CN1634641A - 大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 - Google Patents
大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 Download PDFInfo
- Publication number
- CN1634641A CN1634641A CN 200410096797 CN200410096797A CN1634641A CN 1634641 A CN1634641 A CN 1634641A CN 200410096797 CN200410096797 CN 200410096797 CN 200410096797 A CN200410096797 A CN 200410096797A CN 1634641 A CN1634641 A CN 1634641A
- Authority
- CN
- China
- Prior art keywords
- compound
- organic compound
- pump
- alkaloid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 28
- 150000002894 organic compounds Chemical class 0.000 title claims abstract description 20
- 238000001223 reverse osmosis Methods 0.000 title claims description 26
- 238000000034 method Methods 0.000 title abstract description 16
- 230000008569 process Effects 0.000 title abstract description 11
- 238000010521 absorption reaction Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011347 resin Substances 0.000 claims abstract description 22
- 229920005989 resin Polymers 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 6
- -1 di esters alkaloid Chemical class 0.000 claims description 35
- 238000005516 engineering process Methods 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 22
- 238000000926 separation method Methods 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 20
- 229930013930 alkaloid Natural products 0.000 claims description 19
- 229930003944 flavone Natural products 0.000 claims description 18
- 235000011949 flavones Nutrition 0.000 claims description 18
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 17
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 17
- 239000002250 absorbent Substances 0.000 claims description 16
- 230000002745 absorbent Effects 0.000 claims description 16
- 239000007795 chemical reaction product Substances 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 16
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 13
- 229930182490 saponin Natural products 0.000 claims description 11
- 235000017709 saponins Nutrition 0.000 claims description 11
- 238000010168 coupling process Methods 0.000 claims description 10
- 238000005859 coupling reaction Methods 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 235000014347 soups Nutrition 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 7
- 238000010828 elution Methods 0.000 claims description 7
- 102100030621 Carboxypeptidase A4 Human genes 0.000 claims description 6
- ACVGWSKVRYFWRP-UHFFFAOYSA-N Rutecarpine Chemical compound C1=CC=C2C(=O)N(CCC=3C4=CC=CC=C4NC=33)C3=NC2=C1 ACVGWSKVRYFWRP-UHFFFAOYSA-N 0.000 claims description 6
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 6
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 5
- 150000007949 saponins Chemical class 0.000 claims description 5
- 244000170916 Paeonia officinalis Species 0.000 claims description 4
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 4
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Polymers C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 4
- 239000003480 eluent Substances 0.000 claims description 4
- 101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 claims description 3
- 102100030614 Carboxypeptidase A2 Human genes 0.000 claims description 3
- 101000772572 Homo sapiens Carboxypeptidase A4 Proteins 0.000 claims description 3
- 108091006675 Monovalent cation:proton antiporter-2 Proteins 0.000 claims description 3
- 108091006676 Monovalent cation:proton antiporter-3 Proteins 0.000 claims description 3
- 244000153955 Reynoutria sachalinensis Species 0.000 claims description 3
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 150000002212 flavone derivatives Chemical class 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 claims description 2
- PUQSUZTXKPLAPR-KSSYENDESA-N 4-(beta-D-Glucopyranosyloxy) benzyl alcohol Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-KSSYENDESA-N 0.000 claims description 2
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 claims description 2
- 241000173529 Aconitum napellus Species 0.000 claims description 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims description 2
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 2
- 235000003097 Artemisia absinthium Nutrition 0.000 claims description 2
- 235000001405 Artemisia annua Nutrition 0.000 claims description 2
- 240000000011 Artemisia annua Species 0.000 claims description 2
- 240000001851 Artemisia dracunculus Species 0.000 claims description 2
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims description 2
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims description 2
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 claims description 2
- DYQVDISPPLTLLR-HJQYTNQXSA-N Carthamin Natural products CC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@]2(O)C(=C(C=C/3C(=O)C(=C(O)[C@](O)([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C3=O)C(=O)C=Cc5ccc(O)cc5)C(=O)C(=C2O)C(=O)C=Cc6ccc(O)cc6)O DYQVDISPPLTLLR-HJQYTNQXSA-N 0.000 claims description 2
- 244000020518 Carthamus tinctorius Species 0.000 claims description 2
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 2
- 240000001829 Catharanthus roseus Species 0.000 claims description 2
- 241000218176 Corydalis Species 0.000 claims description 2
- 244000241257 Cucumis melo Species 0.000 claims description 2
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 claims description 2
- 241001016310 Epimedium grandiflorum Species 0.000 claims description 2
- 241000208688 Eucommia Species 0.000 claims description 2
- 241000576429 Forsythia suspensa Species 0.000 claims description 2
- 241000935235 Fritillaria meleagris Species 0.000 claims description 2
- 244000111489 Gardenia augusta Species 0.000 claims description 2
- 235000018958 Gardenia augusta Nutrition 0.000 claims description 2
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 claims description 2
- 239000009636 Huang Qi Substances 0.000 claims description 2
- 241001633628 Lycoris Species 0.000 claims description 2
- 235000003805 Musa ABB Group Nutrition 0.000 claims description 2
- 240000008790 Musa x paradisiaca Species 0.000 claims description 2
- 240000002948 Ophiopogon intermedius Species 0.000 claims description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims description 2
- 235000015266 Plantago major Nutrition 0.000 claims description 2
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims description 2
- 240000003582 Platycodon grandiflorus Species 0.000 claims description 2
- 241000208966 Polygala Species 0.000 claims description 2
- BCPAKGGXGLGKIO-UHFFFAOYSA-N Pseudorutaecarpin Natural products C1=CC=C2C(=O)N(CCC3=C4C5=CC=CC=C5N3)C4=NC2=C1 BCPAKGGXGLGKIO-UHFFFAOYSA-N 0.000 claims description 2
- 244000226566 Psoralea corylifolia Species 0.000 claims description 2
- 241000405414 Rehmannia Species 0.000 claims description 2
- 244000299790 Rheum rhabarbarum Species 0.000 claims description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 2
- 240000006079 Schisandra chinensis Species 0.000 claims description 2
- 235000008422 Schisandra chinensis Nutrition 0.000 claims description 2
- 229930183118 Tanshinone Natural products 0.000 claims description 2
- 241001078983 Tetradium ruticarpum Species 0.000 claims description 2
- 206010047700 Vomiting Diseases 0.000 claims description 2
- 229940039750 aconitine Drugs 0.000 claims description 2
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 claims description 2
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 claims description 2
- 150000004056 anthraquinones Chemical class 0.000 claims description 2
- BPYGTFFYYOWDBC-LOVSFRALSA-N arctiin Natural products COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc3ccc(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c3)cc1OC BPYGTFFYYOWDBC-LOVSFRALSA-N 0.000 claims description 2
- 239000001138 artemisia absinthium Substances 0.000 claims description 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims description 2
- 229930101531 artemisinin Natural products 0.000 claims description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- DSRNKUZOWRFQFO-UHFFFAOYSA-N cephalotaxine Natural products COC1=CC23CCCN2CCc4cc5OCOc5cc4C3=C1O DSRNKUZOWRFQFO-UHFFFAOYSA-N 0.000 claims description 2
- YMNCVRSYJBNGLD-KURKYZTESA-N cephalotaxine Chemical compound C([C@@]12C=C([C@H]([C@H]2C2=C3)O)OC)CCN1CCC2=CC1=C3OCO1 YMNCVRSYJBNGLD-KURKYZTESA-N 0.000 claims description 2
- 235000001671 coumarin Nutrition 0.000 claims description 2
- 150000004775 coumarins Chemical class 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 235000018905 epimedium Nutrition 0.000 claims description 2
- 229930003935 flavonoid Natural products 0.000 claims description 2
- 150000002215 flavonoids Chemical class 0.000 claims description 2
- 235000017173 flavonoids Nutrition 0.000 claims description 2
- 229930193974 gastrodin Natural products 0.000 claims description 2
- 229930182494 ginsenoside Natural products 0.000 claims description 2
- 229940089161 ginsenoside Drugs 0.000 claims description 2
- PUQSUZTXKPLAPR-NZEXEKPDSA-N helicidol Natural products O([C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-NZEXEKPDSA-N 0.000 claims description 2
- 229930013686 lignan Natural products 0.000 claims description 2
- 235000009408 lignans Nutrition 0.000 claims description 2
- SDHTXBWLVGWJFT-XKCURVIJSA-N oridonin Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12[C@@H](O)CCC(C)(C)[C@H]1[C@H](O)[C@@]3(O)OC2 SDHTXBWLVGWJFT-XKCURVIJSA-N 0.000 claims description 2
- CAQAFLRZJHXSIS-UHFFFAOYSA-N oridonin Natural products CC1(C)C=CC(O)C23COC(O)(C(O)C12)C45C(O)C(CCC34)C(=C)C5=O CAQAFLRZJHXSIS-UHFFFAOYSA-N 0.000 claims description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 claims description 2
- 229930183339 qinghaosu Natural products 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N tanshinone IIA Natural products C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 claims description 2
- 150000008130 triterpenoid saponins Chemical class 0.000 claims description 2
- 230000008673 vomiting Effects 0.000 claims description 2
- 150000003436 stilbenoids Chemical class 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 5
- 238000004811 liquid chromatography Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 239000001685 glycyrrhizic acid Substances 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 244000276331 Citrus maxima Species 0.000 description 1
- 235000001759 Citrus maxima Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Chemical class 0.000 description 1
- 229920000036 polyvinylpyrrolidone Chemical class 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100967976A CN100434148C (zh) | 2004-12-08 | 2004-12-08 | 大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100967976A CN100434148C (zh) | 2004-12-08 | 2004-12-08 | 大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1634641A true CN1634641A (zh) | 2005-07-06 |
CN100434148C CN100434148C (zh) | 2008-11-19 |
Family
ID=34847895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100967976A Active CN100434148C (zh) | 2004-12-08 | 2004-12-08 | 大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100434148C (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101130548B (zh) * | 2006-08-25 | 2010-11-03 | 上海诺德生物实业有限公司 | 一种提取制备高含量青蒿素的方法 |
CN102351928A (zh) * | 2011-08-23 | 2012-02-15 | 北京科莱博医药开发有限责任公司 | 一种从车前子中提取环烯醚萜类活性成分的方法 |
CN102649802A (zh) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | 一种三叶豆紫檀苷的制备方法 |
CN102763687A (zh) * | 2012-07-09 | 2012-11-07 | 南京农业大学 | 一种大孔树脂富集纯化菊芋叶中总黄酮的方法 |
CN103599189A (zh) * | 2013-11-21 | 2014-02-26 | 贵州信邦制药股份有限公司 | 贞芪扶正注射制剂及其制备方法 |
CN104277084A (zh) * | 2013-07-07 | 2015-01-14 | 云南健牛生物科技有限公司 | 一种提高中药中极性或弱极性有效成分含量的提取方法 |
CN106496172A (zh) * | 2016-10-21 | 2017-03-15 | 乌鲁木齐上善元生物科技有限公司 | 一种从红花中提取红花黄色素的方法 |
CN106511745A (zh) * | 2016-11-25 | 2017-03-22 | 神威药业集团有限公司 | 一种玄麦甘桔组合物及其制备方法 |
CN107663188A (zh) * | 2017-10-27 | 2018-02-06 | 河南中医药大学 | 一种地骨皮总木脂素酰胺类生物碱提取物及其制备方法和用途 |
CN112724183A (zh) * | 2021-02-01 | 2021-04-30 | 蚌埠学院 | 一种牛蒡子苷的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9212718D0 (en) * | 1992-06-16 | 1992-07-29 | Rohm & Haas | Treatment of food products and by-products |
JPH0640884A (ja) * | 1992-07-24 | 1994-02-15 | Taiyo Kagaku Co Ltd | 美白化粧料 |
CN1515523A (zh) * | 2003-08-26 | 2004-07-28 | 姜浩奎 | 用树脂法从山杏叶中提取异黄酮、黄酮类、内脂的方法 |
CN1273148C (zh) * | 2003-11-28 | 2006-09-06 | 南宁领标生物技术有限责任公司 | 大田基黄降血压产品及其生产工艺 |
-
2004
- 2004-12-08 CN CNB2004100967976A patent/CN100434148C/zh active Active
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101130548B (zh) * | 2006-08-25 | 2010-11-03 | 上海诺德生物实业有限公司 | 一种提取制备高含量青蒿素的方法 |
CN102649802A (zh) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | 一种三叶豆紫檀苷的制备方法 |
CN102351928A (zh) * | 2011-08-23 | 2012-02-15 | 北京科莱博医药开发有限责任公司 | 一种从车前子中提取环烯醚萜类活性成分的方法 |
CN102763687B (zh) * | 2012-07-09 | 2014-04-09 | 南京农业大学 | 一种大孔树脂富集纯化菊芋叶中总黄酮的方法 |
CN102763687A (zh) * | 2012-07-09 | 2012-11-07 | 南京农业大学 | 一种大孔树脂富集纯化菊芋叶中总黄酮的方法 |
CN104277084A (zh) * | 2013-07-07 | 2015-01-14 | 云南健牛生物科技有限公司 | 一种提高中药中极性或弱极性有效成分含量的提取方法 |
CN104277084B (zh) * | 2013-07-07 | 2018-01-16 | 云南健牛生物科技有限公司 | 一种提高中药中极性或弱极性有效成分含量的提取方法 |
CN103599189A (zh) * | 2013-11-21 | 2014-02-26 | 贵州信邦制药股份有限公司 | 贞芪扶正注射制剂及其制备方法 |
CN106496172A (zh) * | 2016-10-21 | 2017-03-15 | 乌鲁木齐上善元生物科技有限公司 | 一种从红花中提取红花黄色素的方法 |
CN106496172B (zh) * | 2016-10-21 | 2018-12-25 | 乌鲁木齐上善元生物科技有限公司 | 一种从红花中提取红花黄色素的方法 |
CN106511745A (zh) * | 2016-11-25 | 2017-03-22 | 神威药业集团有限公司 | 一种玄麦甘桔组合物及其制备方法 |
CN107663188A (zh) * | 2017-10-27 | 2018-02-06 | 河南中医药大学 | 一种地骨皮总木脂素酰胺类生物碱提取物及其制备方法和用途 |
CN107663188B (zh) * | 2017-10-27 | 2020-02-04 | 河南中医药大学 | 一种地骨皮总木脂素酰胺类生物碱提取物及其制备方法和用途 |
CN112724183A (zh) * | 2021-02-01 | 2021-04-30 | 蚌埠学院 | 一种牛蒡子苷的制备方法 |
CN112724183B (zh) * | 2021-02-01 | 2023-08-22 | 蚌埠学院 | 一种牛蒡子苷的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100434148C (zh) | 2008-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102229632B (zh) | 矢车菊-3-o-葡萄糖苷的制备方法 | |
CN102351819B (zh) | 一种高纯度丹参酚酸b的提取纯化制备方法 | |
CN106478836A (zh) | 一种枸杞多糖的制备方法 | |
CN1324043C (zh) | 高纯度罗汉果甜苷v的制备方法和用途 | |
CN101062077A (zh) | 一种同时制备甜叶菊总甜菊苷和甜叶菊总黄酮的方法 | |
CN100434148C (zh) | 大孔吸附树脂-反渗透膜联用分离纯化有机化合物的制备工艺 | |
CN101781351B (zh) | 一种从西洋参中提取人参皂甙Rb1的方法及其粉针剂 | |
CN105132172A (zh) | 一种从鸢尾根中制备烟草用鸢尾根黄酮类物质的方法 | |
CN100439319C (zh) | 一种丹参酚酸a的制备方法 | |
CN1277954A (zh) | 白藜芦醇和白藜芦醇甙分离方法及其应用 | |
CN105061529A (zh) | 桑葚花色苷的提取工艺 | |
CN104892717B (zh) | 一种罗汉果甜苷v的工业级制备液相色谱分离方法 | |
CN106943447A (zh) | 一种罗汉果提取物的制备方法 | |
CN105153253A (zh) | 紫甘薯花色苷的提取工艺 | |
CN105837546B (zh) | 一种从草豆蔻中分离纯化桤木酮、松属素、小豆蔻明、山姜素的方法 | |
CN102351782B (zh) | 一种从桑叶中提取1-脱氧野尻霉素和白藜芦醇的方法 | |
CN106916162B (zh) | 一种岩大戟内酯b原料药的制备方法 | |
CN109293726A (zh) | 二醇型人参皂苷提取物及其制备方法 | |
CN112043733B (zh) | 一种水溶性银杏叶提取物的生产方法 | |
CN101481398B (zh) | 一种从独一味中同时制备高纯度5-羟基-独一味素a苷和独一味素a苷提取物的方法 | |
CN106946833A (zh) | 一种从猫须草中提取高纯度橙黄酮的方法 | |
CN1730027A (zh) | 从獐牙菜属主要药用植物中制备抗肝炎活性部位的方法 | |
CN102399252A (zh) | 一种王不留行黄酮苷单体的制备方法 | |
CN102532219A (zh) | 一种富集纯化蓝靛果忍冬中花色苷的方法 | |
CN111675741A (zh) | 用制备液相法同时获得四种淫羊藿稀有黄酮的分离方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Chen Yanping Document name: payment instructions |
|
DD01 | Delivery of document by public notice |
Addressee: Zhang Ling Document name: Deemed not to have provided notice |
|
DD01 | Delivery of document by public notice | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230803 Address after: No. 21, North Section of Jing'er Road, Qinghai Biotechnology Industrial Park, Xining City, Qinghai Province Patentee after: Qinghai Yangzong Pharm Co.,Ltd. Address before: 100006 Beijing City, Dongcheng District Andingmen East Street, No. 28, building B, room 907 Patentee before: Zhang Ling |
|
TR01 | Transfer of patent right | ||
DD01 | Delivery of document by public notice |
Addressee: Chen Yanping Document name: Notification of Qualified Procedures |
|
DD01 | Delivery of document by public notice |