CN1839116B - 不对称脲化合物和通过用其作催化剂的不对称共轭加成反应制备不对称化合物的方法 - Google Patents

不对称脲化合物和通过用其作催化剂的不对称共轭加成反应制备不对称化合物的方法 Download PDF

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Publication number
CN1839116B
CN1839116B CN2004800240353A CN200480024035A CN1839116B CN 1839116 B CN1839116 B CN 1839116B CN 2004800240353 A CN2004800240353 A CN 2004800240353A CN 200480024035 A CN200480024035 A CN 200480024035A CN 1839116 B CN1839116 B CN 1839116B
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China
Prior art keywords
alkyl
alkylamino
nitro
coor
halogen atom
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Expired - Lifetime
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CN2004800240353A
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Chinese (zh)
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CN1839116A (zh
Inventor
竹本佳司
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Priority claimed from PCT/JP2004/009350 external-priority patent/WO2005000803A1/ja
Publication of CN1839116A publication Critical patent/CN1839116A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/53—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/55—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2004800240353A 2003-06-30 2004-06-25 不对称脲化合物和通过用其作催化剂的不对称共轭加成反应制备不对称化合物的方法 Expired - Lifetime CN1839116B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP189096/2003 2003-06-30
JP2003189096 2003-06-30
JP421688/2003 2003-12-18
JP2003421688 2003-12-18
PCT/JP2004/009350 WO2005000803A1 (ja) 2003-06-30 2004-06-25 不斉尿素化合物およびこれを触媒として用いる不斉共役付加反応による不斉化合物の製造方法

Publications (2)

Publication Number Publication Date
CN1839116A CN1839116A (zh) 2006-09-27
CN1839116B true CN1839116B (zh) 2010-05-26

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CN2004800240353A Expired - Lifetime CN1839116B (zh) 2003-06-30 2004-06-25 不对称脲化合物和通过用其作催化剂的不对称共轭加成反应制备不对称化合物的方法

Country Status (8)

Country Link
US (1) US7632970B2 (enExample)
EP (1) EP1640361B9 (enExample)
JP (1) JP4384635B2 (enExample)
KR (1) KR101099408B1 (enExample)
CN (1) CN1839116B (enExample)
CA (1) CA2531167C (enExample)
ES (1) ES2545903T3 (enExample)
IN (2) IN2009CH01478A (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
JP2011144162A (ja) * 2009-12-17 2011-07-28 Sumitomo Chemical Co Ltd 光学活性４−アミノ−３−（４−クロロフェニル）ブタン酸の新規な結晶およびその製造方法
WO2012113103A1 (en) 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
KR102258630B1 (ko) 2013-08-21 2021-05-28 유레카 에스에이알엘 펩티드-올리고우레아 키메라 화합물 및 이의 사용 방법
RU2555370C1 (ru) * 2014-02-12 2015-07-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" Способ энантиоселективного синтеза диэтил[3-метил-(1s)-(нитрометил)бутил]малоната формулы i
WO2016207726A1 (en) * 2015-06-22 2016-12-29 Ureka Sarl Bioinspired catalysis using oligourea helical foldamers
US10233213B2 (en) 2015-08-31 2019-03-19 Ureka Sarl Foldamer helix bundle-based molecular encapsulation
EP3390355B1 (en) 2016-03-22 2022-12-28 Helsinn Healthcare S.A. Benzenesulfonyl-asymmetric ureas and medical uses thereof
WO2017182873A2 (en) 2016-04-19 2017-10-26 Ureka Sarl Peptide-oligourea foldamer compounds and methods of their use
WO2020088949A1 (en) 2018-10-29 2020-05-07 Basf Se Process for preparation of optically enriched aldol compounds
CN114644603B (zh) * 2020-12-21 2025-11-11 内蒙古工业大学 无机硫催化活化二氧化碳作为羰基化试剂的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
BR0212451A (pt) * 2001-09-13 2004-10-19 Hoffmann La Roche Antagonistas de receptores de ccr-3 v
MXPA04004980A (es) * 2001-11-30 2004-08-11 Hoffmann La Roche Antagonistas del receptor ccr-3.
ES2290346T3 (es) * 2001-11-30 2008-02-16 F. Hoffmann-La Roche Ag Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma.
US6977265B2 (en) 2001-11-30 2005-12-20 Roche Palo Alto Llc Piperidine CCR-3 receptor antagonists
KR100652450B1 (ko) * 2001-11-30 2007-02-28 에프. 호프만-라 로슈 아게 Ｃｃｒ-3 수용체에 대한 길항제 ⅷ로서의ｎ-우레이도-피페리딘
DE10163239A1 (de) 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
DE10224892A1 (de) 2002-06-04 2003-12-18 Aventis Pharma Gmbh Substituierte Thiophene, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10323701A1 (de) 2003-05-22 2004-12-23 Aventis Pharma Deutschland Gmbh Verfahren zur Synthese heterocyclischer Verbindungen
WO2005058805A1 (ja) 2003-12-17 2005-06-30 Sumitomo Chemical Company, Limited 光学活性アミン化合物の製造方法

Also Published As

Publication number Publication date
JPWO2005000803A1 (ja) 2006-08-03
CN1839116A (zh) 2006-09-27
WO2005000803A2 (ja) 2005-01-06
US20060161006A1 (en) 2006-07-20
EP1640361A4 (en) 2007-10-03
CA2531167C (en) 2012-05-22
EP1640361B1 (en) 2015-05-27
EP1640361B9 (en) 2015-11-04
ES2545903T3 (es) 2015-09-16
IN232619B (enExample) 2009-03-27
JP4384635B2 (ja) 2009-12-16
EP1640361A2 (en) 2006-03-29
KR20060033745A (ko) 2006-04-19
IN2006CH00378A (en) 2007-05-11
WO2005000803A3 (ja) 2005-03-03
KR101099408B1 (ko) 2011-12-27
US7632970B2 (en) 2009-12-15
IN2009CH01478A (en) 2009-08-21
CA2531167A1 (en) 2005-01-06
WO2005000803A8 (ja) 2005-05-12

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