WO2021102652A1 - Liquide à vapoter - Google Patents

Liquide à vapoter Download PDF

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Publication number
WO2021102652A1
WO2021102652A1 PCT/CN2019/120744 CN2019120744W WO2021102652A1 WO 2021102652 A1 WO2021102652 A1 WO 2021102652A1 CN 2019120744 W CN2019120744 W CN 2019120744W WO 2021102652 A1 WO2021102652 A1 WO 2021102652A1
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WO
WIPO (PCT)
Prior art keywords
cigarette liquid
electronic cigarette
liquid
quercetin
weight
Prior art date
Application number
PCT/CN2019/120744
Other languages
English (en)
Chinese (zh)
Inventor
许静
李馨铎
姜兴涛
吴泽宏
Original Assignee
深圳雾芯科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳雾芯科技有限公司 filed Critical 深圳雾芯科技有限公司
Priority to PCT/CN2019/120744 priority Critical patent/WO2021102652A1/fr
Publication of WO2021102652A1 publication Critical patent/WO2021102652A1/fr

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F47/00—Smokers' requisites not otherwise provided for

Definitions

  • This application relates to the field of electronic aerosols or electronic atomization devices, and in particular to an electronic cigarette liquid with functional components.
  • the electronic cigarette or electronic atomizer atomizes the smoking material at a low temperature to form an aerosol for the user to inhale, to replace the smoke generated by the traditional tobacco burning at a high temperature.
  • the electronic cigarette liquid has a certain impact on the user's experience and taste, and even the health of the human body.
  • This application provides an e-cigarette liquid containing quercetin.
  • quercetin to the e-cigarette liquid can reduce the cough, phlegm and inflammation that may be caused during the use of the e-cigarette.
  • the functional structure of quercetin which is in aerosol state after being atomized by a nebulizer, is not destroyed so that it can be more easily absorbed by the human oral cavity and respiratory tract, thereby achieving the effects of antibacterial, anti-inflammatory, anti-cough and expectorant.
  • the application provides an e-cigarette liquid comprising quercetin, wherein the content of the quercetin in the e-cigarette liquid is 0.01% based on the total weight of the e-cigarette liquid To 3.0%.
  • the present application provides an atomization device, which includes the above-mentioned electronic cigarette liquid.
  • Fig. 1A is a chromatogram of the quercetin content of an electronic cigarette liquid according to an embodiment of the present application.
  • Fig. 1B is a chromatogram of the quercetin content of the aerosol generated by the electronic cigarette liquid according to an embodiment of the present application.
  • the terms “substantially”, “substantially”, “substantially”, “substantially” and “about” are used to describe and illustrate small changes. When used in conjunction with an event or situation, the term may refer to an example in which the event or situation occurs precisely and an example in which the event or situation occurs very closely.
  • the term when used in conjunction with a value, can refer to a range of variation less than or equal to ⁇ 10% of the stated value, such as less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, Less than or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%.
  • the difference between two values is less than or equal to ⁇ 10% of the average value of the value (for example, less than or equal to ⁇ 5%, less than or equal to ⁇ 4%, less than or equal to ⁇ 3%, less than Or equal to ⁇ 2%, less than or equal to ⁇ 1%, less than or equal to ⁇ 0.5%, less than or equal to ⁇ 0.1%, or less than or equal to ⁇ 0.05%), then the two values can be considered "substantially" the same.
  • a list of items connected by the terms “at least one of”, “at least one of”, “at least one of” or other similar terms may mean the listed items Any combination of. For example, if items A and B are listed, then the phrase “at least one of A and B” means only A; only B; or A and B. In another example, if items A, B, and C are listed, then the phrase "at least one of A, B, and C” means only A; or only B; only C; A and B (excluding C); A and C (exclude B); B and C (exclude A); or all of A, B, and C.
  • Project A can contain a single element or multiple elements.
  • Project B can contain a single element or multiple elements.
  • Project C can contain a single element or multiple elements.
  • aerosol for user inhalation may include, but is not limited to, aerosols, suspended liquids, low-temperature vapors, and volatile gases.
  • the present application provides an e-cigarette liquid, which contains quercetin.
  • quercetin is C 15 H 10 O 7 , and its structural formula is represented by the following formula 1.
  • Quercetin is an expectorant commonly used clinically in Chinese medicine. This product has good expectorant and cough-relieving effects, as well as a certain anti-asthmatic effect. It also lowers blood pressure, improves capillary resistance, and reduces capillary fragility. , Lower blood lipids, expand coronary arteries, increase coronary blood flow pharmacological functions. In addition, quercetin has anti-tumor, anti-oxidant, anti-bacterial and anti-inflammatory effects. Its anti-oxidation effect is mainly achieved through three aspects: direct scavenging of active oxygen free radicals, chelating metal ions, and inhibiting LDL oxidative damage.
  • the quercetin contained in it when the e-liquid is formed into aerosol through the atomization device, due to the effect of low-temperature atomization, the quercetin contained in it can not be damaged by high temperature and can be mixed with the e-liquid through atomization. In the mist, when the user inhales the aerosol, the aerosol-like quercetin can be directly absorbed, thereby having the effects of antibacterial, anti-inflammatory, expectorant and cough relieving on the oral cavity and respiratory tract of the human body.
  • the content of the quercetin in the e-cigarette liquid is approximately, for example, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.7%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 10.0%, or a range composed of any two of these parts. In some embodiments, the content of the quercetin in the e-cigarette liquid is about 0.01% to 1.0% based on the total weight of the e-cigarette liquid.
  • the electronic cigarette liquid of some embodiments of the present application further includes flavor.
  • the flavor includes at least one of vanillin, ⁇ -pinene, linalool, limonene, and ethyl maltol.
  • Vanillin has a pure vanilla flavor, stable, pure, and odor-free aroma, which can make the aroma in the e-liquid more pure and delicate.
  • ⁇ -Pinene has a pure woody aroma, which can make the aroma in the e-liquid more perfect, and has a good regulating effect on other aroma types.
  • Linalool has the scent of lily of the valley, the aroma is quite good, it can improve the aroma and taste of the e-liquid, making the aroma in the e-liquid more transparent and fuller.
  • Limonene has a lemon-like aroma, which can make the aroma in the smoke oil fuller and sweeter.
  • Ethyl maltol has a caramel aroma and a fruity taste, which can improve the aroma in the smoke oil and at the same time make the aroma more full.
  • adding at least one of the above-mentioned flavors can make the mouthfeel of the quercetin-containing e-cigarette liquid after atomization more comfortable and milder, and enrich the aroma of the smoke, thereby improving the quality of smoking food.
  • the flavor further comprises ethyl 3-hydroxybutyrate, 3-carene, ⁇ -pinene, ⁇ -terpineol, myrcene, ⁇ -heptanolide, ⁇ -decanolide, ⁇ -caprolactone, ⁇ -nonanolactone, peach aldehyde, ⁇ -caprolactone, benzyl alcohol, benzoic acid, diethyl malonate, pineapple ester (allyl 3-cyclohexyl propionate), butyric acid , Ethyl butyrate, diphenyl ether, furanone (4-hydroxy-2,5-dimethyl-3(2H)-furanone), caproic acid, hexyl hexanoate, allyl hexanoate, hexyl formate At least one of ester, triethyl citrate, glyceryl triacetate, ⁇ -caryophyllene, phytol, phytol acetate,
  • the weight of the flavor in the e-cigarette liquid is about 0.01% to about 10.0% based on the total weight of the e-cigarette liquid, for example, approximately 0.01%, 0.05%, 0.2%, 0.3%. %, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any two of these weight percentages
  • the composition range of the e-liquid can increase the flavor of the electronic cigarette liquid and optimize the taste of the aerosol generated.
  • the weight of the flavor in the e-cigarette liquid is about 0.5% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid also includes a base solvent, wherein the base solvent includes propylene glycol and glycerol (glycerin).
  • the weight of propylene glycol in the e-liquid is approximately, for example, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, or any two of these weight percentages; and the weight of glycerol in the e-cigarette liquid is roughly, for example, 30%, 35%, 40%, 45%, 50%, 55% , 60%, 65%, 70% or any two of these weight percentages.
  • the weight of the propylene glycol in the electronic cigarette liquid is about 15% to about 60%, and the weight of the glycerol in the electronic cigarette liquid is about 30% to about 70%, so that the electronic cigarette The smoke liquid achieves the best atomization effect and improves the user experience.
  • the e-cigarette liquid further includes a cooling agent.
  • Cooling agents are additives, which are chemicals that can give users a cooling effect when the product is in use and are not very irritating.
  • the cooling agent includes selected from the group consisting of menthol, menthone, isomenthone, 1-menthyl lactate, WS-23 (N,2,3-trimethyl-2-isopropylbutyl Amide), WS-3(N-ethyl-p-menthyl-3-carboxamide), WS-5(N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide), WS-12(N -(4-Methoxyphenyl)-p-menthyl-3-carboxamide) and combinations thereof.
  • the weight of the cooling agent in the e-cigarette liquid is about 0.1% to about 10%, such as approximately 0.1%, 0.2%, 0.3%, 0.5%. %, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 10% or any two of these weight percentages. In some embodiments, the weight of the cooling agent in the e-cigarette liquid is about 0.5% to about 5.0% based on the total weight of the e-cigarette liquid, so as to increase the amount of the e-cigarette liquid generated for users The taste of the inhaled aerosol.
  • the e-cigarette liquid further includes nicotine salt.
  • the weight of the nicotine salt in the e-cigarette liquid is less than 10%, such as approximately 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5%, 7.5%, 10% or a range composed of any two of these weight percentages.
  • the weight of the nicotine salt in the e-cigarette liquid is about 1.5% to about 10.0% based on the total weight of the e-cigarette liquid.
  • the e-cigarette liquid further includes nicotine.
  • the weight of the nicotine in the e-liquid in the e-liquid is less than 5%, for example, approximately 0.001%, 0.01%, 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 5% or any two of these weight percentages.
  • the weight of the nicotine in the e-cigarette liquid is about 0.05% to about 5.0% based on the total weight of the e-cigarette liquid.
  • the present application provides a method for preparing an electronic cigarette liquid, which includes the following steps: dissolving a certain amount of quercetin in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • a method for preparing an electronic cigarette liquid which includes the following steps: dissolving a certain amount of quercetin in a basic solvent, and then adding flavor, cooling agent, nicotine or a salt thereof. Then, it is uniformly mixed to obtain an electronic cigarette liquid.
  • the order of addition of the above-mentioned substances is not limited to the above-defined order, but can be adjusted as required.
  • the present application provides an atomization device, which includes the electronic cigarette liquid described in any of the above embodiments.
  • the e-cigarette liquid can be atomized by the atomizing device to generate an aerosol for the user to inhale, wherein the aerosol contains quercetin that is not damaged by high temperature, and can be produced by the user's oral cavity and respiratory tract after being absorbed by the user. Anti-bacterial, anti-inflammatory, anti-cough and expectorant effects, thereby improving the user experience.
  • the atomization device includes an electronic cigarette, an ultrasonic atomizer, or a mesh atomizer.
  • Flavor preparation :
  • quercetin 0.1 g is added to the basic e-liquid mixed with 49.9 g of propylene glycol and 50 g of glycerol, mixed, and stirred evenly to obtain an electronic cigarette liquid.
  • composition of the fragrance in the above-mentioned embodiment is shown in Table 1 below.
  • the quercetin content of the e-cigarette liquid of Example 1 and its atomized aerosol was measured, and the taste scoring test was performed on the e-cigarette liquid of Examples 1-6.
  • the above test results are used to further illustrate the content of quercetin in the aerosol of the e-cigarette liquid of the present application during use and the improvement of user experience.
  • Quercetin content measurement is carried out by ultra-high performance liquid chromatography (UPLC).
  • the e-cigarette liquid of Example 1 is used to generate aerosol for user inhalation by the following suction methods: the atomization device is an electronic cigarette, the suction time is 3.0 seconds ⁇ 0.1 seconds, and the interval between puffs It is 30.0 seconds ⁇ 0.5 seconds, the number of puffs is 50 times, and the volume of each puff is 55 mL ⁇ 0.3 mL.
  • a Cambridge filter was used to collect the aerosol, and 10 mL of methanol was used to immerse the Cambridge filter. After 30 minutes of ultrasonic extraction, a flue gas extraction solution was obtained. Then use ultra high performance liquid chromatography (UPLC) to determine the content of quercetin in the e-cigarette liquid and its aerosol extraction solution
  • UPLC ultra high performance liquid chromatography
  • Liquid chromatography conditions Waters ACQUITY (H-Class HSS T3 C18) chromatographic column (2.1mm ⁇ 100mm, 1.8 ⁇ m), mobile phase is acetonitrile-0.1% formic acid solution (30:70, v/v), isocratic elution, flow rate is 0.3mL/min , Column temperature 35°C, injection volume 3 ⁇ L, detection wavelength 256, 371nm.
  • 1A and 1B are respectively chromatograms of the quercetin content measured by UPLC of the e-cigarette liquid and the aerosol generated therefrom according to an embodiment of the present application.
  • quercetin is present in the aerosol of the e-cigarette liquid of the present application, and the composition of the quercetin in the aerosol is basically the same as that in the e-cigarette liquid, and is prevented from being destroyed by high-temperature combustion. Therefore, the aerosol of quercetin can be effectively delivered to the mouth and respiratory tract of the user through the electronic cigarette, so that the user can obtain cough and expectorant, antibacterial and anti-inflammatory effects on the mouth and respiratory tract while smoking.
  • Statistical method Randomly select 1000 users to test the use of the e-cigarette liquids of the above examples 1-6 through e-cigarettes, and evaluate their taste and mouthfeel after the use test.
  • the evaluation standard is based on a total score of 10 points. The better or the better the taste, the higher the score.
  • the e-cigarette liquids of Examples 1-6 of the present application have quercetin produced after atomization for users to inhale aerosols, whether in terms of taste or taste. Can achieve a certain degree of customer satisfaction.
  • the e-cigarette liquid added with the flavor provided in the example of the present application has a significant improvement in the taste score test.
  • this application provides an e-cigarette liquid.
  • the quercetin contained in the e-cigarette liquid allows users to inhale the e-cigarette mist while introducing it into the oral cavity and respiratory tract.
  • the aerosol molecules of quercetin can relieve cough, expectorant, antibacterial and anti-inflammatory effects.
  • the e-cigarette liquid can form a uniform and strong aerosol when the user inhales by adding a specific flavor, and the aerosol has a soft mouthfeel and does not have a residual sensation, thereby optimizing the user experience.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un liquide à vapoter contenant de la quercétine, la teneur en quercétine de ce liquide à vapoter représentant de 0,01 % à 3,0 % du poids total du liquide à vapoter. Après atomisation du liquide à vapoter, la quercétine qu'il contient peut être atomisée conjointement avec le liquide, puis absorbée par le corps humain, ce qui permet d'obtenir des effets antibactériens, anti-inflammatoires, expectorants et antitussifs et similaire, pour la cavité orale et les voies respiratoires humaines.
PCT/CN2019/120744 2019-11-25 2019-11-25 Liquide à vapoter WO2021102652A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/120744 WO2021102652A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/120744 WO2021102652A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

Publications (1)

Publication Number Publication Date
WO2021102652A1 true WO2021102652A1 (fr) 2021-06-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/120744 WO2021102652A1 (fr) 2019-11-25 2019-11-25 Liquide à vapoter

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WO (1) WO2021102652A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028306A (zh) * 2010-12-07 2011-04-27 张志军 润喉保健型电子烟烟液
CN102551218A (zh) * 2012-01-20 2012-07-11 易侧位 一种寿命延长的快速戒烟雾化烟
US20130081642A1 (en) * 2011-09-29 2013-04-04 Robert Safari Cartomizer E-Cigarette
CN104336777A (zh) * 2014-09-03 2015-02-11 美国豪顿水香烟科技（香港）有限公司 一种可以提高人体免疫力的电雾化水香烟烟液及包含该烟液的电雾化水香烟
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN110353298A (zh) * 2019-08-30 2019-10-22 深圳雾芯科技有限公司 电子烟液

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028306A (zh) * 2010-12-07 2011-04-27 张志军 润喉保健型电子烟烟液
US20130081642A1 (en) * 2011-09-29 2013-04-04 Robert Safari Cartomizer E-Cigarette
CN102551218A (zh) * 2012-01-20 2012-07-11 易侧位 一种寿命延长的快速戒烟雾化烟
CN104336777A (zh) * 2014-09-03 2015-02-11 美国豪顿水香烟科技（香港）有限公司 一种可以提高人体免疫力的电雾化水香烟烟液及包含该烟液的电雾化水香烟
US20160174603A1 (en) * 2014-12-23 2016-06-23 Sahan Abayarathna Electronic Vapor Liquid Composition and Method of Use
CN110353298A (zh) * 2019-08-30 2019-10-22 深圳雾芯科技有限公司 电子烟液

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