CN110495631B

CN110495631B - Electronic cigarette liquid

Info

Publication number: CN110495631B
Application number: CN201910867422.1A
Authority: CN
Inventors: 许静; 姜兴涛; 李馨铎; 熊赞华; 罗安
Original assignee: Shenzhen Relx Technology Co Ltd
Current assignee: Shenzhen Relx Technology Co Ltd
Priority date: 2019-09-12
Filing date: 2019-09-12
Publication date: 2021-07-06
Anticipated expiration: 2039-09-12
Also published as: CN110495631A; WO2021046919A1

Abstract

The application relates to electronic cigarette liquid. The electronic cigarette liquid contains melatonin, wherein the content of the melatonin in the electronic cigarette liquid is 0.1-6 percent based on the total weight of the electronic cigarette liquid. The electronic cigarette liquid is atomized, and melatonin contained in the electronic cigarette liquid can be atomized out along with the cigarette liquid and absorbed by a human body, so that the electronic cigarette liquid has the effects of delaying aging, improving sleep and the like.

Description

Electronic cigarette liquid

Technical Field

The present application relates to the field of electronic aerosols or electronic nebulization devices, in particular to electronic cigarette liquid.

Background

Due to the pursuit of personal health, environmental protection, and convenience in use, electronic cigarettes are becoming more and more popular with consumers as a substitute for conventional tobacco. The electronic cigarette or the electronic atomizer replaces the smoke generated by the traditional high-temperature combustion mode of tobacco by atomizing the smoking material at low temperature to form aerosol for the user to inhale. The electronic cigarette liquid has certain influence on the experience and the taste of a user and even on the health of a human body.

How to further generate aerosol for inhalation by a user, which reduces harmful effects on the human body and improves beneficial effects on the human body, through low-temperature atomization is a research direction in which electronic cigarette products need to be improved.

Disclosure of Invention

The application provides an electron cigarette liquid that contains melatonin, exists in the produced aerial fog that is used for the user to inhale through atomizing device in this electron cigarette liquid and can produce the melatonin of releiving, the sedative effect to the people, and then is absorbed by the human body in order to reach efficiency such as postponing ageing, improving sleep.

According to one aspect of the present application, there is provided an electronic cigarette liquid comprising melatonin, wherein the melatonin is present in the electronic cigarette liquid in an amount of 0.1% to 6% based on the total weight of the electronic cigarette liquid.

According to yet another aspect of the present application, there is provided an aerosolization device comprising the above-described e-liquid.

Additional aspects and advantages of embodiments of the present application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of embodiments of the present application.

Drawings

Fig. 1A is a chromatogram of melatonin content of an e-liquid according to an embodiment of the application.

Fig. 1B is a chromatogram of melatonin content of an aerosol generated by an e-liquid according to an embodiment of the application.

Detailed Description

Embodiments of the present application will be described in detail below. The examples of the present application should not be construed as limiting the present application.

Additionally, amounts, ratios, and other numerical values are sometimes presented herein in a range format. It is to be understood that such range format is used for convenience and brevity, and should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited.

As used herein, the terms "substantially," "generally," "substantially," "essentially," and "about" are used to describe and illustrate small variations. When used in conjunction with an event or circumstance, the terms can refer to instances where the event or circumstance occurs precisely as well as instances where the event or circumstance occurs in close proximity. For example, when used in conjunction with numerical values, the term can refer to a range of variation that is less than or equal to ± 10% of the stated numerical value, such as less than or equal to ± 5%, less than or equal to ± 4%, less than or equal to ± 3%, less than or equal to ± 2%, less than or equal to ± 1%, less than or equal to ± 0.5%, less than or equal to ± 0.1%, or less than or equal to ± 0.05%. For example, two numerical values are considered to be "substantially" identical if the difference between the two numerical values is less than or equal to ± 10% (e.g., less than or equal to ± 5%, less than or equal to ± 4%, less than or equal to ± 3%, less than or equal to ± 2%, less than or equal to ± 1%, less than or equal to ± 0.5%, less than or equal to ± 0.1%, or less than or equal to ± 0.05%) of the mean of the values.

In the detailed description and claims, a list of items linked by the term "at least one of," "at least one of," or other similar terms may mean any combination of the listed items. For example, if items a and B are listed, the phrase "at least one of a and B" means a only; only B; or A and B. In another example, if items A, B and C are listed, the phrase "at least one of A, B and C" means a only; or only B; only C; a and B (excluding C); a and C (excluding B); b and C (excluding A); or A, B and C. Item a may comprise a single element or multiple elements. Item B may comprise a single element or multiple elements. Item C may comprise a single element or multiple elements.

As used herein, the term "aerosol for inhalation by a user" or "aerosol" can include, but is not limited to, aerosols, suspended liquids, cryogenic vapors, and volatile gases.

According to one aspect of the present application, there is provided an electronic liquid cigarette comprising melatonin.

Melatonin has effects of scavenging free radicals, resisting oxidation, inhibiting lipid peroxidation, protecting cell structure, preventing DNA damage, and reducing peroxide content in vivo. In addition, melatonin also has various physiological functions of promoting sleep, regulating jet lag, resisting aging, regulating immunity, resisting tumor, etc., and has the functions of delaying aging, improving sleep, etc. for human body. In some embodiments, when the electronic cigarette liquid passes through the atomization device to form the aerosol, the melatonin contained in the electronic cigarette liquid can be mixed into the aerosol together with the electronic cigarette liquid through atomization without being damaged by high temperature due to the effect of low-temperature atomization, and when a user inhales the aerosol, the melatonin can be directly absorbed, so that the health care effect on the human body is achieved.

In some embodiments, the melatonin is present in the e-liquid in an amount, based on the total weight of the e-liquid, of approximately, e.g., 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 6.0%, or a range consisting of any two of these parts. In some embodiments, the melatonin is contained in the electronic cigarette liquid in an amount of about 0.1% to about 6.0% based on the total weight of the electronic cigarette liquid, and the melatonin can make the electronic cigarette liquid have a more comfortable and milder mouthfeel after atomization, enrich the fragrance of the cigarette, and improve smoking quality.

According to another aspect of the present application, the electronic smoking fluid of some embodiments of the present application further comprises a flavor composition, wherein the flavor composition comprises the following materials in parts by weight: about 1 to about 10 parts of alpha-hexyl cinnamic aldehyde, about 35 to about 65 parts of linalool, about 0.01 to about 3.0 parts of lavandil, about 20 to about 45 parts of linalyl acetate, about 0.1 to about 10 parts of geranyl acetate, and about 5 to about 20 parts of lavandiyl acetate. In some embodiments, the flavor compositions of the present application can be comprised of the above parts by weight materials. The electronic cigarette liquid with the flavor composition can enable a user to generate lavender flavor when being absorbed, and can form uniform and rich aerial fog, so that the user experience is effectively improved.

In some embodiments, the flavor composition can include α -hexyl cinnamaldehyde in an amount of about 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or a range consisting of any two of these parts by weight; linalool can be present in an amount of about 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, or any combination of two of these parts by weight; the lavandulol may be approximately 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.1 parts, 0.5 parts, 1.0 parts, 2.0 parts, 3.0 parts or a range consisting of any two of these parts by weight; linalyl acetate can be present in an amount of approximately 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, or any combination of two of these parts by weight; geranyl acetate may be present at about 0.1 parts, 0.5 parts, 1.0 parts, 2 parts, 3 parts, 4 parts, 5 parts, 10 parts, or a range consisting of any two of these parts by weight; and lavender acetate may be present in an amount of about 5 parts, 10 parts, 15 parts, 20 parts, or any combination thereof.

The flavor composition is an additive, and when the flavor composition is added into the electronic cigarette liquid, the electronic cigarette liquid can enable a user to generate the taste and smell feeling of lavender flavor when the electronic cigarette liquid is used.

In some embodiments, the weight of the flavor composition in the e-liquid is approximately, e.g., 0.001%, 0.01%, 0.1%, 1%, or a range consisting of any two of these weight percents, based on the total weight of the e-liquid. In some embodiments, the flavor composition is present in the e-liquid in an amount of about 0.001% to about 1% by weight to provide a mild taste to the aerosol generated thereby optimizing the user experience.

The e-liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin). In some embodiments, the weight of propylene glycol in the e-liquid is approximately, e.g., 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or a range consisting of any two of these weight percentages, based on the total weight of the e-liquid; and glycerol, for example, in the range of about 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, or any two of these weight percentages. In some embodiments, the propylene glycol is present in the e-liquid in an amount of about 20% to about 60% by weight, and the glycerin is present in the e-liquid in an amount of about 40% to about 70% by weight, so as to achieve optimal atomization of the e-liquid and improve the user experience.

It will be understood by those skilled in the art that the base solvent may be selected from any solvent known in the art according to specific needs, for example, deionized water, propylene glycol, glycerol, without limitation.

In some embodiments, the e-liquid further comprises a cooling agent.

Cooling agents are additives, which are chemicals that can produce a cooling effect sensation to the user when the product is used and are not irritating. In some embodiments, the cooling agent comprises a cooling agent selected from the group consisting of menthol, menthone, isomenthone, l-menthyl lactate, WS-23(N,2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5(N- (ethoxycarbonylmethyl) -p-alkane-3-carboxamide), WS-12(N- (4-methoxyphenyl) -p-menthyl-3-carboxamide), and combinations thereof.

In some embodiments, the cooling agent is present in the e-liquid in an amount of, for example, about 0.1%, about 0.2%, about 0.3%, about 0.5%, about 1.0%, about 1.5%, about 2.0%, about 2.5%, about 5%, about 10%, or in any two of these weight percentages, based on the total weight of the e-liquid. In some embodiments, the cooling agent is present in the e-liquid in an amount of about 1.0% to about 10% by weight of the e-liquid, based on the total weight of the e-liquid, to enhance the mouthfeel of the aerosol generated by the e-liquid for inhalation by a user.

In some embodiments, the e-liquid further comprises a nicotine salt. In some embodiments, the weight of the nicotine salt in the e-liquid is approximately, e.g., 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10%, or a range consisting of any two of these weight percentages, based on the total weight of the e-liquid. In some embodiments, the nicotine salt is present in the electronic smoking fluid in an amount of about 0.001% to about 10.0% by weight based on the total weight of the electronic smoking fluid.

In some embodiments, the e-liquid further comprises nicotine. In some embodiments, the weight of nicotine in the e-liquid is approximately, e.g., 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, or a range consisting of any two of these weight percentages, based on the total weight of the e-liquid. In some embodiments, the nicotine is present in the electronic smoking fluid in an amount of about 0.001% to about 5.0% by weight based on the total weight of the electronic smoking fluid.

In some embodiments, the e-liquid further comprises a flavorant, wherein the flavorant is selected from the group consisting of alpha-pinene, alpha-terpineol, myrcene, benzaldehyde, ethyl butyrate, isoamyl butyrate, eugenol, beta-caryophyllene, benzyl acetate, butyl acetate, and combinations thereof.

In some embodiments, the flavor is present in the e-liquid in an amount of about 0.01% to about 5.0% by weight of the total weight of the e-liquid to add flavor to the e-liquid and to optimize the mouthfeel of the aerosol generated therefrom.

According to some embodiments of the present application, there is provided a method of preparing an electronic cigarette liquid, comprising the steps of: dissolving a certain amount of melatonin in a basic solvent, then adding flavor components, essence, nicotine or salt thereof, and uniformly mixing to obtain the electronic cigarette liquid.

According to another aspect of the present application, there is provided an atomization device including the electronic cigarette liquid according to any one of the above embodiments. The electronic cigarette liquid can be atomized by the atomizing device to generate aerosol for a user to inhale, wherein the aerosol contains melatonin which is not damaged by high temperature, and the effects of resisting fatigue, regulating immunity, delaying senility, improving sleep and the like can be generated after the aerosol is absorbed by the user.

In some embodiments, the nebulizing device comprises an electronic cigarette, an ultrasonic nebulizer, or a mesh nebulizer.

Examples

In order to facilitate a better understanding of the present application, the following examples are set forth. These examples belong to the scope of protection of the present application, but do not limit the scope of protection of the present application.

Preparing basic tobacco juice:

the base tobacco juice is obtained by blending propylene glycol and glycerol according to the following weight ratio (32:56) and then uniformly mixing.

Preparing essence:

the components were mixed in the following weight ratio in table 1 to obtain the essence.

Example 1

Adding 3 g of melatonin into 97 g of basic tobacco juice, mixing and stirring uniformly to obtain the electronic tobacco juice.

Example 2

Mixing alpha-hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate according to the following weight ratio (1.5: 35: 0.05: 25: 0.5: 10) to obtain a flavor composition, adding 3 g of melatonin and 0.5 g of the flavor composition into 96.5 g of base tobacco juice, and uniformly stirring to obtain the electronic tobacco juice.

Example 3

Mixing alpha-hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate according to the following weight ratio (1.5: 35: 0.05: 25: 0.5: 10) to obtain a flavor composition, mixing 2 g of melatonin, 0.3 g of the flavor composition, 3.0 g of nicotine and 2.0 g of benzoic acid, adding the mixture into 92.7 g of base tobacco juice, and uniformly stirring to obtain the electronic tobacco juice.

Example 4

Mixing alpha-hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate according to the following weight ratio (1.5: 38: 0.05: 25: 0.5: 10) to obtain a flavor composition, then mixing 1 g of melatonin, 0.2 g of the flavor composition, 3.0 g of nicotine, 2.0 g of benzoic acid and 0.02 g of essence, adding the mixture into 93.78 g of basic tobacco juice, and uniformly stirring to obtain the electronic tobacco juice.

Example 5

Mixing alpha-hexyl cinnamaldehyde, linalool, lavender alcohol, linalyl acetate, geranyl acetate and lavender acetate according to the following weight ratio (5: 60: 2: 40: 8: 15) to obtain a flavor composition, then mixing 0.5 g of melatonin, 0.1 g of the flavor composition, 2.0 g of nicotine, 1.5 g of benzoic acid, 1.0 g of WS-23, 0.5 g of menthol and 1.0 g of essence, adding the mixture into 93.4 g of basic tobacco juice, and uniformly stirring to obtain the electronic tobacco juice.

The composition of the perfume in the above examples is shown in table 1 below.

TABLE 1

The e-liquid of example 1 and its atomized aerosol were then subjected to melatonin content measurement and the e-liquid of examples 1-5 were subjected to taste scoring tests. By further illustration of the test results, the content of melatonin in the aerosol of the electronic cigarette liquid in the using process and the experience of the electronic cigarette liquid to a user are improved.

A melatonin content test mode;

melatoninThe content measurement was performed by Ultra Performance Liquid Chromatography (UPLC).

Sample preparation: the electronic cigarette liquid of example 1 was used to generate a gas mist for inhalation by a user in the following manner: the atomization device is an electronic cigarette, the smoking time is 3.0 seconds +/-0.1 second, the interval between smoking is 30.0 seconds +/-0.5 seconds, the smoking times are 50 times, and the smoking amount is 55mL +/-0.3 mL. Collecting aerial fog by using a Cambridge filter, immersing the Cambridge filter by using 10mL of methanol, and performing ultrasonic extraction for 30min to obtain a smoke extraction solution. And then measuring the content of the melatonin in the electronic cigarette liquid and the aerosol extraction solution thereof by adopting Ultra Performance Liquid Chromatography (UPLC).

Liquid chromatography conditions: waters ACQUITY

H-Class HSS T3 C₁₈Chromatographic column (2.1mm × 100mm,1.8 μm), acetonitrile-water solution (40:60, v/v) as mobile phase, isocratic elution, flow rate of 0.3mL/min, column temperature of 35 deg.C, sample injection amount of 3 μ L, and detection wavelength of 223 nm.

Figures 1A and 1B are measured by UPLC of e-liquid and aerosol generated therefrom, respectively, according to embodiments of the present applicationMelatoninChromatogram of content.

As shown in FIGS. 1A and 1B, the electronic cigarette liquid of the present application is present in the aerosolMelatoninIn the form of aerosolMelatoninIs basically the same as the components in the electronic cigarette liquid and is prevented from being damaged by high-temperature combustion. Therefore, the temperature of the molten metal is controlled,melatoninThe atomized aerosol of the electronic cigarette can be effectively absorbed by the human body, so that the user can achieve the effect of health care on the human body while smoking.

Taste scoring test method 1

Please note that 20 evaluators scored the electronic smoke sol experience of examples 1-5 according to each evaluation index in table 2. The evaluation results are shown in table 3 below.

TABLE 2

TABLE 3

A taste scoring test mode 2;

the statistical method comprises the following steps: the electronic cigarette liquid of the embodiment 1-5 is randomly selected 1000 users to carry out use test on the electronic cigarette liquid through the electronic cigarette, and the taste and the mouthfeel of the electronic cigarette liquid are evaluated after the use test, wherein the evaluation standard is calculated by 10 points in total, and the better the taste or the better the mouthfeel, the higher the score.

The results of the sensory testing of the e-liquid of examples 1-4 are shown in table 4 below.

TABLE 4

As can be seen from the data in tables 2 to 4, the electronic cigarette liquids of examples 1 to 5 of the present application can generate the lavender-flavored aerosol for inhalation by the user after atomization, which can effectively improve the satisfaction of the user in terms of both the taste and the appearance of the flavor.

It can be understood from the above embodiments of the present application that the present application provides an electronic cigarette liquid, which can enable a user to generate a lavender flavor without generating harmful substances such as tar and aerosol through a flavor composition contained in the electronic cigarette liquid. Simultaneously, this electron tobacco juice can form the even and strong aerial fog of smell when the user smokes, and this aerial fog taste is gentle and agreeable and do not have and remain the sense to promote user experience.

While the present application has been described and illustrated with reference to particular embodiments thereof, such description and illustration are not intended to limit the present application. It will be clearly understood by those skilled in the art that various changes may be made (e.g., in the addition, subtraction and alteration of ingredients from the flavour compositions of the present application) to adapt a particular situation, material, composition of matter, substance, method or process to the objective, spirit and scope of the present application without departing from the true spirit and scope of the present application as defined by the appended claims. All such modifications are intended to be within the scope of the claims appended hereto. Although the methods disclosed herein have been described with reference to particular operations performed in a particular order, it should be understood that these operations may be combined, sub-divided, or reordered to form equivalent methods without departing from the teachings of the present application. Accordingly, unless specifically indicated herein, the order and grouping of the operations is not a limitation of the present application.

Claims

1. An e-liquid comprising melatonin and a flavor composition, wherein the melatonin is present in the e-liquid at 0.1% to 6% by weight, based on the total weight of the e-liquid, and the flavor composition comprises the following materials in parts by weight:

1 to 10 parts of alpha-hexyl cinnamic aldehyde, 35 to 65 parts of linalool, 0.01 to 3.0 parts of lavender alcohol, 20 to 45 parts of linalyl acetate, 0.1 to 10 parts of geranyl acetate and 5 to 20 parts of lavender acetate.

2. The e-liquid of claim 1, wherein the flavor composition is present in the e-liquid in an amount of 0.001% to 1% by weight based on the total weight of the e-liquid.

3. The e-liquid of claim 1 or 2, further comprising a cooling agent, wherein the cooling agent is selected from the group consisting of menthol, menthone, isomenthone, l-menthyl lactate, WS-23(N,2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5(N- (ethoxycarbonylmethyl) -p-alkane-3-carboxamide), WS-12(N- (4-methoxyphenyl) -p-menthyl-3-carboxamide), and combinations thereof.

4. The e-liquid of claim 3, wherein the cooling agent is present in the e-liquid in an amount of 0.01% to 10% by weight based on the total weight of the e-liquid.

5. The e-liquid of claim 1 or 2, further comprising a nicotine salt, and the nicotine salt is present in the e-liquid in an amount of 0.001% to 10.0% by weight based on the total weight of the e-liquid.

6. The e-liquid of claim 1 or 2, further comprising nicotine, and the weight of the nicotine in the e-liquid is from 0.001% to 5.0% based on the total weight of the e-liquid.

7. The e-liquid of claim 1 or 2, further comprising a flavor, wherein the flavor is selected from the group consisting of alpha-pinene, alpha-terpineol, myrcene, benzaldehyde, ethyl butyrate, isoamyl butyrate, eugenol, beta-caryophyllene, benzyl acetate, butyl acetate, and combinations thereof.

8. The e-liquid of claim 7, wherein the flavor is present in the e-liquid in an amount of 0.01% to 5.0% by weight based on the total weight of the e-liquid.

9. An aerosolization device comprising the e-liquid of any one of claims 1-8.

10. The atomization device of claim 9 in which the atomization device comprises an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.