CN1450896A - 用吲哚衍生物降低眼内压的方法 - Google Patents

用吲哚衍生物降低眼内压的方法 Download PDF

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Publication number
CN1450896A
CN1450896A CN01815096A CN01815096A CN1450896A CN 1450896 A CN1450896 A CN 1450896A CN 01815096 A CN01815096 A CN 01815096A CN 01815096 A CN01815096 A CN 01815096A CN 1450896 A CN1450896 A CN 1450896A
Authority
CN
China
Prior art keywords
indole
unsubstituted
alkynyl
acetylaminohydroxyphenylarsonic acid
acid ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01815096A
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English (en)
Chinese (zh)
Inventor
J·J·平特
M·A·佩拉尔
W·M·彼德森
R·小普罗德
E·G·布朗
B·R·耶扎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madrid Commscope Rutan Adams University
Inspire Pharmaceuticals Inc
Original Assignee
Madrid Commscope Rutan Adams University
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200001916A external-priority patent/ES2172415B2/es
Application filed by Madrid Commscope Rutan Adams University, Inspire Pharmaceuticals Inc filed Critical Madrid Commscope Rutan Adams University
Publication of CN1450896A publication Critical patent/CN1450896A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN01815096A 2000-07-28 2001-07-27 用吲哚衍生物降低眼内压的方法 Pending CN1450896A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200001916 2000-07-28
ES200001916A ES2172415B2 (es) 2000-07-28 2000-07-28 Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina.
US27688501P 2001-03-16 2001-03-16
US60/276,885 2001-03-16

Publications (1)

Publication Number Publication Date
CN1450896A true CN1450896A (zh) 2003-10-22

Family

ID=26156193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01815096A Pending CN1450896A (zh) 2000-07-28 2001-07-27 用吲哚衍生物降低眼内压的方法

Country Status (9)

Country Link
EP (1) EP1307191A2 (ko)
JP (1) JP2004518612A (ko)
KR (1) KR20030046395A (ko)
CN (1) CN1450896A (ko)
AR (1) AR035651A1 (ko)
AU (1) AU2001280984A1 (ko)
CA (1) CA2417489A1 (ko)
MX (1) MXPA03000729A (ko)
WO (1) WO2002009702A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102712584A (zh) * 2009-11-23 2012-10-03 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084128B2 (en) 2002-01-18 2006-08-01 Inspire Pharmaceuticals, Inc. Method for reducing intraocular pressure
ES2298508T3 (es) 2002-03-26 2008-05-16 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos.
CN1684701B (zh) 2002-07-30 2012-10-17 奥默罗斯公司 眼科冲洗液及方法
CN1678306A (zh) * 2002-08-29 2005-10-05 贝林格尔·英格海姆药物公司 在炎性、变应性和增生性疾病中用作糖皮质激素模拟物的3－(磺酰氨基乙基)－吲哚衍生物
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7326683B2 (en) 2004-05-06 2008-02-05 Molichem Medicines, Inc. Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
EP1753445A4 (en) 2004-05-06 2009-05-20 Molichem Medicines Inc TREATMENT OF EYE DISEASES AND EYE TREATMENTS WITH LANTIBIOTIC COMPOSITIONS
EP1836166B1 (en) 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP2102170A2 (en) 2006-12-06 2009-09-23 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN101790381B (zh) 2007-08-28 2014-08-27 巴克斯特国际公司 生产病毒疫苗的方法
ATE541846T1 (de) 2008-06-06 2012-02-15 Boehringer Ingelheim Int Glucocorticoidmimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und anwendungen davon
ME02608B (me) 2010-01-11 2017-06-20 Inotek Pharmaceuticals Corp Kombinacija, komplet i postupak snižavanja intraokularnog pritiska
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
RS56150B1 (sr) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
JP2016513706A (ja) 2013-03-15 2016-05-16 イノテック ファーマシューティカルズ コーポレイション 点眼用製剤
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
JP2022508648A (ja) 2018-10-05 2022-01-19 アンナプルナ バイオ インコーポレイテッド Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物
EP4208446A4 (en) * 2020-09-02 2024-10-30 Enveric Biosciences Canada Inc NITRATED PSILOCYBIN DERIVATIVES AND USE THEREOF FOR MODULATION OF THE 5-HT2A RECEPTOR AND FOR TREATMENT OF A PSYCHIATRIC ILLNESS
WO2023044556A1 (en) 2021-09-24 2023-03-30 Enveric Biosciences Canada Inc. Aminated psilocybin derivatives and methods of using
IL312547A (en) 2021-11-02 2024-07-01 Flare Therapeutics Inc PPARG inverse agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654361A (en) * 1986-01-27 1987-03-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Method of lowering intraocular pressure using melatonin
WO1989001472A1 (en) * 1987-08-17 1989-02-23 Nelson Research & Development Co. Melatonin analogues
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
FR2737725B1 (fr) * 1995-08-08 1997-10-31 Valentonine Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102712584A (zh) * 2009-11-23 2012-10-03 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法
CN102712584B (zh) * 2009-11-23 2014-10-29 阿勒根公司 晶型ii的7-[3,5-二羟基-2-(3-羟基-5-苯基-戊-1-烯基)-环戊基]-n-乙基-庚-5-烯酰胺(比马前列素)、其制备方法和使用方法

Also Published As

Publication number Publication date
WO2002009702A3 (en) 2002-12-27
AR035651A1 (es) 2004-06-23
WO2002009702A2 (en) 2002-02-07
WO2002009702A8 (en) 2003-05-08
KR20030046395A (ko) 2003-06-12
EP1307191A2 (en) 2003-05-07
CA2417489A1 (en) 2002-02-07
JP2004518612A (ja) 2004-06-24
AU2001280984A1 (en) 2002-02-13
MXPA03000729A (es) 2004-11-01

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication