CN1660054A - 快速崩解的甲基纤维素片剂 - Google Patents

快速崩解的甲基纤维素片剂 Download PDF

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Publication number
CN1660054A
CN1660054A CN2004100115143A CN200410011514A CN1660054A CN 1660054 A CN1660054 A CN 1660054A CN 2004100115143 A CN2004100115143 A CN 2004100115143A CN 200410011514 A CN200410011514 A CN 200410011514A CN 1660054 A CN1660054 A CN 1660054A
Authority
CN
China
Prior art keywords
tablet
methylcellulose
sodium
disintegrant
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2004100115143A
Other languages
English (en)
Chinese (zh)
Inventor
B·达盖
N·I·梅塔
P·纳亚克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1660054A publication Critical patent/CN1660054A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN2004100115143A 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂 Pending CN1660054A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5689997P 1997-08-22 1997-08-22
US60/056899 1997-08-22
US8766298P 1998-06-02 1998-06-02
US60/087662 1998-06-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN988102943A Division CN1215833C (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200610162476 Division CN1981747A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Publications (1)

Publication Number Publication Date
CN1660054A true CN1660054A (zh) 2005-08-31

Family

ID=26735831

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2004100115143A Pending CN1660054A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂
CN988102943A Expired - Fee Related CN1215833C (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN988102943A Expired - Fee Related CN1215833C (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Country Status (16)

Country Link
US (9) US6350469B1 (https=)
EP (1) EP1005329A4 (https=)
JP (1) JP2001513545A (https=)
KR (3) KR100743767B1 (https=)
CN (2) CN1660054A (https=)
AR (1) AR017512A1 (https=)
AU (1) AU741326B2 (https=)
BR (1) BR9811980A (https=)
CA (1) CA2301135C (https=)
CO (1) CO4960651A1 (https=)
EA (1) EA004803B1 (https=)
MY (2) MY135183A (https=)
NZ (1) NZ502891A (https=)
PL (1) PL338858A1 (https=)
TW (1) TWI222869B (https=)
WO (1) WO1999009958A1 (https=)

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Also Published As

Publication number Publication date
CN1276719A (zh) 2000-12-13
MY135183A (en) 2008-02-29
US20030215505A1 (en) 2003-11-20
EA004803B1 (ru) 2004-08-26
KR20070040424A (ko) 2007-04-16
EP1005329A1 (en) 2000-06-07
MY128046A (en) 2007-01-31
AU741326B2 (en) 2001-11-29
EA200000246A1 (ru) 2000-08-28
CA2301135C (en) 2007-04-24
US20020086052A1 (en) 2002-07-04
US20050089563A1 (en) 2005-04-28
US20050089565A1 (en) 2005-04-28
AU9202298A (en) 1999-03-16
EP1005329A4 (en) 2006-06-14
TWI222869B (en) 2004-11-01
US6350469B1 (en) 2002-02-26
WO1999009958A1 (en) 1999-03-04
US20050089561A1 (en) 2005-04-28
KR100743767B1 (ko) 2007-07-30
US20050089564A1 (en) 2005-04-28
PL338858A1 (en) 2000-11-20
CO4960651A1 (es) 2000-09-25
US7125562B2 (en) 2006-10-24
AR017512A1 (es) 2001-09-12
NZ502891A (en) 2002-06-28
KR20010023197A (ko) 2001-03-26
US20050089562A1 (en) 2005-04-28
KR20070116291A (ko) 2007-12-07
CN1215833C (zh) 2005-08-24
BR9811980A (pt) 2000-08-15
US20050089560A1 (en) 2005-04-28
CA2301135A1 (en) 1999-03-04
JP2001513545A (ja) 2001-09-04

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