CN1599734A - 作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物 - Google Patents

作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物 Download PDF

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Publication number
CN1599734A
CN1599734A CNA028240529A CN02824052A CN1599734A CN 1599734 A CN1599734 A CN 1599734A CN A028240529 A CNA028240529 A CN A028240529A CN 02824052 A CN02824052 A CN 02824052A CN 1599734 A CN1599734 A CN 1599734A
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compound
alkyl
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unsubstituted
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CNA028240529A
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Chinese (zh)
Inventor
A·G·塔韦拉斯
M·德怀尔
J·A·费雷拉
V·M·吉里亚瓦拉布汉
巢健萍
J·J·巴尔德温
J·R·梅里特
李革
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Merck Sharp and Dohme LLC
Pharmacopeia LLC
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Pharmacopeia Inc
Schering Corp
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Publication of CN1599734A publication Critical patent/CN1599734A/zh
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    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
CNA028240529A 2001-10-12 2002-10-11 作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物 Pending CN1599734A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32900501P 2001-10-12 2001-10-12
US60/329,005 2001-10-12

Publications (1)

Publication Number Publication Date
CN1599734A true CN1599734A (zh) 2005-03-23

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CNA028240529A Pending CN1599734A (zh) 2001-10-12 2002-10-11 作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物

Country Status (7)

Country Link
US (1) US6903131B2 (OSRAM)
EP (1) EP1434775A1 (OSRAM)
JP (1) JP2005505595A (OSRAM)
CN (1) CN1599734A (OSRAM)
CA (1) CA2462862A1 (OSRAM)
MX (1) MXPA04003439A (OSRAM)
WO (1) WO2003031440A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022194240A1 (en) * 2021-03-17 2022-09-22 Biofront Ltd. (Cayman) Modulators of fpr1 and methods of using the same
CN115433115A (zh) * 2022-10-17 2022-12-06 聊城大学 一种3,4-二取代马来酰亚胺类化合物及其合成方法

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MXPA04003439A (es) 2001-10-12 2004-07-08 Schering Corp Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc.
EP1485089B1 (en) * 2002-03-18 2013-04-17 Merck Sharp & Dohme Corp. Combination treatments for chemokine-mediated diseases
JP2005531622A (ja) 2002-06-28 2005-10-20 ノバルティス アクチエンゲゼルシャフト 血管沈静化合物とアルキル化剤を含む腫瘍処置用の組合せ剤
PE20040570A1 (es) * 2002-10-09 2004-08-30 Pharmacopeia Drug Discovery Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
WO2005012256A1 (en) 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
EP1694659B8 (en) 2003-12-19 2008-10-08 Schering Corporation Thiadiazoles as cxc- and cc- chemokine receptor ligands
CA2550540A1 (en) * 2003-12-22 2005-07-28 Schering Corporation Isothiazole dioxides as cxc- and cc- chemokine receptor ligands
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KR20070094963A (ko) 2005-01-10 2007-09-27 아스트라제네카 아베 간 ｘ 수용체 조절제로서 이소티아졸-3(2ｈ)-온1,1-디옥사이드 유도체
SE0500055D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 3
US8440217B1 (en) 2005-06-15 2013-05-14 Mawaheb M. EL-Naggar Method and system with contact lens product for treating and preventing adverse eye conditions
WO2007005403A1 (en) * 2005-06-29 2007-01-11 Schering Corporation 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands
MX2008000366A (es) 2005-06-29 2008-03-07 Schering Corp Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina.
RS55192B1 (sr) * 2005-11-24 2017-01-31 Dompé Farm S P A Derivati (r)-arilkilamina i farmaceutske kompozicije koje ih sadrže
CN101511809A (zh) * 2006-07-07 2009-08-19 先灵公司 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
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TW201341367A (zh) 2012-03-16 2013-10-16 Axikin Pharmaceuticals Inc ３，５－二胺基吡唑激酶抑制劑
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
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