CN1511141B - 10,11-二氢-10-羟基-5H-二苯并[b,f]吖庚因-5-甲酰胺及10,11-二氢-10-氧-5H-二苯并[b,f]吖庚因-5-甲酰胺的制备方法 - Google Patents

10,11-二氢-10-羟基-5H-二苯并[b,f]吖庚因-5-甲酰胺及10,11-二氢-10-氧-5H-二苯并[b,f]吖庚因-5-甲酰胺的制备方法 Download PDF

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Publication number
CN1511141B
CN1511141B CN028105915A CN02810591A CN1511141B CN 1511141 B CN1511141 B CN 1511141B CN 028105915 A CN028105915 A CN 028105915A CN 02810591 A CN02810591 A CN 02810591A CN 1511141 B CN1511141 B CN 1511141B
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CN
China
Prior art keywords
dibenzo
dihydro
azepine
carboxamide
reaction
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN028105915A
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English (en)
Chinese (zh)
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CN1511141A (zh
Inventor
大卫·亚历山大·利尔茅斯
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Bial Portela and Cia SA
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Bial Portela and Cia SA
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Publication of CN1511141A publication Critical patent/CN1511141A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
CN028105915A 2001-05-25 2002-05-22 10,11-二氢-10-羟基-5H-二苯并[b,f]吖庚因-5-甲酰胺及10,11-二氢-10-氧-5H-二苯并[b,f]吖庚因-5-甲酰胺的制备方法 Expired - Fee Related CN1511141B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0112812.3A GB0112812D0 (en) 2001-05-25 2001-05-25 Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
GB0112812.3 2001-05-25
PCT/GB2002/002356 WO2002096881A1 (en) 2001-05-25 2002-05-22 Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101939981A Division CN101172967A (zh) 2001-05-25 2002-05-22 由10,11－二氢－10－羟基－5H－二苯并[b,f]吖庚因－5－甲酰胺制备10,11－二氢－10－氧－5H－二苯并[b,f]吖庚因－5－甲酰胺的方法

Publications (2)

Publication Number Publication Date
CN1511141A CN1511141A (zh) 2004-07-07
CN1511141B true CN1511141B (zh) 2011-06-08

Family

ID=9915332

Family Applications (2)

Application Number Title Priority Date Filing Date
CN028105915A Expired - Fee Related CN1511141B (zh) 2001-05-25 2002-05-22 10,11-二氢-10-羟基-5H-二苯并[b,f]吖庚因-5-甲酰胺及10,11-二氢-10-氧-5H-二苯并[b,f]吖庚因-5-甲酰胺的制备方法
CNA2007101939981A Pending CN101172967A (zh) 2001-05-25 2002-05-22 由10,11－二氢－10－羟基－5H－二苯并[b,f]吖庚因－5－甲酰胺制备10,11－二氢－10－氧－5H－二苯并[b,f]吖庚因－5－甲酰胺的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2007101939981A Pending CN101172967A (zh) 2001-05-25 2002-05-22 由10,11－二氢－10－羟基－5H－二苯并[b,f]吖庚因－5－甲酰胺制备10,11－二氢－10－氧－5H－二苯并[b,f]吖庚因－5－甲酰胺的方法

Country Status (23)

Country Link
US (1) US7241886B2 (cg-RX-API-DMAC10.html)
EP (2) EP1399424B8 (cg-RX-API-DMAC10.html)
JP (3) JP4323309B2 (cg-RX-API-DMAC10.html)
KR (1) KR100931916B1 (cg-RX-API-DMAC10.html)
CN (2) CN1511141B (cg-RX-API-DMAC10.html)
AR (1) AR035460A1 (cg-RX-API-DMAC10.html)
AT (2) ATE506351T1 (cg-RX-API-DMAC10.html)
AU (2) AU2002307863B8 (cg-RX-API-DMAC10.html)
BR (1) BR0210019A (cg-RX-API-DMAC10.html)
CA (2) CA2448094C (cg-RX-API-DMAC10.html)
CY (3) CY1108345T1 (cg-RX-API-DMAC10.html)
CZ (1) CZ303130B6 (cg-RX-API-DMAC10.html)
DE (2) DE60227517D1 (cg-RX-API-DMAC10.html)
DK (2) DK1399424T3 (cg-RX-API-DMAC10.html)
ES (2) ES2362688T3 (cg-RX-API-DMAC10.html)
GB (1) GB0112812D0 (cg-RX-API-DMAC10.html)
HU (1) HU230019B1 (cg-RX-API-DMAC10.html)
LU (1) LU91603I2 (cg-RX-API-DMAC10.html)
MX (1) MXPA03010793A (cg-RX-API-DMAC10.html)
PL (1) PL215305B1 (cg-RX-API-DMAC10.html)
RU (2) RU2311411C2 (cg-RX-API-DMAC10.html)
SI (1) SI1399424T1 (cg-RX-API-DMAC10.html)
WO (1) WO2002096881A1 (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0303615D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
ITMI20042230A1 (it) 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ITMI20042291A1 (it) 2004-11-26 2005-02-26 Farchema S R L Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
GB2422149A (en) * 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
CA2769181C (en) 2009-07-27 2017-11-28 Bial-Portela & Ca., S.A. Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (cg-RX-API-DMAC10.html) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
US12492423B2 (en) 2015-09-16 2025-12-09 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
DK3350343T3 (da) 2015-09-16 2020-07-20 Petaomics Inc Fremgangsmåder og sammensætninger til genommålberigelse og selektiv dna-sekventering
CN111943347B (zh) * 2020-07-16 2022-08-30 同济大学 一种铜离子活化过氧乙酸去除废水中卡马西平的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439390B2 (cg-RX-API-DMAC10.html) * 1971-09-30 1979-11-27
BE789320A (fr) * 1971-09-30 1973-03-27 Takeda Chemical Industries Ltd Derives de dibenzoxirenazepine
CH633271A5 (en) 1978-04-18 1982-11-30 Ciba Geigy Ag Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines
CH642950A5 (en) 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
AT408224B (de) 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von oxcarbazepin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. OF MED. CHEMISTRYVol.16 No.6.1973,16(6),P703-705. *
REACTIVE & FUNCTIONAL POLYMERSVol.40 No.2.1999,40(2),P155-168. *

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DK1399424T3 (da) 2008-09-08
CA2448094C (en) 2011-11-01
EP1958938B1 (en) 2011-04-20
RU2007120532A (ru) 2008-12-10
CY2009017I1 (el) 2012-01-25
HUP0400296A3 (en) 2008-03-28
JP2004532263A (ja) 2004-10-21
AU2007221834B2 (en) 2009-02-05
EP1399424B1 (en) 2008-07-09
CA2750876C (en) 2014-10-28
WO2002096881A1 (en) 2002-12-05
JP4323309B2 (ja) 2009-09-02
CY1108345T1 (el) 2012-01-25
EP1958938A2 (en) 2008-08-20
CN101172967A (zh) 2008-05-07
EP1958938A3 (en) 2008-09-03
DK1958938T3 (da) 2011-07-25
JP5280252B2 (ja) 2013-09-04
CZ303130B6 (cs) 2012-04-18
EP1399424A1 (en) 2004-03-24
US20040158060A1 (en) 2004-08-12
AU2002307863B2 (en) 2007-09-27
BR0210019A (pt) 2004-08-10
HUP0400296A2 (hu) 2004-08-30
WO2002096881A8 (en) 2003-02-27
LU91603I2 (fr) 2009-10-28
RU2003137224A (ru) 2005-05-27
DE60239842D1 (de) 2011-06-01
PL366993A1 (en) 2005-02-07
RU2449992C2 (ru) 2012-05-10
CA2750876A1 (en) 2002-12-05
JP2009167194A (ja) 2009-07-30
MXPA03010793A (es) 2004-07-01
PL215305B1 (pl) 2013-11-29
SI1399424T1 (sl) 2008-10-31
AU2007221834A1 (en) 2007-10-25
US7241886B2 (en) 2007-07-10
AU2002307863B8 (en) 2007-10-18
RU2311411C2 (ru) 2007-11-27
ES2305299T3 (es) 2008-11-01
ES2362688T3 (es) 2011-07-11
HU230019B1 (hu) 2015-05-28
JP2009057376A (ja) 2009-03-19
KR20040030626A (ko) 2004-04-09
AR035460A1 (es) 2004-05-26
KR100931916B1 (ko) 2009-12-15
CZ20033203A3 (cs) 2004-06-16
CY2009017I2 (el) 2012-01-25
CN1511141A (zh) 2004-07-07
ATE400560T1 (de) 2008-07-15
ATE506351T1 (de) 2011-05-15
DE60227517D1 (de) 2008-08-21
CA2448094A1 (en) 2002-12-05
EP1399424B8 (en) 2008-10-01
GB0112812D0 (en) 2001-07-18
CY1111492T1 (el) 2015-08-05

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Granted publication date: 20110608

Termination date: 20190522