CN1642966A - 9－脱氧－9a－氮杂－9a－甲基－9a－高红霉素A的同构假多晶型物 - Google Patents

9－脱氧－9a－氮杂－9a－甲基－9a－高红霉素A的同构假多晶型物 Download PDF

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Publication number
CN1642966A
CN1642966A CNA038063263A CN03806326A CN1642966A CN 1642966 A CN1642966 A CN 1642966A CN A038063263 A CNA038063263 A CN A038063263A CN 03806326 A CN03806326 A CN 03806326A CN 1642966 A CN1642966 A CN 1642966A
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CN
China
Prior art keywords
degree
homoerythromycin
methyl
under
pseudopolymorph
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038063263A
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English (en)
Chinese (zh)
Inventor
M·杜米克
M·温克维克
M·欧斯科
E·麦斯特罗维克
A·丹尼尔弗斯科
A·杜姆泊维克
Z·尼兹维克
G·拉扎勒维斯科
D·辛希
D·菲利克
K·拉扎里克
D－K·布喀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidelta doo
Original Assignee
Pliva Istrazivacki Institut doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Institut doo filed Critical Pliva Istrazivacki Institut doo
Publication of CN1642966A publication Critical patent/CN1642966A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
CNA038063263A 2002-03-18 2003-03-18 9－脱氧－9a－氮杂－9a－甲基－9a－高红霉素A的同构假多晶型物 Pending CN1642966A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
HRP20020231A 2002-03-18
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US60/393,612 2002-07-03
US39470502P 2002-07-08 2002-07-08
US60/394,705 2002-07-08

Publications (1)

Publication Number Publication Date
CN1642966A true CN1642966A (zh) 2005-07-20

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038063263A Pending CN1642966A (zh) 2002-03-18 2003-03-18 9－脱氧－9a－氮杂－9a－甲基－9a－高红霉素A的同构假多晶型物

Country Status (23)

Country Link
US (1) US7569549B2 (enExample)
EP (2) EP1485393B1 (enExample)
JP (1) JP2005529082A (enExample)
KR (1) KR20050002872A (enExample)
CN (1) CN1642966A (enExample)
AT (1) ATE440104T1 (enExample)
AU (1) AU2003215779A1 (enExample)
BG (1) BG108874A (enExample)
BR (1) BR0308644A (enExample)
CA (1) CA2479211A1 (enExample)
DE (1) DE60328872D1 (enExample)
EA (1) EA200401217A1 (enExample)
ES (1) ES2331733T3 (enExample)
HR (2) HRP20020231A2 (enExample)
IL (1) IL163836A0 (enExample)
IS (1) IS7449A (enExample)
MX (1) MXPA04009009A (enExample)
NO (1) NO20044341L (enExample)
NZ (1) NZ535477A (enExample)
PL (1) PL372468A1 (enExample)
RS (1) RS82504A (enExample)
TN (1) TNSN04166A1 (enExample)
WO (1) WO2003077830A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
WO2005009447A1 (en) * 2003-07-24 2005-02-03 Pliva - Research And Development Ltd. Single dose fast dissolving azithromycin
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
ES2308274T3 (es) * 2003-12-04 2008-12-01 Pfizer Products Inc. Procedimiento para fabricar multiparticulados farmaceuticos.
EP1689368B1 (en) * 2003-12-04 2016-09-28 Bend Research, Inc Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
MX12213A (es) * 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2162401C (en) 1993-05-19 1998-11-03 Bingwei V. Yang Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IL143376A0 (en) * 1998-11-30 2002-04-21 Teva Pharma Ethanolate of azithromycin, process for the manufacture, and pharmaceutical compositions thereof
HRP20010956B1 (hr) * 1999-06-29 2010-09-30 Biochemie S.A. Makrolidi
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
IL150564A0 (en) 2000-01-04 2003-02-12 Teva Pharma Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
AU2000270425A1 (en) 2000-07-25 2002-02-13 Instituto De Investigacion En Quimica Aplicada S.C Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydr oxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-ona and obtaining a new form of 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin
AU2001280000A1 (en) * 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
SK287814B6 (sk) 2000-11-27 2011-11-04 Sandoz Ag Azithromycin in the form of a monohydrate, a process for its preparation and pharmaceutical compositions comprising same
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
SK14402003A3 (sk) 2001-05-22 2004-06-08 Pfizer Products Inc. Kryštalické formy azitromycínu
EP1455758A1 (en) 2001-12-21 2004-09-15 Pfizer Products Inc. Directly compressible formulations of azithromycin
IL161259A0 (en) 2001-12-21 2004-09-27 Pfizer Prod Inc Methods for wet granulating azithromycin
PL372394A1 (en) 2002-02-01 2005-07-25 Pfizer Products Inc. Dry granulated formulations of azithromycin
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
IS7449A (is) 2004-09-16
JP2005529082A (ja) 2005-09-29
RS82504A (sr) 2006-12-15
HRP20020231A2 (en) 2003-12-31
BR0308644A (pt) 2005-01-25
EP1627883A1 (en) 2006-02-22
TNSN04166A1 (en) 2007-03-12
IL163836A0 (en) 2005-12-18
MXPA04009009A (es) 2005-06-17
EP1485393A2 (en) 2004-12-15
KR20050002872A (ko) 2005-01-10
US7569549B2 (en) 2009-08-04
NZ535477A (en) 2006-11-30
HRP20040858A2 (en) 2005-06-30
AU2003215779A1 (en) 2003-09-29
US20040014951A1 (en) 2004-01-22
EP1485393B1 (en) 2009-08-19
NO20044341L (no) 2004-11-23
DE60328872D1 (en) 2009-10-01
CA2479211A1 (en) 2003-09-25
BG108874A (en) 2005-12-30
WO2003077830A2 (en) 2003-09-25
WO2003077830A3 (en) 2004-05-13
ATE440104T1 (de) 2009-09-15
PL372468A1 (en) 2005-07-25
EA200401217A1 (ru) 2005-02-24
ES2331733T3 (es) 2010-01-14

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SE01 Entry into force of request for substantive examination
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WD01 Invention patent application deemed withdrawn after publication