CN1926237A - 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 - Google Patents

用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 Download PDF

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Publication number
CN1926237A
CN1926237A CNA2005800062581A CN200580006258A CN1926237A CN 1926237 A CN1926237 A CN 1926237A CN A2005800062581 A CNA2005800062581 A CN A2005800062581A CN 200580006258 A CN200580006258 A CN 200580006258A CN 1926237 A CN1926237 A CN 1926237A
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China
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fsh
fusion rotein
subunit
sequence
connexon
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Chinese (zh)
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苏珊·C·洛
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Bioverativ Therapeutics Inc
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Syntonix Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2005800062581A 2004-01-28 2005-01-27 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 Pending CN1926237A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54023604P 2004-01-28 2004-01-28
US60/540,236 2004-01-28

Publications (1)

Publication Number Publication Date
CN1926237A true CN1926237A (zh) 2007-03-07

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CNA2005800062581A Pending CN1926237A (zh) 2004-01-28 2005-01-27 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白

Country Status (10)

Country Link
US (2) US7601516B2 (enExample)
EP (1) EP1711610A2 (enExample)
JP (1) JP2008504012A (enExample)
CN (1) CN1926237A (enExample)
AU (1) AU2005207960A1 (enExample)
BR (1) BRPI0507174A (enExample)
CA (1) CA2553187A1 (enExample)
IL (2) IL177049A (enExample)
NO (1) NO20063807L (enExample)
WO (1) WO2005073383A2 (enExample)

Cited By (13)

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CN101909642B (zh) * 2007-11-30 2013-04-17 阿斯彭生物制药有限公司 重组型马科动物促卵泡激素的活性
CN103509121A (zh) * 2012-11-22 2014-01-15 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
CN103930134A (zh) * 2011-07-18 2014-07-16 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN104524553A (zh) * 2014-12-12 2015-04-22 薛传校 一种长效促排卵注射液
CN105567733A (zh) * 2016-01-11 2016-05-11 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN107082815A (zh) * 2017-06-28 2017-08-22 杭州皓阳生物技术有限公司 一种fsh‑hsa融合蛋白及其制备方法
CN107540748A (zh) * 2017-09-15 2018-01-05 北京伟杰信生物科技有限公司 长效重组猪fsh融合蛋白及其制备方法与应用
CN107969127A (zh) * 2015-09-08 2018-04-27 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN110305903A (zh) * 2019-07-31 2019-10-08 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113599503A (zh) * 2021-07-28 2021-11-05 安徽中起生物科技有限公司 一种调节卵巢功能的生物制剂及其制备方法和应用
CN115947860A (zh) * 2022-07-06 2023-04-11 华兰基因工程有限公司 一种重组人促卵泡生成素Fc融合蛋白及制备方法
CN115975043A (zh) * 2021-09-30 2023-04-18 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN116768979A (zh) * 2022-07-06 2023-09-19 华兰基因工程有限公司 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法

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US8007805B2 (en) 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7736653B2 (en) 2003-11-13 2010-06-15 Hanmi Pharm. Co., Ltd Pharmaceutical composition comprising an immunoglobulin Fc region as a carrier
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
US20050208470A1 (en) * 2003-12-16 2005-09-22 University Of Massachusetts Toll-like receptor assays
AU2005207960A1 (en) * 2004-01-28 2005-08-11 Syntonix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
GB0510627D0 (en) 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
BRPI0617330A2 (pt) * 2005-10-13 2011-07-19 Virexx Medical Corp antìgeno quimérico contendo polipeptìdeo do vìrus da hepatite c e fragmento fc para despertar uma resposta imunológica
CN103071209A (zh) 2005-11-17 2013-05-01 周吉尼克斯股份有限公司 用无针注射递送粘稠制剂
EP1801121A1 (en) * 2005-12-23 2007-06-27 CONARIS research institute AG Soluble gp130 molecule variants useful as a medicament
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
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AR081755A1 (es) * 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
FR2958936A1 (fr) * 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
EP2686418A4 (en) 2011-03-17 2015-04-22 Minerva Biotechnologies Corp METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
JP2014517690A (ja) * 2011-05-09 2014-07-24 ミネルバ バイオテクノロジーズ コーポレーション 遺伝子操作した成長因子変異体
KR101967345B1 (ko) * 2012-10-18 2019-04-09 삼성전자주식회사 안지오포이에틴-2와 인테그린 간의 결합을 저해하는 펩타이드 및 그 용도
EA201591700A1 (ru) 2013-03-14 2015-12-30 Ридженерон Фармасьютикалз, Инк. Гибридные белки апелина и их применение
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CN103539862B (zh) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 一种长效重组促卵泡激素及其应用
EA201691027A1 (ru) 2013-11-20 2016-12-30 Ридженерон Фармасьютикалз, Инк. Модуляторы aplnr и их применение
EP3260139A4 (en) * 2015-02-17 2018-09-05 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue complex
CN106046176B (zh) 2016-08-16 2019-09-10 中国药科大学 一种高活性长效降糖融合蛋白及其制备方法与医药用途
WO2025140545A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 新型长效人fsh与lh融合蛋白及其制备方法与应用

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101909642B (zh) * 2007-11-30 2013-04-17 阿斯彭生物制药有限公司 重组型马科动物促卵泡激素的活性
CN103930134A (zh) * 2011-07-18 2014-07-16 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN103930134B (zh) * 2011-07-18 2016-12-21 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN103509121A (zh) * 2012-11-22 2014-01-15 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
WO2014079384A1 (zh) * 2012-11-22 2014-05-30 苏州康宁杰瑞生物科技有限公司 促激素融合蛋白及其制备方法和用途
CN103509121B (zh) * 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
US9969786B2 (en) 2012-11-22 2018-05-15 Suzhou Alphamab Co, Ltd. Trophic hormone fusion protein, preparation method and application thereof
CN104524553A (zh) * 2014-12-12 2015-04-22 薛传校 一种长效促排卵注射液
WO2016090701A1 (zh) * 2014-12-12 2016-06-16 薛传校 一种长效促排卵注射液
CN107969127A (zh) * 2015-09-08 2018-04-27 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN107969127B (zh) * 2015-09-08 2022-09-06 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN105567733A (zh) * 2016-01-11 2016-05-11 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN105567733B (zh) * 2016-01-11 2019-04-23 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN107082815A (zh) * 2017-06-28 2017-08-22 杭州皓阳生物技术有限公司 一种fsh‑hsa融合蛋白及其制备方法
CN107540748A (zh) * 2017-09-15 2018-01-05 北京伟杰信生物科技有限公司 长效重组猪fsh融合蛋白及其制备方法与应用
CN110305903A (zh) * 2019-07-31 2019-10-08 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113599503A (zh) * 2021-07-28 2021-11-05 安徽中起生物科技有限公司 一种调节卵巢功能的生物制剂及其制备方法和应用
CN115975043A (zh) * 2021-09-30 2023-04-18 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN115975043B (zh) * 2021-09-30 2024-07-12 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN118562018A (zh) * 2021-09-30 2024-08-30 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN115947860A (zh) * 2022-07-06 2023-04-11 华兰基因工程有限公司 一种重组人促卵泡生成素Fc融合蛋白及制备方法
CN116768979A (zh) * 2022-07-06 2023-09-19 华兰基因工程有限公司 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法

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CA2553187A1 (en) 2005-08-11
US8293707B2 (en) 2012-10-23
WO2005073383A2 (en) 2005-08-11
JP2008504012A (ja) 2008-02-14
BRPI0507174A (pt) 2008-04-01
US20100291079A1 (en) 2010-11-18
WO2005073383A3 (en) 2005-11-24
IL206518A0 (en) 2010-12-30
US7601516B2 (en) 2009-10-13
EP1711610A2 (en) 2006-10-18
NO20063807L (no) 2006-10-25
AU2005207960A1 (en) 2005-08-11
IL177049A (en) 2010-11-30
IL177049A0 (en) 2006-12-10
US20050186662A1 (en) 2005-08-25

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