CN111607461B - Perfume containing secondary metabolite of solanaceae plant, preparation method thereof and perfume product - Google Patents
Perfume containing secondary metabolite of solanaceae plant, preparation method thereof and perfume product Download PDFInfo
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- CN111607461B CN111607461B CN202010595495.2A CN202010595495A CN111607461B CN 111607461 B CN111607461 B CN 111607461B CN 202010595495 A CN202010595495 A CN 202010595495A CN 111607461 B CN111607461 B CN 111607461B
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
Abstract
The invention discloses a spice containing solanaceae plant secondary metabolites, a preparation method thereof and a spice product, wherein the spice containing solanaceae plant secondary metabolites comprises the following raw materials: a secondary metabolite of a solanaceous plant, wherein the secondary metabolite is a nitrogen-containing compound, and the boiling point of the secondary metabolite is 200-300 ℃; and, a complex of said secondary metabolite resulting from the reaction of said secondary metabolite with a weak acid containing a carboxyl group. The technical scheme of the invention ensures the sense of the perfume absorbed by the user and reduces the harm of the perfume to the user.
Description
Technical Field
The invention relates to the field of spices, and in particular relates to a spice of a secondary metabolite of solanaceae plants, a preparation method of the spice and a spice product.
Background
The current devices capable of generating aerosol (e-cigarettes or low-temperature non-burning cigarettes) are products simulating traditional high cigarettes at the consumption level. Wherein, the electronic cigarette oil is added with essence, spice and nicotine, aerosol is generated by atomization, and a user can feel pleasure and satisfaction similar to those brought by traditional cigarettes after smoking. Because the heating temperature is generally not more than 250 ℃, new carcinogenic substances such as tar, benzopyrene and the like are hardly generated only by atomizing the essence, the spice and the nicotine, and the cigarette is an electronic product which is healthier compared with the traditional cigarette.
Free nicotine is generally added in the traditional tobacco tar formula, so that the oral cavity and the throat are easily stimulated, the phenomena of serious oral cavity residue, throat choking and the like are caused after smoking, the nicotine intake efficiency is low, and the sensory experience of users is poor. The large intake of nicotine is harmful to human health, and is not suitable for excessive inhalation, but low concentration nicotine such as 15mg/g, 18mg/g and 30mg/g tobacco tar has very dispersed aerosol, and the throat-hitting feeling is obviously reduced or even not, thus the sensory requirements of consumers can not be met. At present, the perfume which can reduce the nicotine content while ensuring the use sense is urgently needed so as to reduce the harm degree of the perfume and ensure that the perfume is healthier.
Disclosure of Invention
The invention mainly aims to provide a spice containing a secondary metabolite of solanaceae plants, and aims to reduce the consumption of nicotine and the harmfulness of the spice while ensuring the taste of the spice.
In order to achieve the purpose, the spice containing the secondary metabolites of the solanaceae plants, provided by the invention, comprises the following raw materials:
a secondary metabolite of a solanaceous plant, wherein the secondary metabolite is a nitrogen-containing compound, and the boiling point of the secondary metabolite is 200-300 ℃; and the number of the first and second groups,
a complex of said secondary metabolite resulting from a reaction of said secondary metabolite with a weak acid containing a carboxyl group.
Optionally, the flavor containing the secondary metabolites of the solanaceae plant further comprises a nicotine salt obtained by reacting nicotine with a weak acid containing a carboxyl group.
Optionally, the solanaceae plant comprises: one or more of belladonna, tobacco, stramonium, capsicum, potato, tomato, horsetail, eggplant and petunia;
the secondary metabolites include: one or more of demethyl nicotine, neonicotine, dehydroneonicotine, anabasine, mesminne, cotinine, 2,3' -bipyridine and diene nicotine;
the weak acid comprises: one or more of benzoic acid, lactic acid, tartaric acid, citric acid, malic acid, oxalic acid, fumaric acid, salicylic acid, propionic acid, levulinic acid and acetic acid.
Optionally, the flavor containing secondary metabolites of solanaceae plants further comprises nicotine;
in the flavor containing secondary metabolites of solanaceae plants, the ratio of the mass sum of the complexes of the secondary metabolites and the secondary metabolites to the mass sum of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl to pyridyl is (3-5): (5-7).
Optionally, the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is (1-3): (7-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl are (3-5) in sequence: (5-7): (0.0005-0.21): (0.0035 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the neonicotinoid and the dehydroneonicotinoid, and the mass ratio of the neonicotinoid to the dehydroneonicotinoid is (2-5): (5-8); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, piperidyl and tetrahydropyridinyl are (3-5) in sequence: (5-7): (0.001-0.35): (0.0025 to 0.56); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine and the neonicotine, and the mass ratio of the demethyl nicotine to the neonicotine is (1-5): (5-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl and piperidyl are (3-5) in sequence: (5-7): (0.0005-0.35): (0.0025 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine and the dehydro-neonicotine, and the mass ratio of the demethyl nicotine to the dehydro-neonicotine is (0.5-2): (8-9.5); in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is (3-5): (5-7): (0.00025-0.001): (0.004 to 0.665); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine, the neonicotinoid and the dehydroneonicotinoid, and the mass ratio of the demethyl nicotine, the neonicotinoid and the dehydroneonicotinoid is (1-3): (2-5): (2-7); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl are (3-5): (5-7): (0.0005-0.21): (0.001-0.35): (0.001 to 0.49); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine, and the mass ratio of the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine is (3-5) in sequence: (1-2): (3-6): (0.5-1): (0.5 to 1); in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is (3-5): (5-7): (0.0015-0.35): (0.0005-0.14): (0.0015-0.42): (0.00025-0.07): (0.00025-0.07).
Optionally, the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolite to the benzoic acid is (3-6): (4-7); alternatively, the first and second electrodes may be,
the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is (6-8): (2-4); alternatively, the first and second electrodes may be,
the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is (4-6): (1-2): (3-4); alternatively, the first and second electrodes may be,
the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is (3-5): (0.1-1): (3-5); alternatively, the first and second electrodes may be,
the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite, the lactic acid and the levulinic acid is (4-6): (2-4): (1-2).
Optionally, the flavor containing the secondary metabolites of the solanaceae plants further comprises a flavor substance, and the flavor of the flavor substance can be expressed as one or more of tobacco flavor, mint flavor, fruit flavor, milk flavor, wine flavor, coffee flavor, cocoa flavor and tea flavor;
the solanaceae plant secondary metabolite-containing carrier also comprises a dissolving carrier, and the dissolving carrier comprises propylene glycol, glycerol, ethanol and water.
Optionally, the mass sum of the nicotine and the nicotine salt in the flavor containing the secondary metabolites of the solanaceae plant is less than or equal to 10%.
The invention also provides a preparation method of the spice containing the secondary metabolite of the solanaceae plant, which comprises the following steps:
referring to the components of the materials in the spice containing the secondary metabolites of the solanaceae plants;
stirring and mixing the flavor substances with propylene glycol, water and ethanol to obtain a component A;
stirring and mixing the secondary metabolite of the solanaceae plant, the complex of the secondary metabolite, nicotine and nicotine salt to obtain a component B;
mixing the component A and the component B, and stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
adding the required glycerol, and continuously stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
aging for 24-48 h at 30-40 ℃ to obtain the spice containing the secondary metabolites of the solanaceae plants.
The invention also provides a spice product, which is one of an electronic cigarette product, a smokeless tobacco product or a low-temperature non-combustion cigarette product, and the spice product comprises the spice containing the secondary metabolites of the solanaceae plants; alternatively, the first and second electrodes may be,
the flavoring product comprises smoking set and the above flavoring containing secondary metabolites of Solanaceae plants.
According to the technical scheme, the secondary metabolite and the complex thereof have a synergistic effect with nicotine and nicotine salt, so that the sense of smoking of the perfume by a user is guaranteed, and meanwhile, the harm of the perfume to the user is reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic flow chart of an embodiment of the method for preparing the spice containing the secondary metabolites of the solanaceae plants.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
In order to facilitate a better understanding of the invention, the following examples are given to illustrate, but not to limit the scope of the invention.
The invention provides a spice containing a secondary metabolite of solanaceae plants.
In the embodiment of the invention, the spice containing the secondary metabolites of the solanaceae plants comprises the following raw materials: secondary metabolites of solanaceae plants and complexes of the secondary metabolites, wherein the secondary metabolites are nitrogen-containing compounds, and the boiling point of the secondary metabolites is 200-300 ℃; the complex of the secondary metabolite is obtained by reacting the secondary metabolite with a weak acid containing a carboxyl group. The toxicity of the secondary metabolite is far less than that of nicotine, in order to verify the toxicity of the secondary metabolite, nicotine, neonicotinoid, and dehydroneonicotinoid, which are secondary metabolites, are respectively fed to the mice, when the mice are fed with 1.0 mg/kg-3.2 mg/kg of nicotine, 5.6 mg/kg-10.0 mg/kg of nicotine, 5.6 mg/kg-18.0 mg/kg of neonicotinoid and 10.0 mg/kg-32.0 mg/kg of dehydroneonicotinoid, the behavior of the mice begins to be out of control, so that the neurotoxicity of the four alkaloids is ranked as follows: nicotine > nornicotine > neonicotine > dehydroneonicotine. The secondary metabolites cotinine, myosmine and 2,3' -bipyridine are metabolites of nicotine, and a large number of literature studies prove that the acute toxicity is far lower than that of nicotine. Namely, the toxicity of the spice is less than that of the nicotine, and the taste of the tobacco tar can be improved by matching with the tobacco tar, namely, the spice containing the secondary metabolites of the solanaceae plants is added into the tobacco tar or the tobacco cartridge by adopting the technical scheme of the invention, so that a small amount of nicotine can achieve good taste, the situation that a user repeatedly sucks the tobacco tar or the tobacco cartridge to meet the requirement is avoided or reduced, the toxicity of the tobacco tar or the tobacco cartridge is reduced, and the intake of the nicotine is reduced.
Further, the spice containing the secondary metabolites of the solanaceae plants also comprises nicotine salt, and the nicotine salt is obtained by reacting nicotine with weak acid containing carboxyl. The nicotine in the tobacco tar is free nicotine, which easily causes great stimulation to the oral cavity and the throat, and causes the phenomena of serious oral cavity residue, throat choking and the like after being sucked. Free nicotine in the tobacco tar formula is reduced, the proportion of combined nicotine is improved, and the throat is not stimulated by the free nicotine although the oral comfort is improved after smoking.
Further, the solanaceae plant includes: one or more of belladonna, tobacco, stramonium, capsicum, potato, tomato, horsetail, eggplant and petunia; the secondary metabolites include: one or more of demethyl nicotine, neonicotine, dehydroneonicotine, anabasine, mesminne, cotinine, 2,3' -bipyridine and diene nicotine; the weak acid comprises: one or more of benzoic acid, lactic acid, tartaric acid, citric acid, malic acid, oxalic acid, fumaric acid, salicylic acid, propionic acid, levulinic acid and acetic acid.
The secondary metabolite is extracted from the solanaceae plant by using acidification and alkali extraction, nonpolar solvent pH gradient extraction, chromatography, distillation and recombination processes.
More specifically, the extraction method of the secondary metabolite comprises the following steps:
s21, adding dried solanaceae plants and sulfuric acid into a supercritical extraction kettle, and reacting for 30min under the pressure of not less than 20 Mpa;
s22, adding one of gases such as carbon dioxide, nitrous oxide, low molecular weight halogenated hydrocarbon and the like, and extracting under a subcritical state by adjusting pressure;
s23, after the subcritical extraction is finished, adding sodium hydroxide into the material, and reacting for 30min under the pressure of not less than 20 Mpa; then extracting with carbon dioxide as extractant in supercritical state, and collecting extractive solution;
s24, adjusting the extract by using a buffer solution with the pH value of 2-12, and extracting by using chloroform; respectively concentrating the chloroform layer at low temperature to obtain different secondary metabolite crude products;
s25, separating the crude products of different metabolites through silica gel, eluting and concentrating to obtain secondary metabolites with purity higher than 98%.
Further, the spice containing the secondary metabolites of the solanaceae plants also comprises nicotine; in the flavor containing secondary metabolites of solanaceae plants, the ratio of the mass sum of the complexes of the secondary metabolites and the secondary metabolites to the mass sum of the nicotine and the nicotine salt is (0.01-10): (90-99.09); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl to pyridyl is (3-5): (5-7). The quality of the secondary metabolite and the complex is far less than the sum of the quality of the nicotine and the nicotine salt, the improvement degree of the small amount of the secondary metabolite and the complex on the mouth feel of the nicotine and the nicotine salt is large, and the perfume prepared according to the proportion has the characteristics of good mouth feel and low content of the nicotine and the nicotine salt.
Further, the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is (1-3): (7-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl are (3-5) in sequence: (5-7): (0.0005-0.21): (0.0035 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the neonicotinoid and the dehydroneonicotinoid, and the mass ratio of the neonicotinoid to the dehydroneonicotinoid is (2-5): (5-8); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, piperidyl and tetrahydropyridinyl are (3-5) in sequence: (5-7): (0.001-0.35): (0.0025 to 0.56); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine and the neonicotine, and the mass ratio of the demethyl nicotine to the neonicotine is (1-5): (5-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl and piperidyl are (3-5) in sequence: (5-7): (0.0005-0.35): (0.0025 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine and the dehydro-neonicotine, and the mass ratio of the demethyl nicotine to the dehydro-neonicotine is (0.5-2): (8-9.5); in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is (3-5): (5-7): (0.00025-0.001): (0.004 to 0.665); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethyl nicotine, the neonicotinoid and the dehydroneonicotinoid, and the mass ratio of the demethyl nicotine, the neonicotinoid and the dehydroneonicotinoid is (1-3): (2-5): (2-7); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl are (3-5): (5-7): (0.0005-0.21): (0.001-0.35): (0.001 to 0.49); alternatively, the first and second electrodes may be,
the secondary metabolites comprise the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine, and the mass ratio of the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine is (3-5) in sequence: (1-2): (3-6): (0.5-1): (0.5 to 1); in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is (3-5): (5-7): (0.0015-0.35): (0.0005-0.14): (0.0015-0.42): (0.00025-0.07): (0.00025-0.07). The secondary metabolite, nicotine and nicotine salt synergistically promote the taste.
Further, the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolite to the benzoic acid is (3-6): (4-7); or the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is (6-8): (2-4); or the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is (4-6): (1-2): (3-4); or the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid is (3-5): (0.1-1): (3-5); or, the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite, the lactic acid and the levulinic acid is (4-6): (2-4): (1-2). The secondary metabolite complex obtained by the proportion has good effect of synergistically improving the mouthfeel with nicotine and nicotine salt.
Further, the flavor containing the secondary metabolites of the solanaceae plants further comprises a flavor substance, and the flavor of the flavor substance can be expressed by one or more of tobacco flavor, mint flavor, fruit flavor, milk flavor, wine flavor, coffee flavor, cocoa flavor and tea flavor; the solanaceae plant secondary metabolite-containing carrier also comprises a dissolving carrier, and the dissolving carrier comprises propylene glycol, glycerol, ethanol and water. The invention is not limited to the flavor substances, and the specific flavor substances can be acid flavor: acetic acid, propionic acid; b, fruit aroma: ethyl acetate, ethyl butyrate, 2-methylbutyl acetate and raspberry ketone; c, sweet and fragrant note: (1) sweet-to-brown note: furanone, ethyl maltol, methyl cyclopentenolone (2) rose dew sweet: geraniol, rose oil (3) cream sweet: peru balsam, tolu balsam (4) ketonic sweet fragrance: damascone; d green note: (1) green leaves: leaf alcohol, leaf alcohol acetate (2) melon green: cis-6-nonenol, melon aldehyde (3) azure: linalool, linalyl acetate (4) other green notes: acetaldehyde, ethyl acetoacetate; e, bean fragrance: dihydrocoumarin, 6-methylcoumarin; f, flower fragrance: (1) jasmine: methyl dihydrojasmonate, jasmine absolute oil (2) chrysanthemum: marigold oil, cymbidium goeringii oil (3) violet: ionone A, ionone B (4) Aglaia alba: white orchid leaf oil, white orchid flower oil; g, costustoot rhyme: cedar wood oil, alpha-terpineol, vetiver oil; h, spicy note: cinnamon oil, clove oil, anise oil; i, medicine fragrance: angelica essential oil, camphor and borneol; j milk flavor: (1) lactones: c, fermentation of gamma octalactone and coconut aldehyde (2): acetylmethylcarbinol, natural acetoin (3) and others: vanillin, ethyl vanillin; k wine aroma: ethyl caproate, rum alcohol; l cool fragrance note: (1) mint rhythm: peppermint oil, menthol (2) spearmint note: spearmint oil, levo-carveol (3) other cool charms: eucalyptus oil, a freshener; m cocoa note: tincture of cocoa powder (bean or shell), and cocoa fluid extract; n smoked note: guaiacol, guaiacol oil. Different flavor substances can meet the requirements of different users, and the taste can be effectively improved by adding the flavor substances.
Further, the mass ratio of the nicotine and the nicotine salt in the flavor containing the secondary metabolites of the solanaceae plants is less than or equal to 10%. The perfume containing the secondary metabolites of the solanaceae plants has the characteristic of low content of nicotine and nicotine salt, so that the perfume containing the secondary metabolites of the solanaceae plants has lower toxicity to the body of a user.
The invention also provides a preparation method of the spice containing the secondary metabolite of the solanaceae plant, which comprises the following steps:
s11, referring to the components of the materials in the spice containing the secondary metabolites of the solanaceae plants;
s12, stirring and mixing the flavor substances with propylene glycol, water and ethanol to obtain a component A;
s13, stirring and mixing the secondary metabolite of the solanaceae plant, the complex of the secondary metabolite, nicotine and nicotine salt to obtain a component B;
s14, mixing the component A and the component B, and stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
s15, adding the required glycerol, and continuously stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
s16, aging at 30-40 ℃ for 24-48 h to obtain the spice containing the secondary metabolites of the solanaceae plants.
Through the process and the aging step, the spice containing the secondary metabolites of the solanaceae plants can generate further micro condensation reaction under the condition of full contact, and a more stable and softer fragrant substance is formed. Such as lactic acid, propylene glycol and glycerol to form glycerol lactate and propylene glycol lactate; acetic acid and propylene glycol form propylene glycol acetate; levulinic acid forms propylene glycol ketals of levulinic acid, propylene glycol ester of levulinic acid, lactyl lactic acid, lactyl propylene glycol ester of lactic acid, propylene glycol ketals of levulinic acid with glycerol and propylene glycol; vanillin forms vanillin glycerol acetal, vanillin propylene glycol acetal, and the like with glycerol and propylene glycol. The aroma of the finally aged spice containing the secondary metabolites of the solanaceae plants can be kept stable continuously in the using process, and the smoking experience of users is further improved.
The invention also provides a spice product, which is one of an electronic cigarette product, a smokeless tobacco product or a low-temperature non-combustion cigarette product, and the spice product comprises the spice containing the secondary metabolites of the solanaceae plants; alternatively, the first and second electrodes may be,
the flavoring product comprises smoking set and the above flavoring containing secondary metabolites of Solanaceae plants.
Example 1
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is (1-3): (7-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl are (3-5) in sequence: (5-7): (0.0005-0.21): (0.0035 to 0.63);
the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolites to the benzoic acid is (3-6): (4-7).
Specifically, embodiment 1 includes: sub-examples 1-1, sub-examples 1-2, sub-examples 1-3, and so on.
Sub-examples 1-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 5: 94; the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is 2: 8; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl is 3: 7: 0.1: 0.055; the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolite to the benzoic acid is 3: 7.
sub-examples 1-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.01: 90, respectively; the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is 3: 7; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl is 4: 6: 0.0007: 0.62; the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolite to the benzoic acid is 4: 6.
sub-examples 1 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 9: 99; the secondary metabolites comprise the myosmine and the cotinine, and the mass ratio of the myosmine to the cotinine is 1: 9; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl is 5: 5: 0.2: 0.33; the weak acid comprises benzoic acid, and the mass ratio of the secondary metabolite to the benzoic acid is 6: 4.
example 2
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the neonicotinoid and the dehydroneonicotinoid, and the mass ratio of the neonicotinoid to the dehydroneonicotinoid is (2-5): (5-8); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, piperidyl and tetrahydropyridinyl are (3-5) in sequence: (5-7): (0.001-0.35): (0.0025 to 0.56);
the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is (6-8): (2-4).
Specifically, embodiment 2 includes: sub-example 2-1, sub-example 2-2, sub-example 2-3, etc.
Sub-examples 2-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 5: 95; the secondary metabolites include the neonicotinoid and the dehydroneonicotinoid in a mass ratio of the neonicotinoid to the dehydroneonicotinoid of 3: 7; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, piperidyl and tetrahydropyridyl is 3: 7: 0.25: 0.5; the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is 7: 3.
sub-examples 2-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.03: 91; the secondary metabolites include the neonicotinoid and the dehydroneonicotinoid in a mass ratio of the neonicotinoid to the dehydroneonicotinoid of 2: 8; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, piperidyl and tetrahydropyridyl is 4: 5: 0.003: 0.3; the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is 8: 2.
sub-examples 2 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 10: 98, respectively; the secondary metabolites include the neonicotinoid and the dehydroneonicotinoid in a mass ratio of the neonicotinoid to the dehydroneonicotinoid of 4: 5.3; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, piperidyl and tetrahydropyridyl is 5: 6: 0.33: 0.007; the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is 6: 4.
example 3
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the demethyl nicotine and the neonicotine, and the mass ratio of the demethyl nicotine to the neonicotine is (1-5): (5-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl and piperidyl are (3-5) in sequence: (5-7): (0.0005-0.35): (0.0025 to 0.63);
the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is (4-6): (1-2): (3-4).
Specifically, embodiment 3 includes: sub-example 3-1, sub-example 3-2, sub-example 3-3, etc.
Sub-example 3-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 6: 97, a stabilizer; the secondary metabolites include the demethylnicotine and the neonicotine in a mass ratio of 3: 7; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl and piperidyl is 4: 6: 0.18: 0.29; the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is 5: 1.6: 3.7;
sub-examples 3-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.02: 91; the secondary metabolites include the demethylnicotine and the neonicotine in a mass ratio of 1: 9; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl and piperidyl is 3: 5: 0.34: 0.61; the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is 4: 1: 4.
sub-examples 3 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 9.5: 98, respectively; the secondary metabolites include the demethylnicotine and the neonicotine in a mass ratio of 4.7: 5.6; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl and piperidyl are 4.8: 6.8: 0.0008: 0.006; the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is 6: 2: 3.
example 4
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the demethyl nicotine and the dehydro-neonicotine, and the mass ratio of the demethyl nicotine to the dehydro-neonicotine is (0.5-2): (8-9.5); in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is (3-5): (5-7): (0.00025-0.001): (0.004 to 0.665);
the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is (3-5): (0.1-1): (3-5).
Specifically, embodiment 4 includes: sub-example 4-1, sub-example 4-2, sub-example 4-3, etc.
Sub-example 4-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 4: 93; the secondary metabolites include the demethylnicotine and the dehydroneonicotine in a mass ratio of 1.5: 9; in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is 3: 7: 0.0006: 0.33; the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is 3: 0.8: 4.
sub-examples 4-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.03: 91; the secondary metabolites include the demethylnicotine and the dehydroneonicotine in a mass ratio of 0.6: 8.3; in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is 4: 6: 0.001: 0.665; the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is 4: 0.2: 3.
sub-examples 4 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 10: 99; the secondary metabolites include the demethylnicotine and the dehydroneonicotine in a mass ratio of 2: 9.5; in the flavor containing a secondary metabolite of a solanaceae plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is 5: 5.2: 0.0003: 0.4; the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is 5: 0.5: 5.
example 5
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the demethyl nicotine, the neonicotine and the dehydro neonicotine, and the mass ratio of the demethyl nicotine, the neonicotine and the dehydro neonicotine is (1-3): (2-5): (2-7); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl are (3-5): (5-7): (0.0005-0.21): (0.001-0.35): (0.001 to 0.49);
the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite, the lactic acid and the levulinic acid is (4-6): (2-4): (1-2).
Specifically, embodiment 5 includes: sub-example 5-1, sub-example 5-2, sub-example 5-3, etc.
Sub-examples 5-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 5.5: 93; the secondary metabolites comprise the demethylnicotine, the neonicotine and the dehydroneonicotine, and the mass ratios of the demethylnicotine, the neonicotine and the dehydroneonicotine are sequentially 2: 4: 5; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl is 3: 7: 0.1: 0.13: 0.3; the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 5: 3: 1.5.
sub-examples 5-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.03: 99; the secondary metabolites comprise the demethylnicotine, the neonicotine and the dehydroneonicotine, and the mass ratios of the demethylnicotine, the neonicotine and the dehydroneonicotine are sequentially 1.3: 2.2: 7; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl is 5: 5: 0.2: 0.34: 0.45 of; the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 4: 2: 2.
sub-examples 5 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 9: 91; the secondary metabolites comprise the demethylnicotine, the neonicotine and the dehydroneonicotine, and the mass ratio of the demethylnicotine, the neonicotine and the dehydroneonicotine is 3: 5: 3; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl is 4: 6: 0.0006: 0.007: 0.003; the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 6: 4: 1.
example 6
A ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is (0.01-10): (90-99.09);
the secondary metabolites comprise the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine, and the mass ratio of the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine is (3-5) in sequence: (1-2): (3-6): (0.5-1): (0.5 to 1); in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is (3-5): (5-7): (0.0015-0.35): (0.0005-0.14): (0.0015-0.42): (0.00025-0.07): (0.00025-0.07).
Specifically, embodiment 6 includes: sub-example 6-1, sub-example 6-2, sub-example 6-3, etc.
Sub-example 6-1: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 6: 95; the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of, in order, 4: 1.6: 5: 0.7: 0.8; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 4: 6: 0.2: 0.077: 0.19: 0.003: 0.04.
sub-examples 6-2: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 0.6: 91; the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of, in order, 3: 2: 3: 1: 0.52; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 3: 7: 0.33: 0.0005: 0.42: 0.0004: 0.07.
sub-examples 6 to 3: a ratio of a sum of masses of the complex of the secondary metabolite and the secondary metabolite to a sum of masses of the nicotine and the nicotine salt is 9: 99; the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of 5: 1: 6: 0.5: 1; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 5: 5: 0.002: 0.14: 0.0018: 0.07: 0.0003.
example 7
The secondary metabolites comprise the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine, and the mass ratio of the demethylnicotine, the neonicotine, the dehydroneonicotine, the mesmine and the cotinine is (3-5) in sequence: (1-2): (3-6): (0.5-1): (0.5 to 1); in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is (3-5): (5-7): (0.0015-0.35): (0.0005-0.14): (0.0015-0.42): (0.00025-0.07): (0.00025-0.07).
The weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite, the lactic acid and the levulinic acid is (4-6): (2-4): (1-2).
Specifically, embodiment 7 includes: sub-example 7-1, sub-example 7-2, sub-example 7-3, etc.
Sub-example 7-1: the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of, in order, 4: 1.4: 5: 0.8: 0.8; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 4: 6: 0.18: 0.06: 0.2: 0.038: 0.04. the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 5: 3: 2.
sub-examples 7-2: the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of, in order, 3: 2: 3: 1: 0.5; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 3: 7: 0.35: 0.0005: 0.13: 0.07: 0.07. the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 4: 2: 1.
sub-examples 7 to 3: the secondary metabolites include the demethylnicotine, the neonicotine, the dehydroneonicotine, the myosamine, and the cotinine in a mass ratio of 5: 1: 6: 0.5: 1; in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is 5: 5: 0.2: 0.0008: 0.41: 0.00029: 0.0003. the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite to the lactic acid to the levulinic acid is 6: 4: 1.5.
comparative example 1
A flavorant comprising the demethylated nicotine and the neonicotine in a mass ratio of 3: 7; in the spice containing the secondary metabolites of the solanaceae plants, the molar ratio of carboxyl, pyridyl, pyrrolidinyl and piperidyl is 4: 6: 0.18: 0.29; the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is 5: 1.6: 3.7.
Comparative example 2
A flavoring agent comprises nicotine and flavoring substance.
Comparative example 3
A flavour comprising nicotine, a nicotine salt and a flavour material, the ratio of nicotine to nicotine salt remaining the same as in sub-embodiment 3-1.
Preparing spices according to sub-examples 3-1, comparative example 2 and comparative example 3, wherein the types and the contents of the flavor substances in the examples are consistent, and the mass of the solanaceae secondary metabolites, the mass of the solanaceae secondary metabolites in the complex of the solanaceae secondary metabolites, the mass of the nicotine and the mass sum of the nicotine raw materials in the nicotine salt account for 3 percent of the total mass of the spices. In vitro cytotoxicity tests and sensory products were performed under these conditions.
4 types of electronic cigarettes containing different flavors were smoked on the same aerosol-generating device in a standard smoking (ISO) mode, and the median Inhibitory Concentration (IC) was calculated by using Chinese hamster ovary cell line CHO cells as a test object and using a Neutral Red cytotoxicity test (NRU)50，mg·L-1) And detecting the cytotoxicity of the aerosol particle phase substance (TPM).
On the same aerosol-generating device, 10 professional smokers who had undergone sensory product smoking training performed sensory product smoking on tobacco tar containing the above 4 flavors by a whole large circulation method. And the three indexes of physiological satisfaction, throat-hitting feeling and irritation in the sense are scored. Wherein the highest throat-hitting feeling is divided into 20 points, which indicates that the throat-hitting feeling is strongest; the physiological satisfaction is divided into 15 points; the full stimulation score was 12, indicating the most stimulating oral cavity.
The test results are shown in table 1 below:
TABLE 1 sensory evaluation of perfumes prepared in sub-examples 3-1, comparative example 2, and comparative example 3
As can be seen from table 1 above, comparative example 1 does not contain nicotine and nicotine salt, and is lower in both physiological satisfaction and throat-hitting sensation and far lower in cytotoxicity than the other three groups. It should be noted that the higher the irritation, the worse the feeling given to the user, but the higher the throat-hitting feeling, the better the feeling given to the user. Comparative example 1 differs from sub-example 3-1 in that sub-example 3-1 contains nicotine, the physiological satisfaction and throat-strike sensation of comparative example 1 is much less than sub-example 3-1, and the irritation of comparative example 1 is greater than sub-example 3-1, as can be seen, the smoking experience of sub-example 3-1 is better than that of sub-example 1.
The irritation of comparative example 2 was greater than that of the other three groups, and the throat-hit feeling and physiological satisfaction of comparative example 2 were less than those of sub-example 3-1, and thus it was understood that the smoking experience of sub-example 3-1 was better than that of comparative example 2.
The physiological satisfaction and throat hit feeling of comparative example 3 were less than those of sub-example 3-1, and the irritation of comparative example 3 was greater than that of sub-example 3-1, and thus it was understood that the smoking experience of sub-example 3-1 was better than that of comparative example 3.
When the perfume is used, the secondary metabolite complex is easily decomposed, and complex physical and chemical changes occur between the secondary metabolite, the secondary metabolite complex, nicotine, and nicotine salt. The above analysis shows that in the aspect of improving the smoking experience, the complexes of the solanaceae secondary metabolites and the solanaceae secondary metabolites have synergistic effect with nicotine and nicotine salt. Sub-example 3-1 not only had better pumping experience than comparative example 2 and comparative example 3, but also had lower cytotoxicity than comparative example 2 and comparative example 3.
Further, the nicotine contents of sub-examples 1-2, 2-2, 3-2, 4-2, 5-2, 6-2, Juul tobacco tar and Blu tobacco tar were controlled to 8mg/mL while smoking the same amount of the sub-examples 1-2, 2-2, 3-2, 4-2, 5-2 and 6-2.
On the same aerosol-generating device, 10 professional smokers who had undergone sensory product smoking training performed sensory product smoking on tobacco tar containing various flavors by an integral large circulation method. And the three indexes of physiological satisfaction, throat-hitting feeling and irritation in the sense are scored. Wherein the highest throat-hitting feeling is divided into 20 points, which indicates that the throat-hitting feeling is strongest; the physiological satisfaction is divided into 15 points; the full stimulation score was 12, indicating the most stimulating oral cavity. Various electronic cigarettes containing different flavors were smoked on the same aerosol-generating device in a standard smoking mode, and the median Inhibitory Concentration (IC) was calculated by a neutrophilic erythrotoxicity test using CHO cells as a test subject50，mg·L-1) And detecting the cytotoxicity of the aerosol particle phase substance. The obtained test results are shown in table 2 below.
TABLE 2 sensory evaluation and Nicotine content Table
As can be seen from Table 2, the sensory evaluation of sub-examples 1-2, sub-examples 2-2, sub-examples 3-2, sub-examples 4-2, sub-examples 5-2, and sub-examples 6-2 was close to that of Juul tobacco tar and slightly superior to that of Blu tobacco tar, while the nicotine contents of sub-examples 1-2, sub-examples 2-2, sub-examples 3-2, sub-examples 4-2, sub-examples 5-2, and sub-examples 6-2 were 8mg/mL, and the nicotine contents of Juul tobacco tar and Blu tobacco tar were 18 mg/mL. Therefore, the technical scheme of the application can reduce the content of nicotine while ensuring that the sense meets the requirements of users (is beneficial to controlling the smoking times of the users), thereby reducing the harmfulness to the body health of the users. More intuitively, by cellsToxicity parameters are known, IC of Juul tobacco tar and blu tobacco tar50/mg·L-1The parameters are far less than those of sub-example 1-2, sub-example 2-2, sub-example 3-2, sub-example 4-2, sub-example 5-2 and sub-example 6-2, and obviously, under the condition of similar smoking senses, the harm of the adjacent prepared by the technical scheme of the application to the body is far less than that of the tobacco tar on the market, and the tobacco tar has the characteristic of less harm to the body.
The above description is only an alternative embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (8)
1. The spice containing the secondary metabolites of the solanaceae plants is characterized by comprising the following raw materials:
a secondary metabolite of a solanaceous plant, wherein the secondary metabolite is a nitrogen-containing compound, and the boiling point of the secondary metabolite is 200-300 ℃; and the number of the first and second groups,
a complex of said secondary metabolite resulting from the reaction of said secondary metabolite with a weak acid containing a carboxyl group;
nicotine salts obtained by reacting nicotine with a weak acid containing carboxyl groups;
a ratio of the sum of the masses of nicotine, the secondary metabolite and the complex of the secondary metabolite, to the sum of the masses of nicotine and the nicotine salt, of (0.01-10): (90-99.09);
wherein the secondary metabolites comprise mesmine and cotinine, and the mass ratio of the mesmine to the cotinine is (1-3): (7-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolinyl and pyrrolidonyl are (3-5) in sequence: (5-7): (0.0005-0.21): (0.0035 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise neonicotinoid and dehydroneonicotinoid, and the mass ratio of the neonicotinoid to the dehydroneonicotinoid is (2-5): (5-8); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, piperidyl and tetrahydropyridinyl are (3-5) in sequence: (5-7): (0.001-0.35): (0.0025 to 0.56); alternatively, the first and second electrodes may be,
the secondary metabolites comprise demethyl nicotine and neonicotine, and the mass ratio of demethyl nicotine to neonicotine is (1-5): (5-9); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl and piperidyl are (3-5) in sequence: (5-7): (0.0005-0.35): (0.0025 to 0.63); alternatively, the first and second electrodes may be,
the secondary metabolites comprise demethyl nicotine and dehydro-neonicotine, and the mass ratio of the demethyl nicotine to the dehydro-neonicotine is (0.5-2): (8-9.5); in the flavor containing a secondary metabolite of a solanaceous plant, a carboxyl group: pyridyl group: pyrrolidinyl: the molar ratio of the tetrahydropyridinyl is (3-5): (5-7): (0.00025-0.001): (0.004 to 0.665); alternatively, the first and second electrodes may be,
the secondary metabolites comprise demethyl nicotine, neonicotinoid and dehydroneonicotinoid, and the mass ratio of the demethyl nicotine, the neonicotinoid and the dehydroneonicotinoid is (1-3): (2-5): (2-7); in the spice containing the secondary metabolites of the solanaceae plants, the molar ratios of carboxyl, pyridyl, pyrrolidinyl, piperidyl and tetrahydropyridinyl are (3-5) in sequence: (5-7): (0.0005-0.21): (0.001-0.35): (0.001 to 0.49); alternatively, the first and second electrodes may be,
the secondary metabolites comprise demethylnicotine, neonicotinoid, dehydroneonicotinoid, mesmine and cotinine, and the mass ratio of the demethylnicotine, the neonicotinoid, the dehydroneonicotinoid, the mesmine and the cotinine is (3-5): (1-2): (3-6): (0.5-1): (0.5 to 1); in the spice containing the secondary metabolites of the solanaceae plants, the mass ratio of carboxyl, pyridyl, pyrrolidinyl, piperidyl, tetrahydropyridinyl, pyrrolinyl and pyrrolidonyl is (3-5): (5-7): (0.0015-0.35): (0.0005-0.14): (0.0015-0.42): (0.00025-0.07): (0.00025-0.07).
2. The flavor containing secondary metabolites of solanaceous plants as claimed in claim 1, wherein said solanaceous plants comprise: one or more of belladonna, tobacco, stramonium, capsicum, potato, tomato, horsetail, eggplant and petunia;
the weak acid comprises: one or more of benzoic acid, lactic acid, tartaric acid, citric acid, malic acid, oxalic acid, fumaric acid, salicylic acid, propionic acid, levulinic acid and acetic acid.
3. The flavor containing secondary metabolites of solanaceae plants according to claim 2, wherein said weak acid comprises benzoic acid, and the mass ratio of said secondary metabolites to said benzoic acid is (3-6): (4-7); alternatively, the first and second electrodes may be,
the weak acid comprises lactic acid, and the mass ratio of the secondary metabolite to the lactic acid is (6-8): (2-4); alternatively, the first and second electrodes may be,
the weak acid comprises citric acid and lactic acid, and the mass ratio of the secondary metabolite to the citric acid to the lactic acid is (4-6): (1-2): (3-4); alternatively, the first and second electrodes may be,
the weak acid comprises tartaric acid and lactic acid, and the mass ratio of the secondary metabolite to the tartaric acid to the lactic acid is (3-5): (0.1-1): (3-5); alternatively, the first and second electrodes may be,
the weak acid comprises lactic acid and levulinic acid, and the mass ratio of the secondary metabolite, the lactic acid and the levulinic acid is (4-6): (2-4): (1-2).
4. The flavor containing secondary metabolites of Solanaceae plants according to claim 3, further comprising a flavor material exhibiting one or more of a tobacco flavor, a mint flavor, a fruit flavor, a milk flavor, a wine flavor, a coffee flavor, a cocoa flavor, a tea flavor;
the spice containing the secondary metabolites of the solanaceae plants also comprises a dissolving carrier, wherein the dissolving carrier comprises propylene glycol, glycerol, ethanol and water.
5. The flavor containing secondary metabolites of solanaceae plants of claim 4, wherein the mass of said nicotine and said nicotine salt and the ratio in said flavor containing secondary metabolites of solanaceae plants are less than 10%.
6. A method for preparing a spice containing a secondary metabolite of a solanaceous plant, which is used for preparing the spice containing the secondary metabolite of the solanaceous plant as claimed in claim 5, and is characterized by comprising the following steps of:
a component of each material in the flavor containing secondary metabolites of solanaceous plants according to claim 5;
stirring and mixing the flavor substances with propylene glycol, water and ethanol to obtain a component A;
stirring and mixing the secondary metabolite of the solanaceae plant, the complex of the secondary metabolite, nicotine and nicotine salt to obtain a component B;
mixing the component A and the component B, and stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
adding the required glycerol, and continuously stirring at the rotating speed of 600-1000 rpm for 30-60 min at normal temperature;
aging at 30-40 ℃ for 24-48 h to obtain the spice containing the secondary metabolites of the solanaceae plants.
7. A flavourant article, wherein the flavourant article is one of an electronic smoking article, a smokeless tobacco article or a low temperature non-combustible smoking article, and the flavourant article comprises a solanaceous plant secondary metabolite-containing flavourant of any one of claims 1 to 5.
8. A flavor preparation comprising smoking articles and the flavor containing secondary metabolites of Solanaceae according to any one of claims 1 to 5.
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| JP3212271B2 (en) * | 1997-10-09 | 2001-09-25 | 日本たばこ産業株式会社 | Manufacturing method of tobacco flavored articles |
| US10668058B2 (en) * | 2007-03-30 | 2020-06-02 | Philip Morris Products S.A. | Device and method for delivery of a medicament |
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