronic vaping liquid, the electronic vaping liquid comprising: nicotine, wherein the concentration of the nicotine in the e-liquid is from about 14mg/mL to about 20mg/mL, and the acid value of the e-liquid is from about 0.15mgKOH/g to about 26 mgKOH/g.

In some embodiments, the concentration of nicotine in the e-liquid is approximately, for example, 14mg/mL, 15mg/mL, 16mg/mL, 17mg/mL, 18mg/mL, 19mg/mL, 20mg/mL, or a range consisting of any two of these concentrations.

In some embodiments, the acid value of the e-liquid is approximately, for example, 0.15mgKOH/g, 0.20mgKOH/g, 0.5mgKOH/g, 1.0mgKOH/g, 1.5mgKOH/g, 2.0mgKOH/g, 5.0mgKOH/g, 10.0mgKOH/g, 15.0mgKOH/g, 25.0mgKOH/g, 26.0mgKOH/g, or any combination thereof.

In some embodiments, the pH of the e-liquid is about 5.5 to about 8.8. In other embodiments, the e-liquid pH is approximately, for example, 5.5, 5.6, 5.8, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 8.6, 8.7, 8.8, or a range consisting of any two of the foregoing values. The electronic cigarette liquid in the acidity range has less irritation and corrosivity, and can effectively inhibit inflammation or anaphylactic reaction when a user inhales. The safety of the electronic cigarette liquid to mucous membrane cells on the surface of the oral cavity or the thoracic cavity of a human body can be improved. In addition, the electronic cigarette liquid can also improve the mouthfeel of users, and the users can feel softer, smoother and milder mouthfeel when using the electronic cigarette liquid, and do not feel dry, burning, choking nose and the like.

In some embodiments, the viscosity of the e-liquid is from 100mPa · s to 350mPa · s. In other embodiments, the viscosity of the electronic smoking solution is, for example, approximately 100 mPas, 110 mPas, 10 mPas, 150 mPas, 200 mPas, 250 mPas, 300 mPas, 350 mPas, or any combination thereof. The viscosity of the electronic cigarette liquid is within the range, so that the problem of overflow and leakage during storage can be effectively avoided, and the storage convenience of the electronic cigarette liquid is improved. In addition, the transmission and the atomizing efficiency of the electronic cigarette liquid in the atomizing device can be improved, the electronic cigarette liquid is prevented from being blocked in the atomizing device, and therefore the situations that the atomizing device is overheated and deflagrated are reduced.

In some embodiments, the purity of the nicotine added to the e-liquid is greater than or equal to 99%. The high-purity nicotine or nicotine salt can effectively reduce the concentration of impurities in the electronic cigarette liquid. In the atomization process of the electronic cigarette liquid, the content of impurities or harmful substances in the generated aerosol can be reduced by using high-purity nicotine, and the safety of the electronic cigarette liquid to a user is further improved.

The e-liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin). In some embodiments, the weight of propylene glycol in the e-liquid is approximately, e.g., 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or a range consisting of any two of these weight percentages, based on the total weight of the e-liquid; and glycerol, for example, in the range of about 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, or any two of these weight percentages. In some embodiments, the propylene glycol is present in the e-liquid in an amount of about 20% to about 60% by weight, and the glycerin is present in the e-liquid in an amount of about 40% to about 70% by weight, so as to achieve optimal atomization of the e-liquid and improve the user experience.

It will be understood by those skilled in the art that the base solvent may be selected from any solvent known in the art according to specific needs, for example, deionized water, propylene glycol, glycerol, without limitation.

In some embodiments, the e-liquid further comprises a cooling agent.

Cooling agents are additives, which are chemicals that can produce a cooling effect sensation to the user when the product is used and are not irritating. In some embodiments, the cooling agent comprises a cooling agent selected from the group consisting of menthol, menthone, isomenthone, l-menthyl lactate, WS-23(N,2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5(N- (ethoxycarbonylmethyl) -p-alkane-3-carboxamide), WS-12(N- (4-methoxyphenyl) -p-menthyl-3-carboxamide), and combinations thereof.

In some embodiments, the cooling agent is present in the e-liquid in an amount of, for example, about 0.001%, about 0.01%, about 0.1%, about 0.2%, about 0.3%, about 0.5%, about 1.0%, about 1.5%, about 2.0%, about 2.5%, about 5%, about 10%, or in any two of these weight percentages, based on the total weight of the e-liquid. In some embodiments, the cooling agent is present in the e-liquid in an amount of about 0.001% to about 10% by weight of the e-liquid, based on the total weight of the e-liquid, to enhance the mouthfeel of the aerosol generated by the e-liquid for inhalation by a user.

In some embodiments, the e-liquid further comprises a flavoring.

In some embodiments, the weight of the flavoring in the e-liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 10%, or a range consisting of any two of these weight percentages, based on the total weight of the e-liquid. In some embodiments, the flavor is present in the e-liquid in an amount of about 0.001% to about 10% by weight of the e-liquid, based on the total weight of the e-liquid, to add flavor to the e-liquid and to optimize the mouthfeel of the aerosol generated therefrom.

It is understood that the perfume may be any conventional choice in the art, and those skilled in the art can arbitrarily select the perfume commonly used in the art without limitation based on their actual needs within the scope of the above examples.

In some embodiments, the e-liquid further comprises an additive. In some embodiments, the additive can act as a diluent to reduce the viscosity of the e-liquid. In other embodiments, the additive can act as a thickener to increase the viscosity of the e-liquid.

In some embodiments, the additive further comprises an organic acid. In some embodiments, the organic acid is selected from the group consisting of benzoic acid, citric acid, lactic acid, lauric acid, succinic acid, fumaric acid, malic acid, and combinations thereof. The organic acid can adjust the acid value and the pH value of the electronic cigarette liquid and optimize the taste of the aerosol generated by the electronic cigarette liquid. The weight of the organic acid in the e-liquid is about 3mg/mL to about 20mg/mL, for example, 4mg/mL, 5mg/mL, 6mg/mL, 7mg/mL, 8mg/mL, 9mg/mL, 10mg/mL, 12mg/mL, 15mg/mL, or 18mg/mL or a range consisting of any two of these concentrations, based on the total weight of the e-liquid.

It is understood that the additives may be any conventional choice in the art, and those skilled in the art may arbitrarily select additives commonly used in the art without departing from the scope of the above examples based on their actual needs, without being limited thereto.

According to some embodiments of the present application, there is provided a method of preparing an electronic cigarette liquid, comprising the steps of: mixing nicotine and organic acid to obtain nicotine salt, adding appropriate amount of basic tobacco juice, cooling agent and essence, and mixing to obtain electronic tobacco juice.

In some embodiments, the acid value, pH, and viscosity of the e-liquid may be adjusted by altering the proportions of the base liquid and the type and amount of additives.

According to another aspect of the present application, there is provided an aerosolization device, wherein the aerosolization device comprises e-liquid as in the above-described embodiments. The electronic cigarette liquid can be atomized by the atomization device to generate aerosol for a user to inhale.

In some embodiments, the total weight of nicotine in the aerosolization device is less than or equal to 200mg to avoid excessive nicotine intake when the aerosolization device is inadvertently accessed by an infant or a person with poor performance, thereby improving safety.

In some embodiments, the nebulizing device comprises an electronic cigarette, an ultrasonic nebulizer, or a mesh nebulizer. It is to be understood that the atomizing means may be any conventional apparatus in the art without being limited thereto.

The electronic cigarette liquid and the atomizing device provided by the embodiment of the application can effectively improve user experience. Simultaneously, the electron tobacco juice and atomizing device can reduce the harm of smoking to the human body, promotes its security. .

Examples

To facilitate a better understanding of the benefits of the e-liquid and aerosolization apparatus of the present application, specific embodiments will be described below. These examples belong to the scope of protection of the present application, but do not limit the scope of protection of the present application.

Preparation of the diluted solution:

the indicated material was placed in a volumetric flask and subsequently propylene glycol was added to bring the final volume to 1L. And obtaining the specified material diluent with specific concentration after the specified material is completely and uniformly dissolved.

Preparing essence:

perfume raw materials were prepared in the following weight ratio in table 1, and a total weight of 200g of perfume raw materials was put in a volumetric flask, followed by addition of propylene glycol to make a final volume of 1L. And obtaining the essence diluent after the essence is completely and uniformly dissolved.

TABLE 1

Example 1

15mL of nicotine dilution (100mg/mL) was mixed with 5mL of benzoic acid dilution (100mg/mL) and stirred for 20 min. Then, 30mL of propylene glycol and 50mL of glycerol (glycerin) are added and mixed uniformly to obtain the electronic cigarette liquid.

Example 2

15mL of nicotine dilution (100mg/mL) was mixed with 5mL of citric acid dilution (100mg/mL) and stirred for 20 min. Then, 30mL of propylene glycol and 50mL of glycerol (glycerin) are added and mixed uniformly to obtain the electronic cigarette liquid.

Example 3

16mL of nicotine dilution (100mg/mL) was mixed with 7mL of benzoic acid dilution (100mg/mL) and stirred for 20 min. Then adding 10mL of WS-3 diluent (200mg/mL), 10mL of essence diluent, 7mL of propylene glycol and 50mL of glycerol (glycerin) and uniformly mixing to obtain the electronic cigarette liquid.

Example 4

17mL of nicotine dilution (100mg/mL) was mixed with 9mL of benzoic acid dilution (100mg/mL) and stirred for 20 min. Then 10mL of menthol diluent (200mg/mL), 5mL of essence diluent, 7mL of deionized water, 8mL of propylene glycol and 45mL of glycerol (glycerin) are added and uniformly mixed to obtain the electronic cigarette liquid.

Example 5

18mL of nicotine dilution (100mg/mL) was mixed with 9mL of benzoic acid dilution (100mg/mL) and stirred for 20 min. Then 10mL of menthol diluent (200mg/mL), 5mL of WS-3 diluent (200mg/mL), 4mL of essence diluent, 6mL of propylene glycol and 48mL of glycerol (glycerin) are added and uniformly mixed to obtain the electronic cigarette liquid.

Comparative example 1

The electronic cigarette liquid is obtained by uniformly mixing 40mL of nicotine diluent (100mg/mL), 10mL of propylene glycol and 50mL of glycerol (glycerin).

Comparative example 2

50mL of nicotine dilution (100mg/mL) was mixed with 20mL of benzoic acid dilution (100mg/mL) and stirred for 20 min. Then 10mL of deionized water and 20mL of glycerol (glycerin) are added and mixed uniformly to obtain the electronic cigarette liquid.

The E-liquid of the above examples 1-5 and comparative examples 1 and 2 was processed through an 848 tritno plus automatic potentiometric titrator (Metrohm AG, Vantone, Switzerland), a thunder magnetic PHS-3E pH meter (Shanghai apparatus, electrosciences apparatus, Ltd.) and a rotational viscometer Visco QC^TMThe acid number, pH and viscosity were recorded at 100 (Anton Paar, Anton), as shown in Table 2 below. The aerosols generated by the atomization of the e-liquid of examples 1-5 and comparative examples 1 and 2 were then subjected to a cell growth test and a taste scoring test.

TABLE 2

Sample name	Acid value (mgKOH/g)	pH value	Viscosity (mPa. s)
				Example 1	2.6	6.98	234.5
Example 2	1.8	7.02	245.7
				Example 3	3.8	6.71	257.6
Example 4	4.3	6.65	115.5
				Example 5	4.4	6.61	259.8
Comparative example 1	0.4	9.45	243.6
				Comparative example 2	9.2	6.81	52.1

A cell growth test mode;

sample preparation:

the CORESTA (Cooperation Centre for Scientific Research Relative to Tobacco) standard (test document: ISO 20768:2018) is adopted, and the suction mode is as follows: smoking time is 3.0s +/-0.1 s; the interval time is 30.0s plus or minus 0.5 s; the amount of the smoke per mouth is 55.0mL +/-0.3 mL, the sample is atomized by an atomizing device (electronic cigarette) to generate the aerosol, and the aerosol is collected by a Cambridge filter sheet, and the weight of the absorbed aerosol is 0.716 g. Then placing the Cambridge filter into a small beaker, adding 7.16mL of dimethyl sulfoxide (DMSO), and performing ultrasonic extraction for 30mins to prepare an extraction solution with the concentration of 100mg/mL to obtain aerosol extract.

Cell culture:

the human lung epidermal cell BEAS-2B is used as a test cell strain, the cryopreserved BEAS-2B cells are taken out from liquid nitrogen and placed in warm water at 37 ℃ to rapidly thaw the cells. Thawing, quickly transferring into DMEM (Dulbecco's modified eagle medium) cell culture solution (Gibco, U.S.), mixing, centrifuging at 1000r/min for 3min to remove supernatant, adding DMEM cell culture solution, 37 deg.C, and 5% CO₂Was cultured in an incubator (SHELAB, SCO 2W).

When the cell-confluency in the cell culture dish was observed to be 90%, the original culture solution was discarded, rinsed 1 to 2 times with Phosphate Buffered Saline (PBS), and 2mL to 3mL of 0.25% Trypsin solution (Trypsin solution, Gibco u.s.) was added to immerse all the cells in the bottom of the cell culture dish in the solution. Standing at 37 deg.C for 5% CO₂The digestion was carried out in the incubator for about 3 minutes. Cells were observed under an inverted microscope, and as time passed, the cells adhered to the wall gradually tended to be round, and when they had not floated, pancreatic enzymes were removed, and digestion was stopped by adding a suitable volume of DMEM medium. Blowing and beating adherent cells into suspension by using a liquid transfer gunCentrifuging at 1000r/min for 3min to remove supernatant, adding DMEM cell culture solution, separating into two or three cell culture dishes, placing at 37 deg.C and 5% CO₂The culture was continued in the incubator until the cell confluency became 90%, and the subculture was carried out again.

Cell viability assay:

taking BEAS-2B cells in logarithmic growth phase, and adjusting cell density to 2.4 × 10 with DMEM cell culture solution⁴one/mL of the cells were inoculated in a 96-well plate at an inoculum size of 100. mu.L/well, and an equal volume of DMEM cell culture medium was administered to the null wells at 37 ℃ with 5% CO₂The culture box is used for adherent culture for 16 h. After 16h, different concentrations (0.41. mu.g/mL, 1.23. mu.g/mL, 3.7. mu.g/mL, 11.1. mu.g/mL, 33.3. mu.g/mL, and 100. mu.g/mL) of the aerosol extract were added to the 96-well plate in amounts of 100. mu.L/well, and 6 samples were taken for each concentration of the aerosol extract for testing. The blank was added with an equal volume of DMEM cell culture medium. Then, the mixture was placed at 37 ℃ in 5% CO₂The incubator of (1) was continued for 48 hours. After 48h 10. mu.L of CCK-8 test reagent (cell counting kit-8, Dojindo Molecular Technologies, Japan) was added to each well, and the incubation was continued for 4h, and the light transmission intensity (OD value, optical density) was measured at a wavelength of 450nm on a microplate reader. Three replicates were set up in the experiment and cell viability was recorded. Cell viability was calculated using the following formula:

FIG. 1 is a graph of the concentration of the aerosol extracts of examples 1-5 and comparative examples 1 and 2 versus the cell viability of human lung epidermal cells BEAS-2B.

As shown in fig. 1, the aerosol extracts generated from the e-liquid of examples 1-5 have reduced effect on the cell viability of human epidermal cells BEAS-2B compared to comparative examples 1 and 2, and still maintain the cell viability of human epidermal cells BEAS-2B at a high concentration of more than 80%. Therefore, the electronic cigarette liquid of the embodiments 1 to 5 has low influence on human bodies, so that the harm of smoking to the health of the human bodies is reduced.

Cell cloning test:

BEAS-2B cells in the logarithmic growth phase were seeded at about 400 cells/well in a 6-well plate (Corning, 3513), and shaken to add 2mL of DMEM medium per well. After 24h of culture, the aerosol extract is prepared into 25 mug/mL, 50 mug/mL, 100 mug/mL and DMSO blank control group by DMEM culture solution, and after the liquid in the hole is changed, the culture is continued for 15 days. After cloning, the cells were washed twice with PBS and fixed with 4% paraformaldehyde for 45 min. The fixative was removed, washed twice with deionized water, and immediately stained with crystal violet (cloudy day, C0121) for 45 minutes. And removing the coloring agent, cleaning with deionized water, taking a sample picture after reversing and airing, scanning the picture by using an HP scanner and counting.

FIG. 2 is a graph of the concentration of the aerosol extracts of examples 1 to 5 and comparative examples 1 and 2 versus the cell clone number of human lung epidermal cells BEAS-2B.

As shown in FIG. 2, by comparing the cloning test results of the E-liquid of examples 1-5 and comparative examples 1 and 2 on human lung epidermal cells, the aerosol extract of examples 1-5 can effectively reduce the negative effects of the aerosol extract of comparative examples 1 and 2 on human body cells, thereby obtaining a safer and healthier cigarette liquid.

A taste scoring test mode 1;

the statistical method comprises the following steps: please note that 20 evaluators scored the aerosol experiences generated by the electronic cigarette liquids of examples 1-5 and comparative examples 1 and 2 according to the evaluation indexes in table 3.

TABLE 3

The results of the sensory evaluation tests on the electronic cigarette liquids of examples 1 to 5 and comparative examples 1 and 2 are shown in table 4 below.

TABLE 4

Evaluation index	Example 1	Example 2	Example 3	Example 4	Example 5	Comparative example 1	Comparative example 2
								Fineness of flue gas	4.5	4.3	4.5	4.4	4.5	2.9	3.2
Consistent fragrance, no segmentation or fault	4.4	4.3	4.4	4.3	4.5	3.2	3.5
								Smoke and aroma concentration	3.7	3.8	4.5	4.5	4.6	3.5	3.7
Rich fragrance and long smoke	3.9	3.8	4.4	4.5	4.6	3.5	3.6
								Sweet taste and body fluid production feeling	4.5	4.2	4.5	4.6	4.7	3.1	3.3
Irritation and burning sensation	4.5	4.4	4.5	4.6	4.5	2.6	3.5
								Degree of oral cavity cleanliness after smoking	4.4	4.4	4.6	4.5	4.5	3.6	3.4
Presence or absence of bad breath	4.6	4.3	4.6	4.7	4.6	3.6	3.6
								Feeling of hitting throat	4.2	4.3	4.4	4.5	4.5	4.7	4.8
Degree of reduction and discrimination of fragrance	3.9	3.8	4.4	4.5	4.6	3.2	3.5

As can be seen from the data in table 4, the aerosol formed by atomizing the electronic cigarette liquids of examples 1-5 of the present application for inhalation by the user shows better user experience in terms of taste or flavor than the electronic cigarette liquids of comparative examples 1 and 2.

A taste scoring test mode 2;

the statistical method comprises the following steps: the electronic cigarette liquids of the above examples 1-5 and comparative example 1 were tested by randomly selecting 1000 users through an electronic cigarette, and the taste and mouthfeel thereof were evaluated after the use test, wherein the evaluation criteria was 10 points in total, and the better the taste or the better the mouthfeel, the higher the score.

The results of the sensory evaluation tests on the electronic cigarette liquids of examples 1 to 5 and comparative examples 1 and 2 are shown in table 5 below.

TABLE 5

As can be further seen from the data in table 5, the aerosol generated by the e-liquid of the present application for inhalation by the user has good taste and flavor for the user, whether professional analyst or general user.

Can understand through the above-mentioned embodiment of this application, this application provides an electron tobacco juice, and this electron tobacco juice can effectually reduce the produced aerial fog of its atomizing to the influence of human body to improve the user experience of user when inhaling this aerial fog. The electronic cigarette liquid can provide safer, healthier and more comfortable aerosol for a user to inhale.

While the present application has been described and illustrated with reference to particular embodiments thereof, such description and illustration are not intended to limit the present application. It will be clearly understood by those skilled in the art that various changes in form and details may be made therein without departing from the true spirit and scope of the application, as defined by the appended claims, to adapt a particular situation, material, composition of matter, substance, method or process to the objective, spirit and scope of the application. All such modifications are intended to be within the scope of the claims appended hereto. Although the methods disclosed herein have been described with reference to particular operations performed in a particular order, it should be understood that these operations may be combined, sub-divided, or reordered to form equivalent methods without departing from the teachings of the present application. Accordingly, unless specifically indicated herein, the order and grouping of the operations is not a limitation of the present application.

The foregoing outlines features of several embodiments and detailed aspects of the present application. The embodiments described in this application may be readily utilized as a basis for designing or modifying other processes and structures for carrying out the same or similar purposes and/or obtaining the same or similar advantages of the embodiments introduced herein. Such equivalent constructions do not depart from the spirit and scope of the present application, and various changes, substitutions, and alterations can be made therein without departing from the spirit and scope of the present application.

Claims

1. An e-liquid, comprising:

nicotine, wherein the concentration of the nicotine in the electronic cigarette liquid is 14mg/mL to 20mg/mL, the acid value of the electronic cigarette liquid is 0.15mgKOH/g to 26mgKOH/g, and the pH value of the electronic cigarette liquid is 6.5 to 7.0.

2. The e-liquid of claim 1, wherein the e-liquid has a viscosity of 100 to 350 mPa-s.

3. The e-liquid of claim 1, wherein the nicotine has a purity of greater than or equal to 99%.

4. The e-liquid of claim 1, further comprising a cooling agent, wherein the cooling agent is selected from the group consisting of menthol, menthone, isomenthone, l-menthyl lactate, WS-23(N,2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5(N- (ethoxycarbonylmethyl) -p-alkane-3-carboxamide), WS-12(N- (4-methoxyphenyl) -p-menthyl-3-carboxamide), and combinations thereof.

5. The e-liquid of claim 4, wherein the cooling agent is present in the e-liquid in an amount of 0.001% to 10% by weight based on the total weight of the e-liquid.

6. The e-liquid of claim 1, further comprising a flavor, wherein the flavor is present in the e-liquid at 0.001% to 10% by weight based on the total weight of the e-liquid.

7. The e-liquid of claim 1, further comprising an organic acid selected from the group consisting of benzoic acid, citric acid, lactic acid, lauric acid, succinic acid, fumaric acid, malic acid, and combinations thereof.

8. An aerosolization device comprising the e-liquid of any one of claims 1-7, wherein the total weight of nicotine in the aerosolization device is less than or equal to 200 mg.

9. The atomization device of claim 8 in which the atomization device comprises an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.