WO2021102653A1

WO2021102653A1 - E-liquid

Info

Publication number: WO2021102653A1
Application number: PCT/CN2019/120746
Authority: WO
Inventors: 许静; 李馨铎; 姜兴涛; 吴泽宏
Original assignee: 深圳雾芯科技有限公司
Priority date: 2019-11-25
Filing date: 2019-11-25
Publication date: 2021-06-03

Abstract

An e-liquid, comprising matrine, wherein the content of matrine in the e-liquid is 0.1% to 10% of the total weight of the e-liquid. When the e-liquid is atomized, the matrine comprised in the e-liquid may be atomized together with the cigarette liquid and absorbed by a human body, which has antibacterial, anti-inflammatory, anti-virus, liver protection, heat-clearing and dampness-drying effects on the human body.

Description

Electronic cigarette liquid

Technical field

This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid with functional components.

Background technique

Due to the pursuit of personal health, environmental protection and convenience of use, electronic cigarettes are becoming more and more popular among consumers as a substitute for traditional tobacco. The electronic cigarette or electronic atomizer atomizes the smoking material at a low temperature to form an aerosol for the user to inhale, to replace the smoke generated by the traditional tobacco burning at a high temperature. Among them, the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.

How to further generate aerosol for user inhalation that reduces harmful effects on the human body and improves the beneficial effects on the human body through low-temperature atomization is a research direction that needs to be improved in electronic cigarette products.

Summary of the invention

The present application provides an electronic cigarette liquid containing matrine, which can reduce possible inflammation or bacterial infection during the use of electronic cigarettes when matrine is added to the electronic cigarette liquid. The functional structure of matrine, which is in an aerosol state after being atomized by a nebulizer, is not destroyed so that it can be more easily absorbed by the human oral cavity and respiratory tract, thereby achieving the effects of antibacterial and anti-inflammatory, antiviral, liver protection, heat-clearing and damp-drying.

According to one aspect of the application, the application provides an e-cigarette liquid comprising matrine, wherein the content of the matrine in the e-cigarette liquid is 0.1% based on the total weight of the e-cigarette liquid To 10%.

According to another aspect of the present application, the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.

The additional aspects and advantages of the embodiments of the present application will be partially described, shown, or explained through the implementation of the embodiments of the present application in the subsequent description.

Description of the drawings

Fig. 1A is a chromatogram of the matrine content of an electronic cigarette liquid according to an embodiment of the present application.

Fig. 1B is a chromatogram of matrine content in the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.

Detailed ways

The embodiments of this application will be described in detail below. The embodiments of this application should not be construed as limitations on this application.

In addition, sometimes amounts, ratios, and other numerical values are presented in range format herein. It should be understood that such a range format is for convenience and brevity, and should be flexibly understood, not only including the values explicitly designated as range limits, but also encompassing all individual values or sub-ranges within the stated range, as if clearly Specify each value and sub-range in general.

As used herein, the terms "substantially", "substantially", "substantially", "substantially" and "about" are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely. For example, when used in conjunction with a value, the term can refer to a range of variation less than or equal to ±10% of the stated value, such as less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, Less than or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%. For example, if the difference between two values is less than or equal to ±10% of the average value of the value (for example, less than or equal to ±5%, less than or equal to ±4%, less than or equal to ±3%, less than Or equal to ±2%, less than or equal to ±1%, less than or equal to ±0.5%, less than or equal to ±0.1%, or less than or equal to ±0.05%), then the two values can be considered "substantially" the same.

In the detailed description and claims, a list of items connected by the terms "at least one of", "at least one of", "at least one of" or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase "at least one of A and B" means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C" means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C. Project A can contain a single element or multiple elements. Project B can contain a single element or multiple elements. Project C can contain a single element or multiple elements.

In this context, the term "aerosol for user inhalation" or "aerosol" may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.

According to one aspect of the present application, the present application provides an electronic cigarette liquid, which contains matrine.

The chemical formula of matrine is C ₁₅ H ₂₄ N ₂ O, and its structural formula is represented by the following formula 1.

Matrine is an alkaloid extracted from the roots, stems and fruits of the legume Sophora flavescens with ethanol and other organic solvents. It belongs to the lupin alkaloids, a derivative of quinolizidine, and has antibacterial, anti-inflammatory and antibacterial properties. Virus, liver protection, heat-clearing and damp-drying effects. It is used for dysentery, enteritis, hot shower, swelling and itching, eczema, eczema, etc. caused by the accumulation of damp heat. In addition, 0.3% to 1% matrine solution has a strong inhibitory effect on Streptococcus B, Shigella, Proteus, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In some embodiments, when the e-liquid is formed into aerosol through the atomization device, due to the effect of low-temperature atomization, the matrine contained in it can not be damaged by high temperature and can be mixed with the e-liquid through atomization. In the mist, when the user inhales the aerosol, the aerosol-like matrine can be directly absorbed, thereby having antibacterial and anti-inflammatory effects on the oral cavity and respiratory tract of the human body.

In some embodiments, the content of the matrine in the e-cigarette liquid, based on the total weight of the e-cigarette liquid, is approximately, for example, 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 10.0%, or any two of these parts. In some embodiments, the content of the matrine in the e-cigarette liquid is about 0.1% to about 5.0% based on the total weight of the e-cigarette liquid.

According to another aspect of the present application, the electronic cigarette liquid of some embodiments of the present application further includes flavor.

In some embodiments, the flavor includes at least one of methyl dihydrojasmonate, limonene, linalool, ethyl acetate, and benzyl alcohol.

Methyl dihydrojasmonate has a fresh jasmine aroma, which can make the aroma in the e-liquid more natural and longer lasting. Limonene has a lemon-like aroma, which can make the aroma in the smoke oil fuller and sweeter. Linalool has the scent of lily of the valley, the aroma is quite good, it can improve the aroma and taste of the e-liquid, making the aroma in the e-liquid more transparent and fuller. Ethyl acetate has a weak sweet fruit aroma, which can enhance the aroma in the smoke oil and at the same time enhance the solubility of aroma substances. Benzyl alcohol has an aromatic odor, which can make the aroma in the e-liquid release more uniform and lasting. In some embodiments, adding at least one of the above-mentioned flavors can make the matrine-containing e-cigarette liquid more comfortable and milder after being atomized, and enrich the aroma of the smoke, thereby improving the quality of smoking food.

In some embodiments, the flavor further comprises 1,4-cineole, α-pinene, α-terpineol, β-pinene, α-phellandrene, myrcene, β-ionone, γ -Terpinene, benzaldehyde, nerol, nerol, eugenol, p-mengene (1-p-

Ene-8-thiol), n-hexanol, terpineol formate, cis-jasmone, citral, triacetin, geraniol, and leaf alcohol. The flavor in this application may be a flavor in the prior art. In some embodiments, the flavor components are preferably as shown in Table 1.

In some embodiments, the weight of the flavor in the e-cigarette liquid is about 0.01% to about 10.0% based on the total weight of the e-cigarette liquid, for example, approximately 0.01%, 0.05%, 0.2%, 0.3%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any two of these weight percentages The composition range of the e-liquid can increase the flavor of the electronic cigarette liquid and optimize the taste of the aerosol generated. The weight of the flavor in the electronic cigarette liquid is about 0.5% to about 5% based on the total weight of the electronic cigarette liquid.

The e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin). In some embodiments, based on the total weight of the e-liquid, the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages. In some embodiments, the weight of the propylene glycol in the electronic cigarette liquid is about 15% to about 60%, and the weight of the glycerol in the electronic cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.

In some embodiments, the e-cigarette liquid further includes a cooling agent.

Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating. In some embodiments, the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.

In some embodiments, based on the total weight of the e-cigarette liquid, the weight of the cooling agent in the e-cigarette liquid is about 0.1% to about 10.0%, for example, approximately 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 10% or any two of these weight percentages. In some embodiments, the weight of the cooling agent in the e-cigarette liquid is about 0.5% to about 5.0% based on the total weight of the e-cigarette liquid, so as to increase the amount of the e-cigarette liquid generated for users The taste of the inhaled aerosol.

In some embodiments, the e-cigarette liquid further includes nicotine salt. In some embodiments, based on the total weight of the e-cigarette liquid, the weight of the nicotine salt in the e-cigarette liquid is less than 10%, for example, approximately 0.001%, 0.01%, 0.1% , 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages. In some embodiments, the weight of the nicotine salt in the e-cigarette liquid is about 1.0% to about 10.0% based on the total weight of the e-cigarette liquid.

In some embodiments, the e-cigarette liquid further includes nicotine. In some embodiments, based on the total weight of the e-liquid, the weight of the nicotine in the e-liquid in the e-liquid is approximately less than 5%, for example approximately 0.001%, 0.01%, 0.1% , 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages. In some embodiments, the weight of the nicotine in the e-cigarette liquid is about 0.05% to about 5.0% based on the total weight of the e-cigarette liquid.

According to some embodiments of the present application, the present application provides a method for preparing an electronic cigarette liquid, which includes the following steps: dissolving a certain amount of matrine in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid. However, it is well known in the art that the order of addition of the above-mentioned substances is not limited to the above-defined order, but can be adjusted as required.

According to another aspect of the present application, the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the above embodiments. The e-cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains matrine that is not damaged by high temperature, and can be produced by the user's oral cavity and respiratory tract after being absorbed by the user. Anti-bacterial, anti-inflammatory, anti-virus, liver protection, heat-clearing and damp-drying effects.

In some embodiments, the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.

Example

In order to facilitate a better understanding of this application, the following examples are used to illustrate. These examples belong to the protection scope of this application, but do not limit the protection scope of this application.

Flavor preparation:

Configure according to the weight ratio in Table 1 below, and mix to obtain flavor.

Example 1

Add 3 grams of matrine to the basic e-cigarette liquid mixed with 47 grams of propylene glycol and 50 grams of glycerol, and mix them evenly to obtain an electronic cigarette liquid.

Example 2

Add 3 grams of matrine to 44 grams of propylene glycol and 50 grams of glycerin to mix the basic smoke liquid, and stir evenly. Subsequently, 2 grams of menthol and 1 gram of flavor 2 are added to obtain an electronic cigarette liquid.

Example 3

Add 2 grams of matrine to the basic e-liquid mixed with 41.01 grams of propylene glycol and 53 grams of glycerol, and mix them evenly. Then, 0.99 g of nicotine, 2 g of menthol and 1 g of flavor 1 are added to obtain an electronic cigarette liquid.

Example 4

Add 2 grams of matrine to 41 grams of propylene glycol and 50 grams of glycerin to mix the basic smoke liquid, and stir evenly. Then, 1.8 grams of nicotine, 1.2 grams of benzoic acid, 2 grams of WS-23 and 2 grams of flavor 1 were added to obtain an electronic cigarette liquid.

Example 5

Add 1 g of matrine to 39.6 g of propylene glycol and 48 g of glycerin to mix the basic smoke liquid, and stir evenly. Subsequently, 3 g of nicotine, 2.4 g of benzoic acid, 1 g of WS-23, 2 g of menthol and 3 g of flavor 1 were added to obtain an electronic cigarette liquid.

Example 6

Add 1 g of matrine to 37.5 g of propylene glycol and 46 g of glycerin to mix the basic smoke liquid, and stir evenly. Subsequently, 5 g of nicotine, 4.5 g of benzoic acid, 1 g of WS-23, 1 g of menthol and 4 g of flavor 1 are added to obtain an electronic cigarette liquid.

Example 7

Add 1 gram of matrine to 38.5 grams of propylene glycol and 43 grams of glycerin to mix the basic smoke liquid, and stir evenly. Then 4 grams of nicotine, 4.5 grams of benzoic acid, 2 grams of WS-23, 1 grams of menthol and 6 grams of flavor 2 are added to obtain an electronic cigarette liquid.

The composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.

Table 1

The matrine content of the e-cigarette liquid of Example 1 and its atomized aerosol were measured, and the taste scoring test of the e-cigarette liquid of Examples 1-6 was performed. The above test results are used to further illustrate the content of matrine in the aerosol of the electronic cigarette liquid of the present application during use, and the improvement of user experience.

Matrine content test method;

The content of matrine is measured by ultra performance liquid chromatography (UPLC).

Sample preparation: The e-cigarette liquid of Example 1 is used to generate aerosol for user inhalation by the following suction methods: the atomization device is an electronic cigarette, the suction time is 3.0 seconds ± 0.1 seconds, and the interval between puffs It is 30.0 seconds ± 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ± 0.3 mL. A Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then use Ultra Performance Liquid Chromatography (UPLC) to determine the content of matrine in the e-cigarette liquid and its aerosol extraction solution

Liquid chromatography conditions: Waters ACQUITY

(H-Class HSS T3 C18) chromatographic column (2.1mm×100mm, 1.8μm), mobile phase is acetonitrile-0.1% formic acid solution (15:85, v/v), isocratic elution, flow rate is 0.3mL/min , The column temperature is 35℃, the injection volume is 3μL, and the detection wavelength is 220nm.

Figures 1A and 1B are respectively chromatograms of matrine content measured by UPLC of an electronic cigarette liquid and aerosol generated therefrom according to an embodiment of the present application.

As shown in Figures 1A and 1B, matrine is present in the aerosol of the e-cigarette liquid of the present application, and the matrine in the aerosol is basically the same as that in the e-cigarette liquid, and it is prevented from being destroyed by high-temperature combustion. Therefore, matrine can be effectively delivered to the mouth and respiratory tract of the user through the aerosol after the electronic cigarette, so that the user can achieve antibacterial and anti-inflammatory effects on the mouth and respiratory tract while smoking.

Taste score test method 1

20 reviewers were asked to rate the e-cigarette aerosol experience of the foregoing Examples 1-6 according to the evaluation indicators in Table 2. The evaluation results are shown in Table 3 below.

Table 2

table 3

Taste score test method 2;

Statistical method: Randomly select 1000 users to test the use of the e-cigarette liquids of the above examples 1-6 through e-cigarettes, and evaluate their taste and mouthfeel after the use test. The evaluation standard is based on a total score of 10 points. The better or better the taste, the higher the score.

The test results of the e-cigarette liquids of Examples 1-6 through the mouthfeel scoring test are shown in Table 4 below.

Table 4

It can be seen from the data in Table 2-4 that the e-cigarette liquids of Examples 1-6 of the present application produce matrine-containing aerosols for users to inhale after atomization, whether in terms of taste or taste. Can achieve a certain degree of customer satisfaction. In addition, compared to Example 1, the e-cigarette liquid added with the flavor provided in the example of the present application has a significant improvement in the taste score test.

By comparing Examples 2-7, it can be seen that the flavor concentration in the electronic cigarette liquid of the present application has the best user experience in the range of 0.5 wt% to 5.0 wt%.

It should be understood from the above-mentioned embodiments of this application that this application provides an e-cigarette liquid, through which matrine contained in the e-cigarette liquid can allow users to inhale the e-cigarette mist while introducing it into the oral cavity and respiratory tract. The aerosol molecules of matrine can achieve antibacterial and anti-inflammatory effects. At the same time, the e-cigarette liquid can form a uniform and strong aerosol when the user inhales by adding a specific flavor, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby optimizing the user experience.

Although the application has been described and illustrated with reference to the specific embodiments of the application, these descriptions and illustrations do not limit the application. Those skilled in the art can clearly understand that without departing from the true spirit and scope of the application as defined by the appended claims, various changes can be made (for example, the ingredients in the fragrance components of the application can be changed). Appropriate increase, decrease and change) to make the specific situation, material, material composition, substance, method or process suitable for the goal, spirit and scope of the application. All such modifications are intended to be within the scope of the appended claims. Although the methods disclosed herein have been described with reference to specific operations performed in a specific order, it should be understood that these operations can be combined, subdivided, or reordered to form equivalent methods without departing from the teachings of this application. Therefore, unless specifically indicated herein, the order and grouping of operations is not a limitation of the present application.

Claims

An electronic cigarette liquid comprising matrine, wherein the weight of the matrine in the electronic cigarette liquid is 0.1% to 10.0% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising a flavor.
The e-cigarette liquid according to claim 2, wherein the flavor comprises at least one of methyl dihydrojasmonate, limonene, linalool, ethyl acetate, and benzyl alcohol.
The electronic cigarette liquid according to claim 2 or 3, wherein the weight of the flavor in the electronic cigarette liquid is 0.01% to 10.0% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising a cooling agent, wherein the cooling agent is selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23(N,2, 3-trimethyl-2-isopropylbutanamide), WS-3 (N-ethyl-p-menthyl-3-carboxamide), WS-5 (N-(ethoxycarbonylmethyl)-p-alkane) -3-carboxamide), WS-12 (N-(4-methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
The electronic cigarette liquid according to claim 5, wherein the weight of the cooling agent in the electronic cigarette liquid is 0.1% to 10% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising nicotine salt, and the weight of the nicotine salt in the electronic cigarette liquid is less than 10.0% based on the total weight of the electronic cigarette liquid.
The electronic cigarette liquid according to claim 1, further comprising nicotine, and the weight of the nicotine in the electronic cigarette liquid is less than 5.0% based on the total weight of the electronic cigarette liquid.
An atomizing device comprising the electronic cigarette liquid according to any one of claims 1 to 8.
The atomization device according to claim 9, wherein the atomization device comprises an electronic cigarette, an ultrasonic atomizer or a mesh atomizer.