CO5680416A2 - Preparacion de derivados de 3-azabiciclo [3,1,0]hexano - Google Patents
Preparacion de derivados de 3-azabiciclo [3,1,0]hexanoInfo
- Publication number
- CO5680416A2 CO5680416A2 CO06033213A CO06033213A CO5680416A2 CO 5680416 A2 CO5680416 A2 CO 5680416A2 CO 06033213 A CO06033213 A CO 06033213A CO 06033213 A CO06033213 A CO 06033213A CO 5680416 A2 CO5680416 A2 CO 5680416A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkylene
- cycloalkyl
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un procedimiento para la preparación de un compuesto de fórmula en el que X es halógeno, -OH, -CN, -alquilo C1 a C4 sustituido con uno a tres átomos de halógenos, -NH2, -NH(alquilo C1-C4), -N(alquil C1-C4) (alquilo C1-C4), -C(=O)NH2, -C(=O)NH(alquilo C1-C4), -C(=O)N(alquil C1-C4) (alquilo C1-C4), -NHS(=O)2H, o -NHS(=O)2R4;R1 y R2 están unidos, con el carbono al que se unen, para formar un cicloalquilo C3-C7 o un heterocicloalquilo de 4-7 miembros que comprende de uno a tres restos hetero seleccionados de O, S, -C(=O) y N; y en el que dicho cicloalquilo o heterocicloalquilo contiene opcionalmente uno o dos dobles enlaces; y en el que dicho cicloalquilo o heterocicloalquilo está condensado o unido opcionalmente a un arilo C6-C14 o a un grupo heteroarilo de 5-14 miembros;R3 es alquilo C1-C4 que puede contener opcionalmente uno o dos enlaces insaturados, -OH, -CN, -NO2, -O-alquilo C1-C4, -NH2 amida o amida sustituida con alquilo;y n es uno o cero;R4 se selecciona de alquilo C1-C4, -(alquilen C1-C4)-O-(alquilo C1-C4), 4-(1-metilimidazol), -(alquilen C1-C4)-NH2, -(alquilen C1-C4)-NH(alquilo C1-C4), -(alquilen C1-C4)-N(alquil C1-C4)(alquilo C1-C4); que comprende la reacción de un compuesto de fórmula con un compuesto de fórmula en presencia de un agente reductor y un disolvente orgánico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51188903P | 2003-10-16 | 2003-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5680416A2 true CO5680416A2 (es) | 2006-09-29 |
Family
ID=34465290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO06033213A CO5680416A2 (es) | 2003-10-16 | 2006-04-05 | Preparacion de derivados de 3-azabiciclo [3,1,0]hexano |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7129263B2 (es) |
| EP (1) | EP1675829A1 (es) |
| JP (1) | JP2007508367A (es) |
| KR (1) | KR20060096038A (es) |
| CN (1) | CN1867548A (es) |
| AR (1) | AR046592A1 (es) |
| AU (1) | AU2004281229A1 (es) |
| BR (1) | BRPI0415459A (es) |
| CA (1) | CA2540860A1 (es) |
| CO (1) | CO5680416A2 (es) |
| IL (1) | IL174596A0 (es) |
| MX (1) | MXPA06004278A (es) |
| NO (1) | NO20062152L (es) |
| RU (1) | RU2006112576A (es) |
| TW (1) | TW200524866A (es) |
| WO (1) | WO2005037790A1 (es) |
| ZA (1) | ZA200601964B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003296324A1 (en) * | 2002-12-10 | 2004-06-30 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| NZ546012A (en) * | 2003-10-14 | 2009-12-24 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| WO2008075162A2 (en) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| EP2621902B1 (en) | 2010-09-28 | 2017-04-12 | Panacea Biotec Ltd | 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| DK3072884T3 (da) * | 2013-11-20 | 2020-03-09 | Sanwa Kagaku Kenkyusho Co | 3-azabicyclo[3.1.0]hexanderivat og anvendelse deraf til medicinske formål |
| CN107428687B (zh) * | 2015-05-20 | 2021-06-11 | 宇部兴产株式会社 | 一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用 |
| IL276773B2 (en) * | 2018-03-05 | 2023-11-01 | Du Pont | Process and intermediates for the preparation of certain toxic pesticides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| DK1440059T3 (da) * | 2001-10-22 | 2008-07-14 | Pfizer Prod Inc | 3-azabicyclo(3.1.0)hexanderivater som opioidreceptorantagonister |
-
2004
- 2004-10-06 BR BRPI0415459-2A patent/BRPI0415459A/pt not_active IP Right Cessation
- 2004-10-06 WO PCT/IB2004/003261 patent/WO2005037790A1/en not_active Application Discontinuation
- 2004-10-06 AU AU2004281229A patent/AU2004281229A1/en not_active Abandoned
- 2004-10-06 CN CNA2004800305305A patent/CN1867548A/zh active Pending
- 2004-10-06 CA CA002540860A patent/CA2540860A1/en not_active Abandoned
- 2004-10-06 KR KR1020067007220A patent/KR20060096038A/ko not_active Application Discontinuation
- 2004-10-06 RU RU2006112576/04A patent/RU2006112576A/ru not_active Application Discontinuation
- 2004-10-06 EP EP04769571A patent/EP1675829A1/en not_active Withdrawn
- 2004-10-06 MX MXPA06004278A patent/MXPA06004278A/es not_active Application Discontinuation
- 2004-10-06 JP JP2006534849A patent/JP2007508367A/ja not_active Abandoned
- 2004-10-12 TW TW093130881A patent/TW200524866A/zh unknown
- 2004-10-14 AR ARP040103725A patent/AR046592A1/es not_active Application Discontinuation
- 2004-10-15 US US10/966,712 patent/US7129263B2/en not_active Expired - Fee Related
-
2006
- 2006-03-08 ZA ZA200601964A patent/ZA200601964B/en unknown
- 2006-03-27 IL IL174596A patent/IL174596A0/en unknown
- 2006-04-05 CO CO06033213A patent/CO5680416A2/es not_active Application Discontinuation
- 2006-05-12 NO NO20062152A patent/NO20062152L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006112576A (ru) | 2006-08-27 |
| BRPI0415459A (pt) | 2006-12-19 |
| CA2540860A1 (en) | 2005-04-28 |
| ZA200601964B (en) | 2007-04-25 |
| AU2004281229A1 (en) | 2005-04-28 |
| JP2007508367A (ja) | 2007-04-05 |
| MXPA06004278A (es) | 2006-06-28 |
| EP1675829A1 (en) | 2006-07-05 |
| US7129263B2 (en) | 2006-10-31 |
| CN1867548A (zh) | 2006-11-22 |
| NO20062152L (no) | 2006-05-12 |
| KR20060096038A (ko) | 2006-09-05 |
| US20050113437A1 (en) | 2005-05-26 |
| AR046592A1 (es) | 2005-12-14 |
| WO2005037790A1 (en) | 2005-04-28 |
| IL174596A0 (en) | 2006-08-20 |
| TW200524866A (en) | 2005-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |