CN1638759A - 包含双膦酸类化合物和cox－2抑制剂、用于治疗骨病的药物组合物 - Google Patents

包含双膦酸类化合物和cox－2抑制剂、用于治疗骨病的药物组合物 Download PDF

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Publication number
CN1638759A
CN1638759A CNA038049007A CN03804900A CN1638759A CN 1638759 A CN1638759 A CN 1638759A CN A038049007 A CNA038049007 A CN A038049007A CN 03804900 A CN03804900 A CN 03804900A CN 1638759 A CN1638759 A CN 1638759A
Authority
CN
China
Prior art keywords
cox
inhibitor
bis
phosphonic acids
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038049007A
Other languages
English (en)
Chinese (zh)
Inventor
Z·D·霍罗威茨
P·L·西蒙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1638759A publication Critical patent/CN1638759A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA038049007A 2002-02-28 2003-02-28 包含双膦酸类化合物和cox－2抑制剂、用于治疗骨病的药物组合物 Pending CN1638759A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0204756.1 2002-02-28
GBGB0204756.1A GB0204756D0 (en) 2002-02-28 2002-02-28 Organic compounds

Publications (1)

Publication Number Publication Date
CN1638759A true CN1638759A (zh) 2005-07-13

Family

ID=9932008

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038049007A Pending CN1638759A (zh) 2002-02-28 2003-02-28 包含双膦酸类化合物和cox－2抑制剂、用于治疗骨病的药物组合物

Country Status (9)

Country Link
US (1) US20050209198A1 (enExample)
EP (1) EP1480637A1 (enExample)
JP (1) JP2005523291A (enExample)
CN (1) CN1638759A (enExample)
AU (1) AU2003210386A1 (enExample)
BR (1) BR0308105A (enExample)
CA (1) CA2477347A1 (enExample)
GB (1) GB0204756D0 (enExample)
WO (1) WO2003072097A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107540726A (zh) * 2017-08-22 2018-01-05 河北科技大学 一类肽基塞来昔布衍生物及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040053900A1 (en) * 1998-12-23 2004-03-18 Pharmacia Corporation Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2294879A (en) * 1994-10-19 1996-05-15 Merck & Co Inc Cylcooxygenase-2 Inhibitors
WO2000028982A2 (en) * 1998-11-19 2000-05-25 The Board Of Trustees For The University Of Arkansas Increasing bone strength with selected bisphosphonates
WO2000038715A2 (en) * 1998-12-23 2000-07-06 G.D. Searle & Co. Use of an integrin antagonist and radiation in the treatment of neoplasia
DK1296689T3 (da) * 2000-06-20 2005-11-28 Novartis Ag Fremgangsmåde til indgivelse af bisphosphonater
HUP0402061A3 (en) * 2001-10-19 2007-05-29 Novartis Ag Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, cox-2 inhibitor and a taxol

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107540726A (zh) * 2017-08-22 2018-01-05 河北科技大学 一类肽基塞来昔布衍生物及其应用

Also Published As

Publication number Publication date
US20050209198A1 (en) 2005-09-22
GB0204756D0 (en) 2002-04-17
JP2005523291A (ja) 2005-08-04
AU2003210386A1 (en) 2003-09-09
WO2003072097A1 (en) 2003-09-04
EP1480637A1 (en) 2004-12-01
BR0308105A (pt) 2005-01-04
CA2477347A1 (en) 2003-09-04

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