CN1600323A - 一种短棒状杆菌制剂或无细胞短棒状杆菌制剂在制备治疗hiv感染或爱滋病药剂中的应用 - Google Patents
一种短棒状杆菌制剂或无细胞短棒状杆菌制剂在制备治疗hiv感染或爱滋病药剂中的应用 Download PDFInfo
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Abstract
Description
脾指数 | 抑瘤实验 | |
CPP(甲醛灭活,实施例6) | >2.0 | 合格 |
CPP(加热煮沸灭活30分钟,实施例5) | >2.0 | 合格 |
CPP(加热煮沸灭活60分钟,实施例6) | >2.0 | 合格 |
NCP(实施例1) | >2.0 | 合格 |
NCP(实施例2) | >2.0 | 合格 |
NCP(实施例3) | >2.0 | 合格 |
NCP(实施例4) | >2.0 | 合格 |
时间 | 兔号 | NCP组 | CPP组 |
24小时 | 1# | 0.2×0.2cm无红肿、硬结 | 0.8×0.8cm红肿、硬结 |
结果 | 2# | 0.2×0.2cm无红肿、硬结 | 0.8×0.8cm红肿、硬结 |
3# | 0.2×0.2cm无红肿、硬结 | 0.8×0.8cm红肿、硬结 | |
4# | 0.2×0.2cm无红肿、硬结 | 0.8×0.8cm红肿、硬结 | |
48小时结果 | 1# | 0.2×0.2cm无红肿、硬结 | 1.0×1.0cm红肿、硬结 |
2# | 0.2×0.2cm无红肿、硬结 | 1.0×1.0cm红肿、硬结 | |
3# | 0.2×0.2cm无红肿、硬结 | 1.0×1.0cm红肿、硬结 | |
4# | 0.2×0.2cm无红肿、硬结 | 1.0×1.0cm红肿、硬结 | |
72小时结果 | 1# | 0.2×0.2cm无红肿、硬结 | 1.2×1.2cm红肿、硬结 |
2# | 0.3×0.3cm无红肿、硬结 | 1.2×1.2cm红肿、硬结 | |
3# | 0.3×0.4cm无红肿、硬结 | 1.5×1.5cm红肿、硬结 | |
4# | 0.4×0.4cm无红肿、硬结 | 1.5×1.5cm红肿、硬结 |
组别 | 动物 | 剂量 | 给药前体重 | 给药后体重第三天 第七天 | 相当临床用药倍数 |
只 | mg/kg | g | g | ||
NCP组 | 20 | 31.7 | 20.61+0.61 | 20.80+1.50 26.67+2.19 | 452.9 |
对照组 | 20 | 0 | 20.10+0.48 | 22.00+1.70 27.41+1.84 |
Claims (10)
Priority Applications (1)
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CNB031574548A CN1293919C (zh) | 2003-09-22 | 2003-09-22 | 一种短棒状杆菌制剂或无细胞短棒状杆菌制剂在制备治疗hiv感染或爱滋病药剂中的应用 |
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CNB031574548A CN1293919C (zh) | 2003-09-22 | 2003-09-22 | 一种短棒状杆菌制剂或无细胞短棒状杆菌制剂在制备治疗hiv感染或爱滋病药剂中的应用 |
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Publication Number | Publication Date |
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CN1600323A true CN1600323A (zh) | 2005-03-30 |
CN1293919C CN1293919C (zh) | 2007-01-10 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100421677C (zh) * | 2005-04-19 | 2008-10-01 | 中国药品生物制品检定所 | 一种短棒状杆菌制剂或无细胞短棒状杆菌制剂的用途 |
CN108635578A (zh) * | 2018-08-14 | 2018-10-12 | 上海创宏生物科技有限公司 | 一种猪瘟活疫苗用免疫增强剂及其制备方法 |
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2003
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100421677C (zh) * | 2005-04-19 | 2008-10-01 | 中国药品生物制品检定所 | 一种短棒状杆菌制剂或无细胞短棒状杆菌制剂的用途 |
CN108635578A (zh) * | 2018-08-14 | 2018-10-12 | 上海创宏生物科技有限公司 | 一种猪瘟活疫苗用免疫增强剂及其制备方法 |
CN108635578B (zh) * | 2018-08-14 | 2021-01-08 | 上海创宏生物科技有限公司 | 一种猪瘟活疫苗用免疫增强剂及其制备方法 |
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