CN108186566A - A kind of nervous, relieving mental strain and helping sleep Alevaire and preparation method thereof of releiving - Google Patents
A kind of nervous, relieving mental strain and helping sleep Alevaire and preparation method thereof of releiving Download PDFInfo
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Abstract
The invention belongs to drug fields, and in particular to a kind of nervous, relieving mental strain and helping sleep Alevaire of releiving mainly is made of the following raw material：1~20wt% of cannabidiol medicinal extract or cannabidiol powder, 20~40wt% of glycerine, 20~55wt% of propylene glycol, 1~15wt% of grass-leaved sweetflag medicinal extract, 0.1~2wt% of seed of Oriental arborvitae medicinal extract 1~5% and essence.The preparation method of nervous, relieving mental strain and helping sleep the Alevaire of releiving, includes the following steps：Cannabidiol medicinal extract or cannabidiol powder, glycerine, propylene glycol, grass-leaved sweetflag medicinal extract, seed of Oriental arborvitae medicinal extract and essence are weighed by proportioning, cannabidiol medicinal extract or cannabidiol powder, grass-leaved sweetflag medicinal extract, seed of Oriental arborvitae medicinal extract and essence are dissolved in the glycerine and propylene glycol, stand 12~20 hours at room temperature, filtering, abandon filter residue, filtrate is filling into bottle in aseptic area, electronic cigarette liquid is made.The present invention releived patient anxiety nerve and extend sleeping time.
Description
Technical field
The invention belongs to drug fields, and in particular to a kind of nervous, relieving mental strain and helping sleep Alevaire and preparation method thereof of releiving.
Background technology
With the development that society is at full speed, the operating pressure and life stress of people is increasing, causes many people's spirit tight
, palpitaition, sleep absent-minded, uncomfortable, that high quality can not be possessed or even cause insomnia.Insomnia can cause that people's is tired
Labor sense, uneasiness, general malaise, listless, delay of response, headache, attention cannot be concentrated, serious a little to lead to spirit point
It splits and depression, anxiety disorder, the functional diseases such as vegetative nerve functional disturbance.
Although the medicament categories with syngignoscism are various, the main application of wherein most drugs is not that treatment is lost
It sleeps.The drug of clinical treatment insomnia at present mainly includes Benzodiazepines receptor stimulating agent
(benzodiazepinereceptoragonists, BZRAs), melatonin receptors agonist and the antidepression with hypnotic effect
Drug.Antihistamine drug (such as diphenhydramine) although, epiphysin and Valerian root P.E there is syngignoscism, it is existing to face
Bed research evidence is limited, should not be used as insomnia routine administration.General treatment is recommended：Eszopiclone (eszopiclone),
Zolpidem, zolpidem controlled release agent (zolpidem-CR), zopiclone (zopiclone).The drug for treating insomnia is complicated and numerous
It is more, including estazolam (estazolam), Flurazepam (flurazepam), Quazepam (quazepam), Temazepam
(temazepam), triazolam (triazolam), alprazolam (alprazolam), chlordiazepoxide (chlordiazepoxide),
Diazepam (diazepam), Lorazepam (lorazepam), Dormicum (midazolam), zolpidem, zolpidem controlled release agent
(zolpidem-CR), zopiclone (zopiclone), eszopiclone (eszopiclone) and Zaleplon
(zaleplon), Ramelteon (ramelteon), agomelatine (agomelatin), Iricyclic antidepressants, selectivity
5- reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibit (SNRIs), low dose of rice nitrogen
Flat, small-dose trazodone etc..Since some drugs have stronger side effect and drug dependence, so, do not advocate generally to take for a long time
With.
Invention content
One aspect of the present invention technical problems to be solved are to provide a kind of nervous, Alevaire of relieving mental strain and helping sleep and its system of releiving
Preparation Method, to the anxiety nerve for the patient that releives and extension sleeping time.
In order to solve the above-mentioned technical problem, the technical scheme is that：
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving, is mainly made of the following raw material：Cannabidiol medicinal extract or hemp two
1~30wt% of phenol powder, 0.1~2wt% of 10~60wt% of glycerine, 10~65wt% of propylene glycol and essence.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that further include grass-leaved sweetflag medicinal extract 1~
20wt%.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that further include seed of Oriental arborvitae medicinal extract 1~
10%.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that be mainly made of the following raw material：
1~20wt% of cannabidiol medicinal extract or cannabidiol powder, 20~40wt% of glycerine, 20~55wt% of propylene glycol, grass-leaved sweetflag
0.5~2wt% of 1~15wt% of medicinal extract, seed of Oriental arborvitae medicinal extract 1~5% and essence.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that be mainly made of the following raw material：
Cannabidiol medicinal extract or cannabidiol powder 20wt%, glycerine 35wt%, propylene glycol 30wt%, grass-leaved sweetflag medicinal extract 10wt%,
Seed of Oriental arborvitae medicinal extract 4% and essence 1wt%.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that the propylene glycol is 1,2- the third two
Alcohol.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that big in the cannabidiol medicinal extract
The content of numb diphenol is 3~99wt%.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that the preparation of the grass-leaved sweetflag medicinal extract
Method is that grass-leaved sweetflag rhizome is extracted with means of supercritical extraction after drying, crushing or with organic solvent, obtains grass-leaved sweetflag medicinal extract.
In nervous, relieving mental strain and helping sleep Alevaire provided by the invention of releiving, it is preferable that the preparation of the seed of Oriental arborvitae medicinal extract
Method is that the seed of Oriental arborvitae is extracted with means of supercritical extraction after drying, crushing or with organic solvent, obtains seed of Oriental arborvitae medicinal extract.
Another aspect of the present invention problem to be solved is to provide a kind of system for nervous, relieving mental strain and helping sleep Alevaire of releiving
Preparation Method includes the following steps：Cannabidiol medicinal extract or cannabidiol powder, glycerine, propylene glycol, grass-leaved sweetflag are weighed by proportioning
Medicinal extract, seed of Oriental arborvitae medicinal extract and essence, by cannabidiol medicinal extract or cannabidiol powder, grass-leaved sweetflag medicinal extract, seed of Oriental arborvitae medicinal extract and perfume (or spice)
Essence is dissolved in the glycerine and propylene glycol, stands 12~20 hours at room temperature, and filtering abandons filter residue, by filtrate sterile
Area is filling into bottle, and electronic cigarette liquid is made.
Cannabidiol has treatment insomnia a good effects, and the mechanism of action and cannabidiol can block fast caused by anxiety
Fast Eye Movement Sleep phase alternating is not normal related, and cannabidiol can also improve and the complicated relevant various actions of sleep and Pa Jin
The rapid eye movement sleep period of gloomy disease patient is not normal.Cannabidiol have protection nervous centralis effect and analgesic efficacy etc. also can between
The nerve that patient is helped to releive anxiety is connect, is effectively helped for sleep the time, improves sleep quality.
Cannabidiol is atomized by nervous, relieving mental strain and helping sleep the Alevaire of releiving of the present invention in a manner of electronic cigarette, by medicine
Liquid is sprayed with mist, is sucked by exhaling, and is entered therewith in last bronchus and lung and alveolar eventually and is absorbed active ingredient, rapid-action,
Bioavilability is higher.
In being tested for the sleeping of enterprise and business senior executive, the cannabidiol that has been unequivocally established can significantly relax
The nervous nerve of slow patient, averagely extends nearly two hours of sleeping time, and the deep sleep time nearly doubles, and 99% by reality
The person of testing at least wakes up primary annoying symptom when having interrupted the nighttime sleep having for a long time originally.
When grass-leaved sweetflag rhizome volatile oil and oriental arborvitae seed oil are added in cannabidiol, chemical compatibility is good, and can adjust
It releives sleeping Alevaire taste.It studies through Traditional Chinese Medicine, after adding in grass-leaved sweetflag rhizome volatile oil and oriental arborvitae seed oil, can be promoted big
The function for assisting sleep of releiving of numb diphenol.
Specific embodiment
The specific embodiment of the present invention is described further below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but do not form limitation of the invention.In addition, invention described below
Involved technical characteristic can be combined with each other as long as they do not conflict with each other in each embodiment.
Embodiment 1
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol medicinal extract 30wt%, glycerine 33wt%, propylene glycol 35wt% and essence 2wt%.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol medicinal extract, the third three are weighed by proportioning
Cannabidiol medicinal extract, essence are dissolved in glycerine and propylene glycol by alcohol, propylene glycol and essence, stand 20 hours at room temperature,
Filtering, abandons filter residue, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, the content of cannabidiol is 3wt% in cannabidiol medicinal extract.
Embodiment 2
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol powder 4wt%, glycerine 40wt%, propylene glycol 45wt% and essence 1wt%.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol powder, the third three are weighed by proportioning
Cannabidiol powder, essence are dissolved in glycerine and propylene glycol by alcohol, propylene glycol and essence, stand 12 hours at room temperature,
Filtering, abandons filter residue, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, the content of cannabidiol is 99wt% in cannabidiol powder.
Embodiment 3
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol powder 20wt%, glycerine 50wt%, 1,2 propylene glycol 29.9wt% and essence 0.1wt%.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol powder, the third three are weighed by proportioning
Cannabidiol powder, essence are dissolved in glycerine and 1,2-PD by alcohol, 1,2-PD and essence, quiet at room temperature
It puts 16 hours, filters, abandon filter residue, filtrate is filling into bottle in aseptic area, electronic cigarette liquid is made.
In the present embodiment, cannabidiol content is 85wt% in cannabidiol powder.
Embodiment 4
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol medicinal extract 25wt%, glycerine 35wt%, propylene glycol 25wt%, essence 0.2wt% and grass-leaved sweetflag medicinal extract 14.8wt%.
The preparation method of grass-leaved sweetflag medicinal extract is to extract grass-leaved sweetflag rhizome with super critical extraction after drying, crushing,
Obtain grass-leaved sweetflag medicinal extract.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol medicinal extract, the third three are weighed by proportioning
Cannabidiol medicinal extract, essence and grass-leaved sweetflag leaching medicinal extract are dissolved in glycerine and third by alcohol, propylene glycol, essence and grass-leaved sweetflag medicinal extract
In glycol, 14 hours are stood at room temperature, filter residue is abandoned in filtering, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, cannabidiol content is 43wt% in cannabidiol medicinal extract.
Embodiment 5
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol medicinal extract 15wt%, glycerine 34wt%, propylene glycol 30wt%, essence 1wt%, grass-leaved sweetflag medicinal extract 10wt% and seed of Oriental arborvitae medicinal extract
10%.
The preparation method of grass-leaved sweetflag medicinal extract is to extract grass-leaved sweetflag rhizome with super critical extraction after drying, crushing,
Obtain grass-leaved sweetflag medicinal extract.
The preparation method of seed of Oriental arborvitae medicinal extract is, by the seed of Oriental arborvitae by drying, crush after with means of supercritical extraction or with organic molten
Agent is extracted, and obtains seed of Oriental arborvitae medicinal extract.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol medicinal extract, the third three are weighed by proportioning
Cannabidiol medicinal extract, essence and grass-leaved sweetflag medicinal extract are dissolved in glycerine and the third two by alcohol, propylene glycol, essence and grass-leaved sweetflag medicinal extract
In alcohol, 15 hours are stood at room temperature, filter residue is abandoned in filtering, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, cannabidiol content is 56wt% in cannabidiol medicinal extract.
Embodiment 6
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol medicinal extract 20wt%, glycerine 35wt%, propylene glycol 30wt%, essence 1wt%, grass-leaved sweetflag medicinal extract 10wt% and seed of Oriental arborvitae medicinal extract
4%.
The preparation method of grass-leaved sweetflag medicinal extract is to extract grass-leaved sweetflag rhizome with super critical extraction after drying, crushing,
Obtain grass-leaved sweetflag medicinal extract.
The preparation method of seed of Oriental arborvitae medicinal extract is, by the seed of Oriental arborvitae by drying, crush after with means of supercritical extraction or with organic molten
Agent is extracted, and obtains seed of Oriental arborvitae medicinal extract.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol medicinal extract, the third three are weighed by proportioning
Cannabidiol medicinal extract, essence and grass-leaved sweetflag medicinal extract are dissolved in glycerine and the third two by alcohol, propylene glycol, essence and grass-leaved sweetflag medicinal extract
In alcohol, 18 hours are stood at room temperature, filter residue is abandoned in filtering, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, cannabidiol content is 61wt% in cannabidiol medicinal extract.
Embodiment 7
A kind of nervous, relieving mental strain and helping sleep Alevaire of releiving is present embodiments provided, is mainly made of the following raw material：Hemp two
Phenol medicinal extract 20wt%, glycerine 35wt%, propylene glycol 30wt%, essence 1wt%, grass-leaved sweetflag medicinal extract 7wt%, seed of Oriental arborvitae medicinal extract
4% and dendrobium candidum medicinal extract 3%.
The preparation method of grass-leaved sweetflag medicinal extract is to extract grass-leaved sweetflag rhizome with super critical extraction after drying, crushing,
Obtain grass-leaved sweetflag medicinal extract.
The preparation method of seed of Oriental arborvitae medicinal extract is, by the seed of Oriental arborvitae by drying, crush after with means of supercritical extraction or with organic molten
Agent is extracted, and obtains seed of Oriental arborvitae medicinal extract.
Dendrobium candidum medicinal extract preparation method is that will be extracted, be concentrated to give with organic solvent after the stem drying of dendrobium candidum, crushing
To dendrobium candidum medicinal extract.
The preparation method for releiving nervous, relieving mental strain and helping sleep Alevaire is：Cannabidiol medicinal extract, the third three are weighed by proportioning
Cannabidiol medicinal extract, essence and grass-leaved sweetflag medicinal extract are dissolved in glycerine and the third two by alcohol, propylene glycol, essence and grass-leaved sweetflag medicinal extract
In alcohol, 18 hours are stood at room temperature, filter residue is abandoned in filtering, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
In the present embodiment, cannabidiol content is 57wt% in cannabidiol medicinal extract.
Test example
1.1 general information
Insomniac is randomly divided into embodiment 1 as research object during choosing in October, 2016~2017 year October
6 groups of group, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment and embodiment, 7 groups of embodiment and control group, each 40
Example.Age is 26~45 years old；The state of an illness duration is 3~14 months.
1.2 are included in and exclusion criteria
1. 1.2.1 inclusion criteria meets《Chinese Spirit Obstacles classification and diagnostic criteria》Examining about insomnia in the third edition
Disconnected standard；2. all patients sign informed consent form.
1.2.2 1. though exclusion criteria is excluded with insomnia, simultaneously with other organic disease persons；2. it excluded
Quick constitution patient and to this research institute use drug allergy person；3. it excludes with the heart, Liver and kidney function obstacle person；4. exclude body
Insomniac caused by body disease or psychoactive substance abuse or dependence.
1.3 therapy
It is treated, 1h gives embodiment 1 to 7 gained Alevaire respectively before sleep every night of following the doctor's advice, and control group uses mouth
It takes estazolam piece (Beijing Scrianen Pharmaceutical Co., Ltd.) to be treated, 1 time/d, 0.4mg/ times, continuously takes 3d.
1.4 efficacy determination
Curative effect determinate standard is as follows, recovery from illness：Patient's sleeping time reaches normal condition or Nighttime sleep ＞ after treatment
6h, it is full of vitality after wakeing up；It is effective：Patient's sleeping state improving after treatment, increase >=3h before sleeping time relatively treats；Effectively：
Patient's sleep quality makes moderate progress after treatment, increased, but increase time ＜ 3h before sleeping time relatively treatment；In vain：Treatment
Patient's sleep state does not improve or even aggravates afterwards.
1.5 statistical procedures
Data are analyzed using 18.0 statistics softwares of SPSS, are examined using t, enumeration data uses χ2It examines, with
P ＜ 0.05 are statistically significant for difference.
2 results
Each group experiment time for falling asleep, sleep time, night awakening number data be shown in Table 1.
The comparison (n=40) of 1. time for falling asleep of table, sleep time, night awakening number
As can be seen from the above table, the time for falling asleep of 1 to 7 group of embodiment<15min person, sleep time >=6h person, night
No awakening person's proportion is significantly higher than control group, and difference has statistical significance (P<0.05).
Embodiments of the present invention are explained in detail above, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (10)
1. a kind of nervous, relieving mental strain and helping sleep Alevaire of releiving, which is characterized in that be mainly made of the following raw material：Cannabidiol soaks
1~30wt% of cream or cannabidiol powder, 0.1~2wt% of 10~60wt% of glycerine, 10~65wt% of propylene glycol and essence.
2. nervous, relieving mental strain and helping sleep Alevaire according to claim 1 of releiving, which is characterized in that further include grass-leaved sweetflag leaching
1~20wt% of cream.
3. nervous, relieving mental strain and helping sleep Alevaire according to claim 2 of releiving, which is characterized in that further include seed of Oriental arborvitae leaching
Cream 1~10%.
4. nervous, relieving mental strain and helping sleep Alevaire according to claim 3 of releiving, which is characterized in that mainly by the following raw material
Composition：1~20wt% of cannabidiol medicinal extract or cannabidiol powder, 20~40wt% of glycerine, 20~55wt% of propylene glycol, stone
1~15wt% of calamus medicinal extract, 0.5~2wt% of seed of Oriental arborvitae medicinal extract 1~5% and essence.
5. nervous, relieving mental strain and helping sleep Alevaire according to claim 4 of releiving, which is characterized in that mainly by the following raw material
Composition：Cannabidiol medicinal extract or cannabidiol powder 20wt%, glycerine 35wt%, propylene glycol 30wt%, grass-leaved sweetflag medicinal extract
10wt%, seed of Oriental arborvitae medicinal extract 4% and essence 1wt%.
6. releived nervous, relieving mental strain and helping sleep Alevaire according to Claims 1 to 5 any one of them, which is characterized in that described third
Glycol is 1,2- propylene glycol.
7. releived nervous, relieving mental strain and helping sleep Alevaire according to Claims 1 to 5 any one of them, which is characterized in that described big
The content of cannabidiol is 3~99wt% in numb diphenol medicinal extract.
8. releived nervous, relieving mental strain and helping sleep Alevaire according to claim 2~5 any one of them, which is characterized in that the stone
The preparation method of calamus medicinal extract is to extract grass-leaved sweetflag rhizome with means of supercritical extraction after drying, crushing or with organic solvent,
Obtain grass-leaved sweetflag medicinal extract.
9. releived nervous, relieving mental strain and helping sleep Alevaire according to claim 3~5 any one of them, which is characterized in that the cypress
The preparation method of sub- benevolence medicinal extract is that the seed of Oriental arborvitae is extracted with means of supercritical extraction after drying, crushing or with organic solvent, obtains cypress
Sub- benevolence medicinal extract.
10. a kind of preparation method for nervous, relieving mental strain and helping sleep Alevaire of releiving, which is characterized in that include the following steps：By proportioning
Cannabidiol medicinal extract or cannabidiol powder, glycerine, propylene glycol, grass-leaved sweetflag medicinal extract, seed of Oriental arborvitae medicinal extract and essence are weighed, it will be big
Numb diphenol medicinal extract or cannabidiol powder, grass-leaved sweetflag medicinal extract, seed of Oriental arborvitae medicinal extract and essence are dissolved in the glycerine and propylene glycol
In, 12~20 hours are stood at room temperature, filter residue is abandoned in filtering, and filtrate is filling into bottle in aseptic area, and electronic cigarette liquid is made.
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| CN109939160A (en) * | 2019-03-28 | 2019-06-28 | 武汉圣润生物科技有限公司 | A kind of oral solution of calm nerves and preparation method thereof |
| CN110151868A (en) * | 2019-05-28 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of essential oil and preparation method thereof of the extract of CBD containing cannabidiol |
| CN112007080A (en) * | 2020-09-14 | 2020-12-01 | 云南汉木森生物科技有限责任公司 | Aerosol for relieving, helping sleep and resisting depression and preparation method thereof |
| WO2021046919A1 (en) * | 2019-09-12 | 2021-03-18 | 深圳雾芯科技有限公司 | E-liquid |
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| US20150181924A1 (en) * | 2013-10-31 | 2015-07-02 | Michael R. Llamas | Cannabidiol liquid composition for smoking |
| US20160136213A1 (en) * | 2014-11-14 | 2016-05-19 | Charles William Paul | Process to suspend cannabis oil in glycerin |
| GB2540539A (en) * | 2015-07-20 | 2017-01-25 | Edward Thistlethwaite Thomas | A liquid containing 99% pure CBD for use in vapourizers, distinct from smoking or combustion devices |
| WO2017081480A1 (en) * | 2015-11-12 | 2017-05-18 | Jaytee Biosciences Limited | Liquid formulation |
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| CN109077349A (en) * | 2018-08-28 | 2018-12-25 | 河北中烟工业有限责任公司 | Have effects that the composition of antidepression and preparation process and the application in electronics tobacco tar |
| CN109939160A (en) * | 2019-03-28 | 2019-06-28 | 武汉圣润生物科技有限公司 | A kind of oral solution of calm nerves and preparation method thereof |
| CN110151868A (en) * | 2019-05-28 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of essential oil and preparation method thereof of the extract of CBD containing cannabidiol |
| WO2021046919A1 (en) * | 2019-09-12 | 2021-03-18 | 深圳雾芯科技有限公司 | E-liquid |
| WO2021069907A1 (en) * | 2019-10-09 | 2021-04-15 | Nicoventures Trading Limited | Aerosolisable material |
| AU2020365097B2 (en) * | 2019-10-09 | 2023-08-03 | Nicoventures Trading Limited | Aerosolisable material |
| CN112007080A (en) * | 2020-09-14 | 2020-12-01 | 云南汉木森生物科技有限责任公司 | Aerosol for relieving, helping sleep and resisting depression and preparation method thereof |
| CN115944683A (en) * | 2022-03-21 | 2023-04-11 | 广州智焜生物科技有限公司 | Nerve-soothing electronic atomized liquid and preparation method thereof |
| CN114848592A (en) * | 2022-04-18 | 2022-08-05 | 广东万年青制药股份有限公司 | Atomization agent based on quassia injection and preparation process thereof |
| CN114848592B (en) * | 2022-04-18 | 2023-09-26 | 广东万年青制药股份有限公司 | Atomizing agent based on quassia injection and preparation process thereof |
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Application publication date: 20180622 |