IL164899A0 - Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors - Google Patents

Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors

Info

Publication number
IL164899A0
IL164899A0 IL16489904A IL16489904A IL164899A0 IL 164899 A0 IL164899 A0 IL 164899A0 IL 16489904 A IL16489904 A IL 16489904A IL 16489904 A IL16489904 A IL 16489904A IL 164899 A0 IL164899 A0 IL 164899A0
Authority
IL
Israel
Prior art keywords
penems
alkylidene
bicyclic
beta
lactamases inhibitors
Prior art date
Application number
IL16489904A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of IL164899A0 publication Critical patent/IL164899A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL16489904A 2002-05-01 2004-10-28 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors IL164899A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01
PCT/US2003/013428 WO2003093279A1 (en) 2002-05-01 2003-04-30 BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS

Publications (1)

Publication Number Publication Date
IL164899A0 true IL164899A0 (en) 2005-12-18

Family

ID=29401437

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16489904A IL164899A0 (en) 2002-05-01 2004-10-28 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors

Country Status (21)

Country Link
US (3) US7112582B2 (enExample)
EP (2) EP1988093A1 (enExample)
JP (2) JP4602759B2 (enExample)
KR (1) KR20050007368A (enExample)
CN (2) CN101570545A (enExample)
AR (1) AR039774A1 (enExample)
AU (1) AU2003231205A1 (enExample)
BR (1) BR0309757A (enExample)
CA (1) CA2483538A1 (enExample)
CR (3) CR7508A (enExample)
EC (1) ECSP045397A (enExample)
IL (1) IL164899A0 (enExample)
MX (1) MXPA04010663A (enExample)
NO (1) NO20044549L (enExample)
NZ (1) NZ536182A (enExample)
RU (1) RU2339640C2 (enExample)
SG (1) SG162614A1 (enExample)
TW (1) TW200307687A (enExample)
UA (1) UA79117C2 (enExample)
WO (1) WO2003093279A1 (enExample)
ZA (1) ZA200409686B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
BRPI0413908A (pt) * 2003-08-25 2006-10-24 Revaax Pharmaceuticals Llc formulação farmacêutica neuroterapêutica em forma de dosagem oral, composto, e, método de tratamento de um distúrbio comportamental ou um distúrbio cognitivo
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20070129344A1 (en) * 2005-07-27 2007-06-07 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
CN101257902A (zh) * 2005-07-27 2008-09-03 惠氏公司 三环6-亚烷基-青霉烯β-内酰胺酶抑制剂与β-内酰胺抗生素的组合：广谱抗生素
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
PT3419979T (pt) 2016-02-23 2020-03-26 Pfizer Compostos de 6,7-dihidro-5h-pirazolo[5,1-b][1,3]oxazina-2-carboxamida
CN108473510B (zh) * 2016-04-28 2021-10-29 豪夫迈·罗氏有限公司 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
MX2019001918A (es) 2016-08-15 2019-09-06 Bayer Cropscience Ag Derivados del heterociclo biciclico condensado como agentes de control de plagas.
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
WO2022242750A1 (zh) * 2021-05-21 2022-11-24 成都百裕制药股份有限公司 哌嗪衍生物及其在医药上的应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
EP0041768B1 (en) 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
DE3584015D1 (de) 1984-01-30 1991-10-17 Pfizer 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518421D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518422D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
EP0232966B1 (en) 1986-01-17 1997-10-08 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB8724566D0 (en) 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
GB8729613D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
EP0447704A1 (en) 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
GB9326248D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
WO1995028935A1 (en) * 1994-04-25 1995-11-02 Smithkline Beecham Plc Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
EA200100347A1 (ru) * 1998-10-15 2001-10-22 Саравак Медичем Фармасьютикалс, Инк. Метод и композиция для лечения и профилактики туберкулеза
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20070129344A1 (en) * 2005-07-27 2007-06-07 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
SG162614A1 (en) 2010-07-29
NO20044549L (no) 2005-01-25
JP2010215652A (ja) 2010-09-30
JP2005533017A (ja) 2005-11-04
RU2004135082A (ru) 2006-01-20
CN1649883A (zh) 2005-08-03
WO2003093279A1 (en) 2003-11-13
CR10983A (es) 2009-09-09
TW200307687A (en) 2003-12-16
ECSP045397A (es) 2005-01-03
US7812014B2 (en) 2010-10-12
MXPA04010663A (es) 2005-04-20
CN101570545A (zh) 2009-11-04
ZA200409686B (en) 2007-09-26
US20060217361A1 (en) 2006-09-28
KR20050007368A (ko) 2005-01-17
BR0309757A (pt) 2005-03-08
CR10986A (es) 2009-09-09
JP4602759B2 (ja) 2010-12-22
US7112582B2 (en) 2006-09-26
UA79117C2 (en) 2007-05-25
US20080312203A1 (en) 2008-12-18
US20040077622A1 (en) 2004-04-22
EP1988093A1 (en) 2008-11-05
CA2483538A1 (en) 2003-11-13
AR039774A1 (es) 2005-03-02
AU2003231205A1 (en) 2003-11-17
CN1649883B (zh) 2010-05-26
CR7508A (es) 2005-01-05
NZ536182A (en) 2006-10-27
RU2339640C2 (ru) 2008-11-27
EP1499621A1 (en) 2005-01-26

Similar Documents

Publication Publication Date Title
EG25482A (en) Inhibitors
PL373146A1 (en) Pyridazinone-derivatives as pde4 inhibitors
AU2003301302A1 (en) Pyradazine compounds as gsk-3 inhibitors
EP1543009A4 (en) Pyrrolotriazine KINASE INHIBITORS
AU2003271566A8 (en) Pyrrolopyrazines as kinase inhibitors
EP1549316A4 (en) HAMMER OF TFGbeta
AU2003254051A8 (en) Pyrazolopyrimidines as kinase inhibitors
AU153894S (en) Planer
IL164899A0 (en) Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors
EP1532133A4 (en) NF-: B INHIBITORS
IL165475A0 (en) Nitrooxyderivatives of eyclooxygenase-2 inhibitors
ZA200510319B (en) 6-arylamino-5-cyano-4-pyrimidinones as PDE9a inhibitors
IL164898A0 (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
AU2003215635A1 (en) Thiazol-2-yl-imine compounds as pde-7 inhibitors
AU2003295638A8 (en) Novel inhibitors of beta-lactamase
AU2003304374A8 (en) Peptide inhibitors of beta-lactamases
AU2003232362A8 (en) 4-pyrazol-phenylalanine derivatives as ace-nep inhibitors
GB0228658D0 (en) Planer
HK1069390A (en) Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors
AU2003298513A8 (en) Sterically-awkward beta-lactamase inhibitors
AU2003217491A1 (en) Phenanthridinones as parp inhibitors
HK1069391A (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
GB0208094D0 (en) Inhibitors
GB0226149D0 (en) Inhibitors
GB0206031D0 (en) Inhibitors