CN1538960A - 作为激酶抑制剂的氨基-2,3-二氮杂萘酮衍生物,它们的制备方法和含有它们的药物组合物 - Google Patents
作为激酶抑制剂的氨基-2,3-二氮杂萘酮衍生物,它们的制备方法和含有它们的药物组合物 Download PDFInfo
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- CN1538960A CN1538960A CNA028154193A CN02815419A CN1538960A CN 1538960 A CN1538960 A CN 1538960A CN A028154193 A CNA028154193 A CN A028154193A CN 02815419 A CN02815419 A CN 02815419A CN 1538960 A CN1538960 A CN 1538960A
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- dihydro
- oxo
- phenyl
- urea
- benzyl
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Abstract
Description
1. | 3,5-二碘-4-羟基苯甲醛 |
2. | 3-碘代苯甲醛 |
3. | 3,5-二溴苯甲醛 |
4. | 4-溴代噻吩-2-甲醛 |
5. | 2-萘醛 |
6. | 正-乙基-咔唑-3-醛 |
7. | 4-氯-1-甲基吡唑-3-甲醛 |
8. | 乙酸(3-甲酰基-1-苯基-1H-吡唑-5-基)甲酯 |
9. | 1-乙酰基-3-吲哚甲醛 |
10. | 4-甲酰基-1-甲基吡咯-2-甲酸甲酯 |
11. | 3,5-二叔丁基-4-羟基苯甲醛 |
12. | 5-(甲硫基)-2-噻吩甲醛 |
13. | 4-(甲硫基)苯甲醛 |
14. | 3-硝基-4-(2-吡啶基硫基)苯甲醛 |
15. | 5-甲基-2-噻吩甲醛 |
16. | 3-乙酰氧基苯甲醛 |
17. | 4-二甲基苯甲醛 |
18. | 4-吡啶甲醛n-氧化物 |
19. | 4-氟-3-甲基苯甲醛 |
20. | 2,6-二氯异烟酰醛(nicotinaldehyde) |
21. | 5-(2,4-二氟苯基)-2-糠醛 |
22. | 2-(4-溴苯甲酰基)-1-苯并呋喃-5-甲醛 |
23. | 2-苯甲酰基-1-苯并呋喃-5-甲醛 |
24. | 2-丁基-4-甲酰基咪唑 |
25. | 5-苄氧基-1H-吡咯并[2,3-c]吡啶-3-甲醛 |
26. | 6-甲基-2-吡啶甲醛 |
27. | 4-[4-(叔丁基)噻唑-2-基]苯甲醛 |
28. | 5-甲酰基-2,4-二甲氧基-嘧啶 |
29. | 2-[(4-氯代苄基)硫基]嘧啶-4-甲醛 |
30. | 3-氟-2-羟基苯甲醛 |
31. | 3-羟基苯甲醛 |
32. | 3-羧基苯甲醛 |
33. | 4-乙烯基苯甲醛 |
34. | 5-(2,5-二氯苯基)-2-糠醛 |
35. | 2-氟-5-硝基苯甲醛 |
36. | 5-(4-硝基苯基)-2-糠醛 |
37. | 4-二甲基氨基苯甲醛 |
38. | 4-[3-(二甲基氨基)丙氧基]苯甲醛 |
39. | 4-正-丁基苯甲醛 |
40. | 4-(4-苄基哌嗪并)苯甲醛 |
41. | 2,2’-双噻吩-5-甲醛 |
42. | 4-[4-(1-金刚烷基)-1,3-噻唑-2-基]苯甲醛 |
43. | 4-甲酰基-反式-茋 |
44. | 6-氯代咪唑并[2,1-b][1,3]噻唑-5-甲醛 |
45. | 4-(苯基乙炔基)苯甲醛 |
46. | 3,3’-(4-甲酰基苯基亚氨基)二丙腈 |
47. | 6-甲酰基-2-(甲硫基)烟酰腈 |
48. | 4-氰基苯甲醛 |
49. | 3-[(4-甲酰基苯氧基)甲基]噻吩-2-腈 |
50. | 2-(3-甲酰基-1H-吲哚-1-基)苯甲基 |
51. | 2,6-二氟苯甲酸2-甲酰基-6-甲氧基苯基酯 |
52. | 4-甲酰基-2-甲氧基苯基碳酸叔丁酯 |
53. | 4-(二氟甲氧基)苯甲醛 |
54. | 2-[1-甲基-5-(三氟甲基)吡唑-3-基]噻吩-5-甲醛 |
55. | 5-(3-三氟甲基苯基)呋喃-2-甲醛 |
56. | 2,3-二氟-4-甲基苯甲醛 |
57. | 3-氯-5-(三氟甲基)吡啶-2-甲醛 |
58. | 4-(三氟甲氧基)苯甲醛 |
59. | 3-[(2,4-二氟苯基)硫基]-5-(三氟甲基)吡啶-2-甲醛 |
60. | 3,5-双(三氟甲基)苯甲醛 |
61. | 2,3,5,6-四氟苯甲醛 |
62. | 4-(甲基磺酰基)苯甲醛 |
63. | 1-[(4-甲基苯基)磺酰基]-1H-吲哚-3-甲醛 |
64. | 2,4,5-三氯苯磺酸4-甲酰基-2-甲氧基苯基酯 |
65. | 2,3,4,5,6-五甲基苯磺酸4-甲酰基苯基酯 |
66. | 3-(4-甲酰基苯基)-2-(吡啶-2-基磺酰基)丙烯腈 |
67. | 4-乙酰胺苯甲醛 |
68. | 4-[[5-氯-2-氧代嘧啶-1(2H)-基]甲氧基]苯甲醛 |
69. | 4-(5-甲酰基-2-呋喃基)苯-1-磺酰胺 |
70. | 3-苯并[1,3]间二氧杂环戊烯-5-基-2-甲基-丙醛 |
71. | 3-(苯硫基)丁醛 |
72. | 3-氯-4,4,4-三氟-2-苯基丁醛 |
73. | 2-氰基-2-苯乙醛 |
74. | 3-甲氧基苯乙醛 |
75. | 吡啶-3-甲醛 |
76. | 4-氯代苯甲醛 |
77. | 4-氰基苯甲醛 |
78. | 3-氟代苯甲醛 |
79. | 间-甲苯甲醛 |
80. | 2,4-二氯苯甲醛 |
81. | 喹啉-3-甲醛 |
82. | 2-(三氟甲基)苯甲醛 |
83. | 4-甲酰基苯甲酸甲酯 |
84. | 4-氯-3-氟代苯甲醛 |
85. | 4-硝基肉桂醛 |
86. | 3-噻吩甲醛 |
87. | 3-甲氧基苯甲醛 |
88. | 丙醛 |
89. | 3,3-二甲基丁醛 |
90. | 3-苯基丙醛 |
1. | 3,5-双(三氟甲基)苯甲酰氯 |
2. | 苯甲酰氯 |
3. | 2-溴苯甲酰氯 |
4. | 2-氟苯甲酰氯 |
5. | 2,4-二氟苯甲酰氯 |
6. | 2,6-二氟苯甲酰氯 |
7. | 2-氯苯甲酰氯 |
8. | 2,4-二氯苯甲酰氯 |
9. | 2-甲氧基苯甲酰氯 |
10. | 2-(三氟甲基)苯甲酰氯 |
11. | 邻-甲苯甲酰氯 |
12. | 3-溴苯甲酰氯 |
13. | 3-氟苯甲酰氯 |
14. | 3-氯苯甲酰氯 |
15. | 3,4-二氯苯甲酰氯 |
16. | 间-甲氧苯甲酰氯 |
17. | 3,4-二甲氧基苯甲酰氯 |
18. | 3,4,5-三甲氧基苯甲酰氯 |
19. | 3,5-二甲氧基苯甲酰氯 |
20. | 3-(三氟甲基)苯甲酰氯 |
21. | 间-甲苯酰氯 |
22. | 4-溴苯甲酰氯 |
23. | 4-氟苯甲酰氯 |
24. | 4-氯苯甲酰氯 |
25. | 对-甲氧苯甲酰氯 |
26. | 4-乙氧基苯甲酰氯 |
27. | 4-正丁氧基苯甲酰氯 |
28. | 4-联苯基羰基氯 |
29. | 4-(三氟甲基)苯甲酰氯 |
30. | 4-叔丁基苯甲酰氯 |
31. | 对-甲苯酰氯 |
32. | 4-乙基苯甲酰氯 |
33. | 4-正丙基苯甲酰氯 |
34. | 4-正丁基苯甲酰氯 |
35. | 新戊酰氯 |
36. | 异丁酰氯 |
37. | 2-乙基己酰氯 |
38. | 乙酰氯 |
39. | 苯氧乙酰氯 |
40. | 4-氯苯氧乙酰氯 |
41. | 甲氧基乙酰氯 |
42. | 苯基乙酰氯 |
43. | 叔丁基乙酰氯 |
44. | 异戊酰氯 |
45. | 丙酰氯 |
46. | 氢化肉桂酰氯 |
47. | 丁酰氯 |
48. | 戊酰氯 |
49. | 4-碘苯甲酰氯 |
50. | 环丙烷羰基氯 |
51. | 环丁烷羰基氯 |
52. | 环戊烷羰基氯 |
53. | 3-环戊基丙酰氯 |
54. | 环己烷羰基氯 |
55. | 4-氰基苯甲酰氯 |
56. | 2-糠酰氯 |
57. | 1-萘酰氯 |
58. | 2-萘酰氯 |
59. | 噻吩-2-羰基氯 |
60. | 噻吩-2-乙酰氯 |
61. | (3,4-二甲氧基苯基)乙酰氯 |
62. | 3,5-二氯苯甲酰氯 |
63. | 2,5-二氯苯甲酰氯 |
64. | 3,4-二氟苯甲酰氯 |
65. | 9-芴酮-4-羰基氯 |
66. | 3,5-二氟苯甲酰氯 |
67. | 苄氧基乙酰氯 |
68. | 3-氰基苯甲酰氯 |
69. | (2,5-二甲氧基苯基)乙酰氯 |
70. | 3-甲氧基苯乙酰氯 |
71. | 烟酰氯盐酸盐 |
72. | 异烟酰氯盐酸盐 |
73. | 2,4,6-三甲基苯甲酰氯 |
74. | 二苯基乙酰氯 |
75. | 2-甲基戊酰氯 |
76. | 3,4-亚甲基二氧苯甲酰氯 |
77. | 2,4-二甲氧基苯甲酰氯 |
78. | 2-苯氧基丙酰氯 |
79. | 2-苯基丁酰氯 |
80. | 2-乙基丁酰氯 |
81. | 2,3-二氯苯甲酰氯 |
82. | 4-氯苯基乙酰氯 |
83. | dl-2-甲基丁酰氯 |
84. | 2,3-二氟苯甲酰氯 |
85. | 1-(4-氯苯基)-1-环戊烷羰基氯 |
86. | 2-乙氧基-1-萘酰氯 |
87. | 苯并[b]噻吩-2-羰基氯 |
88. | 4-(三氟甲氧基)苯甲酰氯 |
89. | 2-(三氟甲氧基)苯甲酰氯 |
90. | 3-氯苯并[b]噻吩-2-羰基氯 |
91. | 2-氟-3-(三氟甲基)苯甲酰氯 |
92. | 2-氟-4-(三氟甲基)苯甲酰氯 |
93. | 2-氟-5-(三氟甲基)苯甲酰氯 |
94. | 3-氟-5-(三氟甲基)苯甲酰氯 |
95. | 4-氟-2-(三氟甲基)苯甲酰氯 |
96. | 4-氟-3-(三氟甲基)苯甲酰氯 |
97. | 2-氟-6-(三氟甲基)苯甲酰氯 |
98. | 2,3,6-三氟苯甲酰氯 |
99. | 2,4,5-三氟苯甲酰氯 |
100. | 3-(三氟甲氧基)苯甲酰氯 |
101 | 异噁唑-5-羰基氯 |
102 | 2,4,6-三氟苯甲酰氯 |
103 | 2,5-双(三氟甲基)苯甲酰氯 |
104 | 2,3,4-三氟苯甲酰氯 |
105 | 2,4,6-三氯苯甲酰氯 |
106 | 2,4-二氯-5-氟代苯甲酰氯 |
107 | 4-甲氧基苯基乙酰氯 |
108 | 5-氟-2-(三氟甲基)苯甲酰氯 |
109 | 2-氯-6-氟代苯甲酰氯 |
110 | 2-溴-5-甲氧基苯甲酰氯 |
111 | 环戊基乙酰氯 |
112 | 3-氯-4-氟代苯甲酰氯 |
113 | 3-氟-4-(三氟甲基)苯甲酰氯 |
114 | 4-氟苯基乙酰氯 |
115 | 4-叔丁基苯氧基乙酰氯 |
116 | 7-咪唑-1-基-5,6-二氢-萘-2-羰基氯 |
117 | 4-咪唑-1-基甲基-苯甲酰氯 |
118 | 4-溴-3-甲基苯甲酰氯 |
1. | 异氰酸苯酯 |
2. | 异氰酸2-溴苯酯 |
3. | 异氰酸2-氟苯酯 |
4. | 异氰酸2,4-二氟苯酯 |
5. | 异氰酸2,6-二氟苯酯 |
6. | 异氰酸2-氯苯酯 |
7. | 异氰酸2,3-二氯苯酯 |
8. | 异氰酸2,4-二氯苯酯 |
9. | 异氰酸2,5-二氯苯酯 |
10. | 异氰酸2,6-二氯苯酯 |
11. | 异氰酸2-甲氧基苯酯 |
12. | 异氰酸2,4-二甲氧基苯酯 |
13. | 异氰酸2,5-二甲氧基苯酯 |
14. | 异氰酸2-乙氧基苯酯 |
15 | 异氰酸2-(三氟甲基)苯基酯 |
16. | 异氰酸邻-甲苯基酯 |
17. | 异氰酸2,6-二甲基苯酯 |
18. | 异氰酸2-乙基苯酯 |
19. | 异氰酸3-溴苯酯 |
20. | 异氰酸3-氟苯酯 |
21. | 异氰酸3-氯苯酯 |
22. | 异氰酸3,4-二氯苯酯 |
23. | 异氰酸3-甲氧基苯酯 |
24. | 异氰酸3-(三氟甲基)苯基酯 |
25. | 异氰酸间-甲苯基酯 |
26. | 异氰酸4-溴苯酯 |
27. | 异氰酸4-氟苯酯 |
28. | 异氰酸4-氯苯酯 |
29. | 异氰酸4-甲氧基苯酯 |
30. | 异氰酸4-(三氟甲基)苯基酯 |
31. | 异氰酸对-甲苯基酯 |
32. | 异氰酸苯甲酰酯 |
33. | 异氰酸1-萘基酯 |
34. | 异氰酸苄酯 |
35. | 异氰酸3,5-双(三氟甲基)苯酯 |
36. | 异氰酸2,5-二氟苯酯 |
37. | 异氰酸2,4,5-三氯苯酯 |
38. | 异氰酸2,4,6-三氯苯酯 |
39. | 异氰酸2-异丙基苯酯 |
40. | 异氰酸2,3-二甲基苯酯 |
41. | 异氰酸4-甲氧基-2-甲基苯酯 |
42. | 异氰酸2,4-二甲基苯酯 |
43. | 异氰酸2,5-二甲基苯酯 |
44. | 异氰酸2-乙基-6-甲基苯酯 |
45. | 异氰酸3-氰基苯酯 |
46. | 异氰酸5-氯-2,4-二甲氧基苯酯 |
47. | 异氰酸3-氯-4-甲基苯酯 |
48. | 异氰酸3,5-二氯苯酯 |
49. | 异氰酸5-氯-2-甲氧基苯酯 |
50. | 异氰酸3,4,5-三甲氧基苯酯 |
51. | 异氰酸3,5-二甲氧基苯酯 |
52. | 异氰酸3-(甲硫基)苯酯 |
53. | 异氰酸3-乙酰基苯酯 |
54. | 异氰酸3,4-二甲基苯酯 |
55. | 异氰酸3,5-二甲基苯酯 |
56. | 异氰酸2-甲氧基-5-甲基苯酯 |
57. | 异氰酸3-乙基苯酯 |
58. | 异氰酸4-溴-2-(三氟甲基)苯酯 |
59. | 异氰酸4-氯-2-(三氟甲基)苯酯 |
60. | 异氰酸4-氯-3-(三氟甲基)苯酯 |
61. | 异氰酸4-碘苯酯 |
62. | 异氰酸4-苯氧基苯酯 |
63. | 异氰酸4-乙氧基苯酯 |
64. | 异氰酸4-乙酰基苯酯 |
65. | 异氰酸4-异丙基苯酯 |
66. | 异氰酸4-乙基苯酯 |
67. | 异氰酸4-正丁基苯酯 |
68. | 异氰酸2,4,6-三甲基苯酯 |
69. | 异氰酸2-异丙基-6-甲基苯酯 |
70. | 异氰酸2,6-二乙基苯酯 |
71. | 异氰酸5-氯-2-甲基苯酯 |
72. | 异氰酸4-氯-2-甲基苯酯 |
73. | 异氰酸4-(三氟甲氧基)苯酯 |
74. | 异氰酸2-氯-5-(三氟甲基)苯酯 |
75. | 异氰酸2-氯-6-甲基苯酯 |
76. | 异氰酸2,4,5-三甲基苯酯 |
77. | 异氰酸3-氯-2-甲氧基苯酯 |
78. | 异氰酸3-氯-2-甲基苯酯 |
79. | 异氰酸3-氯-4-氟苯酯 |
80. | 异氰酸4-溴-2-甲基苯酯 |
81. | 异氰酸4-溴-2,6-二甲基苯酯 |
82. | 异氰酸2,6-二溴-4-氟苯酯 |
83. | 异氰酸4-丁氧基苯酯 |
84. | 异氰酸3-氟-4-甲基苯酯 |
85. | 异氰酸5-氟-2-甲基苯酯 |
86. | 异氰酸2-联苯基酯 |
87. | 异氰酸4-联苯基酯 |
88. | 异氰酸2-溴-4,6-二氟苯酯 |
89. | 异氰酸(r)-(+)-1-苯基乙酯 |
90. | 异氰酸1-(1-萘基)乙酯 |
91. | 异氰酸(s)-(+)-1-(1-萘基)乙酯 |
92. | 异氰酸3,4-二氟苯酯 |
93. | 异氰酸2-(三氟甲氧基)苯酯 |
94. | 异氰酸4-苄基氧基苯酯 |
95. | 异氰酸4-溴-2-氯苯酯 |
96. | 异氰酸4-溴-2-氟苯酯 |
97. | 异氰酸2-氟-5-甲基苯酯 |
98. | 异氰酸2,3,4-三氟苯酯 |
99. | 异氰酸2-(二氟甲氧基)苯酯 |
100. | 异氰酸4-(二氟甲氧基)苯酯 |
101. | 异氰酸2-甲基苄酯 |
102. | 异氰酸2-氯苄酯 |
103. | 异氰酸4-氟苄酯 |
104. | 异氰酸4-甲氧基苄酯 |
105. | 异氰酸2,6-二氟苯甲酰酯 |
106. | 异氰酸4-氟苯甲酰酯 |
107. | 异氰酸2-氟-3-(三氟甲基)苯酯 |
108. | 异氰酸2-氟-5-(三氟甲基)苯酯 |
109. | 异氰酸2-氟-6-(三氟甲基)苯酯 |
110. | 异氰酸4-氟-2-(三氟甲基)苯酯 |
111. | 异氰酸2-(叔丁基)苯酯 |
112. | 异氰酸3-吡啶基酯 |
Claims (38)
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CNA2007101101264A Pending CN101085759A (zh) | 2001-08-07 | 2002-07-30 | 作为激酶抑制剂的氨基-2,3-二氮杂萘酮衍生物,它们的制备方法和含有它们的药物组合物 |
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CNA2007101101264A Pending CN101085759A (zh) | 2001-08-07 | 2002-07-30 | 作为激酶抑制剂的氨基-2,3-二氮杂萘酮衍生物,它们的制备方法和含有它们的药物组合物 |
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US (2) | US20030073692A1 (zh) |
EP (1) | EP1427708B1 (zh) |
JP (1) | JP2005501085A (zh) |
KR (1) | KR20040029400A (zh) |
CN (2) | CN1538960A (zh) |
AT (1) | ATE407928T1 (zh) |
BR (1) | BR0211807A (zh) |
CA (1) | CA2455759A1 (zh) |
CO (1) | CO5560573A2 (zh) |
CZ (1) | CZ2004305A3 (zh) |
DE (1) | DE60228857D1 (zh) |
DK (1) | DK1427708T3 (zh) |
EA (1) | EA006645B1 (zh) |
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IL (1) | IL159843A0 (zh) |
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NO (1) | NO20040547L (zh) |
NZ (1) | NZ531310A (zh) |
PL (1) | PL368440A1 (zh) |
PT (1) | PT1427708E (zh) |
SI (1) | SI1427708T1 (zh) |
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ZA (1) | ZA200401316B (zh) |
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CN107298640A (zh) * | 2017-07-19 | 2017-10-27 | 曲阜师范大学 | 一种亚甲基酮化合物的制备方法及其应用 |
WO2023143210A1 (zh) * | 2022-01-26 | 2023-08-03 | 上海优理惠生医药有限公司 | 一种酞嗪酮类化合物、其制备方法、包含其药物组合物及其应用 |
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JP2009530330A (ja) * | 2006-03-20 | 2009-08-27 | エフ.ホフマン−ラ ロシュ アーゲー | フタラジノンピラゾール誘導体、その製造および医薬品としての使用 |
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JP2010505961A (ja) * | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
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EP0600831A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Phthalazinonderivate |
EP0634404A1 (en) * | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
JPH0961961A (ja) * | 1995-08-21 | 1997-03-07 | Fuji Photo Film Co Ltd | 熱現像感光材料 |
CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
EP0875512A3 (en) | 1997-04-16 | 1999-04-07 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New naphthylpiperazine derivatives with antipsychotic activity |
KR20020005662A (ko) * | 1999-04-09 | 2002-01-17 | 기따자또 이찌로 | 질소함유 복소환화합물 및 벤즈아미드화합물 및 그 것을함유해서 되는 의약 |
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2001
- 2001-08-07 US US09/922,729 patent/US20030073692A1/en not_active Abandoned
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- 2002-07-30 KR KR10-2004-7001814A patent/KR20040029400A/ko not_active Application Discontinuation
- 2002-07-30 EP EP02758416A patent/EP1427708B1/en not_active Expired - Lifetime
- 2002-07-30 EA EA200400283A patent/EA006645B1/ru not_active IP Right Cessation
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- 2002-07-30 DE DE60228857T patent/DE60228857D1/de not_active Expired - Fee Related
- 2002-07-30 MX MXPA04000905A patent/MXPA04000905A/es unknown
- 2002-07-30 CZ CZ2004305A patent/CZ2004305A3/cs unknown
- 2002-07-30 US US10/486,463 patent/US7432263B2/en not_active Expired - Fee Related
- 2002-07-30 ES ES02758416T patent/ES2315385T3/es not_active Expired - Lifetime
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103058927A (zh) * | 2011-10-21 | 2013-04-24 | 华国媛 | 一种喹啉衍生物及其应用 |
CN103058927B (zh) * | 2011-10-21 | 2015-04-22 | 华国媛 | 一种喹啉衍生物及其应用 |
CN107298640A (zh) * | 2017-07-19 | 2017-10-27 | 曲阜师范大学 | 一种亚甲基酮化合物的制备方法及其应用 |
CN107298640B (zh) * | 2017-07-19 | 2020-08-04 | 曲阜师范大学 | 一种亚甲基酮化合物的制备方法及其应用 |
WO2023143210A1 (zh) * | 2022-01-26 | 2023-08-03 | 上海优理惠生医药有限公司 | 一种酞嗪酮类化合物、其制备方法、包含其药物组合物及其应用 |
Also Published As
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ZA200401316B (en) | 2005-03-10 |
JP2005501085A (ja) | 2005-01-13 |
DK1427708T3 (da) | 2008-11-24 |
US20050020583A1 (en) | 2005-01-27 |
EA006645B1 (ru) | 2006-02-24 |
EP1427708A1 (en) | 2004-06-16 |
PL368440A1 (en) | 2005-03-21 |
CN101085759A (zh) | 2007-12-12 |
CZ2004305A3 (cs) | 2004-08-18 |
PT1427708E (pt) | 2008-11-20 |
WO2003014090A1 (en) | 2003-02-20 |
NO20040547L (no) | 2004-03-03 |
IL159843A0 (en) | 2004-06-20 |
ATE407928T1 (de) | 2008-09-15 |
EA200400283A1 (ru) | 2004-08-26 |
CO5560573A2 (es) | 2005-09-30 |
MXPA04000905A (es) | 2004-04-02 |
BR0211807A (pt) | 2004-09-21 |
NZ531310A (en) | 2006-02-24 |
US7432263B2 (en) | 2008-10-07 |
CA2455759A1 (en) | 2003-02-20 |
SI1427708T1 (sl) | 2008-12-31 |
KR20040029400A (ko) | 2004-04-06 |
US20030073692A1 (en) | 2003-04-17 |
EP1427708B1 (en) | 2008-09-10 |
DE60228857D1 (de) | 2008-10-23 |
ES2315385T3 (es) | 2009-04-01 |
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