CN1678310A - 用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物 - Google Patents

用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物 Download PDF

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Publication number
CN1678310A
CN1678310A CNA038200937A CN03820093A CN1678310A CN 1678310 A CN1678310 A CN 1678310A CN A038200937 A CNA038200937 A CN A038200937A CN 03820093 A CN03820093 A CN 03820093A CN 1678310 A CN1678310 A CN 1678310A
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CN
China
Prior art keywords
alkyl
disorazole
treatment
derivant
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038200937A
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English (en)
Chinese (zh)
Inventor
H·艾斯奇克
R·詹森
F·萨斯
S·巴斯纳
P·施米特
E·冈瑟
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Aeterna Zentaris GmbH
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Zentaris AG
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Publication of CN1678310A publication Critical patent/CN1678310A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P11/06—Antiasthmatics
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    • A61P17/06—Antipsoriatics
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
CNA038200937A 2002-08-24 2003-08-22 用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物 Pending CN1678310A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40559402P 2002-08-24 2002-08-24
US60/405,594 2002-08-24

Publications (1)

Publication Number Publication Date
CN1678310A true CN1678310A (zh) 2005-10-05

Family

ID=31993935

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038200937A Pending CN1678310A (zh) 2002-08-24 2003-08-22 用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物

Country Status (20)

Country Link
US (2) US20040106662A1 (https=)
EP (1) EP1536789A1 (https=)
JP (1) JP2006500398A (https=)
KR (1) KR20050038632A (https=)
CN (1) CN1678310A (https=)
AR (1) AR042617A1 (https=)
AU (1) AU2003296872B2 (https=)
BR (1) BR0313789A (https=)
CA (1) CA2438001A1 (https=)
HR (1) HRP20050277A2 (https=)
IL (1) IL166588A0 (https=)
MX (1) MXPA05002157A (https=)
NO (1) NO20051444L (https=)
NZ (1) NZ538926A (https=)
PL (1) PL376407A1 (https=)
RU (1) RU2322236C2 (https=)
TW (1) TW200404537A (https=)
UA (1) UA79480C2 (https=)
WO (1) WO2004024149A1 (https=)
ZA (1) ZA200501196B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101578287B (zh) * 2006-09-06 2012-09-05 阿特纳赞塔里斯有限公司 地索拉唑及其衍生物与细胞结合分子的轭合物，新的地索拉唑衍生物，其制备方法及其应用
JP5340155B2 (ja) * 2006-09-06 2013-11-13 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞結合分子を有するジソラゾールのコンジュゲート及びそれらの誘導体、新規ジソラゾール誘導体、それらの製法ならびに使用
EP1900742A1 (en) * 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
EP3641891A4 (en) 2017-06-22 2021-01-27 William Marsh Rice University SYNTHESIS OF DISORAZOLES AND THEIR ANALOGUES AS POWERFUL ANTI-CANCER AGENTS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19605024A1 (de) * 1996-01-31 1997-08-07 Schering Ag Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
PT1412332E (pt) * 2001-07-31 2005-06-30 Jerome P Horwitz Derivados de quinolina e sua utilizacao como agentes antitumorais
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
US7364877B2 (en) * 2002-12-06 2008-04-29 Kosan Biosciences, Inc. Polynucleotides encoding disorazole polyketide synthase polypeptides

Also Published As

Publication number Publication date
HRP20050277A2 (en) 2005-04-30
BR0313789A (pt) 2005-07-05
IL166588A0 (en) 2006-01-15
UA79480C2 (en) 2007-06-25
US20090311264A1 (en) 2009-12-17
CA2438001A1 (en) 2004-02-24
MXPA05002157A (es) 2005-05-23
WO2004024149A1 (de) 2004-03-25
EP1536789A1 (de) 2005-06-08
US20040106662A1 (en) 2004-06-03
RU2005108570A (ru) 2005-08-27
AR042617A1 (es) 2005-06-29
NO20051444L (no) 2005-05-19
JP2006500398A (ja) 2006-01-05
KR20050038632A (ko) 2005-04-27
PL376407A1 (en) 2005-12-27
AU2003296872B2 (en) 2008-02-14
RU2322236C2 (ru) 2008-04-20
NZ538926A (en) 2006-03-31
TW200404537A (en) 2004-04-01
AU2003296872A1 (en) 2004-04-30
ZA200501196B (en) 2005-10-26

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