SG162614A1 - Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors - Google Patents

Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors

Info

Publication number
SG162614A1
SG162614A1 SG200607462-9A SG2006074629A SG162614A1 SG 162614 A1 SG162614 A1 SG 162614A1 SG 2006074629 A SG2006074629 A SG 2006074629A SG 162614 A1 SG162614 A1 SG 162614A1
Authority
SG
Singapore
Prior art keywords
penems
alkylidene
bicyclic
beta
lactamases inhibitors
Prior art date
Application number
SG200607462-9A
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
Tarek Suhayl Mansour
Takao Abe
Itsuki Yamamura
Tsuyoshi Takasaki
Atul Agarwal
Osvaldo Dos Santos
Sum Fuk-Wah
Lin Yang-I
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of SG162614A1 publication Critical patent/SG162614A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG200607462-9A 2002-05-01 2003-04-30 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors SG162614A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
SG162614A1 true SG162614A1 (en) 2010-07-29

Family

ID=29401437

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200607462-9A SG162614A1 (en) 2002-05-01 2003-04-30 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors

Country Status (21)

Country Link
US (3) US7112582B2 (enExample)
EP (2) EP1988093A1 (enExample)
JP (2) JP4602759B2 (enExample)
KR (1) KR20050007368A (enExample)
CN (2) CN1649883B (enExample)
AR (1) AR039774A1 (enExample)
AU (1) AU2003231205A1 (enExample)
BR (1) BR0309757A (enExample)
CA (1) CA2483538A1 (enExample)
CR (3) CR7508A (enExample)
EC (1) ECSP045397A (enExample)
IL (1) IL164899A0 (enExample)
MX (1) MXPA04010663A (enExample)
NO (1) NO20044549L (enExample)
NZ (1) NZ536182A (enExample)
RU (1) RU2339640C2 (enExample)
SG (1) SG162614A1 (enExample)
TW (1) TW200307687A (enExample)
UA (1) UA79117C2 (enExample)
WO (1) WO2003093279A1 (enExample)
ZA (1) ZA200409686B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
CA2536910A1 (en) * 2003-08-25 2005-03-10 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cefazolin compositions
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
PE20070403A1 (es) * 2005-07-27 2007-05-15 Wyeth Corp COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA
MX2008001083A (es) * 2005-07-27 2008-03-19 Wyeth Corp Inhibidores de 6-alquiliden-penem b-lactamasa triciclicos y combinacion de antibioticos de beta-lactama: un antibiotico de amplio espectro.
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
KR102148587B1 (ko) 2016-02-23 2020-08-26 화이자 인코포레이티드 6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물
CN108473510B (zh) * 2016-04-28 2021-10-29 豪夫迈·罗氏有限公司 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
AU2017314083B2 (en) 2016-08-15 2020-12-10 Bayer Aktiengesellschaft Condensed bicyclic heterocycle derivatives as pest control agents
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
CN117279917A (zh) * 2021-05-21 2023-12-22 成都百裕制药股份有限公司 哌嗪衍生物及其在医药上的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000525A1 (en) * 1985-07-22 1987-01-29 Beecham Group P.L.C. 6-alkylidene penems
WO1994010178A1 (en) * 1992-10-29 1994-05-11 Smithkline Beecham P L C 6-(substituted methylene) penems and intermediates
WO1995017184A1 (en) * 1993-12-23 1995-06-29 Smithkline Beecham Plc Pharmaceutical compositions containing ceftriaxone and penems
US5911985A (en) * 1994-04-25 1999-06-15 Smithkline Beecham P.L.C. Pharmaceutical formulations containing a β-lactamase inhibiting penem in combination with β-lactam antibiotic and their use in the treatment of bacterial infections

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DE3176517D1 (en) 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
EP0150984B1 (en) 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
GB8518421D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518422D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3752124T2 (de) 1986-01-17 1998-03-26 Beecham Group Plc Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB8724566D0 (en) 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
GB8729613D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
EP0447704A1 (en) 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
WO2000021514A2 (en) * 1998-10-15 2000-04-20 Sarawak Medichem Pharmaceuticals, Inc. Method and composition for treating and preventing tuberculosis
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EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
PE20070403A1 (es) * 2005-07-27 2007-05-15 Wyeth Corp COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000525A1 (en) * 1985-07-22 1987-01-29 Beecham Group P.L.C. 6-alkylidene penems
WO1994010178A1 (en) * 1992-10-29 1994-05-11 Smithkline Beecham P L C 6-(substituted methylene) penems and intermediates
WO1995017184A1 (en) * 1993-12-23 1995-06-29 Smithkline Beecham Plc Pharmaceutical compositions containing ceftriaxone and penems
US5911985A (en) * 1994-04-25 1999-06-15 Smithkline Beecham P.L.C. Pharmaceutical formulations containing a β-lactamase inhibiting penem in combination with β-lactam antibiotic and their use in the treatment of bacterial infections

Also Published As

Publication number Publication date
WO2003093279A1 (en) 2003-11-13
CR10983A (es) 2009-09-09
CR10986A (es) 2009-09-09
US7112582B2 (en) 2006-09-26
JP4602759B2 (ja) 2010-12-22
RU2339640C2 (ru) 2008-11-27
EP1499621A1 (en) 2005-01-26
TW200307687A (en) 2003-12-16
NZ536182A (en) 2006-10-27
AR039774A1 (es) 2005-03-02
CN1649883B (zh) 2010-05-26
ECSP045397A (es) 2005-01-03
US20080312203A1 (en) 2008-12-18
CA2483538A1 (en) 2003-11-13
IL164899A0 (en) 2005-12-18
UA79117C2 (en) 2007-05-25
NO20044549L (no) 2005-01-25
RU2004135082A (ru) 2006-01-20
JP2010215652A (ja) 2010-09-30
ZA200409686B (en) 2007-09-26
EP1988093A1 (en) 2008-11-05
CN1649883A (zh) 2005-08-03
US20040077622A1 (en) 2004-04-22
MXPA04010663A (es) 2005-04-20
CR7508A (es) 2005-01-05
AU2003231205A1 (en) 2003-11-17
KR20050007368A (ko) 2005-01-17
US7812014B2 (en) 2010-10-12
US20060217361A1 (en) 2006-09-28
CN101570545A (zh) 2009-11-04
JP2005533017A (ja) 2005-11-04
BR0309757A (pt) 2005-03-08

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