CN114587008B - Electronic cigarette liquid and atomization device comprising same - Google Patents
Electronic cigarette liquid and atomization device comprising same Download PDFInfo
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- CN114587008B CN114587008B CN202011438700.0A CN202011438700A CN114587008B CN 114587008 B CN114587008 B CN 114587008B CN 202011438700 A CN202011438700 A CN 202011438700A CN 114587008 B CN114587008 B CN 114587008B
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Abstract
The application relates to an electronic cigarette liquid and an atomization device comprising the same. The electronic cigarette liquid comprises nicotine and organic acid, wherein in aerosol generated by heating and atomizing the electronic cigarette liquid, the molar ratio of the protonated nicotine to the unprotonated nicotine is 1:0.1-1:2.5. The electronic cigarette liquid can effectively improve the throat feeling of a user, so that the user obtains better suction experience.
Description
Technical Field
The application relates to the field of electronic aerosol or electronic atomization devices, in particular to electronic cigarette liquid and an atomization device comprising the same.
Background
Electronic cigarettes are becoming increasingly popular with consumers as a substitute for traditional tobacco due to the pursuit of personal health, environmental protection, and ease of use. The electronic cigarette or the electronic atomizer replaces the smoke generated by the traditional way of burning tobacco at high temperature by atomizing the smoke generating material at low temperature to form the aerosol for the user to inhale.
The throat feeling of the current electronic cigarette liquid is poor, so that the user has poor suction experience. Therefore, there is a need to develop an electronic cigarette liquid that can enhance the user's throat feel while ensuring a satisfactory feel.
Disclosure of Invention
The application provides the electronic cigarette liquid, which can improve the throat feeling of a user while ensuring satisfaction, so that the user obtains better suction experience.
The application also provides the electronic cigarette liquid, which can improve the throat feeling and satisfaction of a user at the same time and can reduce the health risk caused by the ingestion of nicotine.
According to an embodiment of the present application, there is provided an electronic vaping liquid comprising nicotine and an organic acid, wherein in an aerosol generated by heating and atomizing the electronic vaping liquid, the molar ratio of protonated nicotine to unprotonated nicotine is from 1:0.1 to 1:2.5.
According to still another embodiment of the present application, an atomization device is provided, which includes the electronic cigarette liquid described above.
Additional aspects and advantages of embodiments of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of embodiments of the application.
Drawings
The drawings that are necessary to describe embodiments of the present application or the prior art will be briefly described below in order to facilitate the description of the embodiments of the present application. It is apparent that the drawings in the following description are only a few embodiments of the application. It will be apparent to those skilled in the art that other embodiments of the drawings may be made in accordance with the structures illustrated in these drawings without the need for inventive faculty.
FIG. 1 is the electrophysiological test results of a portion of the examples and comparative examples.
Fig. 2 is a representative current diagram of acetylcholine receptors induced by e-vaping solutions of example 5.
Detailed Description
Embodiments of the present application will be described in detail below. The examples of the present application should not be construed as limiting the application.
Additionally, amounts, ratios, and other numerical values are sometimes presented herein in a range format. It is to be understood that such range format is used for convenience and brevity and should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited.
As used herein, the terms "substantially," "substantially," and "about" are used to describe and illustrate small variations. When used in connection with an event or circumstance, the terms can refer to instances where the event or circumstance occurs precisely and instances where it occurs to the close approximation. For example, when used in connection with a numerical value, the term can refer to a range of variation of less than or equal to ±10% of the numerical value, such as less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, less than or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%. For example, two values may be considered "substantially" the same if the difference between the two values is less than or equal to ±10% (e.g., less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, less than or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%) of the average value of the values.
In the detailed description and claims, a list of items connected by the terms "at least one of," "at least one of," or other similar terms may mean any combination of the listed items. For example, if items a and B are listed, the phrase "at least one of a and B" means only a; only B; or A and B. In another example, if items A, B and C are listed, then the phrase "at least one of A, B and C" means only a; or only B; only C; a and B (excluding C); a and C (excluding B); b and C (excluding A); or A, B and C. Item a may comprise a single component or multiple components. Item B may comprise a single component or multiple components. Item C may comprise a single component or multiple components.
The materials used in the present application are commercially available unless otherwise specified.
According to one aspect of the present application, there is provided an electronic vaping liquid comprising nicotine and an organic acid, wherein in an aerosol produced by heating and atomizing the electronic vaping liquid, the molar ratio of protonated nicotine to unprotonated nicotine is from 1:0.01 to 1:2.5.
The inventor finds that in aerosol generated by heating and atomizing electronic cigarette liquid, the molar ratio of protonated nicotine to unprotonated nicotine is about 1:0.1 to about 1:2.5, so that the user can ensure satisfaction and simultaneously improve the throat feeling of the user, and the user can obtain the optimal suction experience in the balance of obtaining the throat feeling and the satisfaction.
In some embodiments, in an aerosol produced by heating and atomizing an e-vaping liquid, the molar ratio of protonated nicotine to non-protonated nicotine is about 1:0.1 to about 1:2.5, e.g., may be about 1:0.1, about 1:0.2, about 1:0.5, about 1:0.6, about 1:0.8, about 1:0.95, about 1:1, about 1:1.5, about 1:2, 1:2.2, 1:2.5, or may be in the range of any two values above, e.g., about 1:0.1 to about 1:1, about 1:0.1 to about 1:0.5, or about 1:0.1 to about 1:2. When the molar ratio of protonated nicotine to unprotonated nicotine in the aerosol is less than 1:0.1, the satisfaction is better, but the throat feeling is poor; when the molar ratio of protonated nicotine to unprotonated nicotine in the aerosol is greater than 1:2.5, the throat feel is good, but the satisfaction is poor.
The inventors have further found that the molar ratio of organic acid to nicotine in the e-liquid affects the ratio of protonated nicotine to non-protonated nicotine in the aerosol. Excessive organic acid can lead to reduced throat feeling, but can cause more nicotine to be protonated, so that the nicotine is easy to penetrate through a blood brain barrier, and the satisfaction is improved; a smaller amount of organic acid will increase the proportion of non-protonated nicotine in the aerosol, enhancing the user's throat feel and aspiration experience. Thus, the molar ratio of organic acid to nicotine in the e-vaping liquid of the present application is from about 0.1:1 to about 2:1.
In some embodiments, the molar ratio of organic acid to nicotine is about 0.1:1 to about 2:1. In some embodiments, the molar ratio of organic acid to nicotine may be about 0.1:1, about 0.2:1, about 0.3:1, about 0.4:1, about 0.5:1, about 0.6:1, about 0.7:1, about 0.8:1, about 0.9:1, about 1:1, about 1.1:1, about 1.2:1, about 1.3:1, about 1.4:1, about 1.5:1, about 1.6:1, about 1.7:1, about 1.8:1, about 1.9:1, about 2:1, or may be in the range of any two values above, e.g., about 0.1:1 to about 0.5:1, about 0.1:1 to about 1:1, about 0.5:1 to about 2:1, or about 1:1 to about 2:1.
The inventors have further found that the kind and proportion of organic acids also affects the ratio of protonated nicotine to non-protonated nicotine in the aerosol. Benzoic acid, levulinic acid and lactic acid with different boiling point characteristics are added into the electronic cigarette liquid according to a certain proportion, so that the throat feeling of a user can be further improved while the satisfaction is ensured. Because the boiling point characteristics of three acids, namely benzoic acid, levulinic acid and lactic acid are different, the heating and volatilizing sequences of the three acids with different proportions are different, so that the proportion of protonated nicotine and unprotonated nicotine in aerosol is different, and the throat feeling is influenced. Specifically, benzoic acid, levulinic acid, lactic acid and nicotine are independently atomized, the boiling point of the three acids is different from that of the nicotine, the content of acids at the front, middle and rear sections in aerosol generated by heating volatilization is different, the ratio of the acids to the nicotine combined to form protonated nicotine is also different, and the ratio of the three acids to the nicotine combined to form salts is also different. Therefore, the application can lead the throat feeling of the front, middle and back sections of the aerosol to be equivalent by adjusting the proportion of the three acids, thus leading a aspirator to obtain smooth throat feeling.
In some embodiments, the organic acid comprises at least one of benzoic acid, levulinic acid, lactic acid, citric acid, lauric acid, malic acid, or succinic acid. The inventor finds that the generated protonated nicotine can be distributed more uniformly in the aerosol through reasonable collocation of organic acid types in the electronic cigarette liquid.
The inventor further found that the molecular structure of benzoic acid, levulinic acid and lactic acid can enable the electronic cigarette liquid to have good taste. In some embodiments, the organic acid comprises benzoic acid, levulinic acid, and lactic acid, with a molar ratio of benzoic acid, levulinic acid, and lactic acid of (0.5-1.5): 0.1-0.3): 0.5-1.1. In some embodiments, the molar ratio of benzoic acid, levulinic acid, and lactic acid can be (0.5-1): 0.1-0.3): 0.5-1, or (0.5-1): 0.1-0.2): 0.5-1. For example, in some embodiments, the molar ratio of benzoic acid, levulinic acid, and lactic acid can be 1.5:0.2:1, 1.5:0.2:0.75, 1:0.2:1, 1:0.2:0.5, 1:0.2:0.75, 1:0.3:0.75, 1:0.1:0.75, 1:0.2:1.02, 0.5:0.2:1, 0.5:0.2:0.5, 0.5:0.2:0.75, or 0.5:0.1:1, etc.
In some embodiments, the organic acid may further include at least one additional acid of citric acid, lauric acid, malic acid, or succinic acid, on the basis of benzoic acid, levulinic acid, and lactic acid. The inventor finds that the generated protonated nicotine can be distributed more uniformly in the aerosol through reasonable collocation of organic acid types in the electronic cigarette liquid.
In some embodiments, the at least one additional acid may be present in the e-vaping solution in an amount ranging from about 0% to about 4.5%, e.g., about 0%, about 0.1%, about 0.12%, about 0.14%, about 0.15%, about 0.17%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, or any two of these values, e.g., from about 0% to about 1%, about 0.05% to about 0.2%, about 0.1% to about 0.3%, about 0.1% to about 0.5%, about 1% to about 2%, about 0.5% to about 3%, or about 1% to about 4.5%, based on the total weight of the e-vaping solution.
In some embodiments, the organic acid comprises at least benzoic acid, the weight of benzoic acid being from about 0.1% to about 0.5% based on the total weight of the e-liquid. For example, in some embodiments, the benzoic acid may be present in an amount of about 0.1%, about 0.11%, about 0.15%, about 0.18%, about 0.2%, about 0.22%, about 0.25%, about 0.28%, about 0.3%, about 0.33%, about 0.35%, about 0.38%, about 0.4%, about 0.42%, about 0.45%, about 0.48%, or about 0.5%, or may be in a range of any two of the above values, such as about 0.11% to about 0.22%, about 0.11% to about 0.33%, or about 0.11% to about 0.45%, etc., based on the total weight of the e-liquid.
In some embodiments, the organic acid comprises at least levulinic acid in an amount of from about 0.001% to about 0.5%, such as from about 0.001%, 0.01%, about 0.02%, about 0.03%, about 0.04%, about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.1%, about 0.12%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, or a range of any two of the above, such as from about 0.001% to about 0.05%, about 0.01% to about 0.05%, about 0.03% to about 0.07%, about 0.1% to about 0.5%, or about 0.2% to about 0.5%, and the like, by weight of the electronic cigarette liquid.
In some embodiments, the organic acid comprises at least lactic acid, which may be present in an amount of about 0.01% to about 0.5%, e.g., about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.16%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, or about 0.5%, or may be in a range of any two of the above values, e.g., about 0.01% to about 0.1%, about 0.08% to about 0.12%, about 0.08% to about 0.165%, about 0.1% to about 0.5%, about 0.01% to about 0.5%, or about 0.08% to about 0.45%, based on the total weight of the e-liquid.
In some embodiments, the weight of nicotine is greater than about 0% and less than or equal to about 6% based on the total weight of the e-vaping solution. For example, in some embodiments, the weight of nicotine is about 0%, about 0.5%, about 1%, about 1.5%, about 1.55%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, or may be in the range of any two values above, such as less than or equal to about 1.55%, less than or equal to about 3%, about 1.55% -about 3%, about 1% -about 3%, about 0.5% -about 2%, or about 2% -about 6%, etc., based on the total weight of the e-vaping solution.
According to another aspect of the present application, there is further provided an electronic vaping solution comprising an organic acid, nicotine and cotinine.
Cotinine is the primary metabolite of nicotine after it is absorbed by the human body, and although nicotine and cotinine are very similar in structure, the effects of these two compounds on the nervous system are significantly different.
The inventor researches find that cotinine and nicotine have a synergistic effect, and the cotinine and the nicotine are added into the electronic cigarette liquid together, so that the satisfaction of a user can be effectively improved. Therefore, the electronic cigarette liquid can also contain cotinine on the basis of nicotine, benzoic acid, levulinic acid and lactic acid, so as to improve the throat feeling and satisfaction of a user. In addition, the addition of cotinine in the electronic cigarette liquid can reduce the dosage of nicotine, so that the nicotine intake of a user is reduced, and the health risk of the user caused by the nicotine is reduced.
In some embodiments, the weight of cotinine in the e-vaping solution may be about 0% to about 4.5%, such as about 0%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, 4.5%, or may be in the range of any two of the above values, such as about 0% to about 1%, about 0% to about 2%, about 0.1% to about 1.5%, about 0.1% to about 3%, about 1% to about 2%, about 1% to about 3%, or about 2% to about 4%, etc., based on the total weight of the e-vaping solution.
In some embodiments, the molar ratio of cotinine to nicotine is about 0.1:1 to about 1.5:1. In some embodiments, the molar ratio of cotinine to nicotine may be about 0.1:1, about 0.2:1, about 0.3:1, about 0.4:1, about 0.5:1, about 0.6:1, about 0.7:1, about 0.8:1, about 0.9:1, about 1:1, about 1.1:1, about 1.2:1, about 1.3:1, about 1.4:1, about 1.5:1, or may be in the range of any two values above, such as about 0.1:1 to about 0.5:1, about 0.1:1 to about 1:1, about 0.5:1 to about 1.5:1, about 0.5:1 to about 1:1, or about 1:1 to about 1.5:1.
In some embodiments, the weight of nicotine is greater than 0% and less than or equal to 6%, the weight of cotinine is greater than 0% and less than or equal to 4.5%, and the weight of organic acid is 0.1% to 1% based on the total weight of the electronic cigarette liquid.
In some embodiments, the electronic vaping solution further comprises a cooling agent. In some embodiments, the cooling agent comprises at least one of menthol, menthone, isomenthone, isopulegol, menthyl acetate, menthyl lactate, WS-23 (N, 2, 3-trimethyl-2-isopropyl butyramide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5 (N- (ethoxycarbonylmethyl) -p-alkyl-3-carboxamide), WS-12 (N- (4-methoxyphenyl) -p-menthyl-3-carboxamide).
In some embodiments, the weight of cooling agent in the electronic vaping liquid may be about 0.001% to about 10%, such as about 0.001%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 3%, about 5%, about 7%, about 10%, or may be in the range of any two values above, such as about 0.001% to about 1%, about 0.001% to about 5%, about 0.01% to about 1%, about 0.01% to about 10%, about 0.1% to about 5%, about 0.1% to about 10%, or about 1% to about 10%, based on the total weight of the electronic vaping liquid.
In some embodiments, the electronic vaping solution further comprises a flavor. In some embodiments, the flavor includes, but is not limited to, grape flavor, apple flavor, peach flavor, green tea flavor, peppermint flavor, and the like, commercially available food flavors.
In some embodiments, the fragrance may include at least one of d-limonene, benzyl alcohol, ethyl butyrate, linalool, isobutyl acetate, isoamyl acetate, benzyl benzoate, leaf alcohol, ethyl propionate, citral, gamma-decalactone, decanal, ethyl acetate, ethyl 2-methylbutyrate, 2-methylbutyl acetate, 2-methylbutyraldehyde, myrcene, ethyl caproate, peach aldehyde, ethyl isovalerate, leaf alcohol acetate, acetic acid, benzaldehyde.
In some embodiments, the flavour may be present in the electronic vaping solution in an amount of about 0.001% to about 10%, such as about 0.001%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 3%, about 5%, about 7%, about 10%, or may be in a range of any two values above, such as about 0.001% to about 1%, about 0.01% to about 5%, about 0.01% to about 10%, about 0.1% to about 5%, about 0.1% to about 10%, or about 1% to about 10%, by weight based on the total weight of the electronic vaping solution.
The electronic cigarette liquid also comprises a base solvent, wherein the base solvent comprises propylene glycol and glycerol (glycerin). In some embodiments, the weight percent of propylene glycol in the e-vaping liquid is about 15% to 60%, such as may be about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 50%, about 60%, or may be in the range of any two values above, such as about 15% to 30%, about 20% to 50%, or about 30% to 60%, based on the total weight of the e-vaping liquid. In some embodiments, the weight percent of glycerol in the e-vaping liquid may be about 30% to about 70%, such as about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, or may be in the range of any two values above, such as about 30% to 50%, about 40% to 60%, or about 50% to 70%, based on the total weight of the e-vaping liquid.
In some embodiments, the weight percentage of propylene glycol in the electronic cigarette liquid is about 20% to about 60%, and the weight percentage of glycerol in the electronic cigarette liquid is about 40% to about 70%, so that the electronic cigarette liquid achieves the optimal atomization effect, and the user experience is improved.
It will be appreciated by those skilled in the art that the base solvent may be selected from any solvents known in the art, such as deionized water, propylene glycol, glycerol, without limitation, according to the particular needs.
According to some embodiments of the present application, the present application provides a method for preparing an electronic cigarette liquid, comprising the steps of: benzoic acid, levulinic acid, lactic acid and nicotine were added to the base tobacco juice in specific proportions in the ranges provided in the examples, and they were homogeneously mixed to obtain an electronic tobacco juice. In some embodiments, benzoic acid, levulinic acid, lactic acid, nicotine, cotinine, essence and/or cooling agents are added to a base tobacco juice in a proportion such that they are uniformly mixed to obtain an electronic tobacco juice.
According to another aspect of the present application, there is provided an atomization device, which includes the electronic cigarette liquid according to any of the above embodiments. The electronic cigarette liquid can be atomized through the atomization device to generate aerosol for a user to inhale.
In some embodiments, the atomizing device comprises an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
Examples
In order that the application may be better understood, it is illustrated by the following examples. These examples are included in the scope of the application, but are not intended to limit the scope of the application.
Preparing a basic tobacco juice:
and (3) mixing the propylene glycol, the glycerol, the cooling agent and the essence uniformly according to the following weight ratio (53.5:44:2:0.5) to obtain the basic tobacco juice.
Wherein the cooling agent is WS-23, and the essence is grape essence.
Preparation of electronic cigarette liquid:
and (3) uniformly mixing nicotine and organic acid (and optional cotinine), and adding the mixture into the base tobacco tar to obtain the electronic cigarette liquid for testing. The respective weights of nicotine, organic acid (and optionally cotinine) in the electronic cigarette liquids of each of the comparative examples and examples are shown in table 1 below. Example 15 also includes succinic acid.
After the electronic cigarette liquids of the above comparative examples and examples were completed, electrophysiological tests and taste scoring tests were subsequently performed. The electrophysiological test results are shown in fig. 1, and the taste score test results are shown in table 2 below.
Electrophysiological test method:
cells were co-transfected with acetylcholine receptor alpha 4 and beta 2 subunits and cultured for 24h before electrophysiological experiments were performed. An electrode is obtained by drawing through a two-step method by using an electrode drawing instrument (PP-10, narishige), and common potassium internal solution (KCl 120mM,NaCl 30mM,HEPES 10mM,CaCl) is injected into the electrode 2 0.5mM,MgCl 2 1mM, EGTA 5mM, pH was adjusted to 7.2 using Tris-base, and used after filtration), the water resistance was 3-5 M.OMEGA. Extracellular fluid formulation was NaCl150mM, glucose (glucose. H 2 O)10mM,HEPES 10mM,CaCl 2 2mM,KCl 5mM,MgCl 2 1mM, pH was adjusted to 7.4 using Tris-base. All whole cell currents were obtained using a Axon 200B amplifier, using a Clampfit record in voltage clamp mode. The clamping voltage is-60 mv, the sampling frequency is 10kHz, and the filtering is carried out under the condition of 2 kHz. The administration mode adopts a mode of twice administration on the same cell. The first dose was 100. Mu.M acetylcholine (Ach) and the magnitude of its induced inward current was used as a pre-control. The second administration was a dilution of the e-vaping solution of the different examples or comparative examples (e-vaping solutions of both examples and comparative examples were diluted by a factor of ten). The current generated by the second administration is compared with the current generated by the first Ach, namely the normalized electricity of different examples or comparative examplesAnd (3) flow. Fig. 2 is a representative current diagram of acetylcholine receptors induced by e-vaping solutions of example 5.
Taste scoring test method:
the statistical method comprises the following steps: and randomly selecting 1000 users to perform use tests on the electronic cigarette solutions of the embodiment and the comparative example through the electronic cigarette, and evaluating the satisfaction and the throat feeling of the electronic cigarette solutions after the use tests, wherein the evaluation standard is calculated by 10 minutes of total score, and the score is higher when the satisfaction is better or the throat feeling is better.
Test results:
the respective weights of nicotine, benzoic acid, levulinic acid, lactic acid (and optionally cotinine) in the e-vaping liquid of each example are shown below. After the electronic cigarette liquid of the above embodiment is completed, an electrophysiological test and a taste grading test are then performed. The electrophysiological test results are shown in fig. 1, and the taste score test results are shown in table 2 below.
TABLE 1
(in Table 1, "-" indicates inapplicable) Table 2
As can be seen from the comparative examples and examples in tables 1 and 2, better satisfaction and throat feeling can be obtained by controlling the molar ratio of protonated nicotine to non-protonated nicotine in the e-cigarette liquid aerosol to be 1:0.1 to 1:2.5.
As can be seen from examples 4 to 6 and fig. 1, addition of cotinine can improve satisfaction while securing throat feel.
According to the electronic cigarette liquid, the nicotine and the organic acid are added, and the molar ratio of the protonated nicotine to the unprotonated nicotine in the electronic cigarette liquid aerosol is controlled, so that the throat feeling of the electronic cigarette liquid can be effectively improved, and the satisfaction can be further improved. Therefore, the electronic cigarette liquid provided by the application brings a user with a satisfaction sense and a proper throat-hitting sense, and has a good suction experience.
The electronic cigarette liquid improves the satisfaction of a user by adding cotinine and nicotine, and reduces the dosage of nicotine, so that the health risk brought by nicotine intake can be reduced.
Reference throughout this specification to "some embodiments," "one embodiment," "another example," "an example," "a particular example," or "a partial example" means that at least one embodiment or example in the present application includes the particular feature, structure, material, or characteristic described in the embodiment or example. Thus, descriptions appearing throughout the specification, for example: "in some embodiments," "in an embodiment," "in one embodiment," "in another example," "in one example," "in a particular example," or "example," which do not necessarily reference the same embodiments or examples in the application. Furthermore, the particular features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments or examples.
Although illustrative embodiments have been shown and described, it will be understood by those skilled in the art that the foregoing embodiments are not to be construed as limiting the application, and that changes, substitutions and alterations may be made herein without departing from the spirit, principles and scope of the application.
Claims (14)
1. An electronic vaping liquid comprising nicotine and an organic acid, wherein in an aerosol produced by heating and atomizing the electronic vaping liquid the molar ratio of protonated nicotine to non-protonated nicotine is from 1:0.1 to 1:2.5, wherein the organic acid comprises benzoic acid, levulinic acid and lactic acid, and the molar ratio of benzoic acid, levulinic acid and lactic acid is (0.5-1.5): (0.1-0.3): (0.5-1.1), wherein the weight of levulinic acid is from 0.001% to 0.5% based on the total weight of the electronic vaping liquid.
2. The electronic vaping solution of claim 1, wherein the molar ratio of the organic acid to the nicotine is 0.1:1 to 2:1.
3. The electronic vaping solution of claim 1, wherein the weight of nicotine is greater than 0% and less than or equal to 6% based on the total weight of the electronic vaping solution.
4. The electronic vaping solution of claim 1, wherein the organic acid further comprises at least one of citric acid, lauric acid, malic acid, or succinic acid.
5. The electronic vaping solution of claim 1, wherein the benzoic acid is 0.1 to 0.5 weight percent based on the total weight of the electronic vaping solution.
6. The electronic vaping solution of claim 1, wherein the lactic acid is present in an amount of 0.01% to 0.5% by weight based on the total weight of the electronic vaping solution.
7. The electronic vaping solution of claim 1, wherein the electronic vaping solution further comprises cotinine in an amount of greater than 0% and less than or equal to 4.5% by weight based on the total weight of the electronic vaping solution.
8. The electronic vaping solution of claim 7, wherein the molar ratio of cotinine to nicotine is 0.1:1 to 1.5:1.
9. The electronic vaping solution of claim 1, wherein the electronic vaping solution further comprises a cooling agent, wherein the cooling agent comprises at least one of menthol, menthone, isomenthone, isopulegol, menthyl acetate, menthyl lactate, WS-23, WS-3, WS-5.
10. The electronic vaping liquid of claim 9, wherein the cooling agent is present in the electronic vaping liquid in an amount of 0.001% to 10% by weight based on the total weight of the electronic vaping liquid.
11. The electronic vaping liquid of claim 1, wherein the electronic vaping liquid further comprises a fragrance, wherein the fragrance comprises at least one of d-limonene, benzyl alcohol, ethyl butyrate, linalool, isobutyl acetate, isoamyl acetate, benzyl benzoate, leaf alcohol, ethyl propionate, citral, gamma-decalactone, decanal, ethyl acetate, ethyl 2-methylbutyrate, 2-methylbutyl acetate, 2-methylbutyraldehyde, myrcene, ethyl caproate, peach aldehyde, ethyl isovalerate, leaf alcohol acetate, acetic acid, or benzaldehyde.
12. The electronic vaping solution of claim 11, wherein the essence is present in the vaping solution in an amount of 0.001% to 10% by weight based on the total weight of the vaping solution.
13. An atomising device comprising the electronic vaping liquid of any one of claims 1 to 12.
14. The atomizing device of claim 13, wherein the atomizing device comprises an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011438700.0A CN114587008B (en) | 2020-12-07 | 2020-12-07 | Electronic cigarette liquid and atomization device comprising same |
| PCT/CN2021/120662 WO2022121450A1 (en) | 2020-12-07 | 2021-09-26 | E-liquid and atomization device containing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011438700.0A CN114587008B (en) | 2020-12-07 | 2020-12-07 | Electronic cigarette liquid and atomization device comprising same |
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| Publication Number | Publication Date |
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| CN114587008A CN114587008A (en) | 2022-06-07 |
| CN114587008B true CN114587008B (en) | 2023-09-05 |
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| CN202011438700.0A Active CN114587008B (en) | 2020-12-07 | 2020-12-07 | Electronic cigarette liquid and atomization device comprising same |
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| CN (1) | CN114587008B (en) |
| WO (1) | WO2022121450A1 (en) |
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| KR20230013165A (en) * | 2013-05-06 | 2023-01-26 | 쥴 랩스, 인크. | Nicotine salt formulations for aerosol devices and methods thereof |
| US20150313275A1 (en) * | 2014-04-30 | 2015-11-05 | Altria Client Services, Inc. | Liquid aerosol formulation of an electronic smoking article |
| GB2535427A (en) * | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| CN104473322A (en) * | 2014-12-02 | 2015-04-01 | 河南中烟工业有限责任公司 | Electronic-cigarette liquid tobacco containing nicotine and organic acid |
| GB2542838B (en) * | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| ES2691521T3 (en) * | 2015-12-22 | 2018-11-27 | Philip Morris Products S.A. | A cartridge for an aerosol generating system and an aerosol generating system comprising a cartridge |
| CN107660815B (en) * | 2016-07-27 | 2020-09-11 | 湖南中烟工业有限责任公司 | Electronic cigarette liquid capable of stably releasing cigarette fragrance |
| KR20200037220A (en) * | 2017-06-26 | 2020-04-08 | 누드 니코틴 인코포레이티드 | Nicotine salt and its preparation and use method |
| US20190116863A1 (en) * | 2017-10-24 | 2019-04-25 | Rai Strategic Holdings, Inc. | Method for formulating aerosol precursor for aerosol delivery device |
| FR3093405B1 (en) * | 2019-03-05 | 2022-07-29 | V F P France | VAPING COMPOSITIONS |
| CN110283158B (en) * | 2019-07-11 | 2020-10-30 | 广东省金叶科技开发有限公司 | Method for recovering plant alkali from tobacco leaching liquor |
| CN110384700A (en) * | 2019-09-03 | 2019-10-29 | 云南喜科科技有限公司 | A kind of composition synthesizing nicotine |
| CN110558605B (en) * | 2019-09-27 | 2021-07-06 | 深圳雾芯科技有限公司 | Electronic cigarette liquid |
| CN111607461B (en) * | 2020-06-24 | 2021-07-09 | 深圳昱朋科技有限公司 | Perfume containing secondary metabolite of solanaceae plant, preparation method thereof and perfume product |
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| CN114587008A (en) | 2022-06-07 |
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