DE60328872D1 - 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten - Google Patents

9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Info

Publication number
DE60328872D1
DE60328872D1 DE60328872T DE60328872T DE60328872D1 DE 60328872 D1 DE60328872 D1 DE 60328872D1 DE 60328872 T DE60328872 T DE 60328872T DE 60328872 T DE60328872 T DE 60328872T DE 60328872 D1 DE60328872 D1 DE 60328872D1
Authority
DE
Germany
Prior art keywords
homoerythromycin
aza
methyl
dexo
derivaten
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60328872T
Other languages
German (de)
English (en)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominik Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Hrvatska doo
Original Assignee
Pliva Hrvatska doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska doo filed Critical Pliva Hrvatska doo
Application granted granted Critical
Publication of DE60328872D1 publication Critical patent/DE60328872D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)
DE60328872T 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten Expired - Fee Related DE60328872D1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
DE60328872D1 true DE60328872D1 (en) 2009-10-01

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60328872T Expired - Fee Related DE60328872D1 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Country Status (23)

Country Link
US (1) US7569549B2 (enExample)
EP (2) EP1485393B1 (enExample)
JP (1) JP2005529082A (enExample)
KR (1) KR20050002872A (enExample)
CN (1) CN1642966A (enExample)
AT (1) ATE440104T1 (enExample)
AU (1) AU2003215779A1 (enExample)
BG (1) BG108874A (enExample)
BR (1) BR0308644A (enExample)
CA (1) CA2479211A1 (enExample)
DE (1) DE60328872D1 (enExample)
EA (1) EA200401217A1 (enExample)
ES (1) ES2331733T3 (enExample)
HR (2) HRP20020231A2 (enExample)
IL (1) IL163836A0 (enExample)
IS (1) IS7449A (enExample)
MX (1) MXPA04009009A (enExample)
NO (1) NO20044341L (enExample)
NZ (1) NZ535477A (enExample)
PL (1) PL372468A1 (enExample)
RS (1) RS82504A (enExample)
TN (1) TNSN04166A1 (enExample)
WO (1) WO2003077830A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
DE602004019288D1 (de) * 2003-07-24 2009-03-19 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
AU2004294818A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
EP1689368B1 (en) * 2003-12-04 2016-09-28 Bend Research, Inc Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions
EP1691786A1 (en) 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ATE154806T1 (de) 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
CN100339384C (zh) * 1998-11-30 2007-09-26 特瓦制药工业有限公司 阿齐霉素的乙醇化物，制备方法以及医药组合物
DE20023815U1 (de) * 1999-06-29 2006-06-08 Sandoz Ag Azithromycin enthaltende Zusammensetzungen
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
DE60133083D1 (de) 2000-01-04 2008-04-17 Teva Pharma Verfahren zur herstellung von azithromycin-dihydrat
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
CA2417353C (en) 2000-07-25 2009-09-01 Laboratorio Silanes,S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-one, and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
HU229488B1 (hu) * 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
GEP20084399B (en) 2001-05-22 2008-06-10 Pfizer Prod Inc Crystal forms of azithromycin
AU2002353316A1 (en) 2001-12-21 2003-07-09 Pfizer Products Inc. Methods for wet granulating azithromycin
WO2003053416A1 (en) 2001-12-21 2003-07-03 Pfizer Products Inc. Directly compressible formulations of azithromycin
RU2283092C2 (ru) 2002-02-01 2006-09-10 Пфайзер Продактс Инк. Сухие гранулированные композиции азитромицина
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
JP2005529082A (ja) 2005-09-29
ES2331733T3 (es) 2010-01-14
EP1485393B1 (en) 2009-08-19
IS7449A (is) 2004-09-16
ATE440104T1 (de) 2009-09-15
HRP20020231A2 (en) 2003-12-31
CN1642966A (zh) 2005-07-20
BR0308644A (pt) 2005-01-25
US7569549B2 (en) 2009-08-04
CA2479211A1 (en) 2003-09-25
MXPA04009009A (es) 2005-06-17
EP1627883A1 (en) 2006-02-22
EP1485393A2 (en) 2004-12-15
NO20044341L (no) 2004-11-23
AU2003215779A1 (en) 2003-09-29
IL163836A0 (en) 2005-12-18
US20040014951A1 (en) 2004-01-22
WO2003077830A3 (en) 2004-05-13
TNSN04166A1 (en) 2007-03-12
RS82504A (sr) 2006-12-15
KR20050002872A (ko) 2005-01-10
NZ535477A (en) 2006-11-30
EA200401217A1 (ru) 2005-02-24
PL372468A1 (en) 2005-07-25
HRP20040858A2 (en) 2005-06-30
WO2003077830A2 (en) 2003-09-25
BG108874A (en) 2005-12-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee