WO2021036122A1

WO2021036122A1 - Electronic cigarette liquid

Info

Publication number: WO2021036122A1
Application number: PCT/CN2019/127168
Authority: WO
Inventors: 许静; 姜兴涛; 熊赞华; 李馨铎
Original assignee: 深圳雾芯科技有限公司
Priority date: 2019-08-30
Filing date: 2019-12-20
Publication date: 2021-03-04
Also published as: CN110367582A

Abstract

An electronic cigarette liquid, comprising salidroside, wherein the content of salidroside in the electronic cigarette liquid is 0.09% to 10% based on the total weight of the electronic cigarette liquid. After the electronic cigarette liquid is atomized, the salidroside contained therein can be atomized together with the electronic cigarette liquid and finally absorbed by the human body. The salidroside has anti-fatigue, anti-aging, immune regulating, hypoxic oxygen tolerance improving, and cardiovascular protecting functions on the human body, and can make the mouthfeel of the electronic cigarette liquid after atomization more mellow and delicate and enrich the aroma of the aerosol, thereby improving the user experience.

Description

Electronic cigarette liquid

Technical field

This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid.

Background technique

Traditional tobacco smoking has many possible side effects, causing various diseases such as pharyngitis, bronchitis, pneumonia, emphysema, asthma, lung cancer, cardiovascular disease, gastric cancer, and decreased fertility. Among them, cardiovascular disease has become one of the primary diseases threatening human life and health. The harmful substances released by traditional tobacco burning at high temperature can damage the function of vascular endothelium, cause atherosclerosis, narrow arteries, block arterial blood flow, and cause cardiovascular and cerebrovascular diseases.

The low-temperature atomization of electronic cigarette oil is not easy to produce harmful substances such as tar, suspended particulates and carbon monoxide that are harmful to human health. The harm to users and others is far less than the harm of traditional cigarettes to the human body. Therefore, electronic cigarettes and electronic atomization devices have attracted more and more attention.

How to further generate aerosol for user inhalation that reduces harmful effects on the human body and improves the beneficial effects on the human body through low-temperature atomization is a research direction that needs to be improved in electronic cigarette products.

Summary of the invention

This application provides an e-cigarette liquid containing salidroside, in which the e-cigarette liquid is generated by an atomization device for the user to inhale the aerosol that can maintain salidroside that has a protective effect on the cardiovascular system, In turn, it is absorbed by the body to play a health care role. When the user smokes the e-cigarette liquid, it can meet people's dual needs for cigarette addiction and cardiovascular health care.

According to one aspect of the present application, the present application provides an e-cigarette liquid comprising salidroside, wherein the content of the salidroside in the e-cigarette liquid is calculated by the total weight of the e-cigarette liquid 0.09% to 10%.

According to another aspect of the present application, the present application provides an atomization device, which includes the above-mentioned e-cigarette liquid. The e-cigarette liquid of the present application can provide anti-fatigue, anti-depression, immunity enhancement, removal of reactive oxygen free radicals (ROS), anti-tumor effects, etc., thereby achieving the effect of cardiovascular health care on the human body during smoking.

The additional aspects and advantages of the embodiments of the present application will be partially described, shown, or explained through the implementation of the embodiments of the present application in the subsequent description.

Description of the drawings

Fig. 1A is a chromatogram of salidroside content in an electronic cigarette liquid according to an embodiment of the present application.

Fig. 1B is a chromatogram of salidroside content in aerosol generated by an electronic cigarette liquid according to an embodiment of the present application.

detailed description

The embodiments of this application will be described in detail below. The embodiments of this application should not be construed as limitations on this application.

In addition, sometimes amounts, ratios, and other numerical values are presented in range format herein. It should be understood that such a range format is for convenience and brevity, and should be understood flexibly, not only includes the values explicitly designated as range limits, but also includes all individual values or sub-ranges within the stated range, as if clearly Specify each value and sub-range in general.

As used herein, the terms "substantially", "substantially", "substantially", "substantially" and "about" are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term can refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely. For example, when used in conjunction with a value, the term can refer to a range of variation less than or equal to ±10% of the stated value, such as less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, Less than or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%. For example, if the difference between two values is less than or equal to ±10% of the average value of the value (for example, less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, less than Or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%), then the two values can be considered "substantially" the same.

In the detailed description and claims, a list of items connected by the terms "at least one of", "at least one of", "at least one of" or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase "at least one of A and B" means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C" means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C. Project A can contain a single element or multiple elements. Project B can contain a single element or multiple elements. Project C can contain a single element or multiple elements.

In this context, the term "aerosol for user inhalation" may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.

The present application provides an electronic cigarette liquid containing salidroside, which can have various beneficial effects such as anti-inflammatory, relieving cough, reducing phlegm, and inhibiting bacteria while inhaling the atomized electronic cigarette liquid.

According to one aspect of the present application, the present application provides an electronic cigarette liquid, which contains salidroside.

Salidroside has pharmacological activities such as anti-fatigue, anti-depression, strengthening immunity, scavenging active oxygen free radicals, anti-tumor, etc. It is often used to treat altitude sickness, and has certain effects on cardiovascular, cerebrovascular, nervous, and respiratory diseases. Curative effect. In some embodiments, when the e-liquid is formed into aerosol by the atomization device, the salidroside contained in it can not be damaged by high temperature and can be mixed with the e-liquid through atomization due to the effect of low-temperature atomization. In the aerosol, when the user inhales the aerosol, the salidroside can be directly absorbed, thereby having a protective effect on the cardiovascular system.

In some embodiments, the content of the salidroside in the e-cigarette liquid, based on the total weight of the e-cigarette liquid, is approximately, for example, 0.05%, 0.06%, 0.07%, 0.08%, 0.09% , 0.1%, 0.15%, 0.5%, 1.0%, 1.5%, 5.0%, 10.0%, 15% or any two of these parts. In some embodiments, the content of the salidroside in the electronic cigarette liquid is about 0.09% to about 10% based on the total weight of the electronic cigarette liquid, and the salidroside can atomize the electronic cigarette liquid The mouthfeel is more comfortable and milder, enriching the aroma of the smoke and improving the quality of the smoked food.

The e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin). In some embodiments, based on the total weight of the e-liquid, the content of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70% or any two of these weight percentages; and the content of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages. In some embodiments, the content of the propylene glycol in the e-cigarette liquid is about 20% to about 60%, and the content of the glycerol in the e-cigarette liquid is about 40% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.

Those skilled in the art should understand that the basic solvent can be any solvent known in the art, such as deionized water, propylene glycol, and glycerol, according to specific needs, without being limited.

In some embodiments, the electronic cigarette liquid further comprises a cooling agent, wherein the content of the cooling agent in the electronic cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.3%, 0.5%, 1.0% , 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages.

Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating. In some embodiments, the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutanamide) , WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N-( 4-methoxyphenyl)-p-menthyl-3-carboxamide), menthyl acetate and combinations thereof.

In some embodiments, the e-cigarette liquid further includes flavor components; wherein the flavor components are selected from the group consisting of proanthocyanidins, notoginsenosides, mesotanshinone, gypenosides, puerarin, and combinations thereof.

Proanthocyanidins have a strong antioxidant effect, can effectively scavenge free radicals, and have anti-inflammatory, anti-tumor, and blood vessel protection effects. Panax notoginseng saponins have the functions of promoting blood circulation, dissipating blood stasis, reducing swelling and pain, anti-myocardial ischemia, anti-arrhythmia, and mainly treating cardiovascular and cerebrovascular diseases; it has the effects of promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, clearing the heart and removing irritability, and cooling blood , Used to treat symptoms such as chest pain, abdominal pain, abdominal pain and hypochondriac pain. Tanshinone has the effects of antibacterial, anti-inflammatory, promoting blood circulation and removing blood stasis, and promoting wound healing. Gypenoside has the functions of lowering blood lipid, anti-mutagenic, anti-aging, enhancing immunity and protecting liver. Puerarin has the effects of relieving muscles, reducing fever, relieving alcohol and protecting the liver. It is clinically mainly used for symptoms such as exogenous fever, headache, high blood pressure, strong neck pain, and thirst. The electronic cigarette liquid of the present application can further inhibit the inflammation, cough, and sputum in the oral cavity and respiratory tract through the added flavor components, and achieve the effect of cardiovascular health care during use.

In some embodiments, the content of the flavor component in the e-cigarette liquid, based on the total weight of the e-cigarette liquid, is approximately, for example, 0.001%, 0.005%, 0.01%, 0.05%, 0.06%, 0.07 %, 0.08%, 0.09%, 0.1%, 0.15%, 0.5%, 1.0%, 1.5%, 5.0%, 10.0%, 15% or any two of these parts. In some embodiments, the content of the flavor component in the e-cigarette liquid is about 0.001% to about 10% based on the total weight of the e-cigarette liquid, and the flavor component can enable the e-cigarette liquid to be generated for The mouthfeel of the aerosol inhaled by the user is more mellow and delicate, which enriches the fragrance of the aerosol, thereby enhancing the user experience.

In some embodiments, the e-cigarette liquid further includes nicotine salt. In some embodiments, based on the total weight of the e-cigarette liquid, the content of the nicotine salt in the e-cigarette liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 1.0% , 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages. In some embodiments, the content of the nicotine salt in the e-cigarette liquid is about 0.001% to about 10.0% based on the total weight of the e-cigarette liquid.

It should be understood that those skilled in the art can select any known nicotine salt in the art to add to the e-cigarette liquid according to actual needs without limitation. In some embodiments, the nicotine salt comprises benzoate.

In some embodiments, the e-cigarette liquid further includes nicotine. In some embodiments, based on the total weight of the e-cigarette liquid, the content of the nicotine in the e-cigarette liquid is approximately, for example, 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, or any two of these weight percentages. In some embodiments, the content of the nicotine in the e-cigarette liquid is about 0.001% to about 5.0% based on the total weight of the e-cigarette liquid.

In some embodiments, the above-mentioned e-cigarette liquid can further include flavor.

In some embodiments, the flavor includes: at least one of linalool, citronellol, vanillin, limonene, and β-pinene.

Linalool has the scent of lily of the valley, and the aroma is quite good. Adding to the e-liquid can improve the aroma and taste of the aerosol generated by the e-liquid, thereby making the aroma of the aerosol generated by the e-liquid more transparent and fuller . Citronellol has a special aroma like fresh rose and has a bitter taste. Adding to the e-cigarette liquid can make the aroma in the generated aerosol more fresh. Vanillin has a pure vanilla flavor, a stable, pure, and odor-free aroma. Adding to the electronic cigarette liquid can make the generated aerosol more pure and delicate. Limonene has a lemon-like scent, and when added to the e-cigarette liquid, the aerosol generated can be fuller and sweeter. β-Pinene has a pure woody aroma. Adding to the electronic cigarette liquid can make the aroma of the generated aerosol more perfect, and it has a good adjustment effect on other flavors.

In some embodiments, the content of the flavor in the e-cigarette liquid, based on the total weight of the e-cigarette liquid, is approximately, for example, 0.01%, 0.1%, 0.25%, 0.5%, 1.0%, 2.0% , 3.0%, 4.0%, 5.0%, 6.0%, 8.0%, 10% or any two of these parts. In some embodiments, the content of the flavor in the e-cigarette liquid is about 0.5% to about 6% based on the total weight of the e-cigarette liquid.

According to some embodiments of the present application, the present application provides a method for preparing an e-cigarette liquid, which includes the following steps: dissolve a certain amount of salidroside in a basic solvent, and then add flavor ingredients, flavors, and nicotine salt, and then make it Mix uniformly to obtain e-cigarette liquid.

Those skilled in the art should understand that the electronic cigarette liquid of the embodiments of the present application can be manufactured by any suitable known method according to actual preparation requirements, without limitation.

According to another aspect of the present application, the present application provides an atomization device, wherein the atomization device includes the electronic cigarette liquid in the above embodiment. The electronic cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains salidroside that is not damaged by high temperature, and can produce anti-fatigue and anti-fatigue after being absorbed by the user. Aging, immune regulation, improving blood oxygen tolerance, protecting cardiovascular and other effects.

In some embodiments, the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.

Example

In order to facilitate a better understanding of this application, the following examples are used to illustrate. These examples belong to the scope of protection of this application, but do not limit the scope of protection of this application.

Example 1

Add 3 grams of salidroside to 47 grams of propylene glycol, and then add 50 grams of glycerol to mix, and stir evenly to obtain an electronic cigarette liquid.

Example 2

Add 3 grams of salidroside to 47 grams of propylene glycol, then add 3 grams of proanthocyanidins and 2 grams of tanshinone and mix well, then add 45 grams of glycerin and mix well, and stir well to obtain an electronic cigarette liquid.

Example 3

Add 3 grams of salidroside to 47 grams of propylene glycol, then add 1 gram of panax notoginseng saponins and 3 grams of gypenosides and mix well, then add 45 grams of glycerol and mix well, and stir well to obtain an electronic cigarette liquid.

Example 4

Add 3 grams of salidroside to 47 grams of propylene glycol, then add 2 grams of proanthocyanidins, 1 gram of panax notoginseng saponins, 1 gram of tanshinone and 1 gram of puerarin and mix well, then add 45 grams of glycerol and mix, and mix well to obtain Electronic cigarette liquid.

Example 5

Add 3 grams of salidroside to 47 grams of propylene glycol, and then add 2 grams of nicotine salt and 48 grams of glycerol to mix, and stir evenly to obtain an electronic cigarette liquid.

Example 6

Add 3 grams of salidroside to 47 grams of propylene glycol, then add 1.4 grams of vanillin, 0.005 grams of citronellol, and 48.6 grams of glycerol to mix, and stir evenly to obtain an electronic cigarette liquid.

Example 7

Add 1g of salidroside to 38g of propylene glycol, then add 3g of proanthocyanidin and 2g of tanshinone and mix well, then add 5g of nicotine salt, 0.8g of vanillin, 0.003g of citronellol and 48g of glycerol Mix and stir uniformly to obtain an electronic cigarette liquid.

Example 8

Add 2 grams of salidroside to 34 grams of propylene glycol, then add 1 gram of panax notoginseng saponins and 3 grams of gypenosides and mix well, then add 5 grams of nicotine salt, 1.6 grams of vanillin, 0.005 grams of citronellol and 53.4 grams of propylene The triol is mixed and stirred evenly to obtain an electronic cigarette liquid.

Example 9

Add 1 gram of salidroside to 38 grams of propylene glycol, then add 2 grams of proanthocyanidins, 1 gram of panax notoginseng saponins, 1 gram of tanshinone and 1 gram of gypenoside and mix well, then add 5 grams of nicotine salt, 0.6 grams of vanillin and Mix 50.4 grams of glycerol and stir evenly to obtain an electronic cigarette liquid.

Example 10

Add 3 grams of salidroside to 37 grams of propylene glycol, then add 1 gram of proanthocyanidin, 1 gram of panax notoginseng saponins, 1 gram of tanshinone and 2 grams of puerarin and mix well, then add 1 gram of nicotine salt, 0.5 grams of vanillin, 0.002 grams of citronellol and 52 grams of glycerol are mixed and stirred evenly to obtain an electronic cigarette liquid.

Subsequently, the e-cigarette liquid of Example 1 and its atomized aerosol were measured for salidroside content, and the taste scoring test of the e-cigarette liquids of Examples 1-10 was performed. The above test results are used to further illustrate the content of salidroside in the aerosol of the e-cigarette liquid of the present application during use, and the improvement of user experience.

Salidroside content test method;

The salidroside content is measured by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometer (UPLC/Q-TOF-MS).

Sample preparation: The e-cigarette liquid of Example 1 was used to generate the aerosol for inhalation by the user using the following suction method: the atomization device was an electronic cigarette, the suction time was 3.0 seconds ± 0.1 seconds, and the interval between puffs It is 30.0 seconds ± 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ± 0.3 mL. A Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then, an ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometer (UPLC/Q-TOF-MS) was used to determine the salidroside content of the e-cigarette liquid and its aerosol extraction solution.

Liquid chromatography test: Ultra-high performance liquid chromatography (UPLC) (model: Waters ACQUITY)

The H-Class HSS T3 C ₁₈ chromatographic column (2.1mm×100mm, 1.7μm) is used to measure the salidroside content of the e-cigarette liquid and its aerosol extraction solution. The liquid chromatography conditions are as follows: the mobile phase is acetonitrile formic acid solution (30:70, v/v), isocratic elution, flow rate of 0.3mL/min, column temperature of 35°C, and injection volume of 5μL.

Mass spectrometry conditions: using electrospray ion source (ESI source), in negative ion mode, ion source temperature is 150℃, desolvent gas temperature is 650℃, desolvent gas flow rate is 600 liters/hour, high energy channel collision voltage: 10V To 100V; the scanning range is from 100Da to 1200Da; the capillary voltage is 3.5kV; and the cone voltage is 65V.

1A and 1B are respectively the chromatograms of salidroside content measured by UPLC/Q-TOF-MS of the e-cigarette liquid and the aerosol generated according to an embodiment of the present application.

As shown in Figures 1A and 1B, there is salidroside in the aerosol of the e-cigarette liquid of the present application, and the composition of salidroside in the aerosol is basically the same as that in the e-cigarette liquid, and it is prevented from being destroyed by high-temperature combustion. . Therefore, salidroside can be effectively absorbed by the human body through the aerosol after the electronic cigarette, so that the user can achieve the effect of cardiovascular health care while smoking.

Taste score test method;

Statistical method: 20 reviewers were asked to rate the aerosol experience generated by the e-cigarette liquids of Examples 1-10 according to the evaluation indicators in Table 1.

Table 1

The test results of the e-cigarette liquids of Examples 1-10 through the taste scoring test are shown in Table 2 below.

Table 2

From the data in Table 2, it can be seen that the aerosol formed by the e-cigarette liquids of Examples 1-10 of the present application after atomization for users to inhale has a good user experience in terms of mouthfeel and taste. . In addition, by comparing the examples, it can be seen that adding flavor components to the electronic cigarette liquid can further enhance the taste and mouthfeel of the aerosol generated by the electronic cigarette liquid.

It should be understood from the foregoing embodiments of this application that this application provides an e-cigarette liquid containing salidroside, which can maintain a certain content in the aerosol generated by the atomization device for user inhalation The salidroside, which is absorbed by the human body, has a cardiovascular health effect. At the same time, the e-cigarette liquid further has the effects of anti-fatigue, anti-aging, immune regulation, and improving blood oxygen tolerance. The electronic cigarette liquid of the present application can be atomized by an atomizing device, and the mouthfeel after atomization is more mellow and delicate, which enriches the aroma of the aerosol, thereby enhancing the user experience.

Although the application has been described and illustrated with reference to the specific embodiments of the application, these descriptions and illustrations do not limit the application. Those skilled in the art can clearly understand that without departing from the true spirit and scope of the application as defined by the appended claims, various changes can be made to make specific situations, materials, material compositions, and materials The method or process is suitable for the goal, spirit and scope of this application. All such modifications are intended to be within the scope of the appended claims. Although the methods disclosed herein have been described with reference to specific operations performed in a specific order, it should be understood that these operations can be combined, subdivided, or reordered to form equivalent methods without departing from the teachings of this application. Therefore, unless specifically indicated herein, the order and grouping of operations is not a limitation of the present application.

The foregoing summarizes the features of several embodiments and details of this application. The embodiments described in this application can be easily used as a basis for designing or modifying other processes and structures for performing the same or similar purpose and/or obtaining the same or similar advantages of the embodiments introduced herein. Such equivalent constructions do not depart from the spirit and scope of the present application, and various changes, substitutions and changes can be made without departing from the spirit and scope of the present application.

Claims

An electronic cigarette liquid comprising salidroside, wherein the content of the salidroside in the electronic cigarette liquid is 0.09% to 10% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising nicotine salt, and the content of the nicotine salt in the electronic cigarette liquid is 0.001% to 10% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising nicotine, and the content of the nicotine in the electronic cigarette liquid is 0.001% to 5% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to any one of claims 1 to 3, further comprising a flavor.
The e-cigarette liquid according to claim 4, wherein the flavor includes at least one of linalool, citronellol, vanillin, limonene, and β-limonene.
The electronic cigarette liquid according to claim 5, wherein the content of the flavor in the electronic cigarette liquid is 0.5% to 6% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to any one of claims 1 to 3, further comprising a flavor component; wherein the flavor component is selected from the group consisting of proanthocyanidins, notoginseng saponins, tanshinone, gypenosides, puerarin and combinations thereof 'S group.
The electronic cigarette liquid according to claim 7, wherein the content of the flavor component in the electronic cigarette liquid is 0.001% to 10% based on the total weight of the electronic cigarette liquid.
An atomizing device comprising the electronic cigarette liquid according to any one of claims 1 to 8.
The atomization device according to claim 9, wherein the atomization device comprises an electronic cigarette, an ultrasonic atomizer or a mesh atomizer.