CN1723198A - 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的芳基、芳氧基和烷氧基取代的1h－吲哚－3－基乙醛酸衍生物 - Google Patents

用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的芳基、芳氧基和烷氧基取代的1h－吲哚－3－基乙醛酸衍生物 Download PDF

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Publication number
CN1723198A
CN1723198A CNA2003801054475A CN200380105447A CN1723198A CN 1723198 A CN1723198 A CN 1723198A CN A2003801054475 A CNA2003801054475 A CN A2003801054475A CN 200380105447 A CN200380105447 A CN 200380105447A CN 1723198 A CN1723198 A CN 1723198A
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alkyl
phenyl
oxo
perfluoroalkyl
indol
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Chinese (zh)
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李·道尔顿·詹宁斯
哈桑·马哈茂德·埃洛卡达斯
杰拉尔丁·露丝·麦克法兰
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Wyeth LLC
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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CNA2003801054475A 2002-12-10 2003-12-09 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的芳基、芳氧基和烷氧基取代的1h－吲哚－3－基乙醛酸衍生物 Withdrawn CN1723198A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43232902P 2002-12-10 2002-12-10
US60/432,329 2002-12-10

Publications (1)

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CN1723198A true CN1723198A (zh) 2006-01-18

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CNA2003801054475A Withdrawn CN1723198A (zh) 2002-12-10 2003-12-09 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的芳基、芳氧基和烷氧基取代的1h－吲哚－3－基乙醛酸衍生物

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US (2) US7259182B2 (https=)
EP (1) EP1569901B1 (https=)
JP (1) JP2006510673A (https=)
CN (1) CN1723198A (https=)
AT (1) ATE411288T1 (https=)
AU (1) AU2003296324A1 (https=)
BR (1) BR0316585A (https=)
CA (1) CA2509191A1 (https=)
DE (1) DE60324183D1 (https=)
DK (1) DK1569901T3 (https=)
ES (1) ES2314289T3 (https=)
MX (1) MXPA05006283A (https=)
WO (1) WO2004052854A2 (https=)

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AU2009237657B2 (en) * 2008-04-16 2013-04-04 Oasmia Pharmaceutical Ab Novel estrogen receptor ligands
GB0812192D0 (en) * 2008-07-03 2008-08-13 Lectus Therapeutics Ltd Calcium ion channel modulators & uses thereof
JP2012509941A (ja) 2008-11-26 2012-04-26 ファイブ・プライム・セラピューティクス，インコーポレイテッド Ｓｅｒｐｉｎｅ２によるコラーゲンおよび平滑筋アクチンの発現を調節するための組成物および方法
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102335168B (zh) * 2011-10-25 2014-04-02 合肥博太医药生物技术发展有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗骨质疏松药物中的应用
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AU2003296324A1 (en) 2004-06-30
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EP1569901A2 (en) 2005-09-07
US20070259922A1 (en) 2007-11-08
CA2509191A1 (en) 2004-06-24
JP2006510673A (ja) 2006-03-30
DE60324183D1 (en) 2008-11-27
US7259182B2 (en) 2007-08-21
US7674818B2 (en) 2010-03-09
US20040138283A1 (en) 2004-07-15
ATE411288T1 (de) 2008-10-15
MXPA05006283A (es) 2005-08-19

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