CN109939160A - A kind of oral solution of calm nerves and preparation method thereof - Google Patents

A kind of oral solution of calm nerves and preparation method thereof Download PDF

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Publication number
CN109939160A
CN109939160A CN201910244204.2A CN201910244204A CN109939160A CN 109939160 A CN109939160 A CN 109939160A CN 201910244204 A CN201910244204 A CN 201910244204A CN 109939160 A CN109939160 A CN 109939160A
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parts
lycium ruthenicum
calm nerves
cannabidiol
preservative
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郑俊武
金秀妍
郑成武
卫路
刘群
黄浩
洪磊
聂晓芬
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Wuhan Shengrun Biotechnology Co Ltd
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Wuhan Shengrun Biotechnology Co Ltd
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Abstract

The invention discloses oral solutions of a kind of calm nerves and preparation method thereof, its of the invention raw material includes: 50-250 parts of cannabidiol, 100-300 parts of ganodenic acid, 30-150 parts of lycium ruthenicum, 30-250 parts of spiny jujuba seed powder, 3-10 parts of Sucralose and 0.3-0.6 parts of preservative by weight, preservative is the combination of one or both of sodium benzoate or methyl hydroxybenzoate sodium, and the present invention relates to technical field of health care.Oral solution of the calm nerves and preparation method thereof, being used cooperatively by Chinese medicine and Western medicine can be achieved, it enables the patient to be treated well, keep drug not only quick, and substantially increase drug effect duration, substantially reduce the recurrence period time of patient, cannabidiol has analgesia, calm nerves effect, by being cooperateed with respectively using ganodenic acid, lycium ruthenicum and spiny jujuba seed powder, the effect of can reach blood-enriching tranquillizing, calming heart, tranquilizing the mind and arrest sweating has achieved the purpose that extend the Patients on Recurrence time, thus highly beneficial to the treatment of the overstretched patient of nerve.

Description

A kind of oral solution of calm nerves and preparation method thereof
Technical field
The present invention relates to technical field of health care, specially a kind of oral solution of calm nerves and preparation method thereof.
Background technique
Mental disease is also known as mental disease, refers under the influence of various biology, psychology and social environmental factor, brain Functional disturbance causes the cerebrations such as cognition, emotion, will and behavior the disease that different degrees of obstacle is clinical manifestation occur, Wherein neural overstretched and neurasthenia is disease relatively conventional in mental disease, and neurasthenia is easy with cerebration process Based on by excitation and easily weak, including spirit is easily excited, and is easy fatigue, and mental labour cannot be lasting, absent minded, note Recall power decline, thinking is difficult, retardation of comprehension, mood irritability, and control ability reduces and fatigue and weak, it is often accompanied by sleep disturbance, Tension headache and vegetative nerve functional disturbance, there is patient's dysphoria of this kind of symptom, depressed anxiety, and subjective sensation is past Toward prominent compared with objective sign, be more common in neurasthenia and other neurosises, be also found in mania and schizophrenia stage, Hypertension, infection, poisoning, craniocerebral trauma, cerebrovascular disease and physical disease caused by mental disorder etc., psychologist think contradiction, Crisis, anxiety and wound may result in mental disease, especially hold on the vulnerable person at one, easily cause spiritual damage Wound, spirit is overstretched to will lead to insomnia, memory loss and severe psychiatric damage, and spirit is overstretched to typically belong to psychology Disease, therefore releive spirit and psychotherapy are one of the maximally efficient methods of the overstretched disease for the treatment of spirit.
The drug of the nervous aspect for the treatment of at present is directly quickly to be treated by using narcotic drugs mostly, so And such drug is although quick, but drug effect duration is poor, the Patients on Recurrence period is short, patient cannot be made to take medicine of releiving While object, the purpose for extending the Patients on Recurrence time can be unable to reach long lasting for taking effect, can not achieve through Chinese medicine and Western medicine is used cooperatively, and enables the patient to be treated well, thus very unfavorable to the treatment of the overstretched patient of nerve.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides oral solutions of a kind of calm nerves and preparation method thereof, solve Existing drug is although quick, but drug effect duration is poor, and the Patients on Recurrence period is short, patient cannot be made to take drug of releiving While, it can be unable to reach the purpose for extending the Patients on Recurrence time, can not achieve through Chinese medicine and west long lasting for taking effect Being used cooperatively for medicine, enables the patient to the problem of being treated very well.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs: a kind of oral solution of calm nerves, Raw material includes: 50-250 parts of cannabidiol, 100-300 parts of ganodenic acid, 30-150 parts of lycium ruthenicum, spiny jujuba seed powder by weight 30-250 parts, 3-10 parts of Sucralose and 0.3-0.6 parts of preservative.
Preferably, raw material includes following component: 150 parts of cannabidiol, 200 parts of ganodenic acid, 90 parts of lycium ruthenicum, wild jujube 140 parts of benevolence powder, 7 parts of Sucralose and 0.45 part of preservative.
Preferably, raw material includes following component: 50 parts of cannabidiol, 100 parts of ganodenic acid, 30 parts of lycium ruthenicum, wild jujube 30 parts of benevolence powder, 3 parts of Sucralose and 0.3 part of preservative.
Preferably, raw material includes following component: 250 parts of cannabidiol, 300 parts of ganodenic acid, 150 parts of lycium ruthenicum, acid 250 parts of jujube kernel powder, 10 parts of Sucralose and 0.6 part of preservative.
Preferably, the preservative is the combination of one or both of sodium benzoate or methyl hydroxybenzoate sodium.
Preferably, the ganodenic acid is extracted by growing in the Wild ganoderma of 3-5.
Preferably, the lycium ruthenicum, which is selected under full exposure, develops healthy and strong, the strong wild lycium ruthenicum of salt tolerant alkali ability.
The invention also discloses a kind of preparation methods of the oral solution of calm nerves, specifically includes the following steps:
S1, the lycium ruthenicum of selection is put into service sink first, clear water rinses 2-3 times, is able to carry out lycium ruthenicum sufficiently Cleaning, the lycium ruthenicum after then cleaning are put into storage tank, are sufficiently squeezed using extrusion equipment lycium ruthenicum, be can be obtained Lycium ruthenicum extract;
S2, the lycium ruthenicum extract that S1 is obtained is poured into heating furnace, at the same by the cannabidiol of selection, ganodenic acid, Spiny jujuba seed powder and Sucralose successively pour into heating furnace, then clear water surplus is added into heating furnace, and then lighting heating furnace will 20-30min is heated in heating furnace high fire, until boiling, the tanning 10-15min of small fire heating later can obtain initial liquid;
S3, the initial liquid for obtaining S2 are poured out out of heating furnace, will non-solid filter residue mistake from medical fluid by filter screen It filters out and, then repeat filtering 2-3 times, pure medical fluid can be obtained;
S4, the S3 medical fluid filtered is poured into static air-cooled 10-15min in mixing and blending machine, then by the preservative of selection It pours into mixing and blending machine, is that 400-500r/min stirs 30-50min with revolving speed, oral liquid product can be obtained;
S5, the S4 oral liquid product obtained is put into sterilization treatment in bactericidal unit, sterilize 20-30min;
S6, oral liquid product made from S4 is poured into bottle placer, starting filling apparatus progress is filling, then to canned Oral liquid product packed, storage is carried out to packaged oral liquid product later and preservation or is sold.
Hemp, Cannabaceae, Cannabis plant, You Mingma, Chinese fiber crops, fire fiber crops, mountain silk seedling, jute, with important agricultural and Medical value, pharmacological research show that the main active in hemp is Cannabinoids compound, are currently known natural cannabinoid There are 70 kinds, wherein tetrahydrocannabinol (THC), cannabidiol (CBD) are the main chemical compositions in hemp, although THC is considered It is its most important active constituent, there is neural activity, can be used for vomiting caused by treating cancer, but THC has hallucinogenic action, This also becomes many countries and forbids cultivating the sole cause of hemp, and unlike THC, CBD is the non-additive ingredient in hemp, energy Influence of the THC to nerve system of human body is hindered, and there is anti-spasm, resisting rheumatoid arthritis, antianxiety and treat depressed pharmacology Activity, cannabidiol are present in marihuana, there is cough-relieving, antispastic, analgesic, calmness and sleeping, and cannabidiol has anti- The effect of mental disease, can help the people of schizophrenia and other mental diseases to reduce psychotic symptoms, and cannabidiol has medicine The function of object abuse treatment, can modify circuit related with drug habit in brain, and cannabidiol has antineoplastic action, In test tube and zooscopy, antitumor action is shown in cannabidiol, in animal, it has been proved to prevent The propagation of breast, prostate, brain, colon and lung cancer, cannabidiol have the function of diabetes mellitus prevention, in diabetic mice, The treatment of cannabidiol reduces 56% diabetes morbidity, and considerably reduces inflammation.
Reishi sporule ingredient in ganodenic acid can play anti-inflammatory, analgesia, calmness, anti-aging, poisoning tumour cell and resist The effect of anoxic, experiments have shown that ganoderma lucidum triterpene has the function of improving immunity rapidly, while being capable of activated chemotherapy drug hardly possible With the G0 phase tumour cell of kill, individually kill with joint.
Lycium ruthenicum extract has good tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity, blood-enriching tranquillizing, promotes the production of body fluid to quench thirst and moistening lung to arrest cough Effect, can treat liver-kidney Yin deficiency, soreness and weakness of waist and knees, dizziness, dizzy, the more tears of blurred vision, cough due to consumptive disease, the disease quenched one's thirst and passed out semen.
For spiny jujuba seed powder as a kind of very high Chinese medicine of food therapy value, the effect of spiny jujuba seed powder, is very more, the most frequently used to treat The problem of insomnia, semen ziziphi spinosae itself has the function of nourishing the liver, calming heart, tranquilizing the mind and arrest sweating, cures mainly restlessness of asrhenia type and insomnia and polydipsia abnormal sweating, wild jujube Benevolence powder is fine to part insomnia patients effect, common reason of having a sleepless night have anxiety disorder, diabetes, hyperthyroidism, stress overweight and Encephalasthenia, insomnia effect caused by semen ziziphi spinosae is overweight to stress and encephalasthenia is relatively good, causes to anxiety disorder Have certain effect;Semen ziziphi spinosae has the function of protection to cardiovascular system, and semen ziziphi spinosae has adjustment effect to arrhythmia cordis, to the heart The problem of muscle cell damage plays the role of protection, can prevent arrhythmia cordis to a certain extent;Semen ziziphi spinosae also has significantly Anticonvulsant action can obviously inhibit Benzylpenicillin sodium salt to the excitation of neuronal cell, reduce the raising of glutamate levels, and have Antiepileptic action;Semen ziziphi spinosae can have semen ziziphi spinosae general glycoside, it can help to reduce serum with blood pressure lowering and reducing blood lipid in semen ziziphi spinosae Cholesterol, increasing high density lipoprotein find in clinical studies, these effects of semen ziziphi spinosae artery sclerosis may be formed and Development plays the role of inhibition;Semen ziziphi spinosae can enhance human immunity, and the ingredient in spiny jujuba seed powder has effect of scavenging radical, jujube Benevolence total saposins can be reduced blood brain water content and lipid peroxide (MAD) content, increase the SOD activity in brain tissue, Lactic acid content decline, mitigates ischemic brain damage;Spiny jujuba seed powder is taken with antitumor action, semen ziziphi spinosae is containing alkaloids, soap A variety of pharmaceutical components such as glycosides and flavones, can be effectively anti-radiation, reduces cancered probability.
Sugariness is 400-800 times of sucrose to Sucralose at different conditions, and sweet taste is pure, sweet tea sense presentation speed, maximum The sweet taste characteristics such as the impression intensity of sweet taste, sweet taste duration, rear taste are current without bitter taste after any very similar to sucrose Generally acknowledged intense sweetener in the world.
(3) beneficial effect
The present invention provides oral solutions of a kind of calm nerves and preparation method thereof.Having compared with prior art following has Beneficial effect: oral solution of the calm nerves and preparation method thereof, raw material include: 50-250 parts of cannabidiol, spirit by weight 100-300 parts of sesame triterpene, 30-150 parts of lycium ruthenicum, 30-250 parts of spiny jujuba seed powder, 3-10 parts of Sucralose and preservative 0.3-0.6 Part, preservative is the combination of one or both of sodium benzoate or methyl hydroxybenzoate sodium, and ganodenic acid is the open country by growing 3-5 It is extracted in creature sesame, lycium ruthenicum, which is selected under full exposure, develops healthy and strong, the strong wild lycium ruthenicum of salt tolerant alkali ability, calm nerves Oral solution preparation method, specifically includes the following steps: S1, the lycium ruthenicum of selection is put into service sink first, clear water punching It washes 2-3 times, lycium ruthenicum is made to be able to carry out abundant cleaning, the lycium ruthenicum after then cleaning is put into storage tank, uses extrusion equipment Lycium ruthenicum is sufficiently squeezed, lycium ruthenicum extract can be obtained, the lycium ruthenicum extract that S1 is obtained S2, is poured into heating furnace In, while the cannabidiol of selection, ganodenic acid, spiny jujuba seed powder and Sucralose successively being poured into heating furnace, then Xiang Jiare Clear water surplus is added in furnace, then lights heating furnace for heating furnace high fire and heats 20-30min, until boiling, small fire is heated later 10-15min is boiled, initial liquid can be all obtained, S3, the initial liquid for obtaining S2 are poured out out of heating furnace, by filtering Net filters out non-solid filter residue from medical fluid, then repeats filtering 2-3 times, pure medical fluid can be obtained, S4, filter S3 Medical fluid pour into static air-cooled 10-15min in mixing and blending machine, then the preservative of selection is poured into mixing and blending machine, with Revolving speed is that 400-500r/min stirs 30-50min, and oral liquid product can be obtained, S5, be put into the S4 oral liquid product obtained Sterilization treatment in bactericidal unit, sterilize 20-30min, S6, pours into bottle placer oral liquid product made from S4, starts filling Equipment progress is filling, then packs to canned oral liquid product, enters later to packaged oral liquid product Library saves or sells, it can be achieved that being used cooperatively by Chinese medicine and Western medicine, enables the patient to be treated well, make medicine Object is not only quick, but also substantially increases drug effect duration, substantially reduces the recurrence period time cannabidiol tool of patient There are analgesia, calm nerves effect, collaboration uses ganodenic acid, lycium ruthenicum and spiny jujuba seed powder, can reach blood-enriching tranquillizing, calming heart, peace Mind and the effect of arrest sweating can reach extension trouble long lasting for taking effect while well taking patient to releive drug The purpose of person's recurrence time.
Detailed description of the invention
Fig. 1 is the statistics table figure of use case of the present invention;
Fig. 2 is the statistics table figure of zoopery of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
The embodiment of the present invention provides a kind of three kinds of technical solutions: preparation side of the oral solution of calm nerves referring to FIG. 1-2, Method specifically includes following embodiment:
Embodiment 1
S1, the lycium ruthenicum of selection is put into service sink first, clear water rinses 3 times, is able to carry out lycium ruthenicum sufficiently clear It washes, the lycium ruthenicum after then cleaning is put into storage tank, is sufficiently squeezed using extrusion equipment lycium ruthenicum, be can be obtained black Wolfberry fruit extract;
S2, the 90 parts of lycium ruthenicum extracts acquired from S1, while by 150 parts of cannabidiols of selection, 200 portions of ganoderma lucidums Triterpene, 140 parts of spiny jujuba seed powders and 7 parts of Sucraloses successively pour into heating furnace, then clear water surplus is added into heating furnace, then It lights heating furnace and 25min is heated into heating furnace high fire, until boiling, the tanning 13min of small fire heating later can be obtained initial Medical fluid;
S3, the initial liquid for obtaining S2 are poured out out of heating furnace, will non-solid filter residue mistake from medical fluid by filter screen It filters out and, then repeatedly filter 23 is secondary, and pure medical fluid can be obtained;
S4, the S3 medical fluid filtered is poured into static air-cooled 13min in mixing and blending machine, then by 0.45 part of anti-corrosion of selection Agent is poured into mixing and blending machine, is that 450r/min stirs 40min with revolving speed, oral liquid product can be obtained;
S5, the S4 oral liquid product obtained is put into sterilization treatment in bactericidal unit, sterilize 20-30min;
S6, oral liquid product made from S4 is poured into bottle placer, starting filling apparatus progress is filling, then to canned Oral liquid product packed, storage is carried out to packaged oral liquid product later and preservation or is sold.
Embodiment 2
S1, the lycium ruthenicum of selection is put into service sink first, clear water rinses 2 times, is able to carry out lycium ruthenicum sufficiently clear It washes, the lycium ruthenicum after then cleaning is put into storage tank, is sufficiently squeezed using extrusion equipment lycium ruthenicum, be can be obtained black Wolfberry fruit extract;
S2, the 30 parts of lycium ruthenicum extracts acquired from S1 pour into heating furnace, while by 50 portions of hemps two of selection Phenol, 100 parts of ganodenic acids, 30 parts of spiny jujuba seed powders and 3 parts of Sucraloses successively pour into heating furnace, then are added clearly into heating furnace Then water surplus lights heating furnace for heating furnace high fire and heats 20min, until boiling, the tanning 10min of small fire heating later, i.e., Initial liquid can all be obtained;
S3, the initial liquid for obtaining S2 are poured out out of heating furnace, will non-solid filter residue mistake from medical fluid by filter screen It filters out and, then repeat filtering 2 times, pure medical fluid can be obtained;
S4, the S3 medical fluid filtered is poured into static air-cooled 10min in mixing and blending machine, then by 0.3 part of anti-corrosion of selection Agent is poured into mixing and blending machine, is that 400r/min stirs 30min with revolving speed, oral liquid product can be obtained;
S5, the S4 oral liquid product obtained is put into sterilization treatment in bactericidal unit, sterilize 20-30min;
S6, oral liquid product made from S4 is poured into bottle placer, starting filling apparatus progress is filling, then to canned Oral liquid product packed, storage is carried out to packaged oral liquid product later and preservation or is sold.
Embodiment 3
S1, the lycium ruthenicum of selection is put into service sink first, clear water rinses 3 times, is able to carry out lycium ruthenicum sufficiently clear It washes, the lycium ruthenicum after then cleaning is put into storage tank, is sufficiently squeezed using extrusion equipment lycium ruthenicum, be can be obtained black Wolfberry fruit extract and the remaining mixture of extruding;
It S2, the 150 parts of lycium ruthenicum extracts acquired from S1 and pours into heating furnace, while big by 250 parts of selection Numb diphenol, 300 parts of ganodenic acids, 250 parts of spiny jujuba seed powders and 10 parts of Sucraloses successively pour into heating furnace, then into heating furnace Clear water surplus is added, then lights heating furnace for heating furnace high fire and heats 30min, until boiling, the tanning of small fire heating later 15min can obtain initial liquid;
S3, the initial liquid for obtaining S2 are poured out out of heating furnace, will non-solid filter residue mistake from medical fluid by filter screen It filters out and, then repeatedly filter 23 is secondary, and pure medical fluid can be obtained;
S4, the S3 medical fluid filtered is poured into static air-cooled 15min in mixing and blending machine, then by 0.6 part of anti-corrosion of selection Agent is poured into mixing and blending machine, is that 500r/min stirs 50min with revolving speed, oral liquid product can be obtained;
S5, the S4 oral liquid product obtained is put into sterilization treatment in bactericidal unit, sterilize 20-30min;
S6, oral liquid product made from S4 is poured into bottle placer, starting filling apparatus progress is filling, then to canned Oral liquid product packed, storage is carried out to packaged oral liquid product later and preservation or is sold.
Zoopery
The test specimen that experimental example 1 uses is is prepared by the prescription of embodiment 1.Test process is as follows:
SPF grades kunming mice 40, female, 3 week old, 18~22g of weight.40 animals be divided into 5 groups (Normal group, The high, medium and low dosage group of the oral solution of calm nerves), every group 10.The high, medium and low dosage difference of the oral solution of calm nerves For 0.8,0.6,0.3ml/kg, it is equivalent to 3,2,1 multiple dose of human body recommended amounts;Normal group gives pure water.Daily administration 1 It is secondary, continuous 15d.After 45min is administered, Normal group and other experimental groups carry out scaring processing simultaneously, once a day, continuously 15d.After the processing of last scaring, posterior orbit veniplex blood sampling 1ml stands 20min in centrifuge tube for 24 hours for mouse free water, fasting, 3500rpm/min is centrifuged 10min, separates serum.
According to biochemical measurement kit specification, the adrenergic content of mice serum is detected, testing result is shown in Table Fig. 2.
As the result is shown by table Fig. 2: compared with Normal group, when mouse finally gets a fright, adrenaline in serum Content can significantly rise, and the experimental group adrenal hormone of high, medium and low dosage rise it is unobvious, illustrate that the oral solution can Obvious calm nerves.
Use case
Certain pharmaceutical producing enterprise uses the oral liquor of 1-3 of the embodiment of the present invention, respectively obtains sample liquid 1, sample liquid 2 With sample liquid 3, then the oral solution sample liquid 4 the most of current market sales of equivalent efficacy is chosen, then randomly selects 60 nerves 60 patients are divided into four groups by overstretched and neurastheniac, one group of 15 people, and first group is taken sample liquid 1, and second Group takes sample liquid 2, and third group takes sample liquid 3, and the 4th group is taken sample liquid 4, allows each patient to take corresponding sample liquid one later and arrives Two courses for the treatment of, and observation 2-3 months after taking, while responding time during being taken to each patient and observing after taking Whether there is or not recurrences to be counted, and averages to the result of every group of statistics, and every group of average responding time can be obtained.
Such as table Fig. 1 it is found that responding time is most short in first group of patient for taking 1 sample liquid of embodiment, and without recurrence after taking, And responding time of the responding time of second group and third group than the 4th group is short, and the 4th group has recurrence appearance, therefore Calm nerves oral solution produced by the present invention can realize being used cooperatively by Chinese medicine and Western medicine, enable the patient to obtain well Treatment, keeps drug not only quick, but also substantially increase drug effect duration, substantially reduces the recurrence period time of patient, By using cannabidiol collaboration ganodenic acid, lycium ruthenicum and spiny jujuba seed powder, blood-enriching tranquillizing, calming heart, tranquilizing the mind and arrest sweating can reach The effect of, it, can be long lasting for taking effect, when having reached extension Patients on Recurrence while well taking patient to releive drug Between purpose, thus highly beneficial to the treatment of the overstretched patient of nerve.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (8)

1. a kind of oral solution of calm nerves, it is characterised in that: its raw material includes: 50-250 parts of cannabidiol, spirit by weight 100-300 parts of sesame triterpene, 30-150 parts of lycium ruthenicum extract, 30-250 parts of spiny jujuba seed powder, 3-10 parts of Sucralose and preservative 0.3-0.6 parts.
2. a kind of oral solution of calm nerves according to claim 1, it is characterised in that: its raw material includes following component: 150 parts of cannabidiol, 200 parts of ganodenic acid, 90 parts of lycium ruthenicum, 140 parts of spiny jujuba seed powder, 7 parts of Sucralose and preservative 0.45 Part.
3. a kind of oral solution of calm nerves according to claim 1, it is characterised in that: its raw material includes following component: 50 parts of cannabidiol, 100 parts of ganodenic acid, 30 parts of lycium ruthenicum, 30 parts of spiny jujuba seed powder, 3 parts of Sucralose and 0.3 part of preservative.
4. a kind of oral solution of calm nerves according to claim 1, it is characterised in that: its raw material includes following component: 250 parts of cannabidiol, 300 parts of ganodenic acid, 150 parts of lycium ruthenicum, 250 parts of spiny jujuba seed powder, 10 parts of Sucralose and preservative 0.6 Part.
5. a kind of oral solution of calm nerves according to any one of claims 1-4, it is characterised in that: the preservative For the combination of one or both of sodium benzoate or methyl hydroxybenzoate sodium.
6. a kind of oral solution of calm nerves according to any one of claims 1-4, it is characterised in that: the ganoderma lucidum three Terpene is extracted by growing in the Wild ganoderma of 3-5.
7. a kind of oral solution of calm nerves according to any one of claims 1-4, it is characterised in that: the lycium ruthenicum Healthy and strong, the strong wild lycium ruthenicum of salt tolerant alkali ability is developed under full exposure.
8. a kind of oral solution of calm nerves described in -7 any one according to claim 1, it is characterised in that: preparation method Specifically includes the following steps:
S1, the lycium ruthenicum of selection being put into service sink first, clear water rinses 2-3 times, and so that lycium ruthenicum is able to carry out abundant cleaning, Then the lycium ruthenicum after cleaning is put into storage tank, is sufficiently squeezed using extrusion equipment lycium ruthenicum, black Chinese holly can be obtained Qi extract;
S2, the lycium ruthenicum extract that S1 is obtained is poured into heating furnace, while by the cannabidiol, ganodenic acid, wild jujube of selection Benevolence powder and Sucralose successively pour into heating furnace, then clear water surplus is added into heating furnace, and then lighting heating furnace will heat 20-30min is heated in furnace high fire, until boiling, the tanning 10-15min of small fire heating later can obtain initial liquid;
S3, the initial liquid for obtaining S2 are poured out out of heating furnace, filter out non-solid filter residue from medical fluid by filter screen Come, then repeats filtering 2-3 times, pure medical fluid can be obtained;
S4, the S3 medical fluid filtered is poured into static air-cooled 10-15min in mixing and blending machine, then pours into the preservative of selection In mixing and blending machine, it is that 400-500r/min stirs 30-50min with revolving speed, oral liquid product can be obtained;
S5, the S4 oral liquid product obtained is put into sterilization treatment in bactericidal unit, sterilize 20-30min;
S6, oral liquid product made from S4 is poured into bottle placer, starting filling apparatus progress is filling, then to canned mouth It takes liquid product to be packed, storage preservation is carried out to packaged oral liquid product later or sells.
CN201910244204.2A 2019-03-28 2019-03-28 A kind of oral solution of calm nerves and preparation method thereof Pending CN109939160A (en)

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Application publication date: 20190628