CN1867582B - 制备α-1-抗胰蛋白酶溶液的方法 - Google Patents

制备α-1-抗胰蛋白酶溶液的方法 Download PDF

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Publication number
CN1867582B
CN1867582B CN2004800208911A CN200480020891A CN1867582B CN 1867582 B CN1867582 B CN 1867582B CN 2004800208911 A CN2004800208911 A CN 2004800208911A CN 200480020891 A CN200480020891 A CN 200480020891A CN 1867582 B CN1867582 B CN 1867582B
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a1at
triton
carried out
polysorbate
tnbp
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CN2004800208911A
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Chinese (zh)
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CN1867582A (zh
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彼得拉·舒尔茨
于尔根·勒米施
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Octapharma AG
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Octapharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2004800208911A 2003-08-12 2004-08-12 制备α-1-抗胰蛋白酶溶液的方法 Expired - Fee Related CN1867582B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49409703P 2003-08-12 2003-08-12
US60/494,097 2003-08-12
PCT/EP2004/009043 WO2005014648A1 (en) 2003-08-12 2004-08-12 Process for preparing an alpha-1-antitrypsin solution

Publications (2)

Publication Number Publication Date
CN1867582A CN1867582A (zh) 2006-11-22
CN1867582B true CN1867582B (zh) 2010-06-16

Family

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Family Applications (1)

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CN2004800208911A Expired - Fee Related CN1867582B (zh) 2003-08-12 2004-08-12 制备α-1-抗胰蛋白酶溶液的方法

Country Status (22)

Country Link
US (1) US20060194300A1 (enExample)
EP (1) EP1654284B1 (enExample)
JP (1) JP4668904B2 (enExample)
KR (1) KR20060070543A (enExample)
CN (1) CN1867582B (enExample)
AT (1) ATE428730T1 (enExample)
AU (1) AU2004262578B2 (enExample)
BR (1) BRPI0412835A (enExample)
CA (1) CA2534900A1 (enExample)
DE (1) DE602004020632D1 (enExample)
DK (1) DK1654284T3 (enExample)
ES (1) ES2324168T3 (enExample)
IL (1) IL172868A0 (enExample)
NO (1) NO20060109L (enExample)
PL (1) PL1654284T3 (enExample)
PT (1) PT1654284E (enExample)
RS (1) RS20060077A (enExample)
RU (1) RU2370500C2 (enExample)
SI (1) SI1654284T1 (enExample)
UA (1) UA86775C2 (enExample)
WO (1) WO2005014648A1 (enExample)
ZA (1) ZA200601206B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1664123T4 (da) * 2003-09-22 2012-03-05 Kamada Ltd Storskalafremstilling af alfa-1-proteinaseinhibitor og anvendelse deraf
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
CN100354301C (zh) * 2005-10-13 2007-12-12 南京工业大学 化学合成多肽的新型大规模分离制备技术
CN100562523C (zh) * 2006-07-26 2009-11-25 河北大安制药有限公司 α1-抗胰蛋白酶的制备方法
US20110002909A1 (en) * 2007-11-02 2011-01-06 Vikram Arora Method, composition, and article of manufacture for providing alpha-1 antitrypsin
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
AU2013205138B2 (en) * 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
US10906953B2 (en) * 2015-06-26 2021-02-02 Ferring B.V. Methods of purification and/or viral inactivation
AU2017214678B2 (en) * 2016-02-03 2024-02-01 Plasma Technologies, Llc Methods for extracting proteins from a blood-based material
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0525502A1 (de) * 1991-08-02 1993-02-03 Octapharma Ag Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
WO1994026287A1 (en) * 1993-05-07 1994-11-24 Pharmacia Ab Purification of plasma proteins
US20020082214A1 (en) * 1997-06-10 2002-06-27 Erwin Mattes Alpha 1-antitrypsin preparation as well as a method for producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584728A (ja) * 1981-05-01 1983-01-11 メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン α−１−抗トリプシンの精製
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4684723A (en) * 1985-09-11 1987-08-04 Miles Laboratories, Inc. Method of separating proteins from aqueous solutions
DE3877041T2 (de) * 1987-04-27 1993-04-22 Miles Inc Verfahren zur herstellung von hochgereinigtem alpha-1-proteinase-inhibitor.
KR920005689B1 (ko) * 1989-12-21 1992-07-13 국제약품공업주식회사 혈청으로부터 알파-1-안티트립신의 분리 정제 및 혈중 알파-1-안티트립신 양의 검정키트
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
EP1736483A3 (en) * 1995-09-07 2008-07-30 Pharming Intellectual Property BV Purification of alpha-1 proteinase inhibitor
JP4105249B2 (ja) * 1996-08-09 2008-06-25 財団法人化学及血清療法研究所 α２プラスミンインヒビターの製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0525502A1 (de) * 1991-08-02 1993-02-03 Octapharma Ag Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
WO1994026287A1 (en) * 1993-05-07 1994-11-24 Pharmacia Ab Purification of plasma proteins
US20020082214A1 (en) * 1997-06-10 2002-06-27 Erwin Mattes Alpha 1-antitrypsin preparation as well as a method for producing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
揭志军等.α1-抗胰蛋白酶临床应用的前景.国外医学呼吸系统分册19 4.1999,19(4),192-193. *

Also Published As

Publication number Publication date
WO2005014648A1 (en) 2005-02-17
SI1654284T1 (sl) 2009-10-31
CA2534900A1 (en) 2005-02-17
NO20060109L (no) 2006-02-15
JP2007523883A (ja) 2007-08-23
RS20060077A (sr) 2008-08-07
AU2004262578A1 (en) 2005-02-17
EP1654284B1 (en) 2009-04-15
RU2370500C2 (ru) 2009-10-20
KR20060070543A (ko) 2006-06-23
DK1654284T3 (da) 2009-07-20
PT1654284E (pt) 2009-07-06
IL172868A0 (en) 2006-06-11
AU2004262578B2 (en) 2010-05-06
ES2324168T3 (es) 2009-07-31
JP4668904B2 (ja) 2011-04-13
EP1654284A1 (en) 2006-05-10
ZA200601206B (en) 2007-05-30
PL1654284T3 (pl) 2009-09-30
CN1867582A (zh) 2006-11-22
US20060194300A1 (en) 2006-08-31
ATE428730T1 (de) 2009-05-15
BRPI0412835A (pt) 2006-09-26
RU2006107533A (ru) 2006-07-27
DE602004020632D1 (de) 2009-05-28
UA86775C2 (ru) 2009-05-25

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Granted publication date: 20100616

Termination date: 20120812