WO2021102653A1 - Liquide à vapoter - Google Patents

Liquide à vapoter Download PDF

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Publication number
WO2021102653A1
WO2021102653A1 PCT/CN2019/120746 CN2019120746W WO2021102653A1 WO 2021102653 A1 WO2021102653 A1 WO 2021102653A1 CN 2019120746 W CN2019120746 W CN 2019120746W WO 2021102653 A1 WO2021102653 A1 WO 2021102653A1
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WO
WIPO (PCT)
Prior art keywords
cigarette liquid
electronic cigarette
liquid
matrine
weight
Prior art date
Application number
PCT/CN2019/120746
Other languages
English (en)
Chinese (zh)
Inventor
许静
李馨铎
姜兴涛
吴泽宏
Original Assignee
深圳雾芯科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳雾芯科技有限公司 filed Critical 深圳雾芯科技有限公司
Priority to PCT/CN2019/120746 priority Critical patent/WO2021102653A1/fr
Publication of WO2021102653A1 publication Critical patent/WO2021102653A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid with functional components.
  • the electronic cigarette or electronic atomizer atomizes the smoking material at a low temperature to form an aerosol for the user to inhale, to replace the smoke generated by the traditional tobacco burning at a high temperature.
  • the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.
  • the present application provides an electronic cigarette liquid containing matrine, which can reduce possible inflammation or bacterial infection during the use of electronic cigarettes when matrine is added to the electronic cigarette liquid.
  • the functional structure of matrine which is in an aerosol state after being atomized by a nebulizer, is not destroyed so that it can be more easily absorbed by the human oral cavity and respiratory tract, thereby achieving the effects of antibacterial and anti-inflammatory, antiviral, liver protection, heat-clearing and damp-drying.
  • the application provides an e-cigarette liquid comprising matrine, wherein the content of the matrine in the e-cigarette liquid is 0.1% based on the total weight of the e-cigarette liquid To 10%.
  • the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.
  • Fig. 1A is a chromatogram of the matrine content of an electronic cigarette liquid according to an embodiment of the present application.
  • Fig. 1B is a chromatogram of matrine content in the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single element or multiple elements.
  • aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
  • the present application provides an electronic cigarette liquid, which contains matrine.
  • Matrine is an alkaloid extracted from the roots, stems and fruits of the legume Sophora flavescens with ethanol and other organic solvents. It belongs to the lupin alkaloids, a derivative of quinolizidine, and has antibacterial, anti-inflammatory and antibacterial properties. Virus, liver protection, heat-clearing and damp-drying effects. It is used for dysentery, enteritis, hot shower, swelling and itching, eczema, eczema, etc. caused by the accumulation of damp heat.
  • 0.3% to 1% matrine solution has a strong inhibitory effect on Streptococcus B, Shigella, Proteus, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
  • the matrine contained in it when the e-liquid is formed into aerosol through the atomization device, due to the effect of low-temperature atomization, the matrine contained in it can not be damaged by high temperature and can be mixed with the e-liquid through atomization.
  • the aerosol-like matrine can be directly absorbed, thereby having antibacterial and anti-inflammatory effects on the oral cavity and respiratory tract of the human body.
  • the content of the matrine in the e-cigarette liquid is approximately, for example, 0.1%, 0.2%, 0.5%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 10.0%, or any two of these parts. In some embodiments, the content of the matrine in the e-cigarette liquid is about 0.1% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the electronic cigarette liquid of some embodiments of the present application further includes flavor.
  • the flavor includes at least one of methyl dihydrojasmonate, limonene, linalool, ethyl acetate, and benzyl alcohol.
  • Methyl dihydrojasmonate has a fresh jasmine aroma, which can make the aroma in the e-liquid more natural and longer lasting.
  • Limonene has a lemon-like aroma, which can make the aroma in the smoke oil fuller and sweeter.
  • Linalool has the scent of lily of the valley, the aroma is quite good, it can improve the aroma and taste of the e-liquid, making the aroma in the e-liquid more transparent and fuller.
  • Ethyl acetate has a weak sweet fruit aroma, which can enhance the aroma in the smoke oil and at the same time enhance the solubility of aroma substances.
  • Benzyl alcohol has an aromatic odor, which can make the aroma in the e-liquid release more uniform and lasting.
  • adding at least one of the above-mentioned flavors can make the matrine-containing e-cigarette liquid more comfortable and milder after being atomized, and enrich the aroma of the smoke, thereby improving the quality of smoking food.
  • the flavor further comprises 1,4-cineole, ⁇ -pinene, ⁇ -terpineol, ⁇ -pinene, ⁇ -phellandrene, myrcene, ⁇ -ionone, ⁇ -Terpinene, benzaldehyde, nerol, nerol, eugenol, p-mengene (1-p- Ene-8-thiol), n-hexanol, terpineol formate, cis-jasmone, citral, triacetin, geraniol, and leaf alcohol.
  • the flavor in this application may be a flavor in the prior art.
  • the flavor components are preferably as shown in Table 1.
  • the weight of the flavor in the e-cigarette liquid is about 0.01% to about 10.0% based on the total weight of the e-cigarette liquid, for example, approximately 0.01%, 0.05%, 0.2%, 0.3%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any two of these weight percentages
  • the composition range of the e-liquid can increase the flavor of the electronic cigarette liquid and optimize the taste of the aerosol generated.
  • the weight of the flavor in the electronic cigarette liquid is about 0.5% to about 5% based on the total weight of the electronic cigarette liquid.
  • the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
  • the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages.
  • the weight of the propylene glycol in the electronic cigarette liquid is about 15% to about 60%, and the weight of the glycerol in the electronic cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
  • the e-cigarette liquid further includes a cooling agent.
  • Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
  • the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
  • the weight of the cooling agent in the e-cigarette liquid is about 0.1% to about 10.0%, for example, approximately 0.1%, 0.2%, 0.3%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 10% or any two of these weight percentages. In some embodiments, the weight of the cooling agent in the e-cigarette liquid is about 0.5% to about 5.0% based on the total weight of the e-cigarette liquid, so as to increase the amount of the e-cigarette liquid generated for users The taste of the inhaled aerosol.
  • the e-cigarette liquid further includes nicotine salt.
  • the weight of the nicotine salt in the e-cigarette liquid is less than 10%, for example, approximately 0.001%, 0.01%, 0.1% , 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or any two of these weight percentages.
  • the weight of the nicotine salt in the e-cigarette liquid is about 1.0% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid further includes nicotine.
  • the weight of the nicotine in the e-liquid in the e-liquid is approximately less than 5%, for example approximately 0.001%, 0.01%, 0.1% , 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages.
  • the weight of the nicotine in the e-cigarette liquid is about 0.05% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the present application provides a method for preparing an electronic cigarette liquid, which includes the following steps: dissolving a certain amount of matrine in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • a method for preparing an electronic cigarette liquid which includes the following steps: dissolving a certain amount of matrine in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • the order of addition of the above-mentioned substances is not limited to the above-defined order, but can be adjusted as required.
  • the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the above embodiments.
  • the e-cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains matrine that is not damaged by high temperature, and can be produced by the user's oral cavity and respiratory tract after being absorbed by the user.
  • Anti-bacterial, anti-inflammatory, anti-virus, liver protection, heat-clearing and damp-drying effects are examples of the aerosol.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Flavor preparation :
  • composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.
  • the matrine content of the e-cigarette liquid of Example 1 and its atomized aerosol were measured, and the taste scoring test of the e-cigarette liquid of Examples 1-6 was performed.
  • the above test results are used to further illustrate the content of matrine in the aerosol of the electronic cigarette liquid of the present application during use, and the improvement of user experience.
  • the content of matrine is measured by ultra performance liquid chromatography (UPLC).
  • the e-cigarette liquid of Example 1 is used to generate aerosol for user inhalation by the following suction methods: the atomization device is an electronic cigarette, the suction time is 3.0 seconds ⁇ 0.1 seconds, and the interval between puffs It is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
  • a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then use Ultra Performance Liquid Chromatography (UPLC) to determine the content of matrine in the e-cigarette liquid and its aerosol extraction solution
  • UPLC Ultra Performance Liquid Chromatography
  • Liquid chromatography conditions Waters ACQUITY (H-Class HSS T3 C18) chromatographic column (2.1mm ⁇ 100mm, 1.8 ⁇ m), mobile phase is acetonitrile-0.1% formic acid solution (15:85, v/v), isocratic elution, flow rate is 0.3mL/min , The column temperature is 35°C, the injection volume is 3 ⁇ L, and the detection wavelength is 220nm.
  • Figures 1A and 1B are respectively chromatograms of matrine content measured by UPLC of an electronic cigarette liquid and aerosol generated therefrom according to an embodiment of the present application.
  • matrine is present in the aerosol of the e-cigarette liquid of the present application, and the matrine in the aerosol is basically the same as that in the e-cigarette liquid, and it is prevented from being destroyed by high-temperature combustion. Therefore, matrine can be effectively delivered to the mouth and respiratory tract of the user through the aerosol after the electronic cigarette, so that the user can achieve antibacterial and anti-inflammatory effects on the mouth and respiratory tract while smoking.
  • Statistical method Randomly select 1000 users to test the use of the e-cigarette liquids of the above examples 1-6 through e-cigarettes, and evaluate their taste and mouthfeel after the use test.
  • the evaluation standard is based on a total score of 10 points. The better or better the taste, the higher the score.
  • this application provides an e-cigarette liquid, through which matrine contained in the e-cigarette liquid can allow users to inhale the e-cigarette mist while introducing it into the oral cavity and respiratory tract.
  • the aerosol molecules of matrine can achieve antibacterial and anti-inflammatory effects.
  • the e-cigarette liquid can form a uniform and strong aerosol when the user inhales by adding a specific flavor, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby optimizing the user experience.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un liquide à vapoter comprenant de la matrine, la teneur en matrine dans le liquide à vapoter représentant de 0,1% à 10 % du poids total du liquide à vapoter. Lorsque le liquide à vapoter est atomisé, la matrine contenue dans le liquide à vapoter peut être atomisée conjointement avec le liquide de cigarette et absorbée par un corps humain, ce qui présente des effets antibactériens, anti-inflammatoires, anti-virus, de protection du foie, de dégagement de chaleur et de séchage de l'humidité sur le corps humain.
PCT/CN2019/120746 2019-11-25 2019-11-25 Liquide à vapoter WO2021102653A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/120746 WO2021102653A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/120746 WO2021102653A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

Publications (1)

Publication Number Publication Date
WO2021102653A1 true WO2021102653A1 (fr) 2021-06-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/120746 WO2021102653A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

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WO (1) WO2021102653A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1124604A (zh) * 1994-12-17 1996-06-19 杨昶 香参烟用添加剂
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN108618190A (zh) * 2018-08-15 2018-10-09 云南中烟工业有限责任公司 一种电子烟烟液
CN109588761A (zh) * 2019-01-18 2019-04-09 薪火高科(深圳)有限公司 一种具有止咳化痰功效的电子烟烟液
CN110353298A (zh) * 2019-08-30 2019-10-22 深圳雾芯科技有限公司 电子烟液
CN110419764A (zh) * 2019-07-26 2019-11-08 深圳雾芯科技有限公司 口香糖、电子烟液及其用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1124604A (zh) * 1994-12-17 1996-06-19 杨昶 香参烟用添加剂
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN108618190A (zh) * 2018-08-15 2018-10-09 云南中烟工业有限责任公司 一种电子烟烟液
CN109588761A (zh) * 2019-01-18 2019-04-09 薪火高科(深圳)有限公司 一种具有止咳化痰功效的电子烟烟液
CN110419764A (zh) * 2019-07-26 2019-11-08 深圳雾芯科技有限公司 口香糖、电子烟液及其用途
CN110353298A (zh) * 2019-08-30 2019-10-22 深圳雾芯科技有限公司 电子烟液

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