IL173482A0 - Polysaccharides derivatives with high antithrombotic activity in plasma - Google Patents

Polysaccharides derivatives with high antithrombotic activity in plasma

Info

Publication number
IL173482A0
IL173482A0 IL173482A IL17348206A IL173482A0 IL 173482 A0 IL173482 A0 IL 173482A0 IL 173482 A IL173482 A IL 173482A IL 17348206 A IL17348206 A IL 17348206A IL 173482 A0 IL173482 A0 IL 173482A0
Authority
IL
Israel
Prior art keywords
sulphation
partial
plasma
acetylheparosan
antithrombotic activity
Prior art date
Application number
IL173482A
Other languages
English (en)
Original Assignee
Inalco Spa
Manoni Marco
Salsini Liana
Chini Jacopo
Cipolletti Giovanni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco Spa, Manoni Marco, Salsini Liana, Chini Jacopo, Cipolletti Giovanni filed Critical Inalco Spa
Publication of IL173482A0 publication Critical patent/IL173482A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IL173482A 2003-08-06 2006-01-31 Polysaccharides derivatives with high antithrombotic activity in plasma IL173482A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001618A ITMI20031618A1 (it) 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita'
PCT/EP2004/051391 WO2005014656A1 (en) 2003-08-06 2004-07-07 Polysaccharides derivatives with high antithrombotic activity in plasma

Publications (1)

Publication Number Publication Date
IL173482A0 true IL173482A0 (en) 2006-06-11

Family

ID=34131211

Family Applications (1)

Application Number Title Priority Date Filing Date
IL173482A IL173482A0 (en) 2003-08-06 2006-01-31 Polysaccharides derivatives with high antithrombotic activity in plasma

Country Status (18)

Country Link
US (1) US7687249B2 (enExample)
EP (1) EP1654288B9 (enExample)
JP (1) JP2007501305A (enExample)
KR (1) KR20060063933A (enExample)
CN (1) CN1832966A (enExample)
AT (1) ATE458009T1 (enExample)
AU (1) AU2004262584A1 (enExample)
BR (1) BRPI0413346A (enExample)
CA (1) CA2534709A1 (enExample)
DE (1) DE602004025583D1 (enExample)
DK (1) DK1654288T3 (enExample)
ES (1) ES2341249T3 (enExample)
IL (1) IL173482A0 (enExample)
IT (1) ITMI20031618A1 (enExample)
MX (1) MXPA06001511A (enExample)
RU (1) RU2361881C2 (enExample)
WO (1) WO2005014656A1 (enExample)
ZA (1) ZA200601643B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006316039B2 (en) * 2005-11-21 2011-08-18 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
GB0818255D0 (en) 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
US9498494B2 (en) 2008-09-11 2016-11-22 Agency For Science, Technology And Research Glycosaminoglycans
CN101698838B (zh) * 2008-12-26 2012-05-23 北京大学 尿苷二磷酸葡萄糖醛酸异构酶及其编码基因与应用
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
CN102712942B (zh) * 2009-09-01 2014-05-14 伦斯勒理工学院 K5肝素前体的发酵和纯化
WO2012016216A2 (en) 2010-07-29 2012-02-02 Shire Human Genetic Therapies Assays for detection of glycosaminoglycans
WO2013116677A2 (en) * 2012-02-01 2013-08-08 Shire Human Genetic Therapies, Inc. Assays for detection of glycosaminoglycans
CN102796723A (zh) * 2012-09-11 2012-11-28 深圳市海普瑞药业股份有限公司 肝素酶i的固定化方法
CN102888390B (zh) * 2012-10-30 2014-09-03 深圳市海普瑞药业股份有限公司 肝素酶ⅲ的固定化方法
CN103059165B (zh) * 2012-12-26 2015-04-29 安徽丰原药业股份有限公司 一种多糖酰化物及其制备方法
EP3399044B1 (en) 2015-12-28 2021-02-03 Ajinomoto Co., Inc. Method for producing heparan sulfate having anticoagulant activity
JP6225321B1 (ja) * 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
CN111148749A (zh) 2016-08-31 2020-05-12 王子控股株式会社 酸性低聚木糖的生产方法和酸性低聚木糖
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
US11278485B2 (en) 2017-05-31 2022-03-22 Oji Holdings Corporation Moisturizing topical preparation
SG11202002250VA (en) 2017-09-12 2020-04-29 Oji Holdings Corp Pentosan polysulfate and method for producing pentosan polysulfate
EP3730521B1 (en) 2017-12-20 2023-05-17 Oji Holdings Corporation Pentosan polysulfate and medicine containing pentosan polysulfate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1290814B1 (it) 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
SE9701454D0 (sv) 1997-04-18 1997-04-18 Ulf Lindahl new DNA sequences and a process for enzyme manufacture
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
DE60334617D1 (de) * 2002-06-18 2010-12-02 Glycores 2000 Srl Epimerderivate von k5-polysaccharid mit hohem sulfatierungsgrad

Also Published As

Publication number Publication date
ITMI20031618A1 (it) 2005-02-07
US7687249B2 (en) 2010-03-30
RU2361881C2 (ru) 2009-07-20
EP1654288A1 (en) 2006-05-10
EP1654288B1 (en) 2010-02-17
JP2007501305A (ja) 2007-01-25
DK1654288T3 (da) 2010-09-20
US20070042993A1 (en) 2007-02-22
ATE458009T1 (de) 2010-03-15
ES2341249T3 (es) 2010-06-17
ZA200601643B (en) 2007-05-30
DE602004025583D1 (de) 2010-04-01
AU2004262584A1 (en) 2005-02-17
BRPI0413346A (pt) 2006-10-10
WO2005014656A1 (en) 2005-02-17
CN1832966A (zh) 2006-09-13
EP1654288B9 (en) 2010-06-23
CA2534709A1 (en) 2005-02-17
KR20060063933A (ko) 2006-06-12
MXPA06001511A (es) 2006-05-15
RU2006106790A (ru) 2007-09-20

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