CN1622807A - 用作IgE抑制剂的苯基嘧啶取代的胺 - Google Patents
用作IgE抑制剂的苯基嘧啶取代的胺 Download PDFInfo
- Publication number
- CN1622807A CN1622807A CNA038027372A CN03802737A CN1622807A CN 1622807 A CN1622807 A CN 1622807A CN A038027372 A CNA038027372 A CN A038027372A CN 03802737 A CN03802737 A CN 03802737A CN 1622807 A CN1622807 A CN 1622807A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- hydrogen
- amino
- chemical compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0202381.0 | 2002-02-01 | ||
GB0202381A GB0202381D0 (en) | 2002-02-01 | 2002-02-01 | Organic compounds |
GB0221953A GB0221953D0 (en) | 2002-09-20 | 2002-09-20 | Organic compounds |
GB0221953.3 | 2002-09-20 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910205037A Division CN101684097A (zh) | 2002-02-01 | 2003-01-31 | 用作IgE抑制剂的苯基嘧啶取代的胺 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1622807A true CN1622807A (zh) | 2005-06-01 |
Family
ID=27665364
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038027372A Pending CN1622807A (zh) | 2002-02-01 | 2003-01-31 | 用作IgE抑制剂的苯基嘧啶取代的胺 |
CN200910205037A Pending CN101684097A (zh) | 2002-02-01 | 2003-01-31 | 用作IgE抑制剂的苯基嘧啶取代的胺 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910205037A Pending CN101684097A (zh) | 2002-02-01 | 2003-01-31 | 用作IgE抑制剂的苯基嘧啶取代的胺 |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050119255A1 (ko) |
EP (1) | EP1474146B1 (ko) |
JP (1) | JP4393198B2 (ko) |
KR (1) | KR20040081159A (ko) |
CN (2) | CN1622807A (ko) |
AR (1) | AR038368A1 (ko) |
AT (1) | ATE406165T1 (ko) |
AU (1) | AU2003206810B2 (ko) |
BR (1) | BR0307379A (ko) |
CA (1) | CA2471883C (ko) |
DE (1) | DE60323205D1 (ko) |
EC (1) | ECSP045213A (ko) |
ES (1) | ES2312749T3 (ko) |
IL (1) | IL162766A0 (ko) |
MX (1) | MXPA04007395A (ko) |
NO (1) | NO20043610L (ko) |
NZ (1) | NZ534229A (ko) |
PE (1) | PE20030983A1 (ko) |
PL (1) | PL370666A1 (ko) |
PT (1) | PT1474146E (ko) |
RU (1) | RU2004126614A (ko) |
TW (1) | TW200302728A (ko) |
WO (1) | WO2003063871A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
AU2004261484A1 (en) * | 2003-07-30 | 2005-02-10 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
EP1679309A4 (en) * | 2003-10-24 | 2007-03-28 | Ono Pharmaceutical Co | ANTISTRESS MEDICAMENT AND ITS MEDICAL USE |
EP1933839A1 (en) * | 2005-09-29 | 2008-06-25 | Novartis AG | Phenyl-(4-phenyl-pyrimidin-2-yl)-amines for enhancing immunotolerance |
NZ583351A (en) * | 2007-08-15 | 2012-05-25 | Cytokinetics Inc | Modulate smooth muscle myosin and/or non-muscle myosin |
KR20220150280A (ko) | 2019-12-20 | 2022-11-10 | 이케나 온콜로지, 인코포레이티드 | E.g. 혈관신생 관련 또는 염증성 장애의 치료를 위한 아릴 탄화수소 수용체 (ahr) 작용제로서의 4-페닐-n-(페닐)티아졸-2-아민 유도체 및 관련 화합물 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1185039A (en) | 1966-03-31 | 1970-03-18 | Ici Ltd | Pyrimidine Derivatives and Compositions containing them |
GB2001069B (en) | 1977-07-12 | 1982-01-20 | Scras | Pyrimidine derivatives |
AU5319479A (en) | 1978-12-22 | 1980-06-26 | Ici Australia Limited | Pyrimidinyl amino phenoxy carboxylate derivatives |
US4351939A (en) | 1980-10-16 | 1982-09-28 | Mead Johnson & Company | Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process |
EP0084194B1 (de) | 1982-01-14 | 1986-04-30 | MERCK PATENT GmbH | Flüssigkristallmischungen |
FR2536071B1 (fr) | 1982-11-12 | 1986-07-11 | Sanofi Sa | Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant |
FR2547821B1 (fr) | 1983-06-24 | 1985-12-06 | Sanofi Sa | Sel de 2-piperazinopyrimidine, procede pour sa preparation et compositions pharmaceutiques en contenant |
US4659363A (en) | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
EP0164204A1 (en) | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
US4694009A (en) | 1984-06-25 | 1987-09-15 | Ciba-Geigy Corporation | Pesticidal compositions |
SG47583A1 (en) | 1986-01-13 | 1998-04-17 | American Cyanamid Co | 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines |
DE3614060A1 (de) | 1986-04-23 | 1987-10-29 | Schering Ag | Pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
US4868183A (en) | 1986-07-21 | 1989-09-19 | Otsuka Pharmaceutical Factory, Inc. | N-pyrazinyl substituted P-aminophenols |
EP0264348B1 (de) | 1986-10-13 | 1993-12-15 | Ciba-Geigy Ag | Harnstoffe |
US4826990A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
ES2058589T3 (es) | 1988-04-12 | 1994-11-01 | Ciba Geigy Ag | Ureas. |
US4966622A (en) | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
US4973690A (en) | 1988-04-12 | 1990-11-27 | Ciba-Geigy Corporation | Novel ureas |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
KR100330553B1 (ko) | 1993-10-01 | 2002-11-27 | 노파르티스 아게 | 약물학적활성피리딘유도체및그의제조방법 |
AU693475B2 (en) | 1993-10-01 | 1998-07-02 | Novartis Ag | Pyrimidineamine derivatives and processes for the preparation thereof |
US5705502A (en) | 1993-10-01 | 1998-01-06 | Novartis Corporation | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
NZ274978A (en) * | 1993-10-12 | 1998-04-27 | Du Pont Merck Pharma | 1n-alkyl-n-aryl pyrimidinamine derivatives and pharmaceutical compositions thereof |
WO1996005177A1 (en) | 1994-08-13 | 1996-02-22 | Yuhan Corporation | Novel pyrimidine derivatives and processes for the preparation thereof |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
JP2002514195A (ja) | 1996-12-05 | 2002-05-14 | アムジエン・インコーポレーテツド | 置換ピリミジン化合物およびそれの使用 |
US6187781B1 (en) * | 1997-03-26 | 2001-02-13 | Taisho Pharmaceutical Co., Ltd. | 4-Tetrahydropyridylpyrimidine derivatives |
IN188411B (ko) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
WO1999035140A1 (en) * | 1998-01-12 | 1999-07-15 | Novartis Ag | PYRIDINYLPYRIMIDINE AMINES AS IMMUNOGLOBULINE E (IgE) SYNTHESIS INHIBITORS |
PL341984A1 (en) * | 1998-01-28 | 2001-05-07 | Shionogi & Co | Novel tricycle compounds |
DK0945443T3 (da) | 1998-03-27 | 2003-06-02 | Janssen Pharmaceutica Nv | HIV-hæmmende pyrimidinderivater |
TWI241298B (en) | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
CA2350968C (en) * | 1998-11-17 | 2008-10-28 | Kumiai Chemical Industry Co., Ltd | Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicide |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
DE60035271D1 (en) | 1999-04-28 | 2007-08-02 | Inst Med Molecular Design Inc | Pyrimidincarbonsäurederivate |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
-
2003
- 2003-01-30 AR ARP030100267A patent/AR038368A1/es not_active Application Discontinuation
- 2003-01-30 TW TW092102250A patent/TW200302728A/zh unknown
- 2003-01-31 EP EP03704506A patent/EP1474146B1/en not_active Expired - Lifetime
- 2003-01-31 IL IL16276603A patent/IL162766A0/xx unknown
- 2003-01-31 AT AT03704506T patent/ATE406165T1/de active
- 2003-01-31 CA CA2471883A patent/CA2471883C/en not_active Expired - Fee Related
- 2003-01-31 MX MXPA04007395A patent/MXPA04007395A/es active IP Right Grant
- 2003-01-31 US US10/501,445 patent/US20050119255A1/en not_active Abandoned
- 2003-01-31 CN CNA038027372A patent/CN1622807A/zh active Pending
- 2003-01-31 KR KR10-2004-7011797A patent/KR20040081159A/ko not_active Application Discontinuation
- 2003-01-31 NZ NZ534229A patent/NZ534229A/en unknown
- 2003-01-31 ES ES03704506T patent/ES2312749T3/es not_active Expired - Lifetime
- 2003-01-31 AU AU2003206810A patent/AU2003206810B2/en not_active Ceased
- 2003-01-31 CN CN200910205037A patent/CN101684097A/zh active Pending
- 2003-01-31 WO PCT/EP2003/000973 patent/WO2003063871A1/en active IP Right Grant
- 2003-01-31 BR BR0307379-3A patent/BR0307379A/pt not_active IP Right Cessation
- 2003-01-31 PE PE2003000116A patent/PE20030983A1/es not_active Application Discontinuation
- 2003-01-31 RU RU2004126614/04A patent/RU2004126614A/ru not_active Application Discontinuation
- 2003-01-31 PT PT03704506T patent/PT1474146E/pt unknown
- 2003-01-31 JP JP2003563561A patent/JP4393198B2/ja not_active Expired - Fee Related
- 2003-01-31 PL PL03370666A patent/PL370666A1/xx not_active Application Discontinuation
- 2003-01-31 DE DE60323205T patent/DE60323205D1/de not_active Expired - Fee Related
-
2004
- 2004-07-30 EC EC2004005213A patent/ECSP045213A/es unknown
- 2004-08-30 NO NO20043610A patent/NO20043610L/no not_active Application Discontinuation
-
2007
- 2007-05-23 US US11/805,515 patent/US7759357B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1474146A1 (en) | 2004-11-10 |
KR20040081159A (ko) | 2004-09-20 |
PL370666A1 (en) | 2005-05-30 |
EP1474146B1 (en) | 2008-08-27 |
BR0307379A (pt) | 2004-12-28 |
CA2471883A1 (en) | 2003-08-07 |
ATE406165T1 (de) | 2008-09-15 |
PT1474146E (pt) | 2008-12-05 |
MXPA04007395A (es) | 2005-06-17 |
ECSP045213A (es) | 2004-09-28 |
RU2004126614A (ru) | 2005-05-27 |
CA2471883C (en) | 2010-12-07 |
DE60323205D1 (en) | 2008-10-09 |
PE20030983A1 (es) | 2004-01-26 |
US20050119255A1 (en) | 2005-06-02 |
JP2005516051A (ja) | 2005-06-02 |
US7759357B2 (en) | 2010-07-20 |
US20070281956A1 (en) | 2007-12-06 |
JP4393198B2 (ja) | 2010-01-06 |
IL162766A0 (en) | 2005-11-20 |
AR038368A1 (es) | 2005-01-12 |
NO20043610L (no) | 2004-10-05 |
AU2003206810B2 (en) | 2006-06-29 |
NZ534229A (en) | 2005-04-29 |
ES2312749T3 (es) | 2009-03-01 |
WO2003063871A1 (en) | 2003-08-07 |
CN101684097A (zh) | 2010-03-31 |
TW200302728A (en) | 2003-08-16 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Open date: 20050601 |