CN1780829B - β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 - Google Patents

β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 Download PDF

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Publication number
CN1780829B
CN1780829B CN2004800087813A CN200480008781A CN1780829B CN 1780829 B CN1780829 B CN 1780829B CN 2004800087813 A CN2004800087813 A CN 2004800087813A CN 200480008781 A CN200480008781 A CN 200480008781A CN 1780829 B CN1780829 B CN 1780829B
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CN
China
Prior art keywords
thiophene
fluoro
chloro
sulphonamide
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800087813A
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English (en)
Chinese (zh)
Other versions
CN1780829A (zh
Inventor
A·F·克雷夫特
L·雷斯尼克
S·C·迈尔
G·迪亚曼蒂迪斯
D·C·科尔
王听中
R·J·加兰特
M·霍克
B·L·哈里森
张民生
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Wyeth LLC
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Wyeth LLC
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Publication of CN1780829A publication Critical patent/CN1780829A/zh
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Publication of CN1780829B publication Critical patent/CN1780829B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2004800087813A 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物 Expired - Fee Related CN1780829B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
US60/459,228 2003-03-31
PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Related Child Applications (1)

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CNA2008100013400A Division CN101274926A (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

Publications (2)

Publication Number Publication Date
CN1780829A CN1780829A (zh) 2006-05-31
CN1780829B true CN1780829B (zh) 2010-12-29

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CN2004800087813A Expired - Fee Related CN1780829B (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
CNA2008100013400A Pending CN101274926A (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

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CNA2008100013400A Pending CN101274926A (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物

Country Status (22)

Country Link
US (3) US7300951B2 (enExample)
EP (1) EP1608638A1 (enExample)
JP (1) JP2006522126A (enExample)
KR (1) KR20060002908A (enExample)
CN (2) CN1780829B (enExample)
AR (1) AR043940A1 (enExample)
AU (1) AU2004230844B2 (enExample)
BR (1) BRPI0408962A (enExample)
CA (1) CA2517155A1 (enExample)
CL (1) CL2004000647A1 (enExample)
CO (1) CO5640049A2 (enExample)
CR (1) CR7951A (enExample)
EC (1) ECSP056128A (enExample)
MX (1) MXPA05010368A (enExample)
NO (1) NO20054263L (enExample)
NZ (1) NZ542468A (enExample)
RU (1) RU2342374C2 (enExample)
SG (1) SG167669A1 (enExample)
TW (1) TWI336698B (enExample)
UA (1) UA82093C2 (enExample)
WO (1) WO2004092155A1 (enExample)
ZA (1) ZA200507896B (enExample)

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WO2011084503A1 (en) * 2009-12-16 2011-07-14 North Carolina Central University Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases
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Publication number Publication date
BRPI0408962A (pt) 2006-04-04
EP1608638A1 (en) 2005-12-28
NO20054263D0 (no) 2005-09-15
TWI336698B (en) 2011-02-01
MXPA05010368A (es) 2005-11-17
US20090227667A1 (en) 2009-09-10
CA2517155A1 (en) 2004-10-28
NO20054263L (no) 2005-12-14
TW200504047A (en) 2005-02-01
AU2004230844B2 (en) 2010-12-09
WO2004092155A1 (en) 2004-10-28
CN101274926A (zh) 2008-10-01
US20040198778A1 (en) 2004-10-07
CL2004000647A1 (es) 2005-02-04
ECSP056128A (es) 2006-03-01
CO5640049A2 (es) 2006-05-31
JP2006522126A (ja) 2006-09-28
US7547725B2 (en) 2009-06-16
RU2342374C2 (ru) 2008-12-27
KR20060002908A (ko) 2006-01-09
RU2005133434A (ru) 2006-07-10
SG167669A1 (en) 2011-01-28
US7300951B2 (en) 2007-11-27
US7858658B2 (en) 2010-12-28
ZA200507896B (en) 2007-03-28
NZ542468A (en) 2009-01-31
AR043940A1 (es) 2005-08-17
UA82093C2 (uk) 2008-03-11
US20070254929A1 (en) 2007-11-01
CR7951A (es) 2008-10-29
CN1780829A (zh) 2006-05-31
AU2004230844A1 (en) 2004-10-28

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