CN1867548A - 3－氮杂双环[3.1.0]己烷衍生物的制备 - Google Patents

3－氮杂双环[3.1.0]己烷衍生物的制备 Download PDF

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Publication number
CN1867548A
CN1867548A CNA2004800305305A CN200480030530A CN1867548A CN 1867548 A CN1867548 A CN 1867548A CN A2004800305305 A CNA2004800305305 A CN A2004800305305A CN 200480030530 A CN200480030530 A CN 200480030530A CN 1867548 A CN1867548 A CN 1867548A
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CN
China
Prior art keywords
hydroxyl
phenyl
alkyl
compound
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800305305A
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English (en)
Chinese (zh)
Inventor
乔萨姆·W·科
斯坦顿·F·麦克哈迪
约翰·A·拉根
德里克·L·蒂克纳
布赖恩·C·范德普拉斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1867548A publication Critical patent/CN1867548A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA2004800305305A 2003-10-16 2004-10-06 3－氮杂双环[3.1.0]己烷衍生物的制备 Pending CN1867548A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51188903P 2003-10-16 2003-10-16
US60/511,889 2003-10-16

Publications (1)

Publication Number Publication Date
CN1867548A true CN1867548A (zh) 2006-11-22

Family

ID=34465290

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800305305A Pending CN1867548A (zh) 2003-10-16 2004-10-06 3－氮杂双环[3.1.0]己烷衍生物的制备

Country Status (17)

Country Link
US (1) US7129263B2 (enExample)
EP (1) EP1675829A1 (enExample)
JP (1) JP2007508367A (enExample)
KR (1) KR20060096038A (enExample)
CN (1) CN1867548A (enExample)
AR (1) AR046592A1 (enExample)
AU (1) AU2004281229A1 (enExample)
BR (1) BRPI0415459A (enExample)
CA (1) CA2540860A1 (enExample)
CO (1) CO5680416A2 (enExample)
IL (1) IL174596A0 (enExample)
MX (1) MXPA06004278A (enExample)
NO (1) NO20062152L (enExample)
RU (1) RU2006112576A (enExample)
TW (1) TW200524866A (enExample)
WO (1) WO2005037790A1 (enExample)
ZA (1) ZA200601964B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428687A (zh) * 2015-05-20 2017-12-01 株式会社三和化学研究所 一种新型的3‑氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2314289T3 (es) 2002-12-10 2009-03-16 Wyeth Derivados del acido 1h-indol-3-il glioxilico sustituidos con arilo, ariloxi y alquloxi como inhibidores del inhibidor del activador del plasminogeno-1(pai-1).
MXPA06004279A (es) * 2003-10-14 2006-06-28 Pfizer Prod Inc Derivados biciclicos [3.1.0] como inhibidores del transportador de glicina.
WO2008075162A2 (en) * 2006-12-15 2008-06-26 Pfizer Limited Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
RU2701861C1 (ru) 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. Новое производное 3-азабицикло[3.1.0]гексана и его применение в медицинских целях
WO2019173173A1 (en) * 2018-03-05 2019-09-12 E. I. Du Pont De Nemours And Company Process and intermidiates for the preparation of certain mesoionic pesticides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
EP1440059B1 (en) * 2001-10-22 2008-04-16 Pfizer Products Inc. 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428687A (zh) * 2015-05-20 2017-12-01 株式会社三和化学研究所 一种新型的3‑氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CN107428687B (zh) * 2015-05-20 2021-06-11 宇部兴产株式会社 一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CN113307760A (zh) * 2015-05-20 2021-08-27 宇部兴产株式会社 一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用

Also Published As

Publication number Publication date
US7129263B2 (en) 2006-10-31
TW200524866A (en) 2005-08-01
JP2007508367A (ja) 2007-04-05
ZA200601964B (en) 2007-04-25
IL174596A0 (en) 2006-08-20
AR046592A1 (es) 2005-12-14
MXPA06004278A (es) 2006-06-28
NO20062152L (no) 2006-05-12
CA2540860A1 (en) 2005-04-28
BRPI0415459A (pt) 2006-12-19
WO2005037790A1 (en) 2005-04-28
KR20060096038A (ko) 2006-09-05
US20050113437A1 (en) 2005-05-26
EP1675829A1 (en) 2006-07-05
RU2006112576A (ru) 2006-08-27
CO5680416A2 (es) 2006-09-29
AU2004281229A1 (en) 2005-04-28

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