CN1832966A - 具有在血浆中高抗血栓活性的多糖衍生物 - Google Patents

具有在血浆中高抗血栓活性的多糖衍生物 Download PDF

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Publication number
CN1832966A
CN1832966A CNA2004800223076A CN200480022307A CN1832966A CN 1832966 A CN1832966 A CN 1832966A CN A2004800223076 A CNA2004800223076 A CN A2004800223076A CN 200480022307 A CN200480022307 A CN 200480022307A CN 1832966 A CN1832966 A CN 1832966A
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CN
China
Prior art keywords
sulfation
acetylheparosans
partial
carried out
heparin
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Pending
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CNA2004800223076A
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English (en)
Chinese (zh)
Inventor
马可·马罗尼
利娜·萨思尼
加库波·切尼
贾瓦尼·斯波纳蒂
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Inalco SpA
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Inalco SpA
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Publication of CN1832966A publication Critical patent/CN1832966A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CNA2004800223076A 2003-08-06 2004-07-07 具有在血浆中高抗血栓活性的多糖衍生物 Pending CN1832966A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2003A001618 2003-08-06
IT001618A ITMI20031618A1 (it) 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita'

Publications (1)

Publication Number Publication Date
CN1832966A true CN1832966A (zh) 2006-09-13

Family

ID=34131211

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800223076A Pending CN1832966A (zh) 2003-08-06 2004-07-07 具有在血浆中高抗血栓活性的多糖衍生物

Country Status (18)

Country Link
US (1) US7687249B2 (enExample)
EP (1) EP1654288B9 (enExample)
JP (1) JP2007501305A (enExample)
KR (1) KR20060063933A (enExample)
CN (1) CN1832966A (enExample)
AT (1) ATE458009T1 (enExample)
AU (1) AU2004262584A1 (enExample)
BR (1) BRPI0413346A (enExample)
CA (1) CA2534709A1 (enExample)
DE (1) DE602004025583D1 (enExample)
DK (1) DK1654288T3 (enExample)
ES (1) ES2341249T3 (enExample)
IL (1) IL173482A0 (enExample)
IT (1) ITMI20031618A1 (enExample)
MX (1) MXPA06001511A (enExample)
RU (1) RU2361881C2 (enExample)
WO (1) WO2005014656A1 (enExample)
ZA (1) ZA200601643B (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698838B (zh) * 2008-12-26 2012-05-23 北京大学 尿苷二磷酸葡萄糖醛酸异构酶及其编码基因与应用
CN102712942A (zh) * 2009-09-01 2012-10-03 伦斯勒理工学院 K5肝素前体的发酵和纯化
CN103059165A (zh) * 2012-12-26 2013-04-24 蚌埠丰原涂山制药有限公司 一种多糖酰化物及其制备方法
CN111065654A (zh) * 2016-08-31 2020-04-24 王子控股株式会社 戊聚糖多硫酸酯的生产方法
US11274165B2 (en) 2017-02-28 2022-03-15 Oji Holdings Corporation Pentosan polysulfate, pharmaceutical composition, and anticoagulant
US11278485B2 (en) 2017-05-31 2022-03-22 Oji Holdings Corporation Moisturizing topical preparation
US11286272B2 (en) 2016-08-31 2022-03-29 Oji Holdings Corporation Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide
US11344570B2 (en) 2017-12-20 2022-05-31 Oji Holdings Corporation Pentosan polysulfate and medicine containing pentosan polysulfate
US11390693B2 (en) 2017-09-12 2022-07-19 Oji Holdings Corporation Pentosan polysulfate and method for producing pentosan polysulfate

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006316039B2 (en) * 2005-11-21 2011-08-18 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
US9498494B2 (en) 2008-09-11 2016-11-22 Agency For Science, Technology And Research Glycosaminoglycans
GB0818255D0 (en) * 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
EP2598652A4 (en) 2010-07-29 2014-04-30 Shire Human Genetic Therapies TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES
WO2013116677A2 (en) * 2012-02-01 2013-08-08 Shire Human Genetic Therapies, Inc. Assays for detection of glycosaminoglycans
CN102796723A (zh) * 2012-09-11 2012-11-28 深圳市海普瑞药业股份有限公司 肝素酶i的固定化方法
CN102888390B (zh) * 2012-10-30 2014-09-03 深圳市海普瑞药业股份有限公司 肝素酶ⅲ的固定化方法
JP6879216B2 (ja) * 2015-12-28 2021-06-02 味の素株式会社 抗凝固活性を有するヘパラン硫酸の製造法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104301A (zh) * 1985-05-17 1987-03-04 奥波克伦公司 一种具有抗血栓形成、溶解纤维蛋白、消炎活性的解聚的硫酸氨基己糖聚糖，其制备方法以及有关药品组合物
WO1997043317A1 (en) * 1996-05-10 1997-11-20 Inalco S.P.A. Derivatives of k5 polysaccharide having high anticoagulant activity
US20030023079A1 (en) * 2000-03-30 2003-01-30 Pasqua Oreste Polysaccharides derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1290814B1 (it) 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
SE9701454D0 (sv) 1997-04-18 1997-04-18 Ulf Lindahl new DNA sequences and a process for enzyme manufacture
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
US7838644B2 (en) * 2002-06-18 2010-11-23 Glycores 2000 S.R.L. Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104301A (zh) * 1985-05-17 1987-03-04 奥波克伦公司 一种具有抗血栓形成、溶解纤维蛋白、消炎活性的解聚的硫酸氨基己糖聚糖，其制备方法以及有关药品组合物
WO1997043317A1 (en) * 1996-05-10 1997-11-20 Inalco S.P.A. Derivatives of k5 polysaccharide having high anticoagulant activity
US20030023079A1 (en) * 2000-03-30 2003-01-30 Pasqua Oreste Polysaccharides derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698838B (zh) * 2008-12-26 2012-05-23 北京大学 尿苷二磷酸葡萄糖醛酸异构酶及其编码基因与应用
CN102712942A (zh) * 2009-09-01 2012-10-03 伦斯勒理工学院 K5肝素前体的发酵和纯化
CN102712942B (zh) * 2009-09-01 2014-05-14 伦斯勒理工学院 K5肝素前体的发酵和纯化
CN103059165A (zh) * 2012-12-26 2013-04-24 蚌埠丰原涂山制药有限公司 一种多糖酰化物及其制备方法
CN103059165B (zh) * 2012-12-26 2015-04-29 安徽丰原药业股份有限公司 一种多糖酰化物及其制备方法
US11312790B2 (en) 2016-08-31 2022-04-26 Oji Holdings Corporation Production method for pentosan polysulfate
US11286272B2 (en) 2016-08-31 2022-03-29 Oji Holdings Corporation Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide
CN111065654A (zh) * 2016-08-31 2020-04-24 王子控股株式会社 戊聚糖多硫酸酯的生产方法
CN111065654B (zh) * 2016-08-31 2022-08-26 王子控股株式会社 戊聚糖多硫酸酯的生产方法
US11274165B2 (en) 2017-02-28 2022-03-15 Oji Holdings Corporation Pentosan polysulfate, pharmaceutical composition, and anticoagulant
US11278485B2 (en) 2017-05-31 2022-03-22 Oji Holdings Corporation Moisturizing topical preparation
US11390693B2 (en) 2017-09-12 2022-07-19 Oji Holdings Corporation Pentosan polysulfate and method for producing pentosan polysulfate
US11344570B2 (en) 2017-12-20 2022-05-31 Oji Holdings Corporation Pentosan polysulfate and medicine containing pentosan polysulfate

Also Published As

Publication number Publication date
ITMI20031618A1 (it) 2005-02-07
DK1654288T3 (da) 2010-09-20
EP1654288B1 (en) 2010-02-17
DE602004025583D1 (de) 2010-04-01
EP1654288B9 (en) 2010-06-23
CA2534709A1 (en) 2005-02-17
ZA200601643B (en) 2007-05-30
US7687249B2 (en) 2010-03-30
US20070042993A1 (en) 2007-02-22
KR20060063933A (ko) 2006-06-12
BRPI0413346A (pt) 2006-10-10
AU2004262584A1 (en) 2005-02-17
ATE458009T1 (de) 2010-03-15
ES2341249T3 (es) 2010-06-17
IL173482A0 (en) 2006-06-11
WO2005014656A1 (en) 2005-02-17
EP1654288A1 (en) 2006-05-10
RU2006106790A (ru) 2007-09-20
MXPA06001511A (es) 2006-05-15
JP2007501305A (ja) 2007-01-25
RU2361881C2 (ru) 2009-07-20

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Application publication date: 20060913