CN1649883B - 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯 - Google Patents

作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯 Download PDF

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Publication number
CN1649883B
CN1649883B CN038097338A CN03809733A CN1649883B CN 1649883 B CN1649883 B CN 1649883B CN 038097338 A CN038097338 A CN 038097338A CN 03809733 A CN03809733 A CN 03809733A CN 1649883 B CN1649883 B CN 1649883B
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CN
China
Prior art keywords
oxo
thia
hept
ene
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN038097338A
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English (en)
Chinese (zh)
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CN1649883A (zh
Inventor
A·M·温卡特桑
T·S·曼索尔
T·阿贝
I·雅马穆拉
T·塔卡萨基
A·阿加瓦
O·D·桑托斯
F·-W·岑
Y·-I·林
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Wyeth LLC
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Wyeth LLC
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Publication of CN1649883A publication Critical patent/CN1649883A/zh
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Publication of CN1649883B publication Critical patent/CN1649883B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN038097338A 2002-05-01 2003-04-30 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯 Expired - Fee Related CN1649883B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01
US60/377,052 2002-05-01
PCT/US2003/013428 WO2003093279A1 (en) 2002-05-01 2003-04-30 BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2009101331547A Division CN101570545A (zh) 2002-05-01 2003-04-30 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯

Publications (2)

Publication Number Publication Date
CN1649883A CN1649883A (zh) 2005-08-03
CN1649883B true CN1649883B (zh) 2010-05-26

Family

ID=29401437

Family Applications (2)

Application Number Title Priority Date Filing Date
CN038097338A Expired - Fee Related CN1649883B (zh) 2002-05-01 2003-04-30 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯
CNA2009101331547A Pending CN101570545A (zh) 2002-05-01 2003-04-30 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2009101331547A Pending CN101570545A (zh) 2002-05-01 2003-04-30 作为内酰胺酶抑制剂的二环6-亚烷基-表霉烯

Country Status (21)

Country Link
US (3) US7112582B2 (enExample)
EP (2) EP1988093A1 (enExample)
JP (2) JP4602759B2 (enExample)
KR (1) KR20050007368A (enExample)
CN (2) CN1649883B (enExample)
AR (1) AR039774A1 (enExample)
AU (1) AU2003231205A1 (enExample)
BR (1) BR0309757A (enExample)
CA (1) CA2483538A1 (enExample)
CR (3) CR7508A (enExample)
EC (1) ECSP045397A (enExample)
IL (1) IL164899A0 (enExample)
MX (1) MXPA04010663A (enExample)
NO (1) NO20044549L (enExample)
NZ (1) NZ536182A (enExample)
RU (1) RU2339640C2 (enExample)
SG (1) SG162614A1 (enExample)
TW (1) TW200307687A (enExample)
UA (1) UA79117C2 (enExample)
WO (1) WO2003093279A1 (enExample)
ZA (1) ZA200409686B (enExample)

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US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
EP1660506A4 (en) * 2003-08-25 2009-02-25 Revaax Pharmaceuticals Llc ORAL NEUROTHERAPEUTIC CEFAZOLINE COMPOSITIONS
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
AU2006285308A1 (en) * 2005-07-27 2007-03-08 Wyeth Tricyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
RU2008102912A (ru) * 2005-07-27 2009-09-10 Вайет (Us) Сочетание ингибиторов бетта-лактазмы бициклического 6-алкилиденпенема с бетта-лактанным антибиотиком: антибиотик широкого спектра
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
BR112018015191B1 (pt) 2016-02-23 2023-10-17 Pfizer Inc Compostos de 6,7-di-hidro-5h-pirazolo[5,1-b][1,3]oxazina-2-carboxamida, seu uso e composição farmacêutica que os compreende
CN108473510B (zh) * 2016-04-28 2021-10-29 豪夫迈·罗氏有限公司 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
RU2019107162A (ru) 2016-08-15 2020-09-15 Байер Кропсайенс Акциенгезельшафт Конденсированные бициклические гетероциклические производные в качестве средств для борьбы с вредителями
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
BR112023023866A2 (pt) * 2021-05-21 2024-02-06 Chengdu Baiyu Pharmaceutical Co Ltd Derivado de piperazina e seu uso na medicina

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WO1987000525A1 (en) * 1985-07-22 1987-01-29 Beecham Group P.L.C. 6-alkylidene penems
CN1289766A (zh) * 1992-10-29 2001-04-04 史密丝克莱恩比彻姆有限公司 青霉烯类化合物及其衍生物

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AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
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TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
RU2008102912A (ru) * 2005-07-27 2009-09-10 Вайет (Us) Сочетание ингибиторов бетта-лактазмы бициклического 6-алкилиденпенема с бетта-лактанным антибиотиком: антибиотик широкого спектра

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
WO1987000525A1 (en) * 1985-07-22 1987-01-29 Beecham Group P.L.C. 6-alkylidene penems
CN1289766A (zh) * 1992-10-29 2001-04-04 史密丝克莱恩比彻姆有限公司 青霉烯类化合物及其衍生物

Also Published As

Publication number Publication date
SG162614A1 (en) 2010-07-29
EP1499621A1 (en) 2005-01-26
CR10986A (es) 2009-09-09
US7112582B2 (en) 2006-09-26
NZ536182A (en) 2006-10-27
EP1988093A1 (en) 2008-11-05
JP4602759B2 (ja) 2010-12-22
AR039774A1 (es) 2005-03-02
US20060217361A1 (en) 2006-09-28
RU2004135082A (ru) 2006-01-20
KR20050007368A (ko) 2005-01-17
TW200307687A (en) 2003-12-16
NO20044549L (no) 2005-01-25
UA79117C2 (en) 2007-05-25
CN101570545A (zh) 2009-11-04
CR7508A (es) 2005-01-05
JP2010215652A (ja) 2010-09-30
RU2339640C2 (ru) 2008-11-27
CR10983A (es) 2009-09-09
US20040077622A1 (en) 2004-04-22
WO2003093279A1 (en) 2003-11-13
US7812014B2 (en) 2010-10-12
CN1649883A (zh) 2005-08-03
CA2483538A1 (en) 2003-11-13
AU2003231205A1 (en) 2003-11-17
JP2005533017A (ja) 2005-11-04
US20080312203A1 (en) 2008-12-18
BR0309757A (pt) 2005-03-08
ECSP045397A (es) 2005-01-03
ZA200409686B (en) 2007-09-26
MXPA04010663A (es) 2005-04-20
IL164899A0 (en) 2005-12-18

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Granted publication date: 20100526

Termination date: 20110430