CN1622807A - 用作IgE抑制剂的苯基嘧啶取代的胺 - Google Patents

用作IgE抑制剂的苯基嘧啶取代的胺 Download PDF

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Publication number
CN1622807A
CN1622807A CNA038027372A CN03802737A CN1622807A CN 1622807 A CN1622807 A CN 1622807A CN A038027372 A CNA038027372 A CN A038027372A CN 03802737 A CN03802737 A CN 03802737A CN 1622807 A CN1622807 A CN 1622807A
Authority
CN
China
Prior art keywords
alkyl
hydrogen
amino
chemical compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038027372A
Other languages
English (en)
Chinese (zh)
Inventor
M·布鲁斯
P·埃特迈尔
K·魏甘德
M·沃伊泽奇拉格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0202381A external-priority patent/GB0202381D0/en
Priority claimed from GB0221953A external-priority patent/GB0221953D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1622807A publication Critical patent/CN1622807A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA038027372A 2002-02-01 2003-01-31 用作IgE抑制剂的苯基嘧啶取代的胺 Pending CN1622807A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0202381.0 2002-02-01
GB0202381A GB0202381D0 (en) 2002-02-01 2002-02-01 Organic compounds
GB0221953A GB0221953D0 (en) 2002-09-20 2002-09-20 Organic compounds
GB0221953.3 2002-09-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200910205037A Division CN101684097A (zh) 2002-02-01 2003-01-31 用作IgE抑制剂的苯基嘧啶取代的胺

Publications (1)

Publication Number Publication Date
CN1622807A true CN1622807A (zh) 2005-06-01

Family

ID=27665364

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA038027372A Pending CN1622807A (zh) 2002-02-01 2003-01-31 用作IgE抑制剂的苯基嘧啶取代的胺
CN200910205037A Pending CN101684097A (zh) 2002-02-01 2003-01-31 用作IgE抑制剂的苯基嘧啶取代的胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200910205037A Pending CN101684097A (zh) 2002-02-01 2003-01-31 用作IgE抑制剂的苯基嘧啶取代的胺

Country Status (23)

Country Link
US (2) US20050119255A1 (ko)
EP (1) EP1474146B1 (ko)
JP (1) JP4393198B2 (ko)
KR (1) KR20040081159A (ko)
CN (2) CN1622807A (ko)
AR (1) AR038368A1 (ko)
AT (1) ATE406165T1 (ko)
AU (1) AU2003206810B2 (ko)
BR (1) BR0307379A (ko)
CA (1) CA2471883C (ko)
DE (1) DE60323205D1 (ko)
EC (1) ECSP045213A (ko)
ES (1) ES2312749T3 (ko)
IL (1) IL162766A0 (ko)
MX (1) MXPA04007395A (ko)
NO (1) NO20043610L (ko)
NZ (1) NZ534229A (ko)
PE (1) PE20030983A1 (ko)
PL (1) PL370666A1 (ko)
PT (1) PT1474146E (ko)
RU (1) RU2004126614A (ko)
TW (1) TW200302728A (ko)
WO (1) WO2003063871A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
AU2004261484A1 (en) * 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
EP1679309A4 (en) * 2003-10-24 2007-03-28 Ono Pharmaceutical Co ANTISTRESS MEDICAMENT AND ITS MEDICAL USE
EP1933839A1 (en) * 2005-09-29 2008-06-25 Novartis AG Phenyl-(4-phenyl-pyrimidin-2-yl)-amines for enhancing immunotolerance
NZ583351A (en) * 2007-08-15 2012-05-25 Cytokinetics Inc Modulate smooth muscle myosin and/or non-muscle myosin
KR20220150280A (ko) 2019-12-20 2022-11-10 이케나 온콜로지, 인코포레이티드 E.g. 혈관신생 관련 또는 염증성 장애의 치료를 위한 아릴 탄화수소 수용체 (ahr) 작용제로서의 4-페닐-n-(페닐)티아졸-2-아민 유도체 및 관련 화합물

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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GB1185039A (en) 1966-03-31 1970-03-18 Ici Ltd Pyrimidine Derivatives and Compositions containing them
GB2001069B (en) 1977-07-12 1982-01-20 Scras Pyrimidine derivatives
AU5319479A (en) 1978-12-22 1980-06-26 Ici Australia Limited Pyrimidinyl amino phenoxy carboxylate derivatives
US4351939A (en) 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
EP0084194B1 (de) 1982-01-14 1986-04-30 MERCK PATENT GmbH Flüssigkristallmischungen
FR2536071B1 (fr) 1982-11-12 1986-07-11 Sanofi Sa Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2547821B1 (fr) 1983-06-24 1985-12-06 Sanofi Sa Sel de 2-piperazinopyrimidine, procede pour sa preparation et compositions pharmaceutiques en contenant
US4659363A (en) 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
US4694009A (en) 1984-06-25 1987-09-15 Ciba-Geigy Corporation Pesticidal compositions
SG47583A1 (en) 1986-01-13 1998-04-17 American Cyanamid Co 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines
DE3614060A1 (de) 1986-04-23 1987-10-29 Schering Ag Pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4868183A (en) 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
EP0264348B1 (de) 1986-10-13 1993-12-15 Ciba-Geigy Ag Harnstoffe
US4826990A (en) 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
ES2058589T3 (es) 1988-04-12 1994-11-01 Ciba Geigy Ag Ureas.
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
US4973690A (en) 1988-04-12 1990-11-27 Ciba-Geigy Corporation Novel ureas
JPH02308248A (ja) 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
KR100330553B1 (ko) 1993-10-01 2002-11-27 노파르티스 아게 약물학적활성피리딘유도체및그의제조방법
AU693475B2 (en) 1993-10-01 1998-07-02 Novartis Ag Pyrimidineamine derivatives and processes for the preparation thereof
US5705502A (en) 1993-10-01 1998-01-06 Novartis Corporation Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
NZ274978A (en) * 1993-10-12 1998-04-27 Du Pont Merck Pharma 1n-alkyl-n-aryl pyrimidinamine derivatives and pharmaceutical compositions thereof
WO1996005177A1 (en) 1994-08-13 1996-02-22 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
JP2002514195A (ja) 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジン化合物およびそれの使用
US6187781B1 (en) * 1997-03-26 2001-02-13 Taisho Pharmaceutical Co., Ltd. 4-Tetrahydropyridylpyrimidine derivatives
IN188411B (ko) 1997-03-27 2002-09-21 Yuhan Corp
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WO1999035140A1 (en) * 1998-01-12 1999-07-15 Novartis Ag PYRIDINYLPYRIMIDINE AMINES AS IMMUNOGLOBULINE E (IgE) SYNTHESIS INHIBITORS
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Also Published As

Publication number Publication date
EP1474146A1 (en) 2004-11-10
KR20040081159A (ko) 2004-09-20
PL370666A1 (en) 2005-05-30
EP1474146B1 (en) 2008-08-27
BR0307379A (pt) 2004-12-28
CA2471883A1 (en) 2003-08-07
ATE406165T1 (de) 2008-09-15
PT1474146E (pt) 2008-12-05
MXPA04007395A (es) 2005-06-17
ECSP045213A (es) 2004-09-28
RU2004126614A (ru) 2005-05-27
CA2471883C (en) 2010-12-07
DE60323205D1 (en) 2008-10-09
PE20030983A1 (es) 2004-01-26
US20050119255A1 (en) 2005-06-02
JP2005516051A (ja) 2005-06-02
US7759357B2 (en) 2010-07-20
US20070281956A1 (en) 2007-12-06
JP4393198B2 (ja) 2010-01-06
IL162766A0 (en) 2005-11-20
AR038368A1 (es) 2005-01-12
NO20043610L (no) 2004-10-05
AU2003206810B2 (en) 2006-06-29
NZ534229A (en) 2005-04-29
ES2312749T3 (es) 2009-03-01
WO2003063871A1 (en) 2003-08-07
CN101684097A (zh) 2010-03-31
TW200302728A (en) 2003-08-16

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Open date: 20050601